A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered
A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
대표청구항▼
What is claimed is: 1. A system for processing blood components, the system comprising: a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the cha
What is claimed is: 1. A system for processing blood components, the system comprising: a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior; a flow path in flow communication with the outlet port of the separation chamber; a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from centrifugally separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components; a centrifuge rotor configured to be rotated about an axis of rotation, the rotor comprising a first portion configured to receive the separation chamber and a second portion configured to receive the filter, and wherein the system further comprises a pump configured to pump at least some of the centrifugally separated blood components from the chamber to the filter via the flow path; wherein the first and second portions are positioned with respect to one another so that when the separation chamber is received in the first portion and the filter is received in the second portion, the filter is closer than the interior of the separation chamber to the axis of rotation, and wherein the system is configured so that the rotor rotates during filtering of at least some of said at least one blood component via the filter. 2. The system of claim 1, wherein the system is configured so that when the filter is received in the second portion, the filter is eccentric with respect to the axis of rotation. 3. The system of claim 2, wherein the system is configured so that when the filter is received in the second portion, the axis of rotation does not intersect an interior flow path defined by the filter. 4. The system of claim 2, wherein the filter comprises a filter housing inflow port and a filter housing outflow port, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is located closer than the filter housing inflow port to the axis of rotation. 5. The system of claim 4, wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the porous filtration medium to the axis of rotation. 6. The system of claim 4, wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is above the filter housing inflow port. 7. The system of claim 2, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, wherein the filter inlet and filter outlet are in flow communication with the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter is positioned so that blood components flow in the interior space in a direction facing generally toward the axis of rotation. 8. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the filter housing inflow port to the axis of rotation. 9. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is closer than the porous filtration medium to the axis of rotation. 10. The system of claim 7, wherein the filter housing defines a filter housing inflow port for passing blood components to the interior space and a filter housing outflow port for passing blood components from the interior space, and wherein the system is configured so that when the filter is received in the second portion, the filter housing outflow port is above the filter housing inflow port. 11. The system of claim 1, wherein the second portion comprises at least one of a ledge and a slot configured to receive the filter, the at least one of a ledge and a slot being positioned under a top surface of the rotor. 12. The system of claim 1, wherein the rotor comprises a holder configured to hold the filter with respect to the rotor. 13. The system of claim 1, wherein the flow path comprises a first tubing portion having one end coupled to the outlet port of the separation chamber and another end coupled to the filter inlet, and wherein the system further comprises a second tubing portion having an end coupled to the filter outlet, wherein the second tubing portion extends in a direction facing generally away from the axis of rotation. 14. The system of claim 13, further comprising a third tubing portion downstream from the second tubing portion, wherein the third tubing portion extends in a direction facing generally toward the axis of rotation. 15. The system of claim 14, wherein the rotor comprises a groove configured to receive at least some of the second and third tubing portions. 16. The system of claim 1, wherein the system further comprises a collection container comprising an inlet in flow communication with the filter outlet, and wherein the second portion of the rotor comprises a cavity configured to receive the filter and the collection container. 17. The system of claim 1, wherein the axis of rotation extends through the second portion of the rotor. 18. The system of claim 1, wherein the chamber is configured so that the chamber interior has a variable volume. 19. The system of claim 1, wherein the separation chamber comprises a blood component separation bag. 20. The system of claim 19, wherein at least a portion of the blood component separation bag is formed of at least one of flexible and semi-rigid material so that the chamber interior has a variable volume. 21. The system of claim 19, wherein the bag has a generally annular ring shape defining a central opening. 22. The system of claim 19, wherein the chamber interior includes a tapered portion leading to the outlet port. 23. The system of claim 1, wherein the system comprises a tubing line having an end coupled to the filter outlet, and wherein the rotor comprises at least one support member configured to support the separation chamber, wherein the at least one support member comprises a guide groove configured to receive a portion of the tubing line and at least one of a controllable clamp and a welder associated with the groove. 24. The system of claim 23, wherein the separation chamber comprises at least one guide hole configured to receive the at least one support member. 25. The system of claim 1, wherein the rotor comprises a plurality of support members located in an asymmetric fashion with respect to the axis of rotation, and wherein the separation chamber comprises a plurality of guide holes, each of the guide holes being configured to receive a respective one of the support members. 26. The system of claim 1, wherein the separation chamber has a ring shape. 27. The system of claim 1, further comprising at least one valving member on the centrifuge rotor, the valving member being configured to control flow of at least some of the blood components during rotation of the rotor. 28. The system of claim 27, wherein the valving member comprises a tubing clamp. 29. The system of claim 1, further comprising at least one sealing member on the centrifuge rotor, the sealing member being configured to create a seal during rotation of the rotor. 30. The system of claim 29, wherein the sealing member comprises a tubing welder. 31. The system of claim 1, wherein the system is configured so that the pump pumps blood components from the chamber during rotation of the centrifuge rotor. 32. The system of claim 1, wherein the chamber is configured so that the chamber interior has a variable volume, and wherein the pump is configured to reduce the volume of the chamber interior. 33. The system of claim 32, wherein the pump is configured to apply pressure to the chamber via hydraulic fluid. 34. The system of claim 33, further comprising a sensor configured to sense pressure of pumped blood components, wherein the sensor senses pressure of the hydraulic fluid. 35. The system of claim 1, further comprising a sensor configured to sense pressure of pumped blood components, wherein the system is configured to control the pump based on at least the pressure sensed by the pressure sensor. 36. The system of claim 35, wherein the system is configured to calculate a difference between pressures sensed by the pressure sensor in at least one time interval, determine when the calculated difference is at least a predetermined amount, and control the pump in response to at least the determination that the calculated difference is at least the predetermined amount. 37. The system of claim 35, further comprising an optical sensor, wherein the system is configured to control the pump based on at least information sensed by the optical sensor and pressure sensed by the pressure sensor. 38. The system of claim 1, wherein the filter comprises a filter inflow port upstream of the porous filtration medium and a filter outflow port downstream of the porous filtration medium, and wherein the system is configured so that when the filter is received in the second portion, the filter outflow port is located closer than the filter inflow port to the axis of rotation. 39. A method of processing blood components, comprising: providing the system of claim 1; placing the separation chamber in the first portion of the rotor and the filter in the second portion of the rotor, wherein the filter is located closer than an interior of the separation chamber to the axis of rotation of the rotor; rotating the centrifuge rotor, the separation chamber, and the filter about the axis of rotation of the centrifuge rotor, wherein blood components are centrifugally separated in the chamber interior; removing at least some of the centrifugally separated blood components from the separation chamber via the outlet port; and flowing the removed blood components through the porous filtration medium so as to filter at least some of at least one blood component from the removed blood components, wherein at least a portion of the filtering occurs during said rotating. 40. A method of processing blood components, comprising: placing a separation chamber in a first portion of a centrifuge rotor and a filter in a second portion of the rotor, wherein the filter is located closer than an interior of the separation chamber to an axis of rotation of the centrifuge rotor, and wherein the filter comprises a porous filtration medium; rotating the centrifuge rotor, the separation chamber, and the filter about the axis of rotation, wherein blood components are centrifugally separated in a chamber interior of the separation chamber; removing at least some of the centrifugally separated blood components from the separation chamber via an outlet port of the separation chamber; flowing the removed blood components through the porous filtration medium so as to filter at least some of at least one blood component from the removed blood components; and wherein the flowing comprises pumping the removed blood components from the chamber through the porous filtration medium; wherein at least a portion of the filtering occurs during said rotating. 41. The method of claim 40, wherein the method further comprises passing the filtered blood components into at least one collection container. 42. The method of claim 40, wherein the blood components in the separation chamber are blood components of a buffy coat. 43. The method of claim 40, wherein whole blood is processed in the method. 44. The method of claim 40, wherein the filter comprises a filter housing defining an interior space containing the porous filtration medium, and wherein the method comprises flowing blood components in the interior space in a direction facing generally toward the axis of rotation. 45. The method of claim 40, further comprising causing at least one valving member on the centrifuge rotor to control flow of at least some of the blood components during rotation of the rotor. 46. The method of claim 45, wherein the valving member comprises a tubing clamp. 47. The method of claim 40, further comprising causing at least one sealing member on the centrifuge rotor to create a seal during rotation of the rotor. 48. The method of claim 47, wherein the sealing member comprises a tubing welder. 49. The method of claim 40, wherein the pumping occurs during rotation of the centrifuge rotor. 50. The method of claim 40, wherein the pumping comprises reducing the volume of an interior of the chamber. 51. The method of claim 50, further comprising applying pressure to the chamber via hydraulic fluid. 52. The method of claim 40, further comprising sensing pressure of pumped blood components, and controlling the pumping based on at least the sensed pressure. 53. The method of claim 52, further comprising calculating a difference between pressures sensed in at least one time interval, determining when the calculated difference is at least a predetermined amount, and controlling the pumping in response to at least the determination that the calculated difference is at least the predetermined amount. 54. The method of claim 52, further comprising optically sensing the pumped blood products, and controlling the pumping based on at least one of optically sensed information and sensed pressure. 55. The method of claim 40, wherein the flowing comprises flowing the removed blood components through the porous filtration medium in a direction generally facing toward the axis of rotation. 56. An apparatus for use with a centrifuge for processing blood components, the apparatus comprising: a separation chamber comprising a chamber interior in which blood components are centrifugally separated, and an outlet port for passing at least some of the centrifugally separated blood components from the chamber interior; a flow path in flow communication with the outlet port of the separation chamber; and a filter comprising a filter inlet in flow communication with the flow path, a porous filtration medium configured to filter at least some of at least one blood component from centrifugally separated blood components passed to the filter via the flow path, and a filter outlet for filtered blood components, wherein the centrifuge for use with the apparatus comprises a rotor configured to be rotated about an axis of rotation, the rotor comprising a first portion configured to receive the separation chamber and a second portion configured to receive the filter; and wherein the system further comprises a pump configured to pump at least some of the centrifugally separated blood components from the chamber to the filter via the flow path; wherein the first and second portions are positioned with respect to one another so that when the separation chamber is received in the first portion and the filter is received in the second portion, the filter is closer than the interior of the separation chamber to the axis of rotation, wherein the centrifuge is configured so that the rotor rotates during filtering of at least some of said at least one blood component via the filter. 57. The apparatus of claim 56, wherein the apparatus further comprises a collection container comprising an inlet in flow communication with the filter outlet, and wherein the second portion of the rotor comprises a cavity configured to receive the filter and the collection container. 58. The apparatus of claim 56, wherein the chamber is configured so that the chamber interior has a variable volume. 59. The apparatus of claim 56, wherein the separation chamber comprises a blood component separation bag. 60. The apparatus of claim 59, wherein at least a portion of the blood component separation bag is formed of at least one of flexible and semi-rigid material so that the chamber interior has a variable volume. 61. The apparatus of claim 59, wherein the bag has a generally annular ring shape defining a central opening. 62. The apparatus of claim 59, wherein the chamber interior includes a tapered portion leading to the outlet port. 63. The apparatus of claim 56, wherein the separation chamber comprises at least one guide hole configured to receive at least one support member of the centrifuge. 64. The apparatus of claim 56, wherein the rotor comprises a plurality of support members located in an asymmetric fashion with respect to the axis of rotation, and wherein the separation chamber comprises a plurality of guide holes, each of the guide holes being configured to receive a respective one of the support members. 65. The apparatus of claim 56, wherein the apparatus is configured to be disposed after being used for processing of blood components from a single donor. 66. The apparatus of claim 56, wherein the separation chamber has a ring shape.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (155)
Latham ; Jr. Allen (Jamaica Plain MA) Jorgensen Glen E. (Marlborough MA) Sibinga Theodoor H. S. (Boston MA) Plante Joseph R. (Millis MA) Knapp Tracey E. (Hanover MA), Apheresis apparatus and method.
McMannis John D. (Evergreen CO) London Nicholas (Evington GBX), Apparatus and method for separating microscopic units in a substantially continuous density gradient solution.
Hlavinka Dennis (Golden CO) Langley Robert (Westminster CO) Taylor Linda (Littleton CO) Walker John C. (Boulder CO), Apparatus for separating particles.
Krasnoff Eric J. (Old Brookville NY) Bormann Thomas J. (Melville NY) Gsell Thomas C. (Glen Cove NY) Pascale Frank R. (Glen Cove NY) Matkovich Vlado I. (Glen Cove NY), Automated system for processing biological fluid.
Brown Richard I. (Northbrook IL) Foley John T. (Wheeling IL), Blood processing systems with improved data transfer between stationary and rotating elements.
Dyck Howard F. (G.B. #1301 ; R.R. #1 Trenton ; Ontario CAX K8V 5P4 ), Centrifugal separator for flowable mixtures and having magnets and housing scrapers.
Brown Richard J. (Northbrook IL) Smith Sidney (Lake Forest IL) Cerny David E. (Crystal Lake IL) Foley John T. (Wheeling IL), Centrifugation chamber having an interface detection surface.
Brown Richard I. (Northbrook IL) Smith Sidney (Lake Forest IL) Cerny David E. (Crystal Lake IL) Foley John T. (Wheeling IL), Centrifugation pheresis system.
Galloway Jimmie G. (Missouri City MO) Kelley Lonny R. (Houston TX) Ehrhardt Mark E. (Houston TX) Fowler Tracy A. (Kennewick WA), Centrifuge processor and liquid level control system.
Williamson ; IV Warren P. (Cincinnati OH) Brown Richard I. (Northbrook IL), Centrifuge with separable bowl and spool elements providing access to the separation chamber.
Schoendorfer Donald W. (67 Balboa Coves Santa Ana CA) McLaughlin William F. (67 Balboa Coves Newport Beach CA 92663), Closed hemapheresis system and method.
Bacehowski David V. (Wildwood IL) Cullis Herbert M. (Silver Spring MD) VanBaelen Armand R. (Rolling Meadows IL), Combination disposable plastic blood receiving container and blood component centrifuge.
Bacehowski David V. (Wildwood IL) Cullis Herbert M. (Silver Spring MD) Van Baelen Armand R. (Rolling Meadows IL), Disposable container for a centrifuge.
Brown Richard I. (Northbrook IL) Prisco Michael R. (Aurora IL), Enhanced yield blood processing systems and methods establishing controlled vortex flow conditions.
Dennehey T. Michael (Arlington Heights IL) Pernic Stanley J. (Round Lake IL) West ; Jr. Joseph C. (Vernon Hills IL), High volume centrifugal fluid processing system and method for cultured cell suspensions and the like.
hlin L. Erik (Stocksund SEX) Unger H. Peter (Stockholm SEX) Westberg J. Eric (Liding SEX), Method and apparatus for centrifugal batch separation of blood.
Figdor Carl G. (The Netherlands Cancer Inst. Plesmanlaan 121 1066 CX Amsterdam NLX) Bont Willy S. (The Netherlands Cancer Inst. Plesmanlaan 121 1066 CX Amsterdam NLX), Method and device for the separation and isolation of blood or bone marrow components.
Cullis Herbert M. (Silver Spring MD) Dorsey Evelyn E. (Washington DC) De Vries James H. (McHenry IL), Method and system for fractionating a quantity of blood into the components thereof.
Hagihara Takeaki (Oita JPX) Torii Maho (Yokohama JPX), Method for separating a blood material into blood components by centrifugation, and centrifugal apparatus.
Biesel Wolfgang (Ottweiler DEX) Mathieu Bernd (Spiesen-Elversberg DEX) Weber Wolfram (Spiesen-Elversberg DEX), Method for the continuous conditioning of a cell suspension.
Matkovich Vlado I. (Glen Cove NY) Bormann Thomas J. (Melville NY) Gsell Thomas C. (Glen Cove NY) Pascale Frank R. (Glen Cove NY) Morris Keith S. (Hants GB2), Method for treating transition zone material.
Neumann Hans-Jrgen (St. Wendel DEX) Meisberger Artur (St. Wendel DEX) Weber Wolfram (Spiesen DEX), Method of separating blood and apparatus for carrying out the method.
Brown Richard I. (Northbrook IL) Cerny David E. (Crystal Lake IL) Foley John T. (Wheeling IL) West ; Jr. Joseph C. (Fox Lake IL), Plasma collection set.
Brous Donald (110 Hunt Rd. Peterborough NH 03458) Cox Robert H. (33 Ferncliff Rd. Scarsdale NY 10583), Pressure and fluid flow activated, simplified proportioning system.
Spindler Jorg,DEX, Process and devices for fluid separation of whole blood as a mixture of liquids into individual, differently-colored blood constituents, in particular for separation of concentrated thrombocytes from.
Bacehowski David V. (Wildwood IL) Bucheger Ronald (Arlington Heights IL), Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system.
Bacehowski David V. (Wildwood IL) Bucheger Ronald (Arlington Hgts IL), Rotatable bowl assembly for centrifugal processing apparatus having a bonded and prewound umbilical system.
Khoja Mirza A. (Columbia MD) Gutierrez Louis F. (Silver Spring MD) Perone John T. (Silver Spring MD), Rotor drive assembly for a centrifugal liquid processing apparatus.
Dunn ; Jr. George F. (Wenonah NJ) Irr Joseph D. (Newark DE) Halpern Lise N. (Newton Highlands MA), Simplified method for the preparation of human lymphokine activated killer cells.
Pall David B. (Roslyn Estates NY) Gsell Thomas C. (Glen Cove NY) Matkovich Vlado I. (Glen Cove NY) Bormann Thomas (Seaford NY), System for processing biological fluid.
Brown Richard I. (Northbrook IL), Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic.
Högberg, Niclas; Hällgren, Emanuel; Pihlstedt, Peter; Holmes, Brian M.; Persson, Lars; Strandberg, Lars; Van Waeg, Geert; Corbin, III, Frank, Blood component processing system method.
Stanton, Briden Ray; Van Waeg, Geert, Method and apparatus for separating a composite liquid into at least two components and for determining the yield of at least one component.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.