Multicolumn selectivity inversion generator for production of high purity actinium for use in therapeutic nuclear medicine
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C22B-060/00
C01G-057/00
출원번호
US-0261031
(2002-09-30)
발명자
/ 주소
Bond,Andrew H.
Horwitz,E. Philip
McAlister,Daniel R.
출원인 / 주소
PG Research Foundation
대리인 / 주소
Welsh &
인용정보
피인용 횟수 :
10인용 특허 :
13
초록▼
A multicolumn selectivity inversion generator separation method has been developed in which actinium ions, a desired daughter radionuclide, are selectively extracted from a solution of the thorium parent and daughter radionuclides by a primary separation column, stripped, and passed through a second
A multicolumn selectivity inversion generator separation method has been developed in which actinium ions, a desired daughter radionuclide, are selectively extracted from a solution of the thorium parent and daughter radionuclides by a primary separation column, stripped, and passed through a second guard column that retains any parent or other daughter interferents, while the desired daughter actinium ions and radium ions elute. This separation method minimizes the effects of radiation damage to the separation material and permits the reliable production of radionuclides of high chemical and radionuclidic purity for use in diagnostic or therapeutic nuclear medicine.
대표청구항▼
What is claimed: 1. A method for producing a solution of actinium and optionally present radium daughter radionuclide ions that is substantially free of thorium parental radionuclide ion impurities comprising the steps of: (a) contacting an aqueous parent-daughter radionuclide ion solution having a
What is claimed: 1. A method for producing a solution of actinium and optionally present radium daughter radionuclide ions that is substantially free of thorium parental radionuclide ion impurities comprising the steps of: (a) contacting an aqueous parent-daughter radionuclide ion solution having a pH value of about 8 or less that contains sulfate ions as well as thorium parental radionuclide ions and actinium and optionally present radium desired daughter radionuclide ions with a first solid phase separation medium having a high affinity for the desired daughter radionuclide ions and a low affinity for the parent radionuclide ions, and maintaining that contact for a time period sufficient for said actinium and optionally present radium ions to be bound to form a desired daughter ion-laden first separation medium and a thorium ion-containing, desired daughter-depleted parent-daughter solution; (b) separating the thorium ion-containing desired daughter-depleted parent-daughter solution from the solid phase desired daughter ion-laden first separation medium; (c) stripping the desired daughter radionuclide from the desired daughter-laden first separation medium with an aqueous nitric or hydrochloric acid solution to form an aqueous nitric or hydrochloric acid solution of actinium and optionally present radium desired daughter radionuclide ions that may contain trace amounts of parental thorium ion impurities; (d) contacting said aqueous nitric or hydrochloric acid solution of actinium and optionally present radium desired daughter radionuclide ions that may contain trace amounts of parental thorium ion impurities of step (c) with a second solid phase separation medium that has a high affinity for the parent thorium radionuclide ions and a low affinity for the actinium and optionally present radium desired daughter radionuclide, and maintaining that contact for a time period sufficient for the parent thorium radionuclide to be bound by the second solid phase separation medium to form a solution of actinium and optionally present radium desired daughter radionuclide ions that is highly purified and is substantially free of thorium parental radionuclide ion impurities; and (e) separating the solid and solution phases to provide a solution of actinium and optionally present radium desired daughter radionuclide ions that is highly purified and is substantially free of thorium parental radionuclide ion impurities. 2. The method according to claim 1 wherein the decontamination factor of the first separation medium is about 102 or greater for the actinium desired daughter from the thorium parent radionuclide impurities under the conditions of contact. 3. The method according to claim 1 wherein said first separation medium is particulate. 4. The method according to claim 3 wherein said separation medium is comprised of a water-insoluble polymeric sulfonate group-containing cation-exchange resin. 5. A method f or producing a solution of actinium and optionally present radium daughter radionuclide ions that is substantially free of thorium parental ion impurities comprising the steps of: (a) contacting an aqueous parent-daughter radionuclide ion solution having a pH value of about 8 or less that contains sulfate ions as well as thorium parental radionuclide ions and actinium and optionally present radium desired daughter radionuclide ions with a first solid phase separation medium that provides a decontamination factor of about 102 or greater for the actinium and optionally present radium desired daughter ions from the thorium parent ion impurities under the conditions of contact, said separation medium comprising water-insoluble polymeric sulfonate group-containing cation-exchange resin particles, and maintaining that contact for a time period sufficient for said actinium and optionally present radium ions to be bound by the solid phase first separation medium to form desired daughter ion-laden separation medium and a thorium ion-containing, desired daughter-depleted parent-daughter solution; (b) separating the thorium ion-containing, desired daughter-depleted parent-daughter solution from the solid phase desired daughter ion-laden separation medium; (c) stripping the desired daughter radionuclide from the desired daughter-laden separation medium with an aqueous nitric or hydrochloric acid solution to form an aqueous nitric or hydrochloric acid solution of actinium and optionally present radium desired daughter radionuclide ions that may contain trace amounts of parental thorium ion impurities; (d) contacting said aqueous nitric or hydrochloric acid solution of actinium and optionally present radium desired daughter radionuclide ions that may contain trace amounts of parental thorium ion impurities of step (c) with a second solid phase separation medium that provides a decontamination factor of about 102 or greater for the actinium and optionally present radium desired daughter ions from the thorium parent ion impurities under the conditions of contact, and maintaining that contact for a time period sufficient for the parent thorium radionuclide that may be present to be bound by the second solid phase separation medium to form a solution of actinium and optionally present radium desired daughter radionuclide ions that is highly purified and is substantially free of thorium parental radionuclide ion impurities; and (e) separating the solid and solution phases to provide a solution of actinium and optionally present radium desired daughter radionuclide ions that is highly purified and is substantially free of thorium parental radionuclide ion impurities. 6. The method according to claim 5 wherein the decontamination factor of said second solid phase separation medium is about 102 or more for actinium desired daughter radionuclide ions from thorium parental and other daughter radionuclide ion impurities under the conditions of contact. 7. The method according to claim 5 wherein the sulfate ions of said aqueous sulfate ion-containing parent-daughter radionuclide ion solution are provided by a water-soluble sulfate salt selected from the group consisting of lithium sulfate, sodium sulfate, potassium sulfate, ammonium sulfate, rubidium sulfate, cesium sulfate, magnesium sulfate, manganese sulfate, ferrous sulfate, ferric sulfate, cobalt sulfate, nickel sulfate, copper sulfate, zinc sulfate, and cadmium sulfate. 8. The method according to claim 5 wherein said second solid phase separation medium comprises (a) dipentyl pentylphosphonate extractant coated on an inert solid support, (b) a mixture of trioctyl and tridecyl methyl ammonium chlorides or nitrates sorbed on an inert water-insoluble support, (c) an anion exchange resin, or (d) 40 percent 2-ethylhexyl-2-ethylhexylphosphonic acid on an inert chromatographic substrate. 9. The method according to claim 5 wherein the aqueous nitric acid stripping solution of step (c) has a concentration of about 5 molar or greater. 10. The method according to claim 5 including the further step of recovering said solution of actinium and optionally present radium desired daughter radionuclide ions that is highly purified and is substantially free of thorium parental radionuclide ion impurities. 11. The method according to claim 5 including the further step of maintaining said separated thorium ion-containing, desired daughter-depleted parent-daughter solution of step (b) for a time period sufficient for an additional amount of actinium and optionally present radium daughter radionuclide ions to form by radioactive decay, and repeating said separation using said solution containing the newly formed actinium and radium radionuclide ions as said aqueous parent-daughter radionuclide ion solution having a pH value of about 8 or less that contains sulfate ions as well as parental thorium ions and actinium and optionally present radium desired daughter radionuclide ions. 12. The method according to claim 5 wherein said aqueous parent-daughter radionuclide ion solution having a pH value of about 8 or less that contains sulfate ions as well as actinium and optionally present radium desired daughter radionuclide ions is acidic. 13. The method according to claim 5 wherein radium ions are present in said aqueous parent-daughter radionuclide ion solution of step (a) and are also present in said separated solution of step (e). 14. The method according to claim 13 including the further steps of; (f) contacting said separated solution of step (e) with a solid phase separation medium that provides a decontamination factor of about 102 or greater for the actinium ions from radium ions under the conditions of contact, and maintaining that contact for a time period sufficient to form solid phase actinium-laden separation medium and a radium ion-containing, actinium-depleted solution; (g) separating the solid and liquid phases formed; and (h) stripping the actinium ions from said solid phase actinium-laden separation medium with dilute hydrochloric acid to form a solution of actinium ions in hydrochloric acid. 15. The method according to claim 5 wherein said aqueous parent-daughter radionuclide ion solution having a pH value of about 8 or less that contains sulfate ions as well as actinium and optionally present radium desired daughter radionuclide ions has a sulfate ion concentration of about 0.05 to about 4.0 M. 16. A method for producing a solution of daughter actinium radionuclide ions that is substantially free of thorium parental radionuclide ion impurities comprising the steps of: (a) contacting an aqueous acidic parent-daughter radionuclide ion that contains about 0.05 to about 4.0 M sulfate ions as well as thorium parental radionuclide ions and actinium and radium desired daughter radionuclide ions with a first solid phase separation medium that provides a decontamination factor of about 102 or greater for actinium and radium desired daughter ions from the thorium parent radionuclide ion impurities under the conditions of contact, said separation medium comprising water-insoluble polymeric sulfonate group-containing cation-exchange resin particles, and maintaining that contact for a time period sufficient for said actinium and radium ions to be bound by the solid phase first separation medium to form desired daughter ion-laden separation medium and a thorium ion-containing, desired daughter-depleted parent-daughter solution; (b) separating the desired daughter-depleted parent-daughter solution from the solid phase desired daughter ion-laden separation medium; (c) stripping the desired daughter radionuclide ions from the desired daughter-laden separation medium with an aqueous nitric acid solution whose nitric or hydrochloric acid concentration is about 0.5 to about 8 M or greater to form an aqueous nitric or hydrochloric acid solution of actinium and radium desired daughter radionuclide ions that may contain trace amounts of parental thorium ion impurities; (d) contacting said aqueous nitric or hydrochloric acid solution of actinium and optionally present radium desired daughter radionuclide ions that may contain trace amounts of parental thorium ion impurities of step (c) with a second solid phase separation medium that has a decontamination factor of about 102 or more for actinium desired daughter radionuclide ions from thorium parental ion impurities under the conditions of contact, said second solid phase separation medium comprising (a) dipentyl pentylphosphonate extractant coated on an inert solid support, (b) a mixture of trioctyl and tridecyl methyl ammonium chlorides or nitrates sorbed on an inert water-insoluble support, or an anionic-exchange resin, and maintaining that contact for a time period sufficient for the parent thorium radionuclide that may be present to be bound by the second solid phase separation medium to form a solution of actinium and radium desired daughter radionuclide ions that is highly purified and is substantially free of thorium parental radionuclide ion impurities; (e) separating the solid and solution phases to provide a solution of actinium and optionally present radium desired daughter radionuclide ions that is highly purified and is substantially free of thorium parental radionuclide ion impurities; (f) contacting said separated solution of step (e) with a third solid phase separation medium that that provides a decontamination factor of about 102 or greater for the actinium ions from radium ions under the conditions of contact, and maintaining that contact for a time period sufficient to form solid phase actinium-laden separation medium and a radium ion-containing, actinium-depleted solution; (g) separating the solid and liquid phases formed; and (h) stripping the actinium ions from said solid phase actinium-laden separation medium with dilute hydrochloric acid to form a solution of actinium ions in hydrochloric acid. 17. The method according to claim 16 wherein the sulfate ions of said aqueous sulfate ion-containing parent-daughter radionuclide ion solution are provided by a water-soluble sulfate salt selected from the group consisting of lithium sulfate, sodium sulfate, potassium sulfate, ammonium sulfate, rubidium sulfate, cesium sulfate, magnesium sulfate, manganese sulfate, ferrous sulfate, ferric sulfate, cobalt sulfate, nickel sulfate, copper sulfate, zinc sulfate, and cadmium sulfate. 18. The method according to claim 16 wherein said third solid phase separation medium is comprised of tetra-C1-C10-alkyl diglycolamide extractant coated on inert support particles. 19. The method according to claim 18 wherein said tetra-C 1-C10-alkyl diglycolamide extractant is N,N,N, 'N'-tetra-n-octyl diglycolamide. 20. The method according to claim 16 wherein the pH value of the acidic sulfate ion-containing solution of step (a) is about 1 to about 3. 21. The method according to claim 16 wherein the sulfate ions of said acidic aqueous sulfate ion-containing parent-daughter radionuclide ion solution are provided by ammonium sulfate. 22. The method according to claim 16 wherein the dilute hydrochloric acid solution of step (h) contains hydrochloric acid at a concentration of about 10-5 or less to about 3.0 M. 23. The method according to claim 16 including the further step of maintaining said separated thorium ion-containing, desired daughter-depleted parent-daughter solution of step (b) for a time period sufficient for an additional amount of actinium and radium daughter radionuclide ions to form by radioactive decay, and repeating said separation using said solution containing the newly formed actinium and radium radionuclide ions as said aqueous parent-daughter radionuclide ion solution having a pH value of about 8 or less that contains sulfate ions as well as parental thorium ions and actinium and radium desired daughter radionuclide ions.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (13)
Goldenberg, David M.; Behr, Thomas M., Alpha or beta emitters attached to fragments in radioimmunotherapy.
Horwitz E. Philip (Naperville IL) Kalina Dale G. (Naperville IL), Method for extracting lanthanides and actinides from acid solutions by modification of purex solvent.
Horwitz E. Philip (Naperville IL) Dietz Mark L. (Tucson AZ), Method for the concentration and separation of actinides from biological and environmental samples.
White Weimar W. (East Rochester NY) Kimble Laurie A. (Hilton NY), Process for purifying rare-earth compositions using fractional sulfate precipitation.
Bashkirtsev, Sergey M.; Kuznetsov, Valentin F.; Kevrolev, Valery V.; Morozov, Alexey G., Light-water reactor fuel assembly (alternatives), a light-water reactor, and a fuel element of fuel assembly.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.