[특허]Reference database

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IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G06K-009/00
출원번호	US-0055329 (2005-02-09)
발명자 / 주소	Anderson,Norman G. Anderson,N. Leigh
출원인 / 주소	Large Scale Biology Corporation
인용정보	피인용 횟수 : 0 인용 특허 : 42

초록

Data acquisition and cataloging are used to classify polypeptides into a reference index or database. The database can be used to identify previously unidentified samples. New polypeptides are characterized and added to the database.

대표청구항 ▼

We claim: 1. A method for identifying a polypeptide in a sample from a mammal of a randomly breeding population, comprising: (a) characterizing said polypeptide by isoelectric point; (b) characterizing said polypeptide by molecular weight; and (c) identifying tissues of said subject where said polypeptide is found, wherein at least 5 tissues are examined, to yield distinguishing parameters of said polypeptide comprising isoelectric point, molecular weight and tissue distribution; (d) comparing said distinguishing parameters of said polypeptide with distinguishing parameters of previously tested polypeptides of a set; and (e) determining whether a previously tested polypeptide of said set has said distinguishing parameters of said polypeptide, wherein said polypeptide is identified as being said previously tested polypeptide when said distinguishing parameters of said polypeptide match the parameters of said previously tested polypeptide, or adding said polypeptide and said distinguishing parameters to said set when said distinguishing parameters of said polypeptide are unique to said set. 2. The method of claim 1, wherein said set comprises identifying patterns of at least 10 proteins. 3. The method of claim 2, wherein said set comprises identifying patterns of at least 20 proteins. 4. The method of claim 3, wherein said set comprises identifying patters of at least 30 proteins. 5. The method of claim 4, wherein said set comprises identifying patterns of at 40 proteins. 6. The method of claim 5, wherein said set comprises identifying patterns of at 50 proteins. 7. The method of claim 1, further comprising characterizing said polypeptide yield one or more additional distinguishing parameters of said polypeptide. 8. The method of claim 7, wherein said additional distinguishing parameter comprises a partial primary amino acid sequence of said polypeptide, or fragment thereof. 9. The method of claim 7, wherein said additional distinguishing parameter is mass spectrometry data of said polypeptide, or fragment thereof. 10. The method of claim 9, wherein said spectrometry data is obtained by matrix-assisted laser desorption ionization (MALDI). 11. The method of claim 10, wherein said MALDI spectrometry comprises time of flight (TOF) analysis. 12. The method of claim 1, wherein at least 7 tissues are examined. 13. The method of claim 12, wherein at least 9 tissues are examined. 14. The method of claim 13, wherein at least 11 tissues are examined. 15. The method of claim 14, wherein at least 13 tissues are examined. 16. The method of claim 1, where said step (d) is conducted by a data processing means. 17. The method of claim 16, further comprising characterizing the spatial relationship of said polypeptide with one or more of said previously tested polypeptides on stained two dimensional electrophoresis gels. 18. The method of claim 1, wherein said steps (a) and (b) are obtained by two-dimensional gel electrophoresis. 19. A data processing system for determining identity of an element (N+1) to N elements of a database contained in a storage medium comprising: (a) computer processing means for processing data; (b) data storage means for storing data in said database contained in said storage medium; and (c) means for processing data regarding comparing a parameter of said (N+1) element with said parameter of said N elements of said database, wherein said element is a protein or polypeptide; wherein step (c) is repeated at least M times, wherein each of M parameters is examined at each iteration, wherein M is 3 or more; and wherein when said (N+1) element does not have M identical parameters of one of said N elements, said data storage means (b) adds data of said (N+1) element and of said M parameters thereof to said database to produce a new database comprising (N+1) elements. 20. The system of claim 19, wherein said element is a protein or polypeptide. 21. The system of claim 20, wherein said two of said three parameters are molecular weight and isoelectric point. 22. The system of claim 20, wherein one of said three elements is a mass spectrometry analysis of said element.

이 특허에 인용된 특허 (42)

Anderson Norman G. (Rockville MD), Apparatus for isolating cloned vectors and cells having a recovery device.
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Anderson N. Leigh ; Anderson Norman G. ; Goodman Jack, Automated system for two-dimensional electrophoresis.
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Sammons David W. (Tucson AZ) Ko Wen-Jeng (Tucson AZ) Liu Yi-Cheng (Tucson AZ), Computerized method of matching two-dimensional (2-D) patterns.
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Seilhamer Jeffrey J. ; Akerblom Ingrid E. ; Altus Christina M. ; Klingler Tod M. ; Russo Frank ; Au-Young Janice ; Hillman Jennifer L. ; Maslyn Timothy J., Database system employing protein function hierarchies for viewing biomolecular sequence data.
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Lee Kyu H. (King of Prussia PA), Hollow fiber dialysis.
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Eveleigh John W. D. (Amherst NH), Immobilization of biomolecules on perfluorocarbon surfaces.
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Bezos Jeffrey P. ; Kaphan Sheldon J. ; Ratajak Ellen L. ; Schonhoff Thomas K., Internet-based customer referral system.
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Jarrell Kevin A., Intron-mediated recombinant techniques and reagents.
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Nova Michael P. ; Parandoosh Zahra ; Senyei Andrew E. ; Xiao Xiao-Yi ; David Gary S. ; Satoda Yozo ; Zhao Chanfeng ; Potash Hanan, Matrices with memories and uses thereof.
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Nova Michael P. ; Parandoosh Zahra ; Senyei Andrew E. ; Xiao Xiao-Yi ; David Gary S. ; Satoda Yozo ; Zhao Chanfeng ; Potash Hanan, Matrices with memories and uses thereof.
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Anderson Norman G. (Rockville MD) Anderson Norman L. (Washington DC), Method and apparatus for electronic and visual image comparing.
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Michael J. Allen, Method and apparatus for the quantitative and objective correlation of data from a local sensitive force detector.
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Paulse, Chris D.; Gavin, Edward J.; Braginsky, Leonid; Rich, William E.; Fung, Eric T., Method for analyzing mass spectra.
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Fodor Stephen P.A. ; Solas Dennis W. ; Dower William J., Method of detecting nucleic acids.
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Sosnowski Ronald G. ; Butler William F. ; Tu Eugene ; Nerenberg Michael I. ; Heller Michael J. ; Edman Carl F., Methods and procedures for molecular biological analysis and diagnostics.
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Rava Richard P. (San Jose CA) Fodor Stephen P. A. (Palo Alto CA) Trulson Mark (San Jose CA), Methods for making a device for concurrently processing multiple biological chip assays.
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Keesee Susan K. ; Obar Robert ; Wu Ying-Jye, Methods for the detection of cervical cancer.
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Beattie Kenneth L., Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions.
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Heyneker Herbert L., Oligonucleotide arrays.
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Johnson, Peter C.; Brady, Mary Del, Online database that includes indices representative of a tissue population.
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Tu Ching-Fang (Tucker GA), Optical fiber cable having dripless, non-bleeding and optical fiber coating-compatible waterblocking material in core th.
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Schatz Peter J. (Mountain View CA) Cull Millard G. (Oakland CA) Miller Jeff F. (Los Angeles CA) Stemmer Willem P. C. (Los Gatos CA), Peptide library and screening method.
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Dower William J. ; Cwirla Steven E. ; Barrett Ronald W., Peptide library and screening systems.
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Barrett Ronald W. (Sunnyvale CA) Chernov-Rogan Tania (Belmont CA) Davis Ann M. (Mountain View CA), Peptides that bind IL-2 receptors.
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Maslyn Timothy J. ; Au-Young Janice ; Hillman Jennifer L. ; Hibbert Harold ; Akerblom Ingrid E. ; Cheng Rachel J. ; Tang Yuanhua T., Project-based full-length biomolecular sequence database.
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Braatz James A. (Beltsville MD) Heifetz Aaron H. (Columbia MD) Kehr Clifton L. (Silver Spring MD) Wolfe Richard A. (Ellisville MO), Protein non-adsorptive polyurea-urethane polymer coated devices.
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Okano Kazunori (Shiki JPX) Kambara Hideki (Hachiouji JPX), Separation of polynucleotides using supports having a plurality of electrode-containing cells.
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Palmer Leslie Marie ; Lonetto Michael A ; Nicholas Richard O ; Deresiewicz Robert L ; Pratt Julie M,GBX ; Hodgson John E,FRX ; Beattie David T ; Lowe Adrian M, Staphylococcus aureus 3-hydroxyacyl-CoA dehydrogenase.
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Anderson Norman G. (Rockville MD) Anderson N. Leigh (Washington DC), System for solid phase reactions.
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Anderson Norman G. (Rockville MD) Anderson N. Leigh (Washington DC), System for solid phase reactions.
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Anderson Norman G. (Rockville MD) Anderson N. Leigh (Washington DC), System for solid phase reactions.
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Bevilacqua, Michael P.; Bankaitis-Davis, Danute M.; Cheronis, John C.; Tryon, Victor, Systems and methods for characterizing a biological condition or agent using precision gene expression profiles.
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Yates ; III John R. (Seattle WA) Eng James K. (Seatac WA), Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases.
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Winkler James L. ; Fodor Stephen P. A. ; Buchko Christopher J. ; Ross Debra A. ; Aldwin Lois, Very large scale immobilized polymer synthesis using mechanically directed flow paths.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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