Ethylene oxide sterilization process indicator inks
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01J-010/00
출원번호
US-0880010
(2004-06-29)
발명자
/ 주소
Puntambekar,Shobha Shakher
출원인 / 주소
Illinois Tool Works Inc.
대리인 / 주소
Dinsmore &
인용정보
피인용 횟수 :
4인용 특허 :
14
초록▼
Water-based chemical indicator inks for ethylene oxide sterilization processes and methods for its use. The chemical indicator ink contains at least one pH indicator dye selected from the group consisting of Bromocresol green, Bromophenol blue, Methyl red, Ethyl orange, and combinations thereof. The
Water-based chemical indicator inks for ethylene oxide sterilization processes and methods for its use. The chemical indicator ink contains at least one pH indicator dye selected from the group consisting of Bromocresol green, Bromophenol blue, Methyl red, Ethyl orange, and combinations thereof. The pH indicator dye undergoes an irreversible color change when exposed to ethylene oxide vapor in the presence of low-temperature steam, but when exposed to other sterilization processes either does not undergo a color change or undergoes a color change that is different than is obtained when exposed to ethylene oxide.
대표청구항▼
What is claimed is: 1. A method for indicating that an article has undergone ethylene oxide sterilization processing comprising: providing a water-based chemical indicator ink consisting essentially of at least one pH indicator dye selected from the group consisting of Bromocresol green, Bromopheno
What is claimed is: 1. A method for indicating that an article has undergone ethylene oxide sterilization processing comprising: providing a water-based chemical indicator ink consisting essentially of at least one pH indicator dye selected from the group consisting of Bromocresol green, Bromophenol blue, Methyl red, Ethyl orange, and combinations thereof, and a powdered and crystallized hexahydrate metal salt; wherein said at least one pH indicator dye undergoes an irreversible color change when exposed to ethylene oxide vapor in the presence of low-temperature steam; applying said water-based chemical indicator ink to an article; subjecting said article to a concentration of ethylene oxide vapor in the presence of low-temperature steam; and observing said water-based chemical indicator ink for a color change that is visually indicative of whether said concentration of ethylene oxide vapor has been applied for a time sufficient to sterilize said article. 2. The method of claim 1 further comprising measuring the integrated effect of subjecting said article to said concentration of ethylene oxide vapor in the presence of low-temperature steam for said time sufficient to sterilize said article. 3. The method of claim 1 wherein applying said water-based chemical indicator ink to said article comprises applying said water-based chemical indicator ink to a substrate to form an ethylene oxide sterilization process indicator and applying said ethylene oxide sterilization process indicator to said article. 4. The method of claim 3 further comprising printing said water-based chemical indicator ink on said substrate in the shape of squares or insignia to form said ethylene oxide sterilization process indicator. 5. The method of claim 3 further comprising securing said ethylene oxide sterilization process indicator to a package containing said article and subjecting said package to said concentration of ethylene oxide vapor in the presence of low-temperature steam. 6. The method of claim 1 wherein said at least one pH indicator dye does not undergo a color change when exposed to formaldehyde gas, high-temperature steam, dry heat, or combinations thereof. 7. The method of claim 1 wherein said at least one pH indicator dye undergoes a color change when exposed to formaldehyde gas, high-temperature steam, dry heat, or combinations thereof, that is different than is obtained when exposed to ethylene oxide vapor. 8. The method of claim 1 wherein said water-based chemical indicator ink further consists essentially of an acidic compound, wherein said acidic compound retards a color change of said water-based chemical indicator ink. 9. The method of claim 8 wherein said acidic compound is citric acid. 10. The method of claim 1 wherein said water-based chemical indicator ink further consisting essentially of at least one thickening agent. 11. The method of claim 10 wherein said at least one thickening agent is selected from the group consisting of hydrous aluminum silicates, hydrous magnesium silicates, and combinations thereof. 12. The method of claim 1 wherein said water-based chemical indicator ink further consists essentially of a white pigment. 13. The method of claim 12 wherein said white pigment is titanium dioxide. 14. The method of claim 1 wherein said water-based chemical indicator ink further consists essentially of a binder. 15. The method of claim 14 wherein said binder is a polymeric material. 16. The method of claim 15 wherein said polymeric material is selected from the group consisting of polyvinyl alcohol, methyl cellulose, and combinations thereof. 17. The method of claim 1 wherein said water-based chemical indicator ink further consists essentially of a foam suppressor. 18. The method of claim 17 wherein said foam suppressor is an aliphatic polyol blend. 19. A method for indicating that an article has undergone ethylene oxide sterilization processing comprising: providing a water-based chemical indicator ink consisting essentially of a combination pH indicator dye selected from the group consisting of Bromophenol blue and Ethyl orange, Bromophenol blue and Methyl red, Bromocresol green and Ethyl orange, Bromocresol green and Bromophenol blue, and Methyl red and Ethyl orange, wherein said combination pH indicator dye undergoes an irreversible color change when exposed to ethylene oxide vapor in the presence of low-temperature steam; applying said water-based chemical indicator ink to an article; subjecting said article to a concentration of ethylene oxide vapor in the presence of low-temperature steam; and observing said water-based chemical indicator ink for a color change that is visually indicative of whether said concentration of ethylene oxide vapor has been applied for a time sufficient to sterilize said article. 20. A method for indicating that an article has undergone ethylene oxide sterilization processing comprising: providing a water-based chemical indicator ink consisting essentially of a combination pH indicator dye selected from the group consisting of Bromophenol blue and Ethyl orange, Bromophenol blue and Methyl red, Bromocresol green and Ethyl orange, Bromocresol green and Methyl red, Bromocresol green and Bromophenol blue, and Methyl red and Ethyl orange, wherein said combination pH indicator dye undergoes an irreversible color change when exposed to ethylene oxide vapor in the presence of low-temperature steam wherein said water-based chemical indicator ink is an aqueous ink solution; applying said water-based chemical indicator ink to an article; subjecting said article to a concentration of ethylene oxide vapor in the presence of low-temperature steam; and observing said water-based chemical indicator ink for a color change that is visually indicative of whether said concentration of ethylene oxide vapor has been applied for a time sufficient to sterilize said article.
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이 특허에 인용된 특허 (14)
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