The Board of Trustees of the Leland Stanford Junior University
대리인 / 주소
Womble Carlyle Sandridge & Rice, PLLC
인용정보
피인용 횟수 :
13인용 특허 :
34
초록▼
An electroosmotic micropump having a plurality of thin, closely-spaced, approximately planar, transversel aligned partitions formed in or on a substrate, among which electroosmotic flow (EOF) is generated. Electrodes are located within enclosed inlet and outlet manifolds on either side of the parti
An electroosmotic micropump having a plurality of thin, closely-spaced, approximately planar, transversel aligned partitions formed in or on a substrate, among which electroosmotic flow (EOF) is generated. Electrodes are located within enclosed inlet and outlet manifolds on either side of the partition array. Inlet and outlet ports enable fluid to be pumped into and through the micropump and through an external friction load or head. Insulating layer coatings on the formed substrate limit substrate leakage current during pumping operation.
대표청구항▼
What is claimed is: 1. An electroosmotic micropump that pumps a fluid having a liquid phase upon application of an electric field comprising: a substrate; an array of thin, closely-spaced, approximately planar, transversely aligned partitions formed in or on the substrate, among which electroosmoti
What is claimed is: 1. An electroosmotic micropump that pumps a fluid having a liquid phase upon application of an electric field comprising: a substrate; an array of thin, closely-spaced, approximately planar, transversely aligned partitions formed in or on the substrate, among which electroosmotic flow (EOF) is generated, the partitions being approximately uniform in size, shape, and spacing and having an average height that is at least five times an average gap between partitions; a plurality of electrodes positioned within enclosed manifolds on either side of the partition array for applying the electric field to the fluid during micropump operation; and an inlet and an outlet for a fluid to enter and exit the micropump. 2. The electroosmotic micropump of claim 1 further comprising an approximately conformal insulating layer coating on at least one surface of the partitions and manifolds to limit the flow of leakage current through the substrate during a pumping operation. 3. The electroosmotic micropump of claim 2 further comprising an approximately conformal additional layer which coats at least part of the insulating layers, the additional layer being interposed between the insulating layer and the fluid that is pumped. 4. The electroosmotic micropump of claim 1 wherein the substrate is a silicon substrate patterned using photolithography microfabrication. 5. The electroosmotic micropump of claim 1 wherein the partitions are formed by deep reactive ion enhanced etching. 6. The electroosmotic micropump of claim 1 wherein the average gaps between partitions are less than 5 μm wide. 7. The electroosmotic micropump of claim 1 wherein the electrodes comprise platinum wire. 8. The electroosmotic micropump of claim 1 wherein the electrodes are deposited onto at least one surface of the manifolds. 9. The electroosmotic micropump of claim 7 wherein electrodes are inserted directly into the manifolds through openings in the walls of the manifolds. 10. The electroosmotic micropump of claim 1 wherein the inlet port and the outlet port for the fluid connect a corresponding manifold and a corresponding edge of the partition array. 11. The electroosmotic micropump of claim 1 wherein the partition array and manifolds are enclosed by a structural element separate from the substrate. 12. The electroosmotic micropump of claim 2 wherein the insulating layer is fabricated from silicon nitride. 13. The electroosmotic micropump of claim 2 wherein the insulating layer is fabricated from a compound comprised of silicon and nitrogen elements. 14. The electroosmotic micropump of claim 3 wherein the additional layer is a silicon oxide compound. 15. The electroosmotic micropump of claim 3 wherein the additional layer is an oxidized polysilicon compound. 16. The electroosmotic micropump of claim 3 wherein the additional layer is a material selected based on an electrochemistry property of the selected material at the liquid-solid interface. 17. The electroosmotic micropump of claim 16 wherein the material selected for the additional layer is a dielectric material. 18. A method for manufacturing an electroosmotic micropump that pumps a fluid having a liquid phase upon application of an electric field, comprising the steps of: selecting a substrate for the micropump; forming an array of thin, closely-spaced, approximately planar, transversely aligned partitions in the substrate, the partitions being approximately uniform in size, shape, and spacing and having an average height that is at least five times an average gap between partitions; forming an inlet and an outlet manifold on either side of the partition array; forming a plurality of electrodes within the inlet and outlet manifolds for applying the electric field to the fluid during micropump operation; and forming inlet and outlet ports for the fluid to enter and exit the micropump. 19. The method for manufacturing an electroosmotic micropump of claim 18 further comprising coating at least one surface of the partitions and manifolds with an approximately conformal insulating layer to minimize the flow of leakage current through the substrate during a pumping operation. 20. The method for manufacturing an electroosmotic micropump of claim 19 further comprising coating the insulating layer with at least one approximately conformal additional layer, the additional layer being interposed between the insulating layer and the fluid that is pumped. 21. The method for manufacturing an electroosmotic micropump of claim 18 further comprising depositing electrodes onto a surface of each manifold. 22. The method for manufacturing an electroosmotic micropump of claim 18 further comprising forming the partition array and manifolds in the substrate and enclosing them with a structural element separate from the substrate. 23. The method for manufacturing an electroosmotic micropump of claim 19 wherein the step of coating the substrate with an insulating layer comprises depositing a silicon nitride film on the substrate through chemical vapor deposition at a low pressure. 24. An electroosmotic micropump that pumps fluid having a liquid phase upon application of an electric field comprising: a substrate; a multilevel planar structure formed in the substrate to generate electroosmotic pumping, the planar structure including a pumping channel comprising a pair of substantially flat surfaces that are substantially parallel to each other and separated by a distance that is determined based on a thickness of an electrical double layer associated with the pumped fluid, the multilevel planar structure further comprising an inlet reservoir and an outlet reservoir between which the pumping channel is disposed, each reservoir having a depth that is at least five times a pumping channel depth; and an electrode within each reservoir for the application of the electric field during micropump operation. 25. The electroosmotic micropump of claim 24 wherein the pumping channel depth is within two orders of magnitude of the thickness of the electrical double layer. 26. The electroosmotic micropump of claim 25 wherein the thickness of the electric double layer is on the order of the Debye length of the pumped fluid. 27. The electroosmotic micropump of claim 24 wherein the channel depth is selected to simultaneously optimize a flow capacity and a thermodynamic efficiency of the electroosmotic micropump. 28. The electroosmotic micropump of claim 24 further comprising a plurality of ribs on at least one of the flat surfaces of the pumping channel to improve the structural integrity of the electroosmotic micropump. 29. The electroosmotic micropump of claim 24 wherein an electroosmotic flow of the micropump is changed by application of a transverse electric field. 30. The electroosmotic micropump of claim 29 wherein the transverse electric field alters a zeta potential at a surface of the micropump to enhance, or reduce or reverse electroosmotic flow. 31. An apparatus for dispensing of fluids for drug dosing comprising: a fluid reservoir and a dispensing device; an electroosmotic micropump positioned between the reservoir and dispensing device to dispense fluid uniformly upon application of an electrical field, the electroosmotic micropump comprising: a substrate; an array of thin, closely-spaced, approximately planar, transversely aligned partitions formed in the substrate, the partitions being approximately uniform in size, shape, and spacing and having an average height that is at least five times an average gap between partitions; a manifold disposed on each side of the partition array; a plurality of electrodes located within the manifolds for applying the electrical field to the fluid during micropump operation; and an inlet port and an outlet port to enable the pumped fluid to enter and exit the micropump. 32. An apparatus for extraction of samples comprising: a fluid reservoir and a sample extraction device; an electroosmotic micropump positioned between the reservoir and sample extraction device to extract fluid upon application of an electrical field, the electroosmotic micropump comprising: a substrate; an array of thin, closely-spaced, approximately planar, transversely aligned partitions formed in the substrate, the partitions being approximately uniform in size, shape, and spacing and having an average height that is at least five times an average gap between partitions; an inlet and outlet manifold disposed on either side of the partition array; a plurality of electrodes located within the manifolds for applying the electric field to the fluid during micropump operation; and an inlet port and an outlet port to enable the pumped fluid to enter and exit the micropump. 33. The electroosmotic micropump of claim 1 wherein the pressure differential is at least 1 kPa. 34. The electroosmotic micropump of claim 1 wherein an average height of the larger of the two cross sectional dimensions of the openings between the partitions is at least 50 μm. 35. The electroosmotic micropump of claim 1 wherein a width of each planar partition is less than 20 μm. 36. The electroosmotic micropump of claim 1 wherein the substrate is a noninsulating material. 37. The electroosmotic micropump of claim 11 wherein the partition array and manifolds are enclosed by a glass plate bonded to the substrate.
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