Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene g
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (--NH 2) or thiol (--SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.
대표청구항▼
We claim: 1. A crosslinkable composition comprised of: (a) a first crosslinkable component having m nucleophilic groups, wherein m≧2; and (b) a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein nX
We claim: 1. A crosslinkable composition comprised of: (a) a first crosslinkable component having m nucleophilic groups, wherein m≧2; and (b) a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧2 and m+n≧5, the first component comprises two or more amino acid residues selected from the group consisting of amino acids comprising primary amine groups and amino acids comprising thiol groups, the second component comprises a polyethylene glycol moiety, and each of the first and second crosslinkable components is biocompatible, synthetic, and nonimmunogenic. 2. The composition of claim 1, wherein m>3. 3. The composition of claim 1, wherein m=3. 4. The composition of claim 1, wherein m=4. 5. The composition of claim 1, wherein n=4. 6. The composition of claim 1, wherein the electrophilic groups are succinimidyl moieties. 7. The composition of claim 1, wherein all n are identical, and all m are identical. 8. The composition of claim 1, wherein the amino acid residues are lysine. 9. The composition of claim 8, wherein m>3. 10. The composition of claim 8, wherein m=3. 11. The composition of claim 8, wherein m=4. 12. The composition of claim 8, wherein n=4. 13. The composition of claim 8, wherein the electrophilic groups are succinimidyl moieties. 14. The composition of claim 8, wherein all n are identical, and all m are identical. 15. The composition of claim 1, wherein the amino acid residues are cysteine. 16. The composition of claim 15, wherein m>3. 17. The composition of claim 15, wherein m=3. 18. The composition of claim 15, wherein m=4. 19. The composition of claim 15, wherein n=4. 20. The composition of claim 15, wherein the electrophilic groups are succinimidyl moieties. 21. The composition of claim 15, wherein all n are identical, and all m are identical. 22. A crosslinkable composition comprised of: (a) a first crosslinkable component having m nucleophilic groups, wherein m≧2; and (b) a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧2 and m+n≧5, the first component comprises two or more amino acid residues selected from the group consisting of amino acids comprising primary amine groups and amino acids comprising thiol groups, the second component comprises a polyethylene glycol moiety, the electrophilic groups are succinimidyl moieties, and each of the first and second crosslinkable components is biocompatible, synthetic, and nonimmunogenic. 23. The composition of claim 22, wherein m>3. 24. The composition of claim 22, wherein m=3. 25. The composition of claim 22, wherein m=4. 26. The composition of claim 22, wherein n=4. 27. The composition of claim 22, wherein the electrophilic groups are succinimidyl moieties. 28. The composition of claim 22, wherein all n are identical, and all m are identical. 29. The composition of claim 22, wherein the selected amino acid residues are lysine. 30. The composition of claim 29, wherein m>3. 31. The composition of claim 29, wherein m=3. 32. The composition of claim 29, wherein m=4. 33. The composition of claim 29, wherein n=4. 34. The composition of claim 29, wherein the electrophilic groups are succinimidyl moieties. 35. The composition of claim 29, wherein all n are identical, and all m are identical. 36. The composition of claim 22, wherein the selected amino acid residues are cysteine. 37. The composition of claim 36, wherein m>3. 38. The composition of claim 36, wherein m=3. 39. The composition of claim 36, wherein m=4. 40. The composition of claim 36, wherein n=4. 41. The composition of claim 36, wherein the electrophilic groups are succinimidyl moieties. 42. The composition of claim 36, wherein all n are identical, and all m are identical. 43. A crosslinkable composition comprised of: (a) a first crosslinkable component having m nucleophilic groups, wherein m≧2; and (b) a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧2 and m+n≧5, the first component comprises two or more amino acid residues selected from the group consisting of amino acids comprising primary amine groups and amino acids comprising thiol groups, the second component comprises a multifunctionally activated polyethylene glycol, and each of the first and second crosslinkable components is biocompatible, synthetic, and nonimmunogenic. 44. The composition of claim 43, wherein m>3. 45. The composition of claim 43, wherein m=3. 46. The composition of claim 43, wherein m=4. 47. The composition of claim 43, wherein n=4. 48. The composition of claim 43, wherein the electrophilic groups are succinimidyl moieties. 49. The composition of claim 43, wherein all n are identical, and all m are identical. 50. The composition of claim 43, wherein the multifunctionally activated polyethylene glycol is tetrafunctionally activated polyethylene glycol. 51. The composition of claim 43, wherein the multifunctionally activated polyethylene glycol is a star-branched polyethylene glycol. 52. The composition of claim 43, wherein the amino acid residues are lysine. 53. The composition of claim 52, wherein m>3. 54. The composition of claim 52, wherein m=3. 55. The composition of claim 52, wherein m=4. 56. The composition of claim 52, wherein n=4. 57. The composition of claim 52, wherein the electrophilic groups are succinimidyl moieties. 58. The composition of claim 52, wherein all n are identical, and all m are identical. 59. The composition of claim 52, wherein the multifunctionally activated polyethylene glycol is tetrafunctionally activated polyethylene glycol. 60. The composition of claim 52, wherein the multifunctionally activated polyethylene glycol is a star-branched polyethylene glycol. 61. The composition of claim 43, wherein the amino acid residues are cysteine. 62. The composition of claim 61, wherein m>3. 63. The composition of claim 61, wherein m=3. 64. The composition of claim 61, wherein m=4. 65. The composition of claim 61, wherein n=4. 66. The composition of claim 61, wherein the electrophilic groups are succinimidyl moieties. 67. The composition of claim 61, wherein all n are identical, and all m are identical. 68. The composition of claim 61, wherein the multifunctionally activated polyethylene glycol is tetrafunctionally activated polyethylene glycol. 69. The composition of claim 61, wherein the multifunctionally activated polyethylene glycol is a star-branched polyethylene glycol.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (147)
Cooper Kevin (Warren NJ) Scopelianos Angelo (Whitehouse Station NJ), Absorbable polyalkylene diglycolates.
Fox Adrian S. (New Windsor NY) Czap Christine A. (Montgomery NY) Wiser Robin R. (Chester NY), Adhesive hydrogels having extended use lives and process for the preparation of same.
Yeung Jeffrey E. (San Jose CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Rhee Woonza M. (Palo Alto CA), Anti-adhesion films and compositions for medical use.
Silver Frederick A. (Long Valley NJ) Berg Richard A. (Lambertville NJ) Birk David E. (Somerset NJ) Weadock Kevin (Piscataway NJ) Whyne Conrad (Somerset NJ), Biodegradable matrix and methods for producing same.
Siiman Olavi (Davie FL) Burshteyn Alexander (Miami Lakes FL) Gupta Ravinder K. (Pembroke Pines FL), Biodegradable particle coatings having a protein covalently immobilized by means of a crosslinking agent and processes f.
Juergensen Kay (Murten CHX) Aeschlimann Daniel (Basel CHX) Hunziker Ernst B. (Riedholz CHX), Biological adhesive composition and method of promoting adhesion between tissue surfaces.
Kelman Charles D. (New York NY) Devore Dale P. (Chelmsford MA), Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Deibig Heinrich (Frankfurt am Main Schwalbach DEX) Heide Helmut (Schwalbach DEX) Reiner Roland (Eschborn DEX) Koster Kari (Lorsbach DEX), Bone replacement or prosthesis anchoring material.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA), Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications.
Miyata Teruo (Tokyo NJ JPX) Rubin Albert L. (Englewood NJ) Stenzel Kurt H. (Englewood NJ) Dunn Michael W. (New Rochelle NY), Collagen drug delivery device.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Harner Carol F. H. (Redwood Shores CA) Sakai Naomi (San Mateo CA) Schroeder Jacqu, Collagen-based bioadhesive compositions.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Stol Miroslav (Prague CSX) Tolar Miroslav (Prague CSX) Adam Milan (Prague CSX) Cefelin Pavel (Prague CSX) Kalal Jaroslav (Prague CSX), Composite polymeric material for biological and medical application and the method for its preparation.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Composition for bone repair.
Palefsky Howard (Atherton CA) Pharriss Bruce B. (Palo Alto CA) Chu George (Cupertino CA), Composition of low type III content human placental collagen.
Shadle Paula J. (Richmond CA) Koths Kirston E. (El Cerrito CA) Moreland Margaret (Berkeley CA) Katre Nandini (El Cerrito CA), Conjugation of polymer to colony stimulating factor-1.
Braatz James A. (Rockville MD) Kehr Clifton L. (Silver Spring MD), Contact lenses based on biocompatible polyurethane and polyurea-urethane hydrated polymers.
Soon-Shiong Patrick (Los Angeles CA) Desai Neil P. (Los Angeles CA) Sandford Paul A. (Los Angeles CA) Heintz Roswitha A. (Los Angeles CA) Sojomihardjo Soebianto (Pasadena CA), Gel compositions prepared from crosslinkable polysaccharides, polycations and/or lipids and uses therefor.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Method of augmenting tissue with collagen-polymer conjugates.
Mosbach Klaus H. (Furulund SEX) Nilsson Kurt G. I. (Lund SEX), Method of covalently binding biologically active organic substances to polymeric substances.
Nesburn Anthony B. (Malibu CA) Gorin Michael (Rockville MD) Martinez Marvin (Glendale CA) Kenney M. Cristina (Malibu CA) Maguen Ezra (Los Angeles CA), Method of crosslinking amino acid containing polymers using photoactivatable chemical crosslinkers.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Franz Helmut (Biberach DEX) Muller Thomas (Biberach DEX) Eisert Wolfgang (Biberach DEX), Methods for preventing adhesions to organs and parts of organs by application of tissue plasminogen activator and hydrox.
Wallace Donald G. (Menlo Park CA) Smestad Thomas L. (Palo Alto CA) McPherson John M. (Sunnyvale CA) Piez Karl A. (Menlo Park CA) Seyedin Saeid (Sunnyvale CA) Armstrong Rosa (Palo Alto CA), Methods of bone repair using collagen.
Jiang Ying (North Haven CT) Gruskin Elliott A. (Killingworth CT), Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom.
Cioca Gheorge (Coatesville PA) Feeley George F. (Downingtown PA) Brabson Joseph B. (Wilmington DE) Barth Peter (Neuwied DEX), Moisture vapor permeable sheet materials.
Luck Edward E. (216 Robin Way Menlo Park CA 94025) Daniels John R. (842 Las Casas Pacific Palisades CA 90272), Non-antigenic collagen and articles of manufacture.
Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
Constancis Alain (Lyons FRX) Soula Gerard (Meyzieu FRX), Organic products containing reactive thiol functions, one method for preparing same, and biomaterials containing said pr.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
Zalipsky Samuel (Princeton NJ) Bolikal Durgadas (Edison NJ) Nathan Aruna (Piscataway NJ) Kohn Joachim B. (Highland Park NJ), Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon.
Daniels John R. (Menlo Park CA) Knapp Terry R. (Santa Clara CA), Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Schroeder Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA) F, Process for preparing a sterile, dry crosslinking agent.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Lido Beach NY) Eaton Alexander M. (New York NY), Tissue bonding and sealing composition and method of using the same.
Regula Donald W. (Belle Mead NJ) Cooper Kevin (Warren NJ) Bregen Michael F. (Milford NJ) Huxel Shawn T. (Lakehurst NJ) Rosenman Daniel C. (San Mateo CA), Utilization of biocompatible adhesive/sealant materials for securing surgical devices.
Devore Dale P. (Chelmsford MA) Scherrer Robert A. (White Bear Lake MN) Scholz Matthew T. (Woodbury MN), Viscoelastic collagen solution for opthalmic use and method of preparation.
Hamilton Raymond (Somerville MA) Fox Ellen M. (Cranston RI) Acharya Raksha A. (Northboro MA) Walts Alan E. (Brookline MA), Water insoluble derivatives of hyaluronic acid.
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Palo Alto CA), Xenogeneic collagen/mineral preparations in bone repair.
Kutryk, Michael J. B.; Cottone, Jr., Robert J.; Rowland, Stephen M., Medical device with coating for capturing genetically-altered cells and methods for using same.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.