Spatiotemporal and geometric optimization of sensor arrays for detecting analytes fluids
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12Q-001/68
B01N-015/06
B01N-033/00
B01N-033/48
B32B-005/02
출원번호
US-0842204
(2001-04-24)
발명자
/ 주소
Lewis,Nathan S.
Freund,Michael S.
Briglin,Shawn M.
Tokumaru,Phil
Martin,Charles R.
Mitchell,David T.
출원인 / 주소
University of Florida
The California Institute of Technology
Aerovironment, Inc.
대리인 / 주소
Buchanan Ingersoll &
인용정보
피인용 횟수 :
27인용 특허 :
84
초록▼
Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form
Sensor arrays and sensor array systems for detecting analytes in fluids. Sensors configured to generate a response upon introduction of a fluid containing one or more analytes can be located on one or more surfaces relative to one or more fluid channels in an array. Fluid channels can take the form of pores or holes in a substrate material. Fluid channels can be formed between one or more substrate plates. Sensor can be fabricated with substantially optimized sensor volumes to generate a response having a substantially maximized signal to noise ratio upon introduction of a fluid containing one or more target analytes. Methods of fabricating and using such sensor arrays and systems are also disclosed.
대표청구항▼
What is claimed is: 1. A flow-through fluid analysis system for detecting an analyte in a fluid flow, comprising: a sensor array having a first face and a second face, the sensor array including one or more first sensors located on the first face and one or more fluid channels extending from the fi
What is claimed is: 1. A flow-through fluid analysis system for detecting an analyte in a fluid flow, comprising: a sensor array having a first face and a second face, the sensor array including one or more first sensors located on the first face and one or more fluid channels extending from the first face to the second face, at least one of the first sensors being located at a first position in the sensor array in contact with the first face of the sensor array, the one or more first sensors being configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow; means for introducing a fluid flow containing an analyte to the sensor array, such that upon introduction of a fluid flow to the sensor array, including one or more first sensors located on the first face and one or more fluid channels extending from the first face to the second face, a pressure differential is created and maintained between the first and second faces of the sensor array; and a processor configured to receive the response generated by the one or more first sensors and to process the response to detect at least one analyte in a fluid flow. 2. The system of claim 1, wherein: the sensor array includes a substrate having a first surface and a second surface; and the fluid channels extend from the first surface to the second surface. 3. The system of claim 2, wherein: the fluid channels include a plurality of pores in a microporous substrate material. 4. The system of claim 2, wherein: the fluid channels include a plurality of holes introduced into an impermeable substrate material. 5. The system of claim 4, wherein: the fluid flow system includes a predetermined sampling volume, the sensor array is located within the sampling volume, and the first sensor has a sensor volume, the sensor volume being substantially optimized to cause the first sensor to generate a response having a maximum signal to noise ratio for at least one target analyte. 6. The system of claim 5, wherein: the sensor volume is substantially optimized as a function of a partition coefficient K of at least one target analyte. 7. The system of claim 6, wherein: the predetermined sampling volume includes a headspace proximate to the first sensor, the headspace having a headspace volume Vl; and the sensor volume Vp is substantially optimized based on the function Vp=Vl/k. 8. The system of claim 1, wherein: the one or more first sensors include a vapor sensor for detecting an analyte in a gas. 9. The system of claim 8, wherein: the one or more first sensors include a plurality of vapor sensors for detecting an analyte in a gas. 10. The system of claim 1, wherein: the one or more first sensors include a liquid sensor for detecting an analyte in a liquid. 11. The system of claim 10, wherein: the one or more first sensors include a plurality of liquid sensors for detecting an analyte in a liquid. 12. The system of claim 1, wherein: the sensor array includes at least one second sensor located at a second position in the sensor array, the second position being different from the first position relative to the fluid flow, the first and second sensors each generating a response upon exposure of the sensor array to at least one analyte in a fluid flow, such that the responses generated upon exposure of the sensor array to at least one analyte in a fluid flow include a spatio-temporal difference between the responses for the first and second sensors. 13. The system of claim 12, wherein: the processor is configured to resolve a plurality of analytes in a fluid flow upon exposure of the sensor array to a fluid flow containing the plurality of analytes. 14. The system of claim 1, wherein: the sensor array includes a plurality of second sensors, each of the first sensor and a plurality of the second sensors being located at a different position in the sensor array relative to the fluid flow, the first and second sensors each generating a response upon exposure of the sensor array to at least one analyte in a fluid flow, such that the responses generated upon exposure of the sensor array to at least one analyte in a fluid flow include a spatio-temporal difference between the responses for the first and second sensors. 15. The system of claim 1, wherein: the sensor array includes a first substrate forming a plate having a length, a width, and a depth, such that the length and the width in combination define a pair of substrate faces and the width and the depth in combination define a pair of substrate edges, the first substrate being oriented in the sampling volume such that the substrate faces extend in a direction parallel to a direction of the fluid flow and the substrate edges are situated normal to the fluid flow; and the one or more first sensor are located on one of the pair of substrate edges. 16. The system of claim 15, wherein: the sensor array includes one or more second sensors located on one of the pair of substrate faces. 17. The system of claim 14, wherein: the processor is configured to resolve a plurality of analytes in a fluid flow upon exposure of the sensor array to a fluid flow containing the plurality of analytes. 18. The system of claim 15, wherein: the sensor array includes a plurality of second sensors located at different positions along one of the pair of substrate faces, such that the responses generated upon exposure of the sensor array to at least one analyte in a fluid flow include a spatio-temporal difference between responses generated by each of the first and the plurality of the second sensors. 19. The system of claim 16, wherein: the sensor array includes a plurality of substrates, each substrate forming a plate having a length, a width, and a depth, such that for each of the substrates the length and the width in combination define a pair of substrate faces and the width and the depth in combination define a pair of substrate edges, the substrates being oriented in the sampling volume such that the substrate faces extend in a direction parallel to a direction of the fluid flow and the substrate edges are situated normal to the fluid flow; and for each of the plurality of substrates, the sensor array includes one or more first sensors located on one of the pair of substrate edges and one or more second sensors located on at least one of the pair of substrate faces. 20. The system of claim 16, wherein: at least one of the first sensor or the second sensors has a sensor volume, the sensor volume being substantially optimized to achieve a maximum signal to noise ratio for at least one target analyte. 21. The system of claim 20, wherein: the sensor volume is substantially optimized as a function of a partition coefficient K of at least one target analyte. 22. The system of claim 21, wherein: the predetermined sampling volume includes a headspace proximate to the first sensor, the headspace having a headspace volume Vi; and the sensor volume Vp is substantially optimized based on the function VP=Vl/K. 23. The system of claim 15, wherein: the one or more first sensors include a vapor sensor for detecting an analyte in a gas. 24. The system of claim 23, wherein: the one or more first sensors include a plurality of vapor sensors for detecting an analyte in a gas. 25. The system of claim 15, wherein: the one or more first sensors include a liquid sensor for detecting an analyte in a liquid. 26. The system of claim 25, wherein: the one or more first sensors include a plurality of liquid sensors for detecting an analyte in a liquid. 27. A method of detecting an analyte in a fluid flow, comprising: providing a sensor array having a first face and a second face, the sensor array including one or more first sensors located on the first face and one or more fluid channels extending from the first face to the second face, at least one of the first sensors being located at a first position in the sensor array in contact with the first face of the sensor array, the one or more first sensors being configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow; exposing the sensor array to a fluid flow including an analyte under conditions sufficient to create and maintain a pressure differential between the first and second faces of the sensor array; measuring a response for the one or more first sensors; and detecting the presence of the analyte in the fluid based on the measured response. 28. The method of claim 27, wherein: the sensor array includes a substrate having a first surface and a second surface; and the fluid channels extend from the first surface to the second surface. 29. The method of claim 28, wherein: the fluid channels include a plurality of pores in a microporous substrate material. 30. The method of claim 28, wherein: the fluid channels include a plurality of holes introduced into an impermeable substrate material. 31. The method of claim 30, wherein: the first sensor has a sensor volume, the sensor volume being substantially optimized to cause the first sensor to generate a response having a maximum signal to noise ratio for at least one target analyte. 32. The method of claim 31, wherein: the sensor volume is substantially optimized as a function of a partition coefficient K of at least one target analyte. 33. The method of claim 32, wherein: the predetermined sampling volume includes a headspace proximate to the first sensor, the headspace having a headspace volume Vi; and the sensor volume Vp, is substantially optimized based on the function Vp=Vl/K. 34. The method of claim 27, wherein: the one or more first sensors include a vapor sensor for detecting an analyte in a gas. 35. The method of claim 34, wherein: the one or more first sensors include a plurality of vapor sensors for detecting an analyte in a gas. 36. The method of claim 27, wherein: the one or more first sensors include a liquid sensor for detecting an analyte in a liquid. 37. The method of claim 36, wherein: the one or more first sensors include a plurality of liquid sensors for detecting an analyte in a liquid. 38. The method of claim 27, wherein: the sensor array includes at least one second sensor located at a second position in the sensor array, the second position being different from the first position relative to the fluid flow, the first and second sensors each generating a response upon exposure of the sensor array to at least one analyte in a fluid flow, such that the responses generated upon exposure of the sensor array to at least one analyte in a fluid flow include a spatio-temporal difference between the responses for the first and second sensors. 39. The method of claim 38, wherein: detecting the presence of the analyte in the fluid includes resolving a plurality of analytes in the fluid based on the measured response. 40. The method of claim 27, wherein: the sensor array includes a plurality of second sensors, each of the first sensor and a plurality of the second sensors being located at a different position in the sensor array relative to the fluid flow, the first and second sensors each generating a response upon exposure of the sensor array to at least one analyte in a fluid flow, such that the responses generated upon exposure of the sensor array to at least one analyte in a fluid flow include a spatio-temporal difference between the responses for the first and second sensors. 41. The method of claim 27, wherein: the sensor array includes a first substrate forming a plate having a length, a width, and a depth, such that the length and the width in combination define a pair of substrate faces and the width and the depth in combination define a pair of substrate edges, the first substrate being oriented in the sampling volume such that the substrate faces extend in a direction parallel to a direction of the fluid flow and the substrate edges are situated normal to the fluid flow; and the one or more first sensor are located on one of the pair of substrate edges. 42. The method of claim 41, wherein: the sensor array includes one or more second sensors located on one of the pair of substrate faces. 43. The method of claim 40, wherein: detecting the presence of the analyte in the fluid includes resolving a plurality of analytes in the fluid based on the measured response. 44. The method of claim 41, wherein: the sensor array includes a plurality of second sensors located at different positions along one of the pair of substrate faces, such that the responses generated upon exposure of the sensor array to at least one analyte in a fluid flow include a spatio-temporal difference between responses generated by each of the first and the plurality of the second sensors. 45. The method of claim 42, wherein: the sensor array includes a plurality of substrates, each substrate forming a plate having a length, a width, and a depth, such that for each of the substrates the length and the width in combination define a pair of substrate faces and the width and the depth in combination define a pair of substrate edges, the substrates being oriented in the sampling volume such that the substrate faces extend in a direction parallel to a direction of the fluid flow and the substrate edges are situated normal to the fluid flow; and for each of the plurality of substrates, the sensor array includes one or more first sensors located on one of the pair of substrate edges and one or more second sensors located on at least one of the pair of substrate faces. 46. The method of claim 42, wherein: at least one of the first sensor or the second sensors has a sensor volume, the sensor volume being optimized to achieve a maximum signal to noise ratio for at least one target analyte. 47. The method of claim 46, wherein: the sensor volume is optimized as a function of a partition coefficient K of at least one target analyte. 48. The method of claim 47, wherein: the predetermined sampling volume includes a headspace proximate to the first sensor, the headspace having a headspace volume Vi; and the sensor volume Vp, is optimized based on the function VP=Vl/K. 49. The method of claim 41, wherein: the one or more first sensors include a vapor sensor for detecting an analyte in a gas. 50. The method of claim 49, wherein: the one or more first sensors include a plurality of vapor sensors for detecting an analyte in a gas. 51. The method of claim 41, wherein: the one or more first sensors include a liquid sensor for detecting an analyte in a liquid. 52. The method of claim 51, wherein: the one or more first sensors include a plurality of liquid sensors for detecting an analyte in a liquid. 53. A sensor array for detecting an analyte in a fluid flow, the sensor array having a first face and a second face, the sensor array comprising: one or more substrates, each substrate forming a plate having a length, a width, and a depth, such that the length and the width in combination define a pair of substrate faces and the width and the depth in combination define a first substrate edge and a second substrate edge, the first substrate edge for each of the substrates being aligned with the first face of the array; a plurality of chemically sensitive resistor sensors configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow, the sensors including one or more first sensors, each of the first sensors being located along one of the first substrate edges, the sensors also including one or more second sensors, each of the second sensors being located along one of the substrate faces; and one or more fluid channels extending along one or more of the substrate faces from the first face of the array to the second face of the array. 54. The sensor array of claim 53, wherein: the plurality of sensors includes a plurality of second sensors located at different positions along at least one of the pair of substrate faces, such that the responses generated upon exposure of the sensor array to at least one analyte in a fluid flow include a spatio-temporal difference between responses generated by each of the first and the plurality of the second sensors. 55. The sensor array of claim 53, wherein: the sensors include a vapor sensor for detecting an analyte in a gas. 56. The sensor array of claim 55, wherein: the sensors include a plurality of vapor sensors for detecting an analyte in a gas. 57. The sensor array of claim 53, wherein: the sensors include a liquid sensor for detecting an analyte in a liquid. 58. The sensor array of claim 57, wherein: the sensors include a plurality of liquid sensors for detecting an analyte in a liquid. 59. A device, comprising: a fluid inlet; a fluid outlet; a fluid flow channel disposed between the fluid inlet and the fluid outlet; a sensor array comprising a first face; a second face; one or more fluid pores extending from the first face to the second face; one or more sensors, at least one of the sensors being located at a first position in the sensor array in contact with the first face of the sensor array, the one or more first sensors being configured to generate a response upon exposure of the sensor array to at least one analyte in a fluid flow, the sensor array configured in the fluid flow channel to generate a pressure drop from the first face to the second face, whereby fluid flows through the one or more fluid pores; and a processor configured to receive the response generated by the one or more sensors and to process the response to detect at least one analyte in a fluid flow. 60. The device of claim 59, wherein: the sensor array comprises a microporous material. 61. The device of claim 59, wherein: the one or more sensors comprise one or more vapor sensors for detecting an analyte in a gas. 62. The device of claim 59, wherein: the one or more sensors comprise one or more liquid sensors for detecting an analyte in a liquid.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (84)
Guruswamy Vinodhini (Bethesda MD), Apparatus and methods for sensing fluid components.
Schatzmann Lawrence A. ; Wurzbach James A. ; Newcomb Russell R. ; Ciambrone David F., Automated network of sensor units for real-time monitoring of compounds in a fluid over a distributed area.
Debe Mark K. ; Haugen Gregory M. ; Steinbach Andrew J. ; Thomas ; III John H. ; Ziegler Raymond J., Catalyst for membrane electrode assembly and method of making.
Lewis Nathan S. ; Grubbs Robert H. ; Sanner Robert D. ; Severin Eric J., Compositionally different polymer-based sensor elements and method for preparing same.
Krishnan Chandrasekhar (Grand Island NY) Qi Jian S. (Amherst NY) Incavo Joseph A. (Snyder NY) Reuter William L. (Niagara Falls NY) Jain Vivek (Grand Island NY), Determination of diffusion coefficient.
Wiersma Aaltie E. (Kast. Schaloenstraat 19 6222 TN Maastricht NLX) van de Steeg Lucia M. A. (Maaslaan 87 6163 KN Geleen NLX), Dispersion of electrically conductive particles in a dispersing medium.
Say James ; Tomasco Michael F. ; Heller Adam ; Gal Yoram,ILX ; Aria Behrad ; Heller Ephraim ; Plante Phillip John ; Vreeke Mark S., Electrochemical analyte.
Tomantschger Klaus (Mississauga NY CAX) Janis Allan A. (Snyder NY) Weinberg Norman L. (East Amherst NY) Rait Joseph M. (Buffalo NY), Electrochemical gas sensor cells using three dimensional sensing electrodes.
Kmpf Gnther (Oestrich-Winkel DEX) Feldhues Michael (Bad Soden am Taunus DEX), Electroconductive coating composition, a process for the production thereof and the use thereof.
Brogrdh Torgny (Vsters SEX) Hk Bertil (Vsters SEX) Ovren Christer (Vsters SEX), Fiber-optic luminescence measuring system for measuring light transmission in an optic sensor.
Giedd Ryan E. (Springfield MO) Wang Yongqiang (Springfield MO) Moss Mary G. (Rolla MO) Kaufmann James (Newburg MO) Brewer Terry L. (Rolla MO), Homogeneously conductive polymer films as strain gauges.
LeBihan Denis (Rockville MD) Delannoy Jose (Chevy Chase MD) Levin Ronald L. (Silver Spring MD), In-vivo method for determining and imaging temperature of an object/subject from diffusion coefficients obtained by nucl.
Revsbech Niels Peter,DKX ; Nielsen Lars Peter,DKX ; Pedersen Ole,DKX ; Gundersen Jens Kristian,DKX, Method for measurement of flow velocity or diffusivity, microsensor and application of such microsensor.
Preti George (Horsham PA) Labows John N. (Horsham PA) Daniele Ronald (Philadelphia PA) Kostelc James G. (Creve Coeur MO), Method of detecting the presence of bronchogenic carcinoma by analysis of expired lung air.
Walt David R. (Lexington MA) Barnard Steven M. (Medford MA), Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample.
Reading Christopher L. (Kingwood TX) Smyth Malcolm R. (Dublin IEX) O\Kennedy Richard (Dublin IEX), Methods and apparatus using galvanic immunoelectrodes.
Villarreal James A. (Friendswood TX) Shelton Robert O. (Houston TX), Neural network for processing both spatial and temporal data with time based back-propagation.
Hollis Mark A. (Concord MA) Ehrlich Daniel J. (Lexington MA) Murphy R. Allen (Boxboro MA) Kosicki Bernard B. (Acton MA) Rathman Dennis D. (Ashland MA) Chen Chang-Lee (Sudbury MA) Mathews Richard H. (, Optical and electrical methods and apparatus for molecule detection.
Monkman Andrew P. (Stanhope GBX) Petty Michael C. (Stockton-on-Tees GBX) Agbor Napoleon E. (Durham GBX) Scully Margaret T. (Raynes Park GBX), Polyaniline gas sensor.
Noding Stephen A. (Brusly LA) Miller Charles B. (Denham Springs LA) Wolcott Duane K. (Baton Rouge all of LA) Ribes Carolyn (Baton Rouge all of LA) Wallin Sten A. (Midland MI) Cisneros Beatriz (Baton , Polymeric film-based electrochemical sensor apparatus.
Pittner Fritz (Khekgasse 40-42/11 A-1235 Vienna ATX) Schalkhammer Thomas (Gabelsbergerstrasse 5 A-3100 St. Plten ATX) Urban Gerald (Rembrandtstrasse 19/8 A-1020 Vienna ATX) Mann-Buxbaum Eva (Ulmenstr, Process for immobilizing proteins on a support containing amino, mercapto or hydroxy groups.
Say James ; Tomasco Michael F. ; Heller Adam ; Gal Yoram,ILX ; Aria Behrad ; Heller Ephraim ; Plante Phillip John ; Vreeke Mark S., Process for producing an electrochemical biosensor.
Miller Leroy J. (West Hills CA) van Ast Camille I. (Newbury Park CA) Yamagishi Frederick G. (Newbury Park CA), Reversible sensor for detecting solvent vapors.
Weigl Bernhard H. ; Holl Mark R. ; Zebert Diane ; Kenny Margaret ; Wu Caicai, Simultaneous analyte determination and reference balancing in reference T-sensor devices.
Rose-Pehrsson Susan L. (Alexandria VA) Di Lella Daniel (Lorton VA) Grate Jay W. (West Richland WA), Smart sensor system and method using a surface acoustic wave vapor sensor array and pattern recognition for selective tr.
Guiseppi-Elie Anthony (1017 Randolph Dr. Yardley PA 19067), Surface functionalized and derivatized electroactive polymers with immobilized active moieties.
Lewis, Nathan S.; Severin, Erik J.; Freund, Michael; Matzger, Adam J., Use of an array of polymeric sensors of varying thickness for detecting analytes in fluids.
Hassan, Kazi Z. A.; Cost, William M.; Morse, John Arthur; Doutt, Michael L.; Geis, Glenn Stacey, Analytical system and method for detecting volatile organic compounds in water.
Hassan, Kazi Z. A.; Cost, William M.; Morse, John Arthur; Doutt, Michael L.; Geis, Glenn Stacey, Analytical system and method for detecting volatile organic compounds in water.
Mason, Guy Harvey; Gulliver, James Andrew; Hayes, Derek George; Steel, Paul Franklin; Tomkins, Kenneth; Stevens, Andrew John, Apparatus for determining the concentration of a conductive fluid present in a fluid filled borehole.
Bashir, Rashid; Alam, Ashraf; Akin, Demir; Elibol, Oguz Hasan; Reddy, Bobby; Bergstrom, Donald E.; Liu, Yi-Shao, DNA sequencing and amplification systems using nanoscale field effect sensor arrays.
Tang, Kea-Tiong; Shih, Chung-Hung; Wang, Li-Chun; Chen, Hsin; Liu, Yi-Wen; Shyu, Jyuo-Min; Yang, Chia-Min; Yao, Da-Jeng, Medical ventilator capable of early detecting and recognizing types of pneumonia, gas recognition chip, and method for recognizing gas thereof.
Liu, Xiaoyong; Huang, Yufeng; Poole, John McKinley; Berkowitz, Gene Smith; Kowal, Anthony; Wehe, Shawn D.; Li, Hejie, Method of calibrating a wavelength-modulation spectroscopy apparatus using a first, second, and third gas to determine temperature values to calculate concentrations of an analyte in a gas.
Ali Hassan, Kazi Zulfiqur; Cost, William M.; Mowry, Curtis D.; Siegal, Michael P.; Robinson, Alex; Whiting, Joshua J.; Howell, Stephen W., Portable analytical system for detecting organic chemicals in water.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.