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Medical devices and applications of polyhydroxyalkanoate polymers

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08G-063/08
  • C08G-063/00
출원번호 US-0623593 (2007-01-16)
등록번호 US-7268205 (2007-09-11)
발명자 / 주소
  • Williams,Simon F.
  • Martin,David P.
  • Skraly,Frank A.
출원인 / 주소
  • Metabolix, Inc.
대리인 / 주소
    Pabst Patent Group LLP
인용정보 피인용 횟수 : 70  인용 특허 : 38

초록

Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including int

대표청구항

We claim: 1. A device comprising a biodegradable polyhydroxyalkanoate composition that has a controlled degradation rate, under physiological conditions, wherein the degradation rate of the polyhydroxyalkanoate polymer is manipulated through addition of components to the polymeric composition, sele

이 특허에 인용된 특허 (38)

  1. Stack Richard S. (Chapel Hill NC) Klopovic Zenaida P. (Durham NC), Absorbable stent.
  2. Harwin Steven F., Bio-shim.
  3. Williams, Simon F., Bioabsorbable, biocompatible polymers for tissue engineering.
  4. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers.
  5. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers of 3-hydroxyhexanoate.
  6. Noda Isao (Fairfield OH), Biodegradable copolymers and plastic articles comprising biodegradable copolymers of 3-hydroxyhexanoate.
  7. Buscemi Paul J. (Long Lake MN) Stejskal Elizabeth A. (St. Paul MN) Doyle Erin S. (Minneapolis MN), Biodegradable drug delivery vascular stent.
  8. Hori Yoji,JPX ; Takahashi Yoko,JPX ; Hongo Hideyuki,JPX ; Yamaguchi Akio,JPX ; Hagiwara Toshimitsu,JPX, Biodegradable high molecular composition.
  9. Athanasiou Kyriacos A. ; Boyan Barbara D., Biodegradable implant.
  10. Turnlund Todd H. (Mountain View CA) Eury Robert P. (Cupertino CA), Biodegradable mesh and film stent.
  11. Tokiwa Yutaka (Tsuchiura JPX) Iwamoto Akira (Tsukuba JPX) Takeda Kiyoshi (Tsukuba JPX), Biodegradable plastic composition, biodegradable plastic shaped body and method of producing same.
  12. Goldberg Jay (Northbrook IL) Sinclair Richard (Columbus OH), Biodegradable stent.
  13. Healy Kevin E. (2517 Asbury Ave. Evanston IL 60201) Dorfman Gary S. (11 Sea Ridge Dr. Saunderstown RI 02874), Biodegradable stent.
  14. Caplan Arnold I. ; Fink David J. ; Young Randell G., Biomatrix for soft tissue regeneration.
  15. Hubbs John C. (Kingsport TN) Harrison Marti N. (Kingsport TN), Composition and process for the production of poly(3-hydroxyalkanoates).
  16. Unger Evan C., Compositions of lipids and stabilizing materials.
  17. Sinclair Richard G. (Columbus OH) Lipinsky Edward S. (Worthington OH), Degradable polymer composition.
  18. Sinclair Richard G. ; Lipinsky Edward S., Degradable polymer composition.
  19. Hlavacek Robert A. (New Haven CT) Dumican Barry L. (Fairfield CT) McCusker Edward J. (Fairfield CT), Flat braided ligament or tendon implant device having texturized yarns.
  20. Ishikawa Kenji (Kanagawa JPX), Flexible member for use as a medical bag.
  21. Peoples Oliver P. (Arlington MA) Sinskey Anthony J. (Boston MA), Gene encoding bacterial acetoacetyl-COA reductase.
  22. Asrar Jawed ; Shah Devang T. ; Tran Minhtien, Hydroxy-terminated polyhydroxyalkanoates.
  23. Williams, Simon F.; Martin, David P.; Gerngross, Tillman; Horowitz, Daniel M., Medical device containing polyhydroxyalkanoate treated with oxidizing agent to remove endotoxin.
  24. Mathiowitz Edith (Brookline MA) Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Schwaller Kirsten (Duxbury MA), Method for producing protein microspheres.
  25. Schmitz Klaus-Peter,DEX ; Behrend Detlef,DEX, Method for the manufacture of intraluminal stents of bioresorbable polymeric material.
  26. Bichon Daniel,FRX ; Bussat Philippe,FRX ; Schneider Michel,CHX, Method of making polymeric gas or air filled microballoons for ultrasonic echography.
  27. Williams Simon F. (Sherborn MA) Peoples Oliver P. (Arlington MA), Methods for synthesizing oligomers containing hydroxy acid units.
  28. Eury Robert P. (Cupertino CA), Multilayered biodegradable stent and method of manufacture.
  29. Peoples Oliver P. (Arlington MA) Gerngross Tillman U. (Cambridge MA) Sinskey Anthony J. (Boston MA), Overproduction and purification of soluble PHA synthase.
  30. Peoples Oliver P. (Arlington MA) Sinskey Anthony L. (Boston MA), Polyhydroxyalkanoate polymerase.
  31. Peoples Oliver P. (Arlington MA) Sinskey Anthony J. (Boston MA), Polyhydroxybutyrate polymerase.
  32. Hammond Timothy (Cleveland GBX), Polymer composition containing polyhydroxyalkanoate and metal compound.
  33. Witholt Bernard (Eelde NLX) Lageveen Roland G. (Groningen NLX), Process for producing polyesters by fermentation: a process for producing optically active carboxylic acids and esters:.
  34. Williams Simon F. ; Martin David P. ; Gerngross Tillman ; Horowitz Daniel M., Removing endotoxin with an oxdizing agent from polyhydroxyalkanoates produced by fermentation.
  35. Gogolewski Sylwester (Alvaneu CHX) Perren Stephan M. (Davos CHX), Resorbable fixation device with controlled stiffness for treating bodily material in vivo and introducer therefor.
  36. Holmes Paul A. (Northallerton GBX) Lim Guan B. (Stockton-on-Tees GBX), Separation process.
  37. Martini Francesco (Milan ITX) Perazzo Luigi (Cuneo ITX) Vietto Paolo (Milan ITX), Sheets materials of HB polymers.
  38. McDevitt Dennis ; Rice John, Suture anchor assembly and methods.

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  1. Smith, Craig S.; Blair, Gregory B.; Weisenburgh, II, William B., Adjunct therapy device having driver with cavity for hemostatic agent.
  2. Balek, Stephen J.; Boudreaux, Chad P.; Holcomb, Matthew D.; Rhad, Edward A., Anvil cartridge for surgical fastening device.
  3. Hueil, Geoffrey C.; Hunt, John V.; Vasudevan, Venkataramanan Madakolathur; Nur, Israel; Fanuele, Greg J., Attachment of surgical staple buttress to cartridge.
  4. Koullick, Edouard A.; Jadhav, Balkrishna S.; Grant, Robert C., Bioabsorbable mesh for surgical implants.
  5. Koullick, Edouard A.; Jadhav, Balkrishna S.; Grant, Robert C., Bioabsorbable mesh for surgical implants.
  6. Koullick, Edouard A.; Jadhav, Balkrishna S.; Grant, Robert C., Bioabsorbable mesh for surgical implants.
  7. Rose, John; Hardwick, Steven, Biodegradable polymer systems.
  8. Martin, David P.; Rizk, Said; Montcrieff, Jon I.; Connelly, Dennis W., Coatings for the manufacture and application of polyhydroxyalkanoate medical devices.
  9. Martin, David P.; Rizk, Said; Montcrieff, Jon I.; Connelly, Dennis W., Coatings for the manufacture and application of polyhydroxyalkanoate medical devices.
  10. Martin, David P.; Rizk, Said; Montcrieff, Jon I.; Connelly, Dennis W., Coatings for the manufacture and application of polyhydroxyalkanoate medical devices.
  11. Belcheva, Nadya; Hotter, Joseph; Heinrich, Russell, Composite fixation device.
  12. Belcheva, Nadya; Hotter, Joseph; Heinrich, Russell, Composite fixation device.
  13. Martin, David P.; Guo, Kai; Williams, Simon F., Compositions and devices of poly-4-hydroxybutyrate.
  14. Martin, David P.; Williams, Simon F., Compositions and devices of poly-4-hydroxybutyrate.
  15. Martin, David P.; Williams, Simon F., Compositions and devices of poly-4-hydroxybutyrate.
  16. Pecora, Andrew L.; Preti, Robert A., Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency.
  17. Guo, Kai; Martin, David P., Controlled hydrolysis of poly-4-hydroxybutyrate and copolymers.
  18. Bear, Brian W.; Le, Thu Anh; Lytle, IV, Thomas W.; Overmyer, Mark D.; Setser, Michael; Smith, Bret W.; Zavatsky, Joseph; Modi, Kreena, Device for applying adjunct in endoscopic procedure.
  19. Krumanaker, David T.; Simms, Robert J.; Goldberg, Edit; Osborne, Thomas A., Dual staple cartridge for surgical stapler.
  20. Montes de Oca Balderas, Horacio; Brown, Malcolm, Expansion moulding of shape memory polymers.
  21. Rose, John; Brown, Malcolm; Macauley, Nicola; Hall, Michael, Fiber reinforced composite material.
  22. Miller, Matthew C.; Wang, Yi-Lan; Nur, Israel; Zingman, Aron O., Fibrin pad matrix with suspended heat activated beads of adhesive.
  23. Montes De Oca Balderas, Horacio; Brown, Malcolm; Howling, Graeme; Fenwick, Steve; Cotton, Nicholas; Brumfield, David, Graft fixation.
  24. Rose,John, High strength bioresorbables containing poly-glycolic acid.
  25. Janko, Gordon F.; Radisch, Herbert R.; Trozera, Thomas A., Implantable medical devices comprising bio-degradable alloys.
  26. Janko, Gordon F.; Radisch, Jr., Herbert R.; Trozera, Thomas A., Implantable medical devices comprising bio-degradable alloys.
  27. Carter, Andrew J., Implants for soft and hard tissue regeneration.
  28. Koullick, Edouard A.; Dinh, Thomas Q.; Grant, Robert C., Implants with absorbable and non-absorbable features for the treatment of female pelvic conditions.
  29. Rizk, Said; Connelly, Dennis W.; Bernasconi, Matthew; Carter, Andrew J.; Martin, David P.; Williams, Simon F., Injection molding of poly-4-hydroxybutyrate.
  30. Kutryk, Michael J. B.; Cottone, Jr., Robert J.; Rowland, Stephen M., Medical device with coating for capturing genetically-altered cells and methods for using same.
  31. Williams, Simon F.; Martin, David P.; Skraly, Frank A., Medical devices and applications of polyhydroxyalkanoate polymers.
  32. Cahil, Ryan; Guo, Kai; Martin, David P.; Rizk, Said; Ho, Kicherl; Williams, Simon F., Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers.
  33. Guo, Kai; Felix, Fabio; Martin, David P., Medical devices containing dry spun non-wovens of poly-4-hydroxybutyrate and copolymers with anisotropic properties.
  34. Martin, David P.; Rizk, Said; Ho, Kicherl; Williams, Simon F., Medical devices containing melt-blown non-wovens of poly-4-hydroxybutyrate and copolymers thereof.
  35. Rizk, Said; Martin, David P.; Ho, Kicherl; Williams, Simon F., Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers.
  36. Zakel, Elke; Azdasht, Ghassem, Method and device for drying circuit substrates.
  37. Agarwal, Jayant P., Method for connecting nerves via a side-to-side epineurial window using artificial conduits.
  38. Yu, Harrison, Method of incorporating additives to shaped porous monocomponent biopolymer fibers during fiber orienting step.
  39. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Method of making a medical textile from polyhydroxyalkanoate fibers.
  40. Rizk, Said, Method of making a polyhydroxyalkanoate filament.
  41. Zhou, Chaoyin; Jacobsen, Alan J., Method to control the biodegradation rates of polymer structures.
  42. Agarwal, Jayant P.; Gale, Bruce Kent; Sant, Himanshu Jayant; Lin, Keng-Min, Methods and devices for connecting nerves.
  43. Ganatra, Amit; Felix, Fabio; Shah, Bhavin; Bernasconi, Matthew; Rizk, Said; Martin, David P.; Williams, Simon F., Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof.
  44. Ganatra, Amit; Felix, Fabio; Shah, Bhavin; Bernasconi, Matthew; Rizk, Said; Martin, David P.; Williams, Simon F., Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof.
  45. Brown, Malcolm; Montes De Oca Balderas, Horacio; Hall, Michael; Rose, John, Multi-modal shape memory polymers.
  46. Brown, Malcolm; Montes De Oca Balderas, Horacio; Hall, Michael; Rose, John, Multi-modal shape memory polymers.
  47. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
  48. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
  49. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
  50. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Polyhydroxyalkanoate medical textiles and fibers.
  51. Schmitz, Klaus Peter; Behrend, Detlef; Sternberg, Katrin; Grabow, Niels; Martin, David P.; Williams, Simon F., Polymeric, degradable drug-eluting stents and coatings.
  52. Schmitz, Klaus-Peter; Behrend, Detlef; Sternberg, Katrin; Grabow, Niels; Martin, David P.; Williams, Simon F., Polymeric, degradable drug-eluting stents and coatings.
  53. Schmitz, Klaus-Peter; Behrend, Detlef; Sternberg, Katrin; Grabow, Niels; Martin, David P.; Williams, Simon F., Polymeric, degradable drug-eluting stents and coatings.
  54. Schmitz, Klaus-Peter; Behrend, Detlef; Sternberg, Katrin; Grabow, Niels; Martin, David; Williams, Simon, Polymeric, degradable drug-eluting stents and coatings.
  55. Martin, David P.; Rizk, Said; Ahuja, Ajay; Williams, Simon F., Process of making polyhydroxyalkanoate medical textiles.
  56. Cottone, Jr., Robert John; Yoklavich, Margaret; Parker, Sherry, Progenitor endothelial cell capturing with a drug eluting implantable medical device.
  57. Ganatra, Amit; Shah, Bhavin; Rizk, Said; Martin, David P.; Williams, Simon F., Pultrusion of poly-4-hydroxybutyrate and copolymers thereof.
  58. Bruewer, Dean B.; Kimball, Cory G.; Schmid, Katherine J.; Swensgard, Brett E.; Daunch, William A., Resistive heated surgical staple cartridge with phase change sealant.
  59. Huang, Bin; Kleiner, Lothar W.; Stankus, John, Stent and delivery system with reduced chemical degradation.
  60. Huang, Bin; Kleiner, Lothar W.; Stankus, John, Stent and delivery system with reduced chemical degradation including a Chitooligosaccharide.
  61. Bruewer, Dean B.; Kimball, Cory G.; Daunch, William A.; Swensgard, Brett E.; Schmid, Katherine J., Surgical instrument with filled staple.
  62. Boudreaux, Chad P.; Balek, Stephen J.; Holcomb, Matthew D.; Rhad, Edward A.; Wilson, Jr., Donald F., Surgical instrument with fluid fillable buttress.
  63. Huitema, Thomas W.; Swayze, Jeffrey S.; Siegel, Julianne M.; Kerr, Wendy A.; Hall, Steven G., Surgical instrument with staple reinforcement clip.
  64. Wang, Yi-Lan; Miller, Matthew C.; Zingman, Aron O., Surgical staple assembly with hemostatic feature.
  65. Smith, Bret W.; Lytle, IV, Thomas W.; Miller, Matthew C.; Wang, Yi-Lan; Zavatsky, Joseph; Modi, Kreena; Zingman, Aron O., Surgical staple cartridge with self-dispensing staple buttress.
  66. Balek, Stephen J.; Boudreaux, Chad P.; Holcomb, Matthew D.; Lytle, IV, Thomas W.; Miller, Matthew C.; Scheib, Charles J.; Smith, Bret W.; Wang, Yi-Lan; Wilson, Jr., Donald F.; Rhad, Edward A.; Modi, Kreena R.; Zavatsky, Joseph; Zingman, Aron O., Surgical stapling device with adjunct material application feature.
  67. Bernasconi, Matthew; Connelly, Dennis; Rizk, Said; Martin, David P.; Williams, Simon F., Thermoformed poly-4-hydroxybutyrate medical implants.
  68. Bernasconi, Matthew; Connelly, Dennis; Rizk, Said; Martin, David P.; Williams, Simon F., Thermoformed poly-4-hydroxybutyrate medical implants.
  69. Brown, Malcolm, Tunable segmented polyacetal.
  70. Martin, David P.; Guo, Kai; Rizk, Said; Williams, Simon F., Ultrafine electrospun fibers of poly-4-hydroxybutyrate and copolymers thereof.
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