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Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and NSconjugates for MR contrast media and radiopharmaceuticals

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61B-005/055
출원번호 US-0177129 (2002-06-21)
발명자 / 주소
  • Pandey,Ravindra K.
  • Grossman,Zachary
  • Kanter,Peter
  • Dougherty,Thomas J.
출원인 / 주소
  • Health Research, Inc.
인용정보 피인용 횟수 : 3  인용 특허 : 32

초록

A compound comprising a chemical combination of a photodynamic tetra-pyrrolic compound with a plurality of radionuclide element atoms such that the compound may be used to enhance MR imaging and also be used as a photodynamic compound for use in photodynamic therapy to treat hyperproliferative tissu

대표청구항

The invention claimed is: 1. A composition comprising a chemical combination of a photodynamic tetra-pyrrolic compound having a porphyrin or chlorin structure having four pendant groups attached to at least one pyrolle ring, said compound being provided with a plurality of radionuclide element atom

이 특허에 인용된 특허 (32)

  1. Pandey Ravindra K. ; Potter William R. ; Dougherty Thomas J., Alkyl ether analogs of chlorins having an N-substituted imide ring.
  2. Pandey Ravindra K. (Williamsville NY) Dougherty Thomas J. (Grand Island NY) Smith Kevin M. (Davis CA) Meunier Isabelle (Tournus FRX), Alkyl ether analogues of benzoporphyrin derivatives.
  3. Dougherty Thomas J. (Grand Island NY) Potter William R. (Grand Island NY) Weishaupt Kenneth R. (Sloan NY), Apparatus for treatment of tumors.
  4. Dougherty Thomas J. (Grand Island NY), Bacteriochlorophyll-a derivatives useful in photodynamic therapy.
  5. Dougherty Thomas J. (Grand Island NY), Bacteriochlorophyll-a derivatives useful in photodynamic therapy.
  6. Pandey Ravindra K. ; Potter William R. ; Dougherty Thomas J., Carotene analogs of porphyrins, chlorins and bacteriochlorins as therapeutic and diagnostic agents.
  7. Pandey, Ravindra K.; Grossman, Zachary; Kanter, Peter; Dougherty, Thomas J., Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals.
  8. Dougherty Thomas J. (Grand Island NY) Potter William R. (Grand Island NY) Weishaupt Kenneth R. (Sloan NY), Drugs comprising porphyrins.
  9. Dougherty Thomas J. (Grand Island NY) Potter William R. (Grand Island NY) Weishaupt Kenneth R. (Sloan NY), Drugs comprising porphyrins.
  10. Dougherty Joseph (Hampton NJ) Kuo Ming-Ling (Taipei TWX) Sutkowski Natalie (Gloucester MA) Ron Yacov (East Brunswick NJ), Efficient gene transfer into primary lymphocytes obviating the need for drug selection.
  11. Dougherty Joseph (Hampton NJ) Kuo Ming-ling (Piscataway NJ) Sutkowski Natalie (Edison NJ) Ron Yacov (East Brunswick NJ), Efficient gene transfer into primary lymphocytes obviating the need for drug selection.
  12. Dougherty Joseph ; Ron Yacov, Efficient gene transfer into primary murine lymphocytes obviating the need for drug selection.
  13. Dougherty Thomas J. (Grand Island NY) Potter William R. (Grand Island NY) Weishaupt Kenneth R. (Sloan NY), Hematoporphyrin derivatives and process of preparing.
  14. Dougherty Thomas J. (Grand Island NY), In situ photodynamic therapy.
  15. Pandey Ravindra K. (Williamsville NY) Dougherty Thomas J. (Grand Island NY) Smith Kevin M. (Davis CA) Shiau Fuu-Yau (Sugar Land TX), Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide.
  16. Dougherty Thomas J. (Grand Island NY) Potter William R. (Grand Island NY) Weishaupt Kenneth R. (Sloan NY), Method to destroy or impair target cells.
  17. Dougherty Thomas J. (Grand Island NY) Potter William R. (Grand Island NY) Weishaupt Kenneth R. (Sloan NY), Method to diagnose the presence or absence of tumor tissue.
  18. Dougherty Thomas J. (Grand Island NY) Potter William R. (Grand Island NY) Weishaupt Kenneth R. (Sloan NY), Methods for treatment of tumors.
  19. Pandey Ravindra K. (Buffalo NY) Dougherty Thomas J. (Grand Island NY), Photosensitizing agents.
  20. Pandey Ravindra K. (Buffalo NY) Dougherty Thomas J. (Grand Island NY), Photosensitizing agents.
  21. Dougherty Thomas J. (Grand Island NY) Pandey Ravindra K. (Buffalo NY), Purified hematoporphyrin dimers and trimers useful in photodynamic therapy.
  22. Pandey Ravindra K. (Buffalo NY) Dougherty Thomas J. (Grand Island NY), Pyropheophorbides and their use in photodynamic therapy.
  23. Pandey Ravindra K. (Buffalo NY) Dougherty Thomas J. (Grand Island NY), Pyropheophorbides and their use in photodynamic therapy.
  24. Pandey Ravindra K. (Buffalo NY) Dougherty Thomas J. (Grand Island NY), Pyropheophorbides conjugates and their use in photodynamic therapy.
  25. Chen I. Wen (Cincinnati OH) Maxon ; III Harry R. (Terrace Park OH) Gluckman Jack (Cincinnati OH), Radio labeled dihematophorphyrin ether and its use in detecting and treating neoplastic tissue.
  26. Smith Kevin M. (Davis CA) Pandey Ravindra K. (Williamsville NY) Ryan Joseph M. (Sacramento CA) Jagerovic Nadine (Savigny les Beaune NY FRX) Dougherty Thomas J. (Grand Island NY), Rhodoporphyrin and phylloerythrin related photosensitizers for photodynamic therapy.
  27. Clauss Steven L. (Manville NJ) Pastel Michael J. (Highland Mills NY) Zawadzki Rainer K. (Wuhan CNX), Stable porfimer sodium compositions and methods for their manufacture.
  28. Pandey Ravindra K. ; Kozyrev Andrei N. ; Dougherty Thomas J., Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer.
  29. Pandey Ravindra K. ; Kozyrev Andrei N. ; Dougherty Thomas J., Synthesis of isoimide of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer.
  30. Dougherty Thomas J. (Grand Island NY) Potter William R. (Grand Island NY) Weishaupt Kenneth R. (Sloan NY), Treatment of tumors using chlorins.
  31. Dougherty Thomas J. (Grand Island NY) Pandey Ravindra K. (Buffalo NY), Use of purified hematoporphyrin trimers in photodynamic therapy.
  32. Strong H. Andrew,CAX ; Levy Julia,CAX ; Huber Gustav,CHX ; Fsadni Mario,CHX, Vision through photodynamic therapy of the eye.

이 특허를 인용한 특허 (3)

  1. Pandey, Ravindra K.; Grossman, Zachary; Kanter, Peter; Dougherty, Thomas J., Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals.
  2. Pandey, Ravindra K.; Goswami, Lalit; Spernyak, Joseph; Kanter, Peter; Mazurchuk, Richard, Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents.
  3. Pandey, Ravindra K.; Sajjad, Munawwar; Pandey, Suresh; Gryshuk, Amy; Oseroff, Allan; Pincus, legal representative, Stephanie; Nabi, Hani A., Porphyrin-based compounds for tumor imaging and photodynamic therapy.
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