Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08G-079/02
C08G-079/00
A61M-036/14
A61M-036/00
A61K-051/00
출원번호
US-0257928
(2001-04-10)
등록번호
US-7265199
(2007-09-04)
우선권정보
DE-100 19 982(2000-04-22)
국제출원번호
PCT/DE01/001398
(2001-04-10)
§371/§102 date
20030123
(20030123)
국제공개번호
WO01/080919
(2001-11-01)
발명자
/ 주소
Grunze,Michael
Gries,Claudia
출원인 / 주소
Celonova BioSciences Germany GmbH
대리인 / 주소
Flaster/Greenberg P.C.
인용정보
피인용 횟수 :
5인용 특허 :
41
초록▼
The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing excessive cell proliferation. Furthermore, it relates to films made from the polymer as well as wrappings for
The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing excessive cell proliferation. Furthermore, it relates to films made from the polymer as well as wrappings for medical devices such as stents. It also relates to medical devices that are enclosed by a film or wrapping according to the invention.
대표청구항▼
The invention claimed is: 1. A method of manufacturing a polymer film comprising: dissolving in solvent a biocompatible polymer with the following general formula (I), wherein n is 2 to ∞, and wherein R1 to R6 are either the same or different, and represent an alkoxy, alkylsulfonyl, dialk
The invention claimed is: 1. A method of manufacturing a polymer film comprising: dissolving in solvent a biocompatible polymer with the following general formula (I), wherein n is 2 to ∞, and wherein R1 to R6 are either the same or different, and represent an alkoxy, alkylsulfonyl, dialkyl amino or aryloxy group, or a heterocyclic alkyl or heteroaryl group with nitrogen as the heteroatom, applying the polymer dissolved in the solvent to a substrate, evaporating the solvent to form the polymer film, removing the film from the substrate, wherein the film is configured for use as a wrapping or sheath and placing the wrapping or sheath around a medical device. 2. The method according to claim 1, wherein the polymer film is antithrombogenic. 3. The method according to claim 1, wherein the device is selected from the group consisting of artificial implants, plasters, tapes, artificial blood vessels, stents, catheters, and ureters. 4. A therapeutic device comprising an implant or device substrate enveloped by a wrapping or a sheath, wherein the wrapping or sheath comprises the polymer of formula (I), wherein n is 2 to ∞, and wherein R1 to R6 are either the same or different, and represent an alkoxy, alkylsulfonyl, dialkyl amino or aryloxy group, or a heterocyclic alkyl or heteroaryl group with nitrogen as the heteroatom. 5. The device according to claim 4, wherein the device is a sheathed stent. 6. The device according to claim 4, wherein the device is an artificial implant. 7. The device according to claim 6, wherein the artificial implant comprises a substrate comprising an implant material having a biocompatible coating thereon, the biocompatible coating is at least partially applied to a surface of the substrate, and the coating comprises the polymer of formula (I). 8. The device according to claim 7, wherein a layer containing an adhesion promoter is situated between the surface of the substrate and the biocompatible coating. 9. The device according to claim 8, wherein the adhesion promoter contains a polar end group, and wherein the polar end group is an organosilicon compound. 10. The device according to claim 9, wherein the organosilicon compound is aminopropyltrimethoxysilane. 11. The device according to claim 4, wherein the device is a sheathed implant substrate, the implant comprises a substrate comprising an implant material and having a biocompatible coating, the biocompatible coating is at least partially applied to the surface of the substrate, and the implant material comprises the polymer according to formula (I). 12. A microstructured polymer film of the formula (I), wherein n is 2 to ∞, and wherein R1 to R6 are either the same or different, and represent an alkoxy, alkylsulfonyl, dialkyl amino or aryloxy group, or a heterocyclic alkyl or heteroaryl group with nitrogen as the heteroatom. 13. The microstructured film according to claim 12, wherein the structures are uniform, and have a favorable flow profile. 14. The film according to claim 12, wherein the structures of the film are generated directly by means of laser, electron, or x-rays, or with a heated wire on the film. 15. The method according to claim 1, wherein the substrate is a microstructured stamp. 16. The microstructured polymer according to claim 12, wherein the film is an antithrombogenic wrapping or a sheathed substrate. 17. The method according to claim 1, wherein the medical device has a coating applied to a surface of the device according to formula (I).
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