Inhibition of exoprotein production using isoprenoid compositions
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/05
A61K-031/045
A61K-009/00
출원번호
US-0900251
(2004-07-27)
등록번호
US-7294651
(2007-11-13)
발명자
/ 주소
Syverson,Rae Ellen
Proctor,Richard A.
출원인 / 주소
Kimberly Clark Worldwide, Inc.
대리인 / 주소
Armstrong Teasdale LLP
인용정보
피인용 횟수 :
8인용 특허 :
53
초록
Methods and compositions for inhibiting the production of exotoxins are disclosed. The compositions include an effective amount of an isoprenoid inhibitory compound to substantially inhibit the production of exotoxins by Gram positive bacteria.
대표청구항▼
What is claimed is: 1. A vaginal cleanser comprising a douche and a formulation, the formulation comprising an effective amount of a first active ingredient, a second active ingredient, and myreth-3-myristate, wherein the first active ingredient comprises an isoprenoid compound and a pharmaceutical
What is claimed is: 1. A vaginal cleanser comprising a douche and a formulation, the formulation comprising an effective amount of a first active ingredient, a second active ingredient, and myreth-3-myristate, wherein the first active ingredient comprises an isoprenoid compound and a pharmaceutically acceptable carrier and is effective in inhibiting the production of exoprotein from Gram positive bacteria, and wherein the second active ingredient has the general formulation: description="In-line Formulae" end="lead"R10--O--R11description="In-line Formulae" end="tail" wherein R10 is a straight or branched alkyl or straight or branched alkenyl having from 8 to about 18 carbon atoms and R11 is selected from the group consisting of an alcohol, a polyalkoxylated sulfate salt, and a polyalkoxylated sulfosuccinate salt. 2. The vaginal cleanser as set forth in claim 1 wherein the isoprenoid compound is a polyisoprenoid. 3. The vaginal cleanser as set forth in claim 1 wherein the isoprenoid compound is a terpene. 4. The vaginal cleanser as set forth in claim 1 wherein the isoprenoid compound is a terpenoid. 5. The vaginal cleanser as set forth in claim 1 wherein the isoprenoid compound is selected from the group consisting of geraniol, cis-terpin, trans-terpin, terpineol, alpha-terpinene, beta-terpinene, gamma-terpinene, beta-myrcene, dipentene, alpha-myrcene, menthol, 2-methyl-6-methylene-1,7-octadiene, linalool, alpha-ionone, beta-ionone, alpha-pinen, beta-pinen, nerol, campher, citral a, nerolidol, farnesol, phytol, alpha-carotin, beta-carotin, and limonen. 6. The vaginal cleanser as set forth in claim 1 wherein the formulation comprises from about 0.25 millimoles/liter to about 10 millimoles/liter of isoprenoid compound. 7. The vaginal cleanser as set forth in claim 1 wherein the R10 is a straight or branched alkyl group. 8. The vaginal cleanser as set forth in claim 1 wherein R10 is a straight or branched alkenyl group. 9. The vaginal cleanser as set forth in claim 1 wherein R10 is selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, and stearic acid. 10. The vaginal cleanser as set forth in claim 1 wherein R11 is an aliphatic alcohol. 11. The vaginal cleanser as set forth in claim 1 wherein the second active ingredient is selected from the group consisting of laureth-3, laureth-4, laureth-5, PPG-5 lauryl ether, 1-0-dodecyl-rac-glycerol, sodium laureth sulfate, potassium laureth sulfate, disodium laureth (3) sulfosuccinate, dipotassium laureth (3) sulfosuccinate, and polyethylene oxide (2) sorbitol ether. 12. The vaginal cleanser as set forth in claim 1 comprising from about 0.25 millimoles/liter to about 10 millimoles/liter of the second active ingredient. 13. The vaginal cleanser as set forth in claim 1 further comprising a pharmaceutically active material selected from the group consisting of antimicrobials, antioxidants, anti-parasitic agents, antipruritics, astringents, local anaesthetics, and anti-inflammatory agents. 14. A vaginal cleanser comprising a douche and a formulation, the formulation comprising an effective amount of a first active ingredient, and myreth-3-myristate, wherein the first active ingredient comprises an isoprenoid compound and a pharmaceutically acceptable carrier and is effective in inhibiting the production of exoprotein from Gram positive bacteria. 15. The vaginal cleanser as set forth in claim 14 wherein the isoprenoid compound is a polyisoprenoid. 16. The vaginal cleanser as set forth in claim 14 wherein the isoprenoid compound is a terpene. 17. The vaginal cleanser as set forth in claim 14 wherein the isoprenoid compound is a terpenoid. 18. The vaginal cleanser as set forth in claim 14 wherein the isoprenoid compound is selected from the group consisting of geraniol, cis-terpin, trans-terpin, terpineol, alpha-terpinene, beta-terpinene, gamma-terpinene, beta-myrcene, dipentene, alpha-myrcene, menthol, 2-methyl-6-methylene-1,7-octadiene, linalool, alpha-ionone, beta-ionone, alpha-pinen, beta-pinen, nerol, campher, citral a, nerolidol, farnesol, phytol, alpha-carotin, beta-carotin, and limonen. 19. The vaginal cleanser as set forth in claim 14 wherein the formulation comprises from about 0.25 millimoles/liter to about 10 millimoles/liter of isoprenoid compound. 20. The vaginal cleanser as set forth in claim 14 further comprising a pharmaceutically active material selected from the group consisting of antimicrobials, antioxidants, anti-parasitic agents, antipruritics, astringents, local anaesthetics, and anti-inflammatory agents. 21. The vaginal cleanser as set forth in claim 14 further comprising an effective amount of a second active ingredient, the second active ingredient comprising a compound with an ether, ester, amide, glycosidic, or amine bond linking a C8-C18 fatty acid to an aliphatic alcohol wherein the second active ingredient is effective in substantially inhibiting the production of exoprotein from Gram positive bacteria.
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