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The present invention provides a dental paste, methods of making and using the dental paste, and compositions prepared therefrom. The dental paste includes (a) a filler including porous, non-pyrogenic silica having a silane treated surface and being substantially free of heavy metals and (b) a fill

The present invention provides a dental paste, methods of making and using the dental paste, and compositions prepared therefrom. The dental paste includes (a) a filler including porous, non-pyrogenic silica having a silane treated surface and being substantially free of heavy metals and (b) a filler including non-agregated primary silica particles, with the fillers being dispersed in a hardenable resin. Fillers including porous, non-pyrogenic silica, and methods of making and using the fillers, are also provided.

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What is claimed is: 1. A composition comprising a hardenable resin; and an acid-reactive filler disposed in the resin, wherein the filler is selected from the group consisting of metal oxides, metal salts, glasses, and mixtures thereof, wherein the filler comprises a silane-treated surface, wherein

What is claimed is: 1. A composition comprising a hardenable resin; and an acid-reactive filler disposed in the resin, wherein the filler is selected from the group consisting of metal oxides, metal salts, glasses, and mixtures thereof, wherein the filler comprises a silane-treated surface, wherein the silane comprises a poly(alkylene oxide) group-containing silane, wherein the composition is a dental paste, and wherein the paste forms a material selected from the group consisting of dental restoratives, dental adhesives, casting materials, dental cements, dental sealants, and dental coatings. 2. The composition of claim 1 wherein the acid-reactive filler is selected from the group consisting of metal oxides, glasses, and combinations thereof. 3. A composition comprising: a hardenable resin; and an acid-reactive filler disposed in the resin, wherein the acid-reactive filler is a glass selected from the group consisting of borate glasses, phosphate glasses, and fluoroaluminosilicate glasses, wherein the filler comprises a silane-treated surface, wherein the silane comprises a poly(alkylene oxide) group-containing silane, and wherein the composition is a dental paste. 4. The composition of claim 3 wherein the acid-reactive filler is a fluoroaluminosilicate glass. 5. The composition of claim 4 wherein the paste comprises at least about 5% by weight of the fluoroaluminosilicate glass. 6. The composition of claim 4 wherein the paste further comprises a fatty acid. 7. The composition of claim 6 wherein the fatty acid is selected from the group consisting of caprylic acid and/or dimers thereof, capric acid and/or dimers thereof, stearic acid and/or dimers thereof, oleic acid and/or dimers thereof, and combinations thereof. 8. The composition of claim 1 wherein the alkylene of the poly(alkylene oxide) group is selected from the group consisting of ethylene, propylene, butylene, and combinations thereof. 9. The composition of claim 8 wherein the poly(alkylene oxide) group-containing silane has the formula: Xn Si--(--Y--(OCmH2m)w--Z)4-n wherein X is a hydrolyzable group; Y is a saturated or unsaturated, substituted or unsubstituted, aliphatic and/or aromatic group, which may optionally include heteroatorns; Z is a saturated or unsaturated, aliphatic and/or aromatic group, which may optionally include heteroatoms; m=2-4; n=1-3; and w=2-30. 10. A composition comprising: a hardenable resin; and an acid-reactive filler disposed in the resin, wherein the filler is selected from the group consisting of metal oxides, metal salts, glasses, and mixtures, wherein the filler comprises a silane-treated surface, wherein the silane comprises a poly(alkylene oxide) group-containing silane and a silane that does not contain a poly(alkylene oxide) group, and wherein the composition is a dental paste. 11. The composition of claim 10 wherein the silane that does not contain a poly(alkylene oxide) group is selected from the group consisting of isooctyltrimethoxysilane, phenyltrimethoxysilane, n-octyltrimethoxysilane, dodecyltrimethoxysilane, octadecyltrimethoxysilane, propyltrimethoxysilane, hexyltrimethoxysilane, 3-mercaptopropyltrimethoxysilane, 3-aminopropyltrimethoxysilane, 3-gylcidoxypropyltrimethoxysilane, and combinations thereof. 12. The composition of claim 10 wherein the silane that does not contain a poly(alkylene oxide) group comprises a polymerizable functionality. 13. The composition of claim 12 wherein the silane that does not contain a poly(alkylene oxide) group is selected from the group consisting of 3-(methacryloxy)propyltriinethoxysilane, 3-acryloxypropyltrimethoxysilane, 3-(methacryloxy)propyltriethoxysilane, 3-(methacryloxy)propylmethyldimethoxysilane, 3-(acryloxypropyl) methyldimethoxysilane, 3-(methacryloxy)propyldimethylethoxysilane, 3-(methacryloxy)methyltriethoxysilane, 3-(methacryloxy) methyltrimethoxysilane, 3(methacryloxy)propyldimethylethoxysilane, 3-methacryloxypropenyl trimethoxysilane, vinyldimethylethoxysilane, vinylmethyldiacetoxysilane, vinylmethyldiethoxysilane, vinyltriacetoxysilane, vinyltriethoxysilane, vinyltriisopropoxysilane, vinyltrimethoxysilane, vinyltriphenoxysilane, vinyltri-t-butoxysilane, vinyl-tris-isobutoxysilane, vinyltriisopropenoxysilane, vinyl-tris(2-methoxyethoxy)silane, and combinations thereof. 14. The composition of claim 4 wherein the paste is free of fatty acid and comprises at least about 70% by weight of the fluoroaluminosilicate glass filler and the paste has a consistency value of at least about 35 mm. 15. The composition of claim 4 wherein the paste is free of fatty acid and comprises at least about 74% by weight of the fluoroaluminosilicate glass filler and the paste has a consistency value of at least about 30 mm. 16. The composition of claim 4 wherein the paste is free of fatty acid and comprises at least about 76% by weight of the fluoroaluminosilicate glass filler and the paste has a consistency value of at least about 25 mm. 17. The composition of claim 4 wherein the paste is free of fatty acid and comprises at least about 80% by weight of the fluoroaluminosilicate glass filler and the paste has a consistency value of at least about 20 mm. 18. A composition comprising: a hardenable resin; an acid-reactive filler disposed in the resin; and a fatty acid, wherein the acid-reactive filler is a fluoroalumnnosilicate glass, wherein the filler comprises a silane-treated surface, wherein the silane comprises a poly(alkylene oxide) group-containing silane, and wherein the composition is a dental paste that exhibits no substantial settling after 5 days of storage at about 25째 C. 19. The composition of claim 1 wherein the hardenable resin is selected from the group consisting of acrylates, methacrylates, epoxies, and combinations thereof. 20. The composition of claim 1 further comprising an initiator. 21. The composition of claim 1 wherein the paste exhibits one or more properties selected from the group consisting of no substantial settling after 5 days of storage at about 25째 C., and a consistency value of at least about 30 mm. 22. The composition of claim 1 wherein the paste, upon hardening, has one or more properties selected from the group consisting of: a diametral tensile strength of at least about 10 MPa, a compressive strength of at least about 80 MPa, and an adhesion value of at least about 4 MPa. 23. A method of preparing a composition comprising combining an acid-reactive filler selected from the group consisting of metal oxides, metal salts, glasses, and mixtures thereof, and comprising a silane-treated surface with a hardenable resin to form a dental paste, wherein the silane comprises a poly(alkylene oxide) group-containing silane, and wherein the paste forms a material selected from the group consisting of dental restoratives, dental adhesives, casting materials, dental cements, dental sealants, and dental coatings. 24. A method of lowering the viscosity of a dental paste comprising a hardenable resin and an acid-reactive filler selected from the group consisting of metal oxides, metal salts, glasses, and mixtures thereof, the method comprising contacting the acid-reactive filler with a composition preparable by combining components comprising a medium and a poly(alkylene oxide) group-containing silane, to form a dental paste comprising a filler having a silane-treated surface. 25. The method of claim 24 wherein the medium comprises water. 26. The method of claim 24 wherein the medium is acidic or basic. 27. A kit comprising: a part A comprising: (i) an acid-reactive filler comprising a silane-treated surface, wherein the silane comprises a poly(alkylene oxide) group-containing silane; and (ii) a fatty acid; and a part B comprising at least one polyacid, wherein the kit further comprises a resin and an initiator, each independently residing in Part A and/or Part B. 28. The kit of claim 27 further comprising a dual barrel syringe having a first band and a second barrel, wherein the part A resides in the first barrel and the part B resides in the second barrel. 29. A method of using the kit of claim 27 comprising: dispensing a quantity of part A and a quantity of part B onto a mixing pad; mixing the quantity of part A and the quantity of part B together to form a dental composition; and applying the dental composition to a dental structure. 30. The method of claim 29 wherein the dental composition has a working time of at least about 30 seconds. 31. The method of claim 30 wherein the dental composition has a working time of at least about 60 seconds. 32. An article comprising: a hardened resin; and an acid-reactive filler disposed in the hardened resin, wherein the filler is selected from the group consisting of metal oxides, metal salts, glasses, and mixtures wherein the filler comprises a silane-treated surface, wherein the silane comprises a poly(alkylene oxide) group-containing silane, and wherein the article is a dental article. 33. The article of claim 32 wherein the article is selected from the group consisting of dental mill blanks, dental prostheses, orthodontic devices, artificial crowns, anterior fillings, posterior fillings, and cavity liners. 34. The article of claim 32 having one or more properties selected from the group consisting of: a diametral tensile strength of at least about 10 MPa, a compressive strength of at least about 80 MPa, and an adhesion value of at least about 4 MPa. 35. A method of preparing a dental article comprising: dispersing an acid-reactive filler in a hardenable resin to form a dental paste, wherein the filler is selected from the group consisting of metal oxides, metal salts, glasses, and mixtures thereof, wherein the filler comprises a silane-treated surface, and wherein the silane comprises a poly(alkylene oxide) group-containing silane; and hardening the paste to fabricate a dental article selected from the group consisting of dental mill blanks, dental prostheses, orthodontic devices, artificial crowns, anterior fillings, posterior fillings, and cavity liners. 36. The method of claim 35 further comprising changing the topography of the paste before hardening the dental paste. 37. An acid-reactive filler selected from the group consisting of metal oxides, metal salts, glasses, and mixtures thereof, and comprising a silane-treated surface, wherein the silane comprises a poly(alkylene oxide) group-containing silane and a silane that does not contain a poly(alkylene oxide) group. 38. An acid-reactive filler comprising a silane-treated surface, wherein the acid-reactive filler is a fluoroaluminosilicate glass, and wherein the silane comprises a poly(alkylene oxide) group-containing silane and a silane that does not contain a poly(alkylene oxide) group. 39. A method of preparing a surface-treated acid-reactive filler comprising: combining components comprising a medium, a poly(alkylene oxide) group-containing silane, and a silane that does not contain a poly(alkylene oxide) group, to provide a surface-treatment composition; and contacting the surface treatment composition with the acid-reactive filler, wherein the filler is selected from the group consisting of metal oxides, metal salts, glasses, and mixtures thereof. 40. A dental paste comprising: a hardenable resin; and an acid-reactive filler disposed in the resin, wherein the filler is selected from the group consisting of metal oxides, metal salts, glasses, and mixtures thereof, wherein the filler comprises a silane-treated surface, and wherein the silane comprises a poly(alkylene oxide) group-containing silane and a silane that does not contain a poly(alkylene oxide) group.