Provided are surface modified contact lenses formed from one or more fumaric-or itaconic-containing prepolymers having reactive functionality that is complimentary to reactive hydrophilic polymers.
대표청구항▼
What is claimed is: 1. A method of forming a surface modified medical device, the method comprising: providing a medical device comprising a copolymer prepared by polymerizing a monomer mixture comprising, (A) 20 to 80 weight % of at least one prepolymer selected from the group consisting of compou
What is claimed is: 1. A method of forming a surface modified medical device, the method comprising: providing a medical device comprising a copolymer prepared by polymerizing a monomer mixture comprising, (A) 20 to 80 weight % of at least one prepolymer selected from the group consisting of compounds having the following formula: YCO--CH═CHCOW(R1)n(SiR2R3O)m (SiR2R3)(R1)nWOCCH═CH--COY and CH2 ═C(CH2COY)COW(R1)n(SiR2R 3O)m(SiR2R3)(R1)n WOC(CH2COY)C═CH2 wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are independently selected from the group consisting of alkyl groups, phenyl groups, alkyl groups substituted with halogen, phenyl groups substituted with halogen, alkyl groups containing ether linkages and phenyl groups containing ether linkages, W is O or NH, n is an integer between 1 and 10, m is an integer between 2 and 200, and Y is a residue having a reactive functional group selected from the group consisting of hydroxyl, carboxyl, oxazolone, epoxy and anhydride functional groups, and (B) 5 to 50 weight % of at least one copolymerizable device-forming monomer, contacting a surface of the device with a solution containing a surface modifying agent having functionality complementary to the functionalized silicone-containing copolymer; and subjecting the device surface and surface modifying agent to reaction conditions suitable for forming a covalent bond between the functionalized silicone-containing copolymer and the surface modifying agent having functionality complementary to the functionalized silicone-containing copolymer while the surface modifying agent is in contact with the device surface to form a surface modified medical device. 2. The method of claim 1 wherein R1 contains 1 to 10 carbon atoms. 3. The method of claim 1 wherein the copolymer prepared by polymerizing a monomer mixture further comprises, 10 to 50 weight % of at least one additional silicone-containing monomer and 10 to 50 weight % of at least one copolymerizable device-forming hydrophilic monomer. 4. The method of claim 1 wherein, component (A) has the following formula: YCO--CH═CHCOW(R1)n(SiR2R3O)m (SiR2R3)(R1)nWOCCH═CH--COY wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, n is 4, m is an integer between 5 and 200, W is O, and Y is OH and is in a trans configuration. 5. The method of claim 1 wherein, component (A) has the following formula: CH2 ═C(CH2COY)COW(R1)n(SiR2R 3O)m(SiR2R3)(R1)n WOC(CH2COY)C═CH2 wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, n is 4, m is an integer between 5 and 200, W is O, and Y is OH. 6. The method of claim 1 wherein, component (A) has the following formula: YCO--CH═CHCOW(R1)n(SiR2R3O)m (SiR2R3)(R1)nWOCCH═CH--COY wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, n is 4, m is an integer between 5 and 200, W is O, and Y is OH and is in a cis configuration. 7. The method of claim 1 wherein the medical device formed is selected from the group consisting of heart valves, intraocular lenses, contact lenses, intrauterine devices, vessel substitutes, artificial ureters and artificial breast tissue. 8. The method of claim 7 wherein the medical device formed is a contact lens. 9. The method of claim 8 wherein the medical device formed is a soft contact lens. 10. The method of claim 3 wherein, component (A) has the following formula: YCO--CH═CHCOW(R1)n(SiR2R3O)m (SiR2R3)(R1)nWOCCH═CH--COY wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, n is 4, m is an integer between 5 and 200, W is O and Y is OH and is in a trans configuration. 11. The method of claim 3 wherein, component (A) has the following formula: CH2 ═C(CH2COY)COW(R1)n(SiR2R 3O)m(SiR2R3)(R1)n WOC(CH2COY)C═CH2 wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, n is 4, m is an integer between 5 and 200, W is O and Y is OH. 12. The method of claim 3 wherein, component (A) has the following formula: YCO--CH═CHCOW(R1)n(SiR2R3O)m (SiR2R3)(R1)nWOCCH═CH--COY wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, n is 4, m is an integer between 5 and 200, W is O, and Y is OH and is in a cis configuration. 13. The method of claim 3 wherein the medical device formed is selected from the group consisting of heart valves, intraocular lenses, contact lenses, intrauterine devices, vessel substitutes, artificial ureters and artificial breast tissue. 14. The method of claim 13 wherein the medical device formed is a contact lens. 15. The method of claim 14 wherein the medical device formed is a soft contact lens.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (40)
Vanderlaan Douglas G. ; Turner David C. ; Wood Joe M., Biomedical devices with hydrophilic coatings.
Bambury Ronald E. (63 Matthew Dr. Fairport NY 14450) Choo Dong J. (Department of Chemistry ; Kyung-Hee University Dongdaemun-ku ; Seoul ; 131 KRX), Hydrophilic oxygen permeable polymers.
Appleton William J. (Rochester NY) Hahn Dennis (Rochester NY) Moucha William E. (Bergen NY) Ruscio Dominic V. (Webster NY) Shannon John H. (Hamlin NY) Silbermann Steven D. (Rochester NY) Weaver ; Jr., Method for molding lenses.
Gagnon David R. (St. Paul MN) Coleman Patrick L. (Minneapolis MN) Ortina Gary J. (Woodbury MN) Lyons Christopher S. (St. Paul MN) Milbrath Dean S. (West Lakeland Township ; Washington County MN) Rasm, Porous supports having azlactone-functional surfaces.
Mazurek Mieczyslaw H. (Roseville MN) Kantner Steven S. (St. Paul MN) Kinning David J. (Woodbury MN) Bogaert Yvan A. (Ghent BEX), Radiation-curable acrylate/silicone pressure-sensitive adhesive compositions.
McGee, Joseph A.; Valint, Jr., Paul L.; Bonafini, Jr., James A., Renewable surface treatment of silicone medical devices with reactive hydrophilic polymers.
O\Lenick ; Jr. Anthony J. (Lilburn GA) Parkinson Jeff K. (Lawrenceville GA) Torbush Robert T. (Snellville GA), Silicone alkoxylated esters carboxylates.
Mueller Karl F. (New York NY) Heiber Sonia J. (Bedford Hills NY) Plankl Walter L. (Yorktown Heights NY), Strong, silicone containing polymers with high oxygen permeability.
Paul L. Valint, Jr. ; Joseph A. McGee ; Joseph C. Salamone ; Ricahrd M. Ozark, Surface treatment of silicone medical devices with reactive hydrophilic polymers.
Su Kai C. (Alpharetta GA) Robertson J. Richard (Alpharetta GA), Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing block copolymer polysiloxane-p.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.