[특허]Surgical devices having a polymeric material with a therapeutic agent and methods for making same

Surgical devices having a polymeric material with a therapeutic agent and methods for making same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61B-017/04
출원번호	US-0630321 (2003-07-30)
발명자 / 주소	Bonutti,Peter M. Brillhart,Mark V.
출원인 / 주소	Bonutti,Peter M. Brillhart,Mark V.
대리인 / 주소	Fleit Kain Gibbons Gutman Bongini &
인용정보	피인용 횟수 : 40 인용 특허 : 75

초록 ▼

Surgical devices such as implants or suture fastenings are assembled from a plurality of discrete components, one of which components includes a heat bondable plastic material for bonding the components together. At least two components are bonded to each other by the applying heat to the heat bondable plastic material of one component. The heat bondable plastic material is preferably a polymeric or composite material suitable for surgical applications and implantation in humans, and may be a biodegradable material. A laser may be used as the heat source. The present invention is advantageously embodied in heat bonded fastenings for sutures or K-wires, in which a variety of different suture anchors are usable, including expandable distal suture anchors. Other embodiments include a metal bone plate which is held to bone by a metal bone screw and a nut of bondable material bonded to the plate to secure the connection; a piece of bondable material bonded to a metal prosthesis to custom fit the prosthesis; and a surgical implant custom formed by bonding together a plurality of discrete elements one or more of which is bondable.

대표청구항 ▼

What is claimed is: 1. A surgical device for implantation in a body comprising: an implant, at least a portion of which is expandable; and a polymeric material bonded to the implant, wherein the polymeric material is a thermoplastic, includes a therapeutic agent, is non-flowable and non-adherent at room temperature, and becomes flowable, tacky, and adherent upon the application of heat. 2. The surgical device of claim 1 wherein the therapeutic agent is a tissue ingrowth promoter. 3. The surgical device of claim 1 wherein the therapeutic agent is an antibiotic. 4. The surgical device of claim 3 wherein at least a portion of the implant is made of metal. 5. The surgical device of claim 4 wherein the implant includes a plurality of transverse ribs and a plurality of longitudinal ribs. 6. The surgical device of claim 4 wherein the implant includes a plurality of barbs for enhancing tissue engagement. 7. The surgical device of claim 6 wherein the polymeric material covers at least a portion of the implant. 8. The surgical device of claim 7 wherein the polymeric material is bonded to the implant by the application of heat. 9. The surgical device of claim 8 wherein the heat is limited to a temperature tolerated by a human body. 10. The surgical device of claim 9 wherein the polymeric material has a transition temperature below about 190째 C. 11. An implantable device for implantation in a human patient having a generally cylindrical body with a lumen extending longitudinally therethrough, at least a portion of the body including a metallic material and at least another portion of the body including a polymeric material bonded to the metallic material, the polymeric material including a therapeutic agent, being non-flowable and non-adherent at room temperature, and becoming flowable, tacky, and adherent upon the application of heat. 12. The device of claim 11 wherein a tissue-contacting surface of the body includes the polymeric material. 13. The device of claim 12 wherein the therapeutic agent is included within the polymeric material. 14. The device of claim 13 wherein the therapeutic agent is an antibiotic. 15. The device of claim 11 wherein at least a portion of the body is expandable. 16. The device of claim 15 wherein the expandable portion of the body conforms to tissue against which the expandable portion abuts. 17. The device of claim 16 wherein a tissue-contacting surface of the expandable portion of the body conforms to the tissue. 18. The device of claim 17 wherein the tissue-contacting surface is a vessel-contacting surface. 19. The device of claim 11 wherein the body includes ribs. 20. The device of claim 19 wherein the ribs are generally longitudinal to the body.

이 특허에 인용된 특허 (75)

Jacobs Randall W. (Memphis TN), Absorbable suture apparatus, method and installer.
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Wilk Peter J. (185 West End Ave. New York NY 10023), Anastomosis method.
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Raad Issam I. (Houston TX) Darouiche Rabih O. (Houston TX), Antibacterial coated medical implants.
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Greco Ralph S. (Princeton NJ) Harvey Richard A. (East Brunswick NJ) Trooskin Stanley Z. (North Brunswick NJ) Strauss George (Piscataway NJ), Antibiotic bonded prosthesis and process for producing same.
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Kim Ducksoo, Apparatus and method for closing a vascular perforation after percutaneous puncture of a blood vessel in a living subje.
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MacGregor David C. (Miami FL), Bifurcating stent apparatus and method.
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Boyan Barbara D. (San Antonio TX) Agrawal Chandra M. (San Antonio TX) Heckman James D. (San Antonio TX), Biodegradable implant for fracture nonunions.
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Gerhart Tobin N. (Brookline MA) Hayes Wilson C. (Lincoln MA), Bioerodable implant composition.
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Hench Larry L. (Gainesville FL) Walker Michael M. (Troy NY), Bonding of bone to materials presenting a high specific area, porous, silica-rich surface.
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Reese H. William (1940 E. Southern Tempe AZ 85282) Pape Harry A. (70 Merram Rd. Princeton MA 01541) Thatcher G. Lawrence (77 Linwood St. Chelmsford MA 01824), Bone clamp and installation tool.
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Riess Guido (Garmisch-Partenkirchen DEX) Geiger Albert (Garmisch-Partenkirchen DEX), Bone implant member for prostheses and bone connecting elements and process for the production thereof.
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Sanderson John E. (North Miami FL), Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone.
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Sawyer Philip N. (Brooklyn NY), Collagen welding rod material for use in tissue welding.
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Del Mundo Alfredo R. (Cerritos CA) Klivans Dean S. (Chatsworth CA), Composite blind fasteners.
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Drews Robert C. (211 N. Meramac Ave. Clayton MO 63105), Corneal rivet.
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Murphy Christopher J. (Davis CA) Reid Ted W. (Davis CA) Mannis Mark J. (Carmichael CA) Foster Bradley A. (Davis CA) Cullor James S. (Woodland CA) Selsted Michael E. (Los Angeles CA) Lehrer Robert I. , Defensin peptide compositions and methods for their use.
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Eitenmuller Jurgen (Brauweiler DEX) Offergeld Heinz (Monchen-Gladbach DEX) Michaeli Walter (Aachen DEX), Device for osteosynthesis and process for producing it.
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Bregen Michael (Lebanon NJ) Luscombe Brian H. (Washington Crossing PA), Endoscopic suture clip applying device with heater.
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Ashman Arthur (200 Central Park South New York NY 10019), Endosseous plastic implant method.
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Palmaz Julio C. (San Antonio TX), Expandable intraluminal graft, and method and apparatus for implanting an expandable intraluminal graft.
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Lichty Terry K. (Suite 105 ; St. Francis Professional Bldg. Waterloo IA 50702), External compression bone fixation device.
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Stol Israel (Monroeville PA), Fastener improvement including introduction of selected capsule of adhesive into porous basket hung in bore for activati.
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Winston Emanuel A. (1448 Old Skokie Rd. Highland Park IL 60035), Fastening device.
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Hlavacek Robert A. (New Haven CT) Dumican Barry L. (Fairfield CT) McCusker Edward J. (Fairfield CT), Flat braided ligament or tendon implant device having texturized yarns.
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Carl Richard M. (Rochester MI) Potochnik Ventzel J. (Grosse Pointe Woods MI), Harness retainer stud.
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van der Zel Joseph M. (Zwaag NLX) de Groot Klaas (Heemstede NLX), Implant of ceramic material.
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Kampner Stanley L. (1270 Armsby Dr. Hillsborough CA 94010), Implant with resorbable stem.
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Heide Helmut (Kelkheim DEX) Poeschel Eva (Altenhain DEX) Roth Ulrich (Darmstadt DEX), Implantable bone replacement materials based on calcium phosphate ceramic material in a matrix and process for the produ.
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Wiktor Dominik M. (Cranford NJ), Intravascular stent.
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Fischell Robert E. (Silver Spring MD) Fischell Tim A. (Palo Alto CA), Intravascular stent and percutaneous insertion catheter system for the dilation of an arterial stenosis and the preventi.
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Cardinal John R. (Old Lyme CT), Laminate device for controlled and prolonged release of substances to an ambient environment and method of use.
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Charlson Paul M. (Longmont CO) Schwieters Clarence R. (Rochester MN) Souk Jun H. (Rochester MN), Laser joining of thermoplastic and thermosetting materials.
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Trml Pertti (Reikonkatu 7 C 7 SF-33730 Tampere FIX) Vainionp Seppo (Orapihlajatie 21-27 B 12 SF-00320 Helsinki FIX) Rokkanen Pentti (Marjaniemenranta 29 SF-00930 Helsinki FIX) Helevirta Pertti (Ojava, Layered surgical biocomposite material.
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Kalnberz ; Viktor Konstantinovich ; Yanson ; Kharald Arnoldovich ; Kn ets ; Ivar Valterovich ; Saulgozis ; Jury Zhanovich, Material for making bone endoprosthesis and endoprosthesis made of said material.
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Ding Ni ; Helmus Michael N., Medical devices with long term non-thrombogenic coatings.
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McDaniel John M. (Warsaw IN) Miller Clayton R. (Bremen IN), Metal and plastic composite tibial component for knee joint.
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Hodorek Robert A. (Warsaw IN), Metal-backed prosthetic implant with enhanced bonding of polyethylene portion to metal base.
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Brown Byron L. (2315 Hendricks Fort Smith AR 72903), Method and apparatus for cementing a femoral stem prosthesis within a femoral canal.
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Morris Harold B. (Newnan GA), Method for bonding porous coating to rigid structural member.
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Ku Ming-Chou (13F-2 ; No. 1-28 ; Hsi Ping Nan Lane ; Sec 3 Hsi Tun Load ; Taichung City TWX), Method for fixation of avulsion fracture.
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Oser Zale (Bound Brook NJ), Method for fixation of prostheses to bone.
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Bruins, Paul F.; Ashman, Arthur, Method for producing a porous prosthesis.
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Fletcher James C. Administrator of the National Aeronautics and Space Administration ; with respect to an invention of ( La Crescenta CA) Knoell Albert C. (La Crescenta CA) Maxwell Hugh G. (La Canada, Method of adhering bone to a rigid substrate using a graphite fiber reinforced bone cement.
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Ammann Arthur J. (San Rafael CA) Rudman Christopher G (San Francisco CA), Method of inducing bone growth using TGF-b 상세보기

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Surgical devices having a polymeric material with a therapeutic agent and methods for making same 원문보기

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