IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
|
출원번호 |
US-0970017
(2004-10-21)
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등록번호 |
US-7294353
(2007-11-13)
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발명자
/ 주소 |
- Gow,Robert T.
- Sypert,George W.
- Pierce,John
- Li,Dan
- Yan,Xun
- Marentis,Rodger M.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
4 인용 특허 :
50 |
초록
▼
The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the
The present invention comprises methods for making compositions derived from Ilex species, particularly Ilex paraguariensis, having lowered caffeine and tannin concentrations, compositions made by such methods, oral delivery formulations, and methods of use of such compositions. In particular, the present invention comprises methods for making mat챕 compositions that have a predetermined characeteristic, such as a lowered amount of caffeine, elevated amounts of caffeoyls, and/or lowered amounts of tannin compounds compared to the native mat챕 plant materials. Further, the invention comprises methods of additional processing steps tp produce compositions having a predetermined alkaloid ratio or profiles to meet particular considerations for final products. The compositions of the present invention may be processed for specific uses such as tablets or other oral delivery vehicles. These compositions may be used in methods for treatment of physiological and medical conditions.
대표청구항
▼
What is claimed is: 1. A method for making a mat챕 extract composition having at least one predetermined characteristic, comprising, extracting native mat챕 plant material using supercritical CO2 conditions to obtain a mate extract composition, wherein the supercritical CO2 conditions comprise a pres
What is claimed is: 1. A method for making a mat챕 extract composition having at least one predetermined characteristic, comprising, extracting native mat챕 plant material using supercritical CO2 conditions to obtain a mate extract composition, wherein the supercritical CO2 conditions comprise a pressure of between about 7,250 and about 10,150 psi; and wherein the caffeine concentration is less than or equal to the theobromine concentration in the mat챕 extract composition, and wherein at least one predetermined characteristic comprises a reduction in the tannin concentration when compared to tannin concentration of native mat챕 plant material. 2. The method of claim 1, wherein at least one predetermined characteristic comprises a caffeoyl concentration that is greater than or equal to that of native mat챕 plant material. 3. The method of claim 1, wherein the supercritical CO2 conditions comprise an operating temperature between about 45째 C. and about 100째 C. 4. The method of claim 1, wherein ethanol is used as a cosolvent. 5. The method of claim 4, wherein the supercritical CO2 conditions comprise an operating temperature between about 45째 C. and about 100째 C. 6. The method of claim 1, further comprising extracting the native mat챕 plant material with a solution comprising water or a hydroalcoholic solution before extracting the native mat챕 material using the supercritical CO2 conditions. 7. The method of claim 1, wherein water is used as a cosolvent. 8. The method of claim 1, further comprising extracting the mat챕 extract composition with a solution comprising water or a hydroalcoholic solution. 9. A method for making a mat챕 extract composition having at least one predetermined characteristic, comprising, extracting native mat챕 plant material using supercritical CO2 conditions to obtain a mate extract composition, wherein the supercritical CO2 conditions comprise a pressure of between about 9,000 psi and 10,000 psi, and wherein at least one predetermined characteristic is a reduction in the tannin concentration when compared to tannin concentration of native mat챕 plant material. 10. The method of claim 9, wherein at least one predetermined characteristic comprises a reduction in the caffeine concentration compared to caffeine concentration of native plant material, or a caffeoyl concentration that is greater than or equal to that of native mat챕 plant material. 11. The method of claim 10, wherein the caffeine concentration is less than or equal to the theobromine concentration in the mate extract composition. 12. The method of claim 9, wherein the supercritical CO2 conditions comprise an operating temperature between about 45째 C. and about 100째 C. 13. The method of claim 9, wherein ethanol is used as a cosolvent. 14. The method of claim 9, wherein water is used as a cosolvent. 15. The method of claim 9, further comprising extracting the native mat챕 plant material with a solution comprising water or a hydroalcoholic solution before extracting the native mat챕 material using the supercritical CO2 conditions. 16. The method of claim 9, further comprising extracting the mat챕 extract composition with a solution comprising water or a hydroalcoholic solution. 17. A method for making a mat챕 extract composition having at least one predetermined characteristic, comprising, extracting native mat챕 plant material using supercritical CO2 conditions to obtain a mate extract composition comprising at least one predetermined characteristic, wherein the supercritical CO2 conditions comprise a pressure of about 9,000 psi, and wherein the temperature is about 55째 C. 18. The method of claim 17, wherein at least one predetermined characteristic comprises a reduction in the caffeine concentration compared to caffeine concentration of native plant material, a reduction in the tannin concentration when compared to tannin concentration of native mat챕 plant material, or a caffeoyl concentration that is greater than or equal to that of native mat챕 plant material. 19. The method of claim 18, wherein the caffeine concentration is less than or equal to the theobromine concentration. 20. The method of claim 17, further comprising extracting the native mat챕 plant material with a solution comprising water or a hydroalcoholic solution, before using the supercritical CO2 conditions. 21. The method of claim 17, further comprising extracting the mat챕 extract composition with a solution comprising water or a hydroalcoholic solution. 22. The method of claim 17, wherein ethanol or water is used as a cosolvent. 23. A method for making a mat챕 extract composition having at least one predetermined characteristic, comprising, extracting native mat챕 plant material using supercritical CO2 conditions to obtain a mate extract composition, wherein the supercritical CO2 conditions comprise a pressure of between about 7,250 and about 10,150 psi; wherein the caffeine concentration is less than or equal to the theobromine concentration in the mat챕 extract composition, and wherein at least one predetermined characteristic comprises a caffeoyl concentration that is greater than or equal to that of native mat챕 plant material. 24. The method of claim 23, further comprising at least one predetermined characteristic comprising a reduction in the tannin concentration when compared to tannin concentration of native mat챕 plant material.
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