IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0024143
(2001-12-21)
|
| 등록번호 |
US-7255874
(2007-08-14)
|
|
발명자
/ 주소 |
- Bobo,John S.
- Quintero,Julian A.
- Jonn,Jerry Y.
- Barefoot,Joe B.
- Clark,Jeffrey G.
- Narang,Upvan
- Cannizaro,Scott Marc
- Marmo,J. Christopher
|
| 출원인 / 주소 |
- Closure Medical Corporation
|
| 인용정보 |
피인용 횟수 :
25 인용 특허 :
85 |
초록
▼
Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as
Biocompatible polymers and adhesives have a cyanoacrylic core and other substituents such as therapeutic agents, targeting moieties, imaging agents, amino acid residues or other organic moieties. Exemplary uses of inventive compositions include use as sealants and adhesives for medical uses, and as polymeric formulations for biocompatible implants and matrices and drug delivery.
대표청구항
▼
We claim: 1. A composition comprising a chemical moiety comprising the structure: wherein: K is H; X is NR; R is--H,--(CH2)nalkyl,--(CH2)nalkenyl,--(CH2)nalkynyl,--(CH2)ncycloalkyl,--(CH2)nheterocyclyl,--(CH2)naryl or--(CH2)nheteroaryl; n is an integer from 0 to 10; R' is CH(Z)--CO--; Z is H or s
We claim: 1. A composition comprising a chemical moiety comprising the structure: wherein: K is H; X is NR; R is--H,--(CH2)nalkyl,--(CH2)nalkenyl,--(CH2)nalkynyl,--(CH2)ncycloalkyl,--(CH2)nheterocyclyl,--(CH2)naryl or--(CH2)nheteroaryl; n is an integer from 0 to 10; R' is CH(Z)--CO--; Z is H or substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclyl moiety; and [R'--X] comprises an amino acid residue. 2. A composition comprising a chemical moiety comprising the structure: wherein: K is H; X is NR; R is--H,--(CH2)nalkyl,--(CH2)nalkenyl,--(CH2)nalkynyl,--(CH2)ncycloalkyl,--(CH2)nheterocyclyl,--(CH2)naryl or--(CH2)nheteroaryl; n is an integer from 0 to 10; R' is CH(Z)--CO--; Z is H or substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl or heterocyclyl moiety; and [R'--X] comprises a residue of an amino acid selected from the group consisting of glycine, alanine, valine, cysteine, leucine, isoleucine, serine, threonine, methionine, glutamic acid, aspartic acid, glutamine, asparagine, lysine, arginine, proline, histidine, phenylalanine, tyrosine and tryptophan. 3. The composition of claim 1, wherein said residue is of an amino acid selected from the group consisting or glycine, alanine, valine, cysteine, leucine, isoleucine, serine, threonine, methionine, glutamic acid, aspartic acid, glutamine, asparagine, lysine, arginine, proline, histidine, phenylalanine, tyrosine, tryptophan, and an analog, derivative or congener of any of the foregoing. 4. The composition of claim 2, wherein said amino acid is an (L) stereoisomer.
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