A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction of a pharmacological additive having a release rate that is within acceptable pharmacokinetic criteria.
A lubricant coating vehicle for medical devices used to reduce the coefficient of friction of such devices upon exposure thereof to moisture. The lubricant coating vehicle allows the introduction of a pharmacological additive having a release rate that is within acceptable pharmacokinetic criteria. The release rate is adjusted by utilizing different salt forms of the additive and adjusting the concentration of a urethane pre-polymer.
대표청구항▼
What is claimed is: 1. A medical article lubricant composition having a delivery vehicle for a pharmacological additive comprising: a solvent selected from the group consisting of tetrahydrofuran, dimethylformamide, methylene chloride and cyclohexanone, and mixtures thereof, a hydrophilic polymer o
What is claimed is: 1. A medical article lubricant composition having a delivery vehicle for a pharmacological additive comprising: a solvent selected from the group consisting of tetrahydrofuran, dimethylformamide, methylene chloride and cyclohexanone, and mixtures thereof, a hydrophilic polymer other than an isocyanate-terminated prepolymer, an isocyanate-termintated prepolymer and an alkylester of a carboxylic acid selected from the group consisting of ethyl lactate and methylbenzoate and a pharmacological additive. 2. The composition of claim 1 wherein said hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid and polyethylene oxide. 3. The composition of claim 1 wherein said hydrophilic polymer is polyvinylpyrrolidone. 4. The composition of claim 1 wherein said isocyanate-terminated prepolymer is selected from the group consisiting of polyoxyethylene-based isocyanate prepolymers, toluene and isophorone diisocyanate-based prepolymers and hexamethylene isocyanate-terminated polyether prepolymer. 5. The composition of claim 1 wherein said pharmacological additive is an anti-microbial selected from a group consisting of chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, chlorhexidine sulfate, silver acetate, silver benzoate, silver carbonate, silver iodate, silver iodide, silver lactate, silver chloride, silver laurate, silver nitrate, silver oxide, silver palmitate, silver protein, silver sulfadiazine, polymyxin, tetracycline, tobramycin, gentamicin, rifampician, bacitracin, neomycin, chloramphenical, oxolinic acid, norfloxacin, nalidix acid, pefloxacin, enoxacin and ciprofloxacin, penicillin, ampicillin, amoxicillin, piracil, cephalosporins and vancomycin. 6. A method for producing a lubricant composition for a medical article containing a pharmacological additive comprising: blending a solvent selected from the group consisting of tetrahydrofuran, dimethylformamide, methylene chloride, cyclohexanone, and mixtures thereof, a hydrophilic polymer other than an isocyanate-terminated prepolymer, an isocyanate terminated prepolymer, an alkylester of a carboxylic acid selected from the group consisting of ethyl lactate and methylbenzoate, and a pharmacological additive until dissolved. 7. The method of claim 6 wherein said hydrophilic polymer is selected from the group consisting of polyvinylpyrrolidone, polyvinyl alcohol, polyacrylic acid and polyethylene oxide. 8. The method of claim 6 wherein said hydrophilic polymer is polyvinylpyrrolidone. 9. The method of claim 6 wherein said isocyanate-terminated prepolymer is selected from the group consisting of polyoxyethylene-based isocyanate prepolymers, toluene and isophorone diisocyanate-based prepolymers and hexamethylene isocyanate-terminated polyether prepolymer. 10. The method of claim 6 wherein said pharmacological additive is an anti-microbial selected from a group consisting of chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride, chlorhexidine sulfate, silver acetate, silver benzoate, silver carbonate, silver iodate, silver iodide, silver lactate, silver chloride, silver laurate, silver nitrate, silver oxide, silver palmitate, silver protein, silver sulfadiazine, polymyxin, tetracycline, tobramycin, gentamicin, rifampician, bacitracin, neomycin, chloramphenical, oxolinic acid, norfloxacin, nalidix acid, pefloxacin, enoxacin and ciprofloxacin, penicillin, ampicillin, amoxicillin, piracil, cephalosporins and vancomycin.
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이 특허에 인용된 특허 (10)
Condon Duane R. (Ramona CA) Brown Larry D. (San Diego CA), Adjustable tube and fitting cleaning brush.
Hudgin Donald Edward (Princeton Junction NJ) Blair Edgar Allan (Cranbury NJ), Hydrophilic or hydrogel carrier systems such as coatings, body implants and other articles.
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