초록 ▼

Method of electrostatically applying powder material to a substrate, wherein the substrate is a pharmaceutical substrate and the powder material is pharmaceutically acceptable. At least some of the particles of the material comprise a core and a shell surrounding the core, and the material of the co

Method of electrostatically applying powder material to a substrate, wherein the substrate is a pharmaceutical substrate and the powder material is pharmaceutically acceptable. At least some of the particles of the material comprise a core and a shell surrounding the core, and the material of the core and the shell have different physical and/or chemical properties.

대표청구항 ▼

The invention claimed is: 1. A method of preparing a powder material and application to a pharmaceutical substrate or substrates, which method comprises preparing a range of pharmaceutically acceptable powder materials, the particles of each of the powder materials comprising a core and a shell sur

The invention claimed is: 1. A method of preparing a powder material and application to a pharmaceutical substrate or substrates, which method comprises preparing a range of pharmaceutically acceptable powder materials, the particles of each of the powder materials comprising a core and a shell surrounding the core; for each powder material, encapsulating a desired core material with a shell material, the core material comprising a component which can be varied selected from a binder polymer, one or more additives selected from a colorant, an opacifier, a pharmaceutically active material and a filler and optionally one or more other additives, the shell material having different physical and/or chemical properties from the core material and comprising a binder polymer and optionally one or more other additives, and wherein the same shell material is used for the range of powder materials produced; and electrostatically applying one or more of said powder materials produced to a pharmaceutical substrate or substrates; whereby a universal shell material is provided for use with various variable core compositions, permitting alterations to the components in the core without affecting electrostatic application of the powder material to a substrate. 2. A method according to claim 1, wherein different pharmaceutically active materials and/or different amounts of pharmaceutically active material are included in the range of powders prepared. 3. A method according to claim 1, wherein the core contains pharmaceutically active material. 4. A method according to claim 3, wherein active material and filler are present in the core. 5. A method according to claim 3, wherein the substrate contains a different pharmaceutically active material from the powder material. 6. A method according to claim 3, wherein the substrate contains the same pharmaceutically active material as the powder material. 7. A method according to claim 3, wherein the substrate contains no pharmaceutically active material. 8. A method according to claim 3, wherein the substrate is a pharmaceutical solid dosage form. 9. A method according to claim 1, wherein the shell comprises a binder polymer material having charge-control functionality and/or a separate charge-control agent. 10. A method according to claim 9, wherein the shell comprises a binder polymer having charge-control functionality. 11. A method according to claim 1, wherein the powder material contains one or more polymer binders selected from methacrylate polymers, polyvinylpyrrolidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose phthalate and hydroxypropyl methylcellulose acetate succinate. 12. A method according to claim 1, wherein the powder material contains a methacrylate. 13. A method according to claim 12, wherein the powder material contains an ammonio-methacrylate copolymer. 14. A method according to claim 1, wherein the powder material contains polyvinylpyrrolidone. 15. A method according to claim 1, wherein the core contains a binder polymer having charge-control functionality and/or a separate charge-control agent. 16. A method according to claim 1, wherein the shell has a thickness in the range of from 0.1 μm to 5 μm. 17. A method of preparing a powder material and application to a substrate which is a solid dosage form or to a plurality of such substrates, which method comprises: preparing a range of powder materials, the particles of each of the powder materials comprising a core and a shell surrounding the core; for each powder material, encapsulating a desired core material with a shell material, the core material comprising a component which can be varied selected from a binder polymer, one or more additives selected from a colorant, an opacifier, an active material for release in the environment in which the substrate is to be used and a filler and optionally one or more other additives, the shell material having different physical and/or chemical properties from the core material and comprising a binder polymer and optionally one or more other additives, and wherein the same shell material is used for the range of powder materials produced; and electrostatically applying one or more of said powder materials produced to a solid dosage form or forms; whereby a universal shell material is provided for use with various variable core compositions, permitting alterations to the components in the core without affecting electrostatic application of the powder material to a substrate. 18. A method according to claim 17, wherein different active materials and/or different amounts of active material are included in the range of powders prepared. 19. A method according to claim 17, wherein the shell comprises a binder polymer material having charge-control functionality and/or a separate charge-control agent. 20. A method according to claim 19, wherein the shell comprises a binder polymer having charge-control functionality. 21. A method according to claim 17, wherein the powder material contains one or more polymer binders selected from methacrylate polymers, polyvinylpyrrolidone, hydroxypropyl cellulose, hydroxypropyl methylcellulose phthalate and hydroxypropyl methylcellulose acetate succinate.