초록 ▼

A particle coated with a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material includes an internal matrix core having at least one a nanostructured liquid phase, or at least on nanostructured liquid crystalline

A particle coated with a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material includes an internal matrix core having at least one a nanostructured liquid phase, or at least on nanostructured liquid crystalline phase or a combination of the two is used for the delivery of active agents such as pharmaceuticals, nutrients, pesticides, etc. The coated particle can be fabricated by a variety of different techniques where the exterior coating is a nonlamellar material such as a nonlamellar crystalline material, a nonlamellar amorphous material, or a nonlamellar semi-crystalline material.

대표청구항 ▼

I claim: 1. A method of making a contiguous solid comprising non-lamellar domains with a plurality of microparticles of matrix dispersed therein, wherein each matrix consists essentially of i. a nanostructured liquid phase or a dehydrated variant thereof, ii. a nanostructured liquid crystalline pha

I claim: 1. A method of making a contiguous solid comprising non-lamellar domains with a plurality of microparticles of matrix dispersed therein, wherein each matrix consists essentially of i. a nanostructured liquid phase or a dehydrated variant thereof, ii. a nanostructured liquid crystalline phase or a dehydrated variant thereof or iii. a combination of (1) a nanostructured liquid phase or a dehydrated variant thereof and (2) a nanostructured liquid crystalline phase or a dehydrated variant thereof comprising the steps of: dispersing a volume of said matrix in a form of said nonlamellar material selected from the group consisting of liquefied form, solution, or fluid precursor, and solidifying said nonlamellar material by a technique selected from the group consisting of cooling, evaporating a volatile solvent, or implementing a chemical reactions, wherein said step of solidifying results in production of said contiguous solid comprising non-lamellar domains with a plurality of microparticles of matrix dispersed therein. 2. A conglomerate of coated particles, each of said coated particles comprising a. an interior core comprising a matrix consisting essentially of i. at least one nanostructured liquid phase or a dehydrated variant thereof, ii. at least one nanostructured liquid crystalline phase or a dehydrated variant thereof or iii. a combination of (1) at least one nanostructured liquid phase or a dehydrated variant thereof and (2) at least one nanostructured liquid crystalline phase or a dehydrated variant thereof and b. an exterior coating comprising nonlamellar domains; wherein a plurality of said coated particles are aggregated together to form a conglomerate. 3. A dispersion of coated microparticles within a contiguous solid comprising a plurality of coated microparticles, each of said coated microparticles comprising a. an interior core comprising a matrix consisting essentially of i. at least one nanostructured liquid phase or a dehydrated variant thereof, ii. at least one nanostructured liquid crystalline phase or a dehydrated variant thereof or iii. a combination of (1) at least one nanostructured liquid phase or a dehydrated variant thereof and (2) at least one nanostructured liquid crystalline phase or a dehydrated variant thereof and b. an exterior coating comprising nonlamellar domains; and a contiguous solid comprising non-lamellar domains in which said plurality of coated microparticles are dispersed. 4. The dispersion of coated microparticles of claim 3 wherein non-lamellar domains of said contiguous solid are the same material as said nonlamellar domains of said exterior coating. 5. A dispersion of microparticles within a contiguous solid, comprising: a plurality of microparticles, each of said microparticles comprising a matrix consisting essentially of i. at least one nanostructured liquid phase or a dehydrated variant thereof, ii. at least one nanostructured liquid crystalline phase or a dehydrated variant thereof or iii. a combination of (1) at least one nanostructured liquid phase or a dehydrated variant thereof and (2) at least one nanostructured liquid crystalline phase or a dehydrated variant thereof; and a continuous solid comprising non-lamellar domains in which said plurality of microparticles are dispersed. 6. A dispersed particle comprising a nanostructured liquid or liquid crystalline matrix with a coating precursor localized preferentially at the surface of said particle. 7. The dispersed particle of claim 6, wherein said coating is nonlamellar. 8. The dispersed particle of claim 7, wherein said particle becomes encapsulated upon conversion of said coating precursor to a solid nonlamellar coating. 9. The dispersed particle of claim 6, wherein the precursor to the coating is a surface-active compound. 10. The dispersed particle of claim 9, wherein said coating precursor will be converted to a solid nonlamellar coating by a chemical reaction. 11. The dispersed particle of claim 6, wherein said particle is dispersed in an aqueous medium. 12. The dispersed particle of claim 6 wherein said nanostructured liquid crystalline matrix is a reversed liquid crystalline matrix. 13. The dispersed particle of claim 12 wherein said reversed liquid crystalline matrix is a reversed cubic phase liquid crystalline matrix. 14. The dispersed particle of claim 6 wherein said coating precursor is a salt of N-acetyltryptophan. 15. A composition comprising a divalent ion salt of N-acetyltryptophan, a surfactant, a pharmaceutical active compound, and water. 16. The composition of claim 15 wherein the surfactant is a poloxamer.