Coatings for drug delivery devices based on poly (orthoesters)
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08G-065/48
C08G-065/00
C08G-004/00
출원번호
US-0382197
(2003-03-04)
등록번호
US-7288609
(2007-10-30)
발명자
/ 주소
Pacetti,Stephen D.
출원인 / 주소
Advanced Cardiovascular Systems, Inc.
대리인 / 주소
Squire, Sanders & Dempsey, LLP
인용정보
피인용 횟수 :
26인용 특허 :
43
초록
A polymer coating for implantable medical devices based on polyorthoesters and methods for fabricating the coating are disclosed. The implantable medical devices made of polyorthoesters and methods for fabricating thereof are also disclosed.
대표청구항▼
What is claimed is: 1. A coating for a medical device comprising: a block copolymer having a first block comprising a soft segment having a Tg below 37째 C. wherein the soft segment is a reaction product of a spirodiketene acetal and a non-fouling moiety selected from the group consisting of a poly(
What is claimed is: 1. A coating for a medical device comprising: a block copolymer having a first block comprising a soft segment having a Tg below 37째 C. wherein the soft segment is a reaction product of a spirodiketene acetal and a non-fouling moiety selected from the group consisting of a poly(alkylene glycol), poly(ethylene oxide-co-propylene oxide) (PLURONIC짰), hydroxylated poly(vinyl pyrrolidone), dextran, dextrin, hyaluronic acid and derivatives thereof, poly(2-hydroxyethyl methacrylate) and mixtures thereof; and, a second block comprising a hard segment having a Tg above 37째 C. wherein the hard segment is a reaction product of a spirodiketene acetal and a C2-C16 alkylene glycol, a cycloaliphatic diol, a cyclohexanedimethanol, and an oligoaliphatic diol selected from the group consisting of diethylene glycol, triethylene glycol or tetraethylene glycol. 2. A coating for a medical device wherein the coating comprises a polymer having the formula wherein R and R1, are each independently a straight-chained, branched or cyclic alkyl radical C1-C8, or an aryl radical; R2 is selected from the group consisting of methylene (--CH2--), poly(alkylene glycol), poly(vinyl pyrrolidone), dextran, dextrin, hyaluronic acid, derivatives of hyaluronic acid, poly(2-hydroxyethyl methacrylate), or mixtures thereof; R3 is an aliphatic group; m, n, p, and q are all integers, where the value of m is between 5 and 500, the value of n is between 2 and 350, the value of p is 1, and the value of q is between 10 and 550; and, the "n" block has a Tg less than 37째 C. and the "q" block has a Tg above 37째 C. 3. The coating of claim 2, wherein R2 is methylene (--CH2--). 4. The coating of claim 2, wherein R2 is selected from the group consisting of poly(alkylene glycol), poly(vinyl pyrrolidone), dextran, dextrin, hyaluronic acid, and poly(2-hydroxyethyl methacrylate). 5. The coating of claim 1 wherein the spirodiketene acetal is 3,9-dipentylidene-2,4,8,10-tetraoxaspiro-[5,5]-heptadecane (DPTOSH). 6. The coating of claim 1 wherein the medical device is a stent. 7. The coating of claim 1 wherein the non-fouling moiety is selected from the group consisting of poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene glycol), hydroxylated poly(vinyl pyrrolidone), dextran, dextrin, hyaluronic acid and poly(2-hydroxyethyl methacrylate). 8. The coating of claim 1 wherein the alkylene glycol is selected from the group consisting of ethylene glycol, propylene glycol, butane-1,4-diol, pentane-1,5-diol, hexane-1,6-diol, heptane-1,7-diol, octane-1,8-diol, nonane-1,9-diol, decane-1,10-diol, undecane-1,11-diol, dodecane-1,12-diol, tridecane-1,13-diol, tetradecane-1,14-diol, pentadecane-1,15-diol, hexadecane-1,16-diol, butane-1,3-diol, pentane-2,5-diol and hexane-2,5-diol. 9. The coating of claim 1 wherein the spirodiketene acetal has the formula wherein R and R1 are independently selected from the group consisting of straight-chained, branched, or cyclic alkyl radicals C1-C8, and aryl radicals. 10. The coating of claim 9 wherein the spirodiketene acetal is selected from the group consisting of 3,9-diethylidene-2,4,8,10-tetraoxaspiro-[5,5]-undecane, 3,9-dipentylidene-2,4,8,10-tetraoxaspiro-[5,5]-heptadecane, 3,9-dibutylidene-2,4,8,10-tetraoxaspiro-[5,5]-pentadecane and 3,9-dipropylidene-2,4,8,10-tetraoxaspiro-[5,5]-tridecane. 11. The coating of claim 9 wherein the alkylene glycol is selected from the group consisting of ethylene glycol, propylene glycol, butane-1,4-diol, pentane-1,5-diol, hexane-1,6-diol, heptane-1,7-diol, octane-1,8-diol, nonane-1,9-diol, decane-1,10-diol, undecane-1,11-diol, dodecane-1,12-diol, tridecane-1,13-diol, tetradecane-1,14-diol, pentadecane-1,15-diol, hexadecane-1,16-diol, butane-1,3-diol, pentane-2,4-diol and hexane-2,5-diol.
Eury Robert P. (Cupertino CA) Garguilo Darlene (Fremont CA) Villareal Plaridel (San Jose CA), Drug loaded polymeric material and method of manufacture.
Hubbell Jeffrey A. ; Pathak Chandrashekhar P. ; Sawhney Amarpreet S. ; Desai Neil P. ; Hill Jennifer L. ; Hossainy Syed F. A., Gels for encapsulation of biological materials.
Hostettler Fritz ; Rhum David ; Forman Michael R. ; Helmus Michael N. ; Ding Ni, Medical device coated with interpenetrating network of hydrogel polymers.
Clapper David L. ; Swanson Melvin J. ; Hu Sheau-Ping ; Amos Richard A. ; Everson Terrence P., Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups.
Tartaglia Joseph M. (Redwood City CA) Loeffler Joseph P. (Mountain View CA) Turnlund Todd H. (Mountain View CA), Polymer film for wrapping a stent structure.
Leidner Jacob,CAX ; Amellal Karim,CAX, Porous protheses and methods for making the same wherein the protheses are formed by spraying water soluble and water insoluble fibers onto a rotating mandrel.
Hostettler Fritz ; Rhum David ; Forman Michael R. ; Helmus Michael N. ; Ding Ni, Process for preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coating, coated polymer and metal substrate materials, and coated medical devices.
Marchant Roger E. (Shaker Hts. OH), Process for producing hydroxylated plasma-polymerized films and the use of the films for enhancing the compatiblity of b.
Ragheb Anthony O. ; Bates Brian L. ; Fearnot Neal E. ; Osborne Thomas A. ; Kozma Thomas G. ; Roberts Joseph W. ; Voorhees ; III William D., Silver implantable medical device.
Trollsas, Mikael O.; Ngo, Michael H.; Hossainy, Syed; Sherman, David J., Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block.
Pacetti, Stephen D.; Hossainy, Syed F. A.; Tang, Yiwen; Tung, Andrew C.; Glauser, Thierry, Coatings for drug delivery devices having gradient of hydration.
Kutryk, Michael J. B.; Cottone, Jr., Robert J.; Rowland, Stephen M., Medical device with coating for capturing genetically-altered cells and methods for using same.
Pacetti, Stephen D.; Hossainy, Syed F. A.; Tang, Yiwen; Tung, Andrew C.; Glauser, Thierry, Methods for fabricating coatings for drug delivery devices having gradient of hydration.
Pacetti, Stephen D.; Hossainy, Syed F. A.; Tang, Yiwen; Tung, Andrew C.; Glauser, Thierry, Methods for fabricating coatings for drug delivery devices having gradient of hydration.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.