Devices and methods for treating defects in the tissue of a living being
IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0641629
(2003-08-14)
|
발명자
/ 주소 |
- Evans,Douglas G.
- Goldman,Scott M.
- Kronengold,Russell T.
|
출원인 / 주소 |
|
인용정보 |
피인용 횟수 :
178 인용 특허 :
41 |
초록
▼
An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or additives, where the implant may also be used for therapy delivery. Additionally, the implant may be "
An implantable material for deployment in select locations or select tissue for tissue regeneration is disclosed. The implant comprises collagen, ceramics, and or other bio-resorbable materials or additives, where the implant may also be used for therapy delivery. Additionally, the implant may be "matched" to provide the implant with similar physical and/or chemical properties as the host tissue.
대표청구항
▼
What is claimed is: 1. An implant for the repair or regeneration of a defect in a bone of a living being, said implant comprising an osteoconductive matrix and at least one calcium salt blended into said matrix, wherein at least a portion of said matrix comprises a mixture of native insoluble colla
What is claimed is: 1. An implant for the repair or regeneration of a defect in a bone of a living being, said implant comprising an osteoconductive matrix and at least one calcium salt blended into said matrix, wherein at least a portion of said matrix comprises a mixture of native insoluble collagen and soluble collagen, wherein said native insoluble collagen is in the form of native collagen fibers, wherein said implant is porous and is suitable for placement into a body of a living being during an implant procedure, and wherein said pores are at least about 100 microns in size. 2. The implant of claim 1, wherein said calcium salt is at least one of a calcium phosphate and a calcium sulfate. 3. The implant of claim 2, wherein said calcium phosphate is at least one of tricalcium phosphate and hydroxyapatite. 4. The implant of claim 2, wherein said calcium phosphate comprises from about ten to about ninety percent of the weight of the implant. 5. The implant of claim 4, wherein the ratio of said native insoluble collagen to soluble collagen is from about 10:1 to 1:20. 6. The implant of claim 1, wherein said matrix additionally comprises at least one additive. 7. The implant of claim 6, wherein said at least one additive comprises at least one of ceramics, biologically active agents, drugs, and therapies. 8. The implant of claim 7, wherein said at least one additive is dispersed throughout the implant. 9. The implant of claim 7, wherein said biologically active agent comprises at least one of bone marrow, autologous blood, and bone morphogenic protein. 10. The implant of claim 6, wherein said additive is added to the implant at, or immediately prior to, placement of said implant into said tissue. 11. The implant of claim 10, wherein said osteoconductive matrix is dry and said additive is liquid, such that said additive hydrates said matrix upon the addition thereof. 12. The implant of claim 2, wherein said matrix is arranged to be compressed. 13. The implant of claim 12, wherein said compression occurs during the implant procedure. 14. The implant of claim 13, wherein said compression causes said implant to conform to the shape of the defect being treated. 15. The implant of claim 1, wherein said soluble collagen is not cross-linked.
이 특허에 인용된 특허 (41)
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Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Bone graft material for osseous defects and method of making same.
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Johnson James R. ; Marx Jeffrey G. ; Johnson Wesley D., Bone substitutes.
-
Bell Eugene (Dedham MA), Bone-equivalent and method for preparation thereof.
-
Piez Karl A. (Menlo Park CA) Pharriss Bruce B. (Palo Alto CA) Chu George H. (Sunnyvale CA) Smestad Thomas L. (Palo Alto CA) Hendricks Diana (Brea CA), Calcium phosphate/atelopeptide collagen compositions for bone repair.
-
Cioca Gheorghe (Coatesville PA), Collagen sponge.
-
Sierra David H., Collagen-polymer matrices with differential biodegradability.
-
Liu LinShu ; Spiro Robert, Collagen-polysaccharide matrix for bone and cartilage repair.
-
Liu, Sung-Tsuen, Composite materials for hard tissue replacement.
-
Harvey Wilson,GBX ; Light Nicholas D.,GBX ; Haynes Carla A.,GBX, Composite surgical material.
-
Snyders ; Jr. Robert V. (645 S. New Ballas Rd.-Apt. No. 1D St. Louis MO 63141), Composition of material for osseous repair.
-
Jefferies Steven R., Delayed drug delivery system.
-
Brekke John H. (4921 Pike La. ; Rte. #1 Duluth MN 55811), Device and method for treating and healing a newly created bone void.
-
Kensey Kenneth (Hinsdale IL), Device for sealing percutaneous puncture in a vessel.
-
Smestad Thomas L. (Palo Alto CA) Prows Daniel (Santa Clara CA) Chu George H. (Sunnyvale CA) Hendricks Diana M. (Brea CA), Gamma irradiation of collagen/mineral mixtures.
-
Smestad, Thomas L.; Prowse, Daniel; Chu, George H.; Hendricks, Diana M., Gamma irradiation of collagen/mineral mixtures.
-
Nathan Ranga (Newark CA) Seyedin Saied (Mountain View CA) Piez Karl (Menlo Park CA) Bentz Hanne (Palo Alto CA), Inductive collagen based bone repair preparations.
-
Chu George (Sunnyvale CA) Nathan Ranga (Newark CA) Seyedin Saeid (Mountain View CA), Inductive collagen-based bone repair preparations.
-
Morganti Pierfrancesco (49 Via Montoggio 00168 Rome ITX), Insoluble collagen support matrix containing releaseable soluble collagen and method of making the same.
-
Casale John (Oakland NJ), Laparoscopic hemostat delivery system and method for using said system.
-
Boyce Todd M. ; Shimp Lawrence A. ; Manrique Albert, Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same.
-
Nguyen Hoc M. (Sunnyvale CA) Chu George H. (Sunnyvale CA), Mechanically sheared collagen implant material and method.
-
Brekke John H. (Duluth MN), Method and apparatus for biodegradable, osteogenic, bone graft substitute device.
-
Nigam Alok (Phoenixville PA), Method of preparing collagen dressing sheet material.
-
Ries Peter (Reinach CHX) Bamgart Frank (Grenchen CHX) Mittelmeier Heinz (Homburg-Schwarzenbach DEX), Method of producing a bone substitute material.
-
Hardwick William R. ; Thomson Robert C. ; Cleek Robert L. ; Mane Shrikant M. ; Cook Alonzo D., Methods and articles for regenerating living tissue.
-
Devore Dale P. ; Putnam Charles ; Pachence James M., Methods and products for sealing a fluid leak in a tissue.
-
Mathiowitz Edith ; Mullon Claudy J.P. ; Domb Abraham J. ; Langer Robert S., Microspheres comprising polymer and drug dispersed there within.
-
Mathiowitz Edith ; Langer Robert S., Multiwall polymeric microspheres.
-
Smestad Thomas L. (San Jose CA), Nonstress-bearing implantable bone prosthesis.
-
Glowacki Julianne (Jamaica Plain MA) Pharriss Bruce B. (Palo Alto CA), Osteogenic composition and method.
-
McGinity James W. (Austin TX) Iwata Motokazu (Osaka JPX), Preparation and uses of multi-phase microspheres.
-
Chu George (Sunnyvale CA), Preparation of collagen hydroxyapatite matrix for bone repair.
-
Gardner David L. (Bellville OH), Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or
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