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A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted wit

A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressuring and, in turn, dispensing substance through the one-way valve and out of the dispenser.

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What is claimed is: 1. A dispenser comprising: a housing; a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed; a piston mounted within the housing; a one-way

What is claimed is: 1. A dispenser comprising: a housing; a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed; a piston mounted within the housing; a one-way valve mounted within the housing and coupled in fluid communication with the variable-volume storage chamber; a compression chamber coupled in fluid communication between the piston and one-way valve, wherein at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressuring and, in turn, dispensing substance through the one-way valve and out of the dispenser. 2. A dispenser as defined in claim 1, further comprising a biasing member for biasing at least one of the piston and valve in the direction from the second position toward the first position. 3. A dispenser as defined in claim 1, wherein the biasing member is at least one of a coil spring and a resilient, elastomeric spring. 4. A dispenser as defined in claim 1, wherein the resilient, elastomeric spring is approximately dome shaped. 5. A dispenser as defined in claim 1, wherein the one-way valve includes an axially-extending valve seat, an axially-extending flexible valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat, and at least one outlet aperture coupled in fluid communication between the compression chamber and the seam, wherein the flexible valve cover is movable relative to the valve seat and the seam is connectable in fluid communication with the outlet aperture to allow the passage of substance from the compression chamber through the seam and out of the dispenser. 6. A dispenser as defined in claim 5, wherein the valve seat defines at least one tapered portion that tapers radially outwardly in the direction from the interior to the exterior of the valve. 7. A dispenser as defined in claim 5, wherein the flexible valve cover forms an interference fit with the valve seat. 8. A dispenser as defined in claim 5, wherein the flexible valve cover is responsive to a flow of substance in the outlet aperture exceeding a valve opening pressure to move between (i) a normally-closed closed condition, and (ii) an open condition wherein portions of the valve cover axially spaced relative to each other substantially sequentially move substantially radially relative to the valve seat to allow the passage of substance through the seam and out of the dispenser. 9. A dispenser as defined in claim 1, further comprising a flexible bladder mounted within the housing and defining the variable-volume storage chamber between the bladder and housing. 10. A dispenser as defined in claim 1, further comprising a slidable wail mounted within the housing and defining the variable-volume storage chamber between the slidable wall and the housing. 11. A dispenser as defined in claim 1, wherein the compression chamber defines a first radial dimension that is substantially equal to or less than a radial dimension of the piston for forming a fluid-tight seal therebetween. 12. A dispenser as defined in claim 11, wherein the piston includes at least one annular sealing surface forming said radial dimension and fluid tight seal. 13. A dispenser as defined in claim 12, wherein the annular sealing surface is formed by an elastomeric sealing member on the piston. 14. A dispenser as defined in claim 1, wherein the piston is fixed relative to the valve, and the valve is manually depressible relative to the piston between the first and second positions. 15. A dispenser as defined in claim 14, wherein the valve includes a valve body defining the compression chamber for receiving therein the piston, and an axially-extending valve seat, and the valve further includes an axially-extending flexible valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. 16. A dispenser as defined in claim 15, wherein the valve body defines a first bore for receiving the piston in the first position, and a passageway between the first bore and piston for permitting the flow of substance therethrough from the variable-volume storage chamber into the compression chamber. 17. A dispenser as defined in claim 16, wherein the valve body further defines at least one outlet aperture coupled in fluid communication between the compression chamber and the valve seam, and a second bore formed between the first bore and the outlet aperture and defining therein the compression chamber. 18. A dispenser as defined in claim 17, wherein the valve body further defining an annular surface that tapers radially inwardly between the first and second bores. 19. A dispenser as defined in claim 15, wherein the flexible valve cover includes a first portion connected to the valve body on one side of the seam, and a second portion connected to the housing on an opposite side of the seam relative to the first portion, and a movable portion extending between the second portion and the seam for permitting movement of the valve between the first and second positions. 20. A dispenser as defined in claim 19, wherein the valve body is manually depressible relative to the piston between the first and second positions. 21. A dispenser as defined in claim 20, wherein the valve body includes a manually engagable surface, and the seam extends about a peripheral portion of the manually engagable surface. 22. A dispenser as defined in claim 19, further comprising a guide extending between the valve and housing for guiding movement of the valve between the first and second positions. 23. A dispenser as defined in claim 22, further comprising a spring coupled between the guide and housing for biasing the valve in the direction from the second to the first position. 24. A dispenser as defined in claim 1, wherein the valve and piston are axially aligned, and the variable-volume storage chamber is spaced radially relative to the valve and piston. 25. A dispenser as defined in claim 1, wherein the variable-volume storage chamber is substantially airless. 26. A dispenser as defined in claim 1, further comprising a slidable wall received within the housing and forming a substantially fluid-tight seal therebetween, wherein the variable-volume storage chamber is formed between the plunger and the piston, and the plunger is movable axially upon dispensing a dosage from the storage chamber to reduce the volume of the storage chamber in an amount approximately equal to the volume of the dose dispensed. 27. A dispenser as defined in claim 1, further comprising a filling port mounted on the housing, and a second one-way valve coupled in fluid communication between the filling port and the variable volume storage chamber. 28. A dispenser as defined in claim 27, wherein the second one-way valve includes an axially-extending valve seat and an axially-extending flexible valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat, and the flexible valve cover is movable relative to the valve seat and the seam is connectable in fluid communication with variable-volume storage chamber to permit the passage of substance through the seam and into the storage chamber. 29. A dispenser as defined in claim 14, wherein the piston defines a flow conduit therein coupled in fluid communication between the variable-volume storage chamber and the compression chamber for permitting the flow of substance from the variable-volume storage chamber and into the compression chamber. 30. A device for storing and dispensing a substance comprising: first means for storing a substance; and second means for dispensing the substance and preventing the substance from flowing therethrough in an opposite direction, the second means includes a piston, a one-way valve in fluid communication with the first means, and a compression chamber in fluid communication with the piston and one-way valve, wherein at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the first means into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressuring and, in turn, dispensing the substance through the one-way valve and out of the dispenser. 31. A device as defined in claim 30, wherein the first means is a variable volume storage chamber for receiving and storing the substance. 32. The device as defined in claim 31, wherein the second means further includes a manually depressible surface for dispensing a metered dose of the substance at and/or adjacent to the manually depressible surface.