$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone der derivatives as protein kinase inhibitors 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/5377
  • A61K-031/5375
  • C07D-413/14
  • C07D-413/00
출원번호 US-0511981 (2006-08-28)
등록번호 US-7256189 (2007-08-14)
발명자 / 주소
  • Guan,Huiping
  • Liang,Congxin
  • Sun,Li
  • Tang,Peng Cho
  • Wei,Chung Chen
  • Vojkovsky,Tomas
  • Jin,Qingwu (Alan)
  • Herrinton,Paul M.
  • Mauragis,Michael A.
출원인 / 주소
  • Sugen, Inc.
  • Pharmacia & Upjohn Company
인용정보 피인용 횟수 : 2  인용 특허 : 71

초록

The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

대표청구항

What is claimed is: 1. A compound of formula: or a pharmaceutically acceptable salt thereof. 2. A pharmaceutical composition, comprising a compound or salt of claim 1 and a pharmaceutically acceptable carrier or excipient.

이 특허에 인용된 특허 (71)

  1. Rovnyak George C. (Hopewell NJ) Narayanan Venkatachala Lakshmi (Hightstown NJ) Haugwitz Rudiger D. (Titusville NJ), 1,3,Thiazolinyl and 1,3 thiazinyl substituted indolinones.
  2. Malcolm Wilson Moon ; Walter Morozowich ; Ping Gao, 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives.
  3. Eissenstat Michael A. (West Sand Lake NY) Weaver ; III John D. (Northumberland NY) Kuo Gee-Hong (East Greenbush NY) Wentland Mark P. (Colonie NY), 1-cyclopropyl-4-pyridyl-quinolinones.
  4. Shiraishi Tadayoshi (Takasago JPX) Kameyama Keiji (Kakogawa JPX) Domoto Takeshi (Kakogawa JPX) Imai Naohiro (Kakogawa JPX) Shimada Yoshio (Kakogawa JPX) Ariki Yutaka (Himeji JPX) Hosoe Kazunori (Taka, 1-phenyl-3,5-pyrazolidinedione hydroxystyrene compounds which have tyrosine kinase inhibiting activity.
  5. Cross Peter E. (Canterbury GB2) Dickinson Roger P. (Dover GB2), 2-(Imidazol-1-ylmethyl)pyrroles.
  6. Buzzetti Franco (Monza ITX) Longo Antonio (Milan ITX) Colombo Maristella (Cesano Boscone ITX), 2-oxindole compounds which are useful as tyrosine kinase inhibitors.
  7. Tang Peng Cho ; Sun Li ; McMahon Gerald, 3-(2'-alkoxybenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease.
  8. Tang Peng Cho ; Sun Li ; McMahon Gerald, 3-(2'-halobenzylidenyl)-2-indolinone compounds for the treatment of disease.
  9. Tang Peng Cho ; Sun Li ; McMahon Gerald, 3-(4'-Bromobenzylindenyl)-2-indolinone and analogues thereof for the treatment of disease.
  10. Tang Peng Cho ; Sun Li ; McMahon Gerald, 3-(4'-dimethylaminobenzylidenyl)-2-indolinone and analogues thereof for the treatment of disease.
  11. Guan, Huiping; Liang, Congxin; Sun, Li; Tang, Peng Cho; Wei, Chung Chen; Vojkovsky, Tomas; Jin, Qingwu; Herrinton, Paul M.; Mauragis, Michael A., 3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as protein kinase inhibitors.
  12. Tang Peng Cho ; Sun Li ; McMahon Gerald, 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity.
  13. Connor David T. (Ann Arbor MI) Sircar Ila (Ann Arbor MI) Sircar Jagadish C. (Ann Arbor MI), 3-5-ditertiarybutylphenyl-4-hydroxymethylidene derivatives of 1,3-dihydro-2H-indole-2-ones as antiinflammatory agents.
  14. Tang Peng Cho ; Sun Li ; McMahon Gerald, 3-heteroaryl-2-indolinone compounds for the treatment of disease.
  15. Shiraishi Tadayoshi (Takasago JPX) Imai Naohiro (Kakogawa JPX) Domoto Takeshi (Kakogawa JPX) Kameyama Keiji (Kakogawa JPX) Katsumi Ikuo (Kobe JPX) Hidaka Takayoshi (Kobe JPX) Hosoe Kazunori (Takasago, 3-phenylthiomethylstyrene derivative, process for preparing the same, and antiallergic agent and tyrosinekinase inhibiti.
  16. Ehrgott Frederick J. (Norwich CT) Goddard Carl J. (Groton CT) Schulte Gary R. (Stonington CT), 3-substituted-2-oxindole derivatives.
  17. Chen Yi ; Corbett Wendy Lea ; Dermatakis Apostolos ; Liu Jin-Jun ; Luk Kin-Chun ; Mahaney Paige E. ; Mischke Steven Gregory, 4-Alkenyl- and 4-alkynyloxindoles.
  18. Lehr Matthias,DEX, Acylpyrroledicarboxylic acids and acylindoledicarboxylic acids and their derivatives as inhibitors of cytosolic phospholipase A2.
  19. Gregorovich ; Basil V. ; MacDonald ; Stewart F., Alkylation process.
  20. Carmosin Richard J. (Quakertown PA) Carson John R. (Norristown PA) Pitis Philip M. (North Wales PA), Anti-convulsant aroyl aminoacylpyrroles.
  21. Tang Peng Cho ; Sun Li ; McMahon Gerald, Benzylidene-Z-indoline compounds for the treatment of disease.
  22. Michel Helmut (Mannheim DEX) Kampe Wolfgang (Heddesheim DEX) Strein Klaus (Hemsbach DEX) Bartsch Wolfgang (Viernheim DEX), Beta-blocking oxindole derivatives.
  23. Spada Alfred P. (Lansdale PA) Maquire Martin P. (King of Prussia PA) Persons Paul E. (King of Prussia PA) Myers Michael R. (Reading PA), Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase.
  24. Spada Alfred P. ; Myers Michael R. ; Maguire Martin P. ; Persons Paul E., Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase.
  25. Vallee Bert L. (Brookline MA) Kurachi Kotoku (Ann Arbor MI), CDNA and genes for human angiogenin (angiogenesis factor) and methods of expression.
  26. Muenster Peter (Neulussheim DEX) Steiner Gerd (Kirchheim DEX) Freund Wolfgang (Neustadt DEX) Wuerzer Bruno (Otterstadt DEX) Westphalen Karl-Otto (Speyer DEX), Carboxamides, their preparation and their use as herbicides.
  27. Levitzki Alexander (Jerusalem) Gilon Chaim (Jerusalem) Gazit Aviv (Jerusalem ILX), Certain indole compounds which inhibit EGF receptor tyrosine kinase.
  28. Still W. Clark (Clinton NY) Wigler Michael H. (Lloyd Harbor NY) Ohlmeyer Michael H. J. (Plainsboro NJ) Dillard Lawrence W. (Plainsboro NJ) Reader John C. (Princeton NJ), Complex combinatorial chemical libraries encoded with tags.
  29. Thomas P. Parks ; Vivien Mak ; Jung-Chung Lee ; Charles Lee, Compositions and methods for the treatment of anorectal disorders.
  30. Wriede Ulrich (Mutterstadt DEX) Hamprecht Gerhard (Weinheim DEX) Koehler Hermann (Bobenheim DEX) Wuerzer Bruno (Otterstadt DEX), Crop protection agents based on 1-aryl- or 1-hetarylimidazolecarboxylic esters.
  31. Gregory S. Hamilton ; David C. Limburg, Cyclic ester or amide derivatives.
  32. Kato Shozo,JPX ; Tamura Shigeo,JPX ; Kitajima Toshio,JPX ; Fukada Noriyuki,JPX, Ethenyl amide compound production process.
  33. Schwartz Donna P. (San Mateo CA) Shawver Laura K. (San Francisco CA), Formulations for lipophilic compounds.
  34. Furuzawa Kunihiko (Takarazuka JPX) Funaki Yuji (Toyonaka JPX) Hisada Yoshio (Amagasaki JPX) Izumi Kazuo (Takarazuka JPX), Fungicidal N-(phenyl-lower alkanoyl-)-imidazole derivatives, composition, and method of use.
  35. Phillion Dennis Paul ; Braccolino Diane Susan ; Graneto Matthew James ; Phillips Wendell Gary ; Van Sant Karey Alan ; Walker Daniel Mark ; Wong Sai Chi, Fungicides for the control of take-all disease of plants.
  36. Shiraishi Tadayoshi (Takasago) Kameyama Keiji (Kakogawa) Domoto Takeshi (Kakogawa) Imai Naohiro (Kakogawa) Shimada Yoshio (Kakogawa) Ariki Yutaka (Himeji) Hosoe Kazunori (Takasago) Kawatsu Masaji (Ta, Hydroxystyrene compounds having tyrosine kinase inhibiting activity.
  37. Shiraishi Tadayoshi (Takasago JPX) Kameyama Keiji (Kakogawa JPX) Domoto Takeshi (Kakogawa JPX) Imai Naohiro (Kakogawa JPX) Shimada Yoshio (Kakogawa JPX) Ariki Yutaka (Himeji JPX) Hosoe Kazunori (Taka, Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors.
  38. Shiraishi Tadayoshi (Takasago JPX) Kameyama Keiji (Kakogawa JPX) Domoto Takeshi (Kakogawa JPX) Imai Naohiro (Kakogawa JPX) Shimada Yoshio (Kakogawa JPX) Ariki Yutaka (Himeji JPX) Hosoe Kazunoro (Taka, Hydroxystyrene compounds which have useful pharmaceutical utility.
  39. Sircar Ila (Ann Arbor MI) Sircar Jagadish C. (Clarks Summit PA), Imidazole and 1,2,4-triazole derivatives with angiotensin II antagonist properties.
  40. Sircar Ila (Ann Arbor MI) Sircar Jagadish C. (Clarks Summit PA), Imidazole with angiotensin II antagonist properties.
  41. Zondler Helmut (Bottmingen CHX) Lohse Friedrich (Oberwil CHX) Moser Roland (Basel CHX), Imidazolides.
  42. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
  43. Michel Helmut (Mannheim DEX) Marzenell Klaus (Ladenburg DEX) Kampe Wolfgang (Heddesheim DEX) Bartsch Wolfgang (Viernheim DEX) Schaumann Wolfgang (Heidelberg DEX), Indolin-2-one derivatives preparation thereof and intermediates for the preparation thereof.
  44. Nadler Guy (Saint Gregoie FRX) Martin Michel (Saint Gregoie FRX) Zimmermann Richard (Saint Gregoie FRX), Indolythiadiazines for treating heart failure.
  45. Haga Nobuhiro (Osaka JPX) Inagaki Masanao (Osaka JPX) Matsumoto Saichi (Ikeda JPX) Kamata Susumu (Takarazuka JPX), Method for producing benzylidene derivatives.
  46. Buzzetti Franco (Monza ITX) Longo Antonio (Milan ITX) Colombo Maristella (Cesano Boscone ITX), Methylen-oxindole derivatives compositions and tyrosine kinase inhibition therewith.
  47. Rentzea Costin (Heidelberg DEX) Sauter Hubert (Mannheim DEX) Karbach Stefan (Ludwigshafen DEX) Will Wolfgang (Mannheim DEX) Ammermann Eberhard (Ludwigshafen DEX) Pommer Ernst-Heinrich (Limburgerhof D, N-(azolylcarbamyl)-hydroxylamines and fungicides containing these compounds.
  48. Rohde Ralph (Berlin DEX) Biere Helmut (Berlin DEX) Schmiechen Ralph (Berlin DEX) Andrews John S. (Berlin DEX) Stephens David N. (Berlin DEX), N-hetaryl imidazole derivatives.
  49. Le Baut Guillaume (St Sebastien sur Loire FRX) Nourrisson Marie-Rene (La Chapelle sur Erdre FRX) Renaud de la Faverie Jean-Francois (Le Chesnay FRX) Bizot Espiard Jean-Guy (Paris FRX) Caignard Daniel, New 3-(hydroxybenzylidenyl)-indolin-2-ones.
  50. Schmid Rolf (Schwarzenburg CHX) Zondler Helmut (Bottmingen CHX) Fischer Michael (Tafers CHX) Stauffer Werner (Fribourg CHX), Novel imidazolides and their use as curing agents for polyepoxide compounds.
  51. Kawaguchi Akihiro (Honjo JPX) Sato Atsushi (Saitama JPX) Kajitani Makoto (Saitama JPX) Yasumoto Mitsugi (Honjo JPX) Yamamoto Junji (Tokushima JPX), Oxindole derivative.
  52. Takamura Norio (Asaka JPX) Oda Kuniyuki (Urawa JPX) Kodato Shinichi (Kawaguchi JPX) Yamaguchi Isao (Tokyo JPX) Yano Koji (Hoya JPX), Phenoxyacetic acid derivatives composition and use.
  53. Carson John Robert (Norristown PA), Preparation of b 상세보기
  • West Michael (Wilmington DE), Preparation of N-acylimidazoles.
  • Hesse Michael (Ludwigshafen DEX) Hoelderich Wolfgang (Frankenthal DEX) Dockner Toni (Meckenheim DEX) Koehler Hermann (Beindersheim DEX), Preparation of acylated imidazoles.
  • Lenox Ronald S. (Lancaster PA) Schwartz Anne L. (Columbia PA), Process for reducing the acid dye uptake of polyamide textile materials with N-acylimidazole compound.
  • Zoller Gerhard (Schneck DEX) Kujath Eckard (Maintal DEX) Delpy Klaus (Dietzenbach DEX) Schrod Manfred (Weiterstadt DEX), Process for the preparation of pyrrole derivates.
  • Schnettler, Richard A.; Dage, Richard C.; Grisar, J. Martin, Pyrrole-3-carboxylate cardiotonic agents.
  • Taniguchi Masao (Machida JPX) Shirasaka Tadashi (Machida JPX) Umezu Kohei (Yokohama JPX) Hirata Mayumi (Machida JPX), Pyrrolealdehyde derivative.
  • Zoller Gerhard (Schneck DEX) Beyerle Rudi (Frankfurt DEX) Schindler Ursula (Morfelden-Walld DEX), Pyrrolealdehydes, their preparation and their use.
  • Taniguchi Masao (Machida JPX) Umezu Kohei (Yokohama JPX) Shirasaka Tadashi (Machida JPX) Inoue Shinya (Yokohama JPX) Shinpuku Tetsuro (Yokohama JPX) Mitsuka Masayuki (Machida JPX) Hirata Mayumi (Yoko, Pyrrolecarboxylic acid derivatives.
  • Taniguchi Masao (Machida JPX) Umezu Kohei (Yokohama JPX) Shirasaka Tadashi (Machida JPX) Inoue Shinya (Yokohama JPX) Shinpuku Tetsuro (Yokohama JPX) Mitsuka Masayuki (Machida JPX) Hirata Mayumi (Yoko, Pyrrolecarboxylic acid derivatives.
  • Levitzki Alexander (Jerusalem ILX) Gilon Chaim (Jerusalem ILX) Chorev Michael (Jerusalem ILX) Gazit Aviv (Jerusalem ILX), Styryl compounds which inhibit EGF receptor protein tyrosine kinase.
  • Spada Alfred P. (Lansdale PA) Persons Paul E. (King of Prussia PA) Levitzki Alexander (Jerusalem ILX) Gilon Chaim (Jerusalem ILX), Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase.
  • Wright ; Jr. William B. (Woodcliff Lake NJ) Press Jeffrey B. (Tuxedo NY), Substituted N-[w 상세보기
  • Rovnyak George C. (Hopewell NJ), Substituted indolinones.
  • Battistini Carlo,ITX ; Ballinari Dario,ITX ; Ermoli Antonella,ITX ; Penco Sergio,ITX ; Vioglio Sergio,ITX, Substituted indolylmethylene-oxindole analogues as tyrosine kinase inhibitors.
  • Larok Richard C. (Ames IA) Babu Srinivasan (Maryland Heights MO), Synthesis of nitrogen heterocycles.
  • Artico Marino (Rome ITX) Corelli Federico (Siena ITX) Massa Silvio (Rome ITX) Mai Antonello (Rome ITX) Tramontano Enzo (Nuoro ITX), Synthetic derivatives of pyrrole and pyrrolidine suitable for the therapy of infections caused by rhinoviruses.
  • Tang Peng C. ; Harris G. Davis, Synthetic methods for the preparation of indolyquinones.
  • Buzzetti Franco (Milan ITX) Crugnola Angelo (Varese ITX) Ballinari Dario (Milan ITX) Greco Felicita (Brescia ITX), Vinylene-azaindole derivatives.
  • 이 특허를 인용한 특허 (2)

    1. Zack, Donald J.; Bannister, Thomas; Vojkovsky, Tomas; Yang, Zhiyong; Berlinicke, Cynthia, Compositions and methods for treatment of neurodegenerative disease.
    2. Zack, Donald Jeffrey; Bannister, Thomas; Vojkovsky, Tomas; Yang, Zhiyong; Berlinicke, Cynthia, Compositions and methods for treatment of neurodegenerative disease.

    문의처: helpdesk@kisti.re.kr전화: 080-969-4114

    AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

    AI-Helper 아이콘
    AI-Helper
    안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
    ※ AI-Helper는 부적절한 답변을 할 수 있습니다.

    선택된 텍스트

    맨위로