초록

Surface coatings including azlactone-functional hydrogels and articles with the coatings disposed thereon are disclosed. Methods of making the coating and controlling the gellation time of the hydrogels are also disclosed.

대표청구항 ▼

What is claimed is: 1. An article comprising: a substrate; and a material disposed upon the substrate, the material comprising i) at least one azlactone-functional copolymer comprising a plurality of azlactone moieties and a plurality of azlactone functional groups, wherein the copolymer is derived

What is claimed is: 1. An article comprising: a substrate; and a material disposed upon the substrate, the material comprising i) at least one azlactone-functional copolymer comprising a plurality of azlactone moieties and a plurality of azlactone functional groups, wherein the copolymer is derived from monomers comprising at least one alkenyl azlactone monomer and at least one hydrophilic or water soluble comonomer; ii) a first crosslinker comprising a first nucleophilic moiety and a second thermally reactive moiety; and iii) optionally, a second crosslinker comprising a first nucleophilic moiety and a second thermally reactive moiety; wherein a) the first moiety of a first crosslinker is covalently bound to a first azlactone moiety; and b) the second moiety of the first crosslinker is covalently bound to i) a second azlactone moiety or ii) the second moiety of the second crosslinker, with the first moiety of the second crosslinker being bound to the second azlactone moiety; and wherein the material is a crosslinked hydrogel. 2. The article of claim 1 wherein the substrate comprises a plate, a film, a particle, a fiber, a column, a bead, a web, or a membrane. 3. The article of claim 1 further comprising a primer. 4. The article of claim 3 wherein the primer is polyethylenimine, polyvinylidene chloride, a colloidal dispersion of metal oxides, or an ambifunctional silane. 5. The article of claim 1 wherein the first crosslinker and the second crosslinker have the same chemical structure. 6. The article of claim 1 wherein the first crosslinker and the second crosslinker have different chemical structures. 7. The article of claim 1 wherein the chemical structure of the second moiety of the first crosslinker is the same as the chemical structure of the first moiety of the first crosslinker. 8. The article of claim 1 wherein the chemical structure of the second moiety of the first crosslinker is different than the chemical structure of the first moiety of the first crosslinker. 9. The article of claim 1 wherein the chemical structure of the second moiety of the second crosslinker is the same as the chemical structure of the first moiety of the second crosslinker. 10. The article of claim 1 wherein the chemical structure of the second moiety of the second crosslinker is different than the chemical structure of the first moiety of the second crosslinker. 11. A composite comprising: (a) a substrate; (b) a hydrogel material disposed upon the substrate wherein the hydrogel material comprises: i) at least one azlactone-functional copolymer comprising a plurality of azlactone moieties and a plurality of azlactone functional groups, wherein the copolymer is derived from monomers comprising at least one alkenyl azlactone monomer and at least one hydrophilic or water soluble comonomer; ii) a first crosslinker comprising a first nucleophilic moiety and a second thermally reactive moiety; and iii) optionally, a second crosslinker comprising a first nucleophilic moiety and a second thermally reactive moiety; wherein: a) the first moiety of the first crosslinker is covalently bound to a first azlactone moiety; and b) the second moiety of the first crosslinker is covalently bound to i) a second azlactone moiety or ii) the second moiety of the second crosslinker, with the first moiety of the second crosslinker being bound to the second azlactone moiety; and wherein the hydrogel material is a crosslinked hydrogel; and (c) a functional material comprising (i) a nucleophilic group reacted with a third azlactone moiety of the azlactone-functional copolymer and (ii) another reactive site. 12. The composite of claim 11 wherein the substrate comprises a plate, a film, a particle, a fiber, a column, a bead, a web, or a membrane. 13. The composite of claim 11 further comprising a primer. 14. The composite of claim 13 wherein the primer is polyethylenimine, polyvinylidene chloride, a colloidal dispersion of metal oxides, or an ambifunctional silane. 15. The composite of claim 11 wherein the functional material is a polypeptide, a polynucleotide, a polysaccharide, or any combination thereof. 16. The composite of claim 11 wherein the first crosslinker and the second crosslinker have the same chemical structure. 17. The composite of claim 11 wherein the first crosslinker and the second crosslinker have different chemical structures. 18. The composite of claim 11 wherein the chemical structure of the second moiety of the first crosslinker is the same as the chemical structure of the first moiety of the first crosslinker. 19. The composite of claim 11 wherein the chemical structure of the second moiety of the first crosslinker is different than the chemical structure of the first moiety of the first crosslinker. 20. The composite of claim 11 wherein the chemical structure of the second moiety of the second crosslinker is the same as the chemical structure of the first moiety of the second crosslinker. 21. The composite of claim 11 wherein the chemical structure of the second moiety of the second crosslinker is different than the chemical structure of the first moiety of the second crosslinker. 22. The composite of claim 11 wherein the functional material comprises a biologically active material.