초록 ▼

Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment ele

Techniques are described for detecting ischemia, hypoglycemia or hyperglycemia based on intracardiac electrogram (IEGM) signals. Ischemia is detected based on a shortening of the interval between the QRS complex and the end of a T-wave (QTmax), alone or in combination with a change in ST segment elevation. Alternatively, ischemia is detected based on a change in ST segment elevation combined with minimal change in the interval between the QRS complex and the end of the T-wave (QTend). Hypoglycemia is detected based on a change in ST segment elevation along with a lengthening of either QTmax or QTend. Hyperglycemia is detected based on a change in ST segment elevation along with minimal change in QTmax and in QTend. By exploiting QTmax and QTend in combination with ST segment elevation, changes in ST segment elevation caused by hypo/hyperglycemia can be properly distinguished from changes caused by ischemia.

대표청구항 ▼

What is claimed is: 1. A method for use with an implantable medical device for detecting hyperglycemia in a patient in which the device is implanted, the method comprising: tracking repolarization peak-based intervals representative of intervals between depolarization events and peaks of correspond

What is claimed is: 1. A method for use with an implantable medical device for detecting hyperglycemia in a patient in which the device is implanted, the method comprising: tracking repolarization peak-based intervals representative of intervals between depolarization events and peaks of corresponding repolarization events within electrical cardiac signals; tracking repolarization end-based intervals representative of intervals between depolarization events and ends of corresponding repolarization events within electrical cardiac signals; tracking elevations of segments of the cardiac signals between depolarization events and corresponding repolarization events; and detecting an episode of hyperglycemia based on a change in the elevations of the segments in combination with a lack of change in the repolarization peak-based intervals and the repolarization end-based intervals. 2. The method of claim 1 wherein the repolarization peak-based intervals are representative of intervals between QRS complexes and peaks of corresponding T-waves (QTmax intervals) and wherein the repolarization end-based intervals are representative of intervals between QRS complexes and ends of corresponding T-waves (QTend intervals). 3. The method of claim 1 wherein the segment elevations are representative of the elevations of segments of cardiac signals between QRS-complexes and corresponding T-waves (ST segments). 4. The method of claim 1 further including the step of tracking patient heart rate and wherein the repolarization-peak based intervals and the repolarization-end based intervals are normalized based on heart rate. 5. The method of claim 1 wherein the step of detecting an episode of hyperglycemia based on significant changes in the segment elevations of a plurality of heartbeats compared to a baseline elevation combined with a lack of significant change in repolarization-based intervals of a plurality of heartbeats compared to baseline intervals. 6. The method of claim 1 further including the step of recording diagnostic information representative of the intervals and segment elevations. 7. The method of claim 1 further including the step of controlling therapy in response to the detection of an episode of hyperglycemia. 8. The method of claim 7 wherein an implantable insulin pump is provided and wherein the step of controlling therapy in response to the detection of an episode of hyperglycemia includes the step of controlling insulin delivery to the patient using the insulin pump. 9. The method of claim 1 further including the step of generating a warning signal in response to detection of an episode of hyperglycemia. 10. The method of claim 9 wherein an implantable warning device is provided and wherein the step of generating a warning signal includes the step of delivering a perceptible warning signal to the patient via the implantable warning device. 11. The method of claim 10 for use with an external warning device and wherein the step of generating a warning signal includes the step of transmission control signals to the external warning device for controlling the external device to generate warning signals for warning the patient. 12. A system for use with an implantable medical device for detecting hyperglycemia in a patient in which the device is implanted comprising: a timing unit operative to track repolarization peak-based intervals representative of intervals between depolarization events and peaks of corresponding repolarization events within electrical cardiac signals, to track repolarization end-based intervals representative of intervals between depolarization events and ends of corresponding repolarization events within electrical cardiac signals and to track elevations of segments of the cardiac signals between depolarization events and corresponding repolarization events; and a hyperglycemia detection unit operative to detect an episode of hyperglycemia based on changes or lack of changes in the elevations of the segments, the repolarization peak-based intervals, and the repolarization end-based intervals. 13. A system for use with an implantable medical device for detecting hyperglycemia in a patient in which the device is implanted comprising: means for tracking repolarization peak-based intervals between depolarization events and peaks of corresponding repolarization events within electrical cardiac signals; means for tracking repolarization end-based intervals between depolarization events and ends of corresponding repolarization events within electrical cardiac signals; means for tracking elevations of segments of the cardiac signals between ends of depolarization events and corresponding repolarization events; and means for detecting an episode of hyperglycemia based on changes, if any, in the elevations of the segments, the repolarization peak-based intervals, and the repolarization end-based intervals. 14. A method for use with an implantable medical device for distinguishing among hypoglycemia, hyperglycemia and cardiac ischemia within a patient in which the device is implanted comprising the steps of: tracking repolarization-based intervals between depolarization events and corresponding repolarization events within electrical cardiac signals; and tracking elevations of segments of the cardiac signals between ends of depolarization events and corresponding repolarization events; and distinguishing among hypoglycemia, hyperglycemia and cardiac ischemia based on changes, if any, in the elevations of the segments in combination with changes, if any, in the repolarization-based intervals.