Ultrafine-L-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/14
A61K-009/20
A61K-009/26
A61K-009/50
A61K-009/54
A61K-009/52
출원번호
US-0041272
(2005-01-25)
등록번호
US-7303765
(2007-12-04)
발명자
/ 주소
Hassan,Ken
출원인 / 주소
Sigma Tau HealthScience S.p.A.
대리인 / 주소
Lucas & Mercanti, LLP
인용정보
피인용 횟수 :
0인용 특허 :
8
초록
L-carnitine which has a particle size such that it substantially passes through a 100 USBS mesh sieve exhibits an increased bioavailability, a decreased hygroscopicity, and may be conveniently formulated with oil-based materials.
대표청구항▼
What is claimed as new and desired to be secured by Letters Patent of the United States is: 1. A composition, consisting of L-carnitine particles, having a particle size such that the particles substantially pass through a 100 USBS mesh sieve blended with a silica having an overall surface area of
What is claimed as new and desired to be secured by Letters Patent of the United States is: 1. A composition, consisting of L-carnitine particles, having a particle size such that the particles substantially pass through a 100 USBS mesh sieve blended with a silica having an overall surface area of from 190 to 475 square meters per gram and a tapped density of from 80 to 275 grams per liter wherein L-carnitine is present in an amount of 10% to 99% by weight, based on the total weight of the composition. 2. The composition of claim 1, which is selected from the group consisting of L-carnitine, salts of L-carnitine, alkanoyl L-carnitines, and salts of alkanoyl L-carnitine. 3. The composition of claim 1, which is selected from the group consisting of L-carnitine chloride, L-carnitine bromide, L-carnitine orotate, L-carnitine acid aspartate, L-carnitine acid phosphate, L-carnitine fumarate, L-carnitine lactate, L-carnitine maleate, L-carnitine acid maleate, L-carnitine acid oxalate, L-carnitine acid sulfate, L-carnitine glucose phosphate, L-carnitine tartrate, L-carnitine acid tartrate, L-carnitine iodate, L-carnitine aspartate, L-carnitine citrate, L-carnitine acid citrate, L-carnitine acid fumarate, L-carnitine glycerophosphate, L-carnitine mucate, L-carnitine orotate, L-carnitine oxalate, L-carnitine sulfate, L-carnitine trichloroacetate, L-carnitine trifluoroacetate, L-carnitine methanesulfonate, L-carnitine pamoate, L-carnitine acid pamoate, C2-8 alkanoyl L-carnitines, C2-8 alkanoyl L-carnitine chloride, C2-8 alkanoyl L-carnitine bromide, C2-8 alkanoyl L-carnitine orotate, C2-8 alkanoyl L-carnitine acid aspartate, C2-8 alkanoyl L-carnitine acid phosphate, C2-8 alkanoyl L-carnitine fumarate, C2-8 alkanoyl L-carnitine lactate, C2-8 alkanoyl L-carnitine maleate, C2-8 alkanoyl L-carnitine acid maleate, C2-8 alkanoyl L-carnitine acid oxalate, C2-8 alkanoyl L-carnitine acid sulfate, C2-8 alkanoyl L-carnitine glucose phosphate, C2-8 alkanoyl L-carnitine tartrate, C2-8 alkanoyl L-carnitine acid tartrate, C2-8 alkanoyl L-carnitine iodate, C2-8 alkanoyl L-carnitine aspartate, C2-8 alkanoyl L-carnitine citrate, C2-8 alkanoyl L-carnitine acid citrate, C2-8 alkanoyl L-carnitine acid fumarate, C2-8 alkanoyl L-carnitine glycerophosphate, C2-8 alkanoyl L-carnitine mucate, C2-8 alkanoyl L-carnitine orotate, C2-8 alkanoyl L-carnitine oxalate, C2-8 alkanoyl L-carnitine sulfate, C2-8 alkanoyl L-carnitine trichloroacetate, C2-8 alkanoyl L-carnitine trifluoroacetate, C2-8 alkanoyl L-carnitine methanesulfonate, C2-8 alkanoyl L-carnitine pamoate, and C2-8 alkanoyl L-carnitine acid pamoate. 4. A method of preparing a composition, consisting of (1) subjecting L-carnitine having a particle size such that it does not pass through a 100 USBS mesh sieve to size reduction, to obtain size-reduced L-carnitine; (2) subjecting said size-reduced L-carnitine to sieving through a 100 USBS mesh sieve (3) selecting the portion which passes through said 100 USBS mesh sieve and blending said portion with a silica having an overall surface area of from 190 to 475 square meters per gram and a tapped density of from 80 to 275 grams per liter wherein L-carnitine is present in amount of 10% to 99% by weight, based on the total weight of the composition. 5. The method of claim 4, wherein said L-carnitine is selected from the group consisting of L-carnitine, salts of L-carnitine, alkanoyl L-carnitines, and salts of alkanoyl L-carnitine. 6. The method of claim 4, wherein said L-carnitine is selected from the group consisting of L-carnitine chloride, L-carnitine bromide, L-carnitine orotate, L-carnitine acid aspartate, L-carnitine acid phosphate, L-carnitine fumarate, L-carnitine lactate, L-carnitine maleate, L-carnitine acid maleate, L-carnitine acid oxalate, L-carnitine acid sulfate, L-carnitine glucose phosphate, L-carnitine tartrate, L-carnitine acid tartrate, L-carnitine iodate, L-carnitine aspartate, L-carnitine citrate, L-carnitine acid citrate, L-carnitine acid fumarate, L-carnitine glycerophosphate, L-carnitine mucate, L-carnitine orotate, L-carnitine oxalate, L-carnitine sulfate, L-carnitine trichloroacetate, L-carnitine trifluoroacetate, L-carnitine methanesulfonate, L-carnitine pamoate, L-carnitine acid pamoate, C2-8 alkanoyl L-carnitines, C2-8 alkanoyl L-carnitine chloride, C2-8 alkanoyl L-carnitine bromide, C2-8 alkanoyl L-carnitine orotate, C2-8 alkanoyl L-carnitine acid aspartate, C2-8 alkanoyl L-carnitine acid phosphate, C2-8 alkanoyl L-carnitine fumarate, C2-8 alkanoyl L-carnitine lactate, C2-8 alkanoyl L-carnitine maleate, C2-8 alkanoyl L-carnitine acid maleate, C2-8 alkanoyl L-carnitine acid oxalate, C2-8 alkanoyl L-carnitine acid sulfate, C2-8 alkanoyl L-carnitine glucose phosphate, C2-8 alkanoyl L-carnitine tartrate, C2-8 alkanoyl L-carnitine acid tartrate, C2-8 alkanoyl L-carnitine iodate, C2-8 alkanoyl L-carnitine aspartate, C2-8 alkanoyl L-carnitine citrate, C2-8 alkanoyl L-carnitine acid citrate, C2-8 alkanoyl L-carnitine acid fumarate, C2-8 alkanoyl L-carnitine glycerophosphate, C2-8 alkanoyl L-carnitine mucate, C2-8 alkanoyl L-carnitine orotate, C2-8 alkanoyl L-carnitine oxalate, C2-8 alkanoyl L-carnitine sulfate, C2-8 alkanoyl L-carnitine trichloroacetate, C2-8 alkanoyl L-carnitine trifluoroacetate, C2-8 alkanoyl L-carnitine methanesulfonate, C2-8 alkanoyl L-carnitine pamoate, and C2-8 alkanoyl L-carnitine acid pamoate. 7. The composition of claim 1, which is suitable for oral ingestion. 8. The composition of claim 1, wherein the L-carnitine particles have a particle size such that they substantially pass through a 150 USBS mesh sieve. 9. The composition of claim 1, wherein the L-carnitine particles have a particle size such that they substantially pass through a 200 USBS mesh sieve. 10. The L-carnitine containing composition of claim 1 wherein the L-carnitine is L-carnitine fumarate. 11. A composition, consisting of L-carnitine particles, having a particle size such that the particles substantially pass through a 100 USBS mesh sieve blended with a silica having an overall surface area of from 190 to 475 square meters per gram and a tapped density of from 80 to 275 grams per liter, and a member of the group consisting of hydroxycitric acid, Co-enzyme Q10, chromium picolinate, gamma linolenic acid, resveratrol, omega 3 acids, antioxidants, and vitamins, wherein L-carnitine is present in an amount of 10% to 99% by weight, based on the total weight of the composition.
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