초록 ▼

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one em

A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into which a plurality of cavities may be formed. A series of chemically sensitive particles are, in one embodiment positioned within the cavities. The particles may be configured to produce a signal when a receptor coupled to the particle interacts with the analyte. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized.

대표청구항 ▼

What is claimed is: 1. A sensor array system for detecting an analyte in a fluid comprising: a body; a light source disposed within the body; a cartridge, wherein the cartridge is configured to be removably positionable in the body, and wherein the cartridge comprises a cartridge body and a sensor

What is claimed is: 1. A sensor array system for detecting an analyte in a fluid comprising: a body; a light source disposed within the body; a cartridge, wherein the cartridge is configured to be removably positionable in the body, and wherein the cartridge comprises a cartridge body and a sensor array disposed within the cartridge body, and wherein the sensor array comprises: a sensor layer comprising a plurality of cavities fabricated within the sensor layer to form an ordered array; a particle, wherein the particle is positioned in a cavity, and wherein the particle comprises a receptor coupled to a polymeric bead, and wherein the particle is configured to produce a signal when the particle interacts with an analyte during use, and wherein the cavity is configured such that a particle is substantially contained within the cavity during use; a plurality of assembled layers comprising a support layer, a cover layer and a spacer layer, wherein the cover layer is positioned over the cavity and is configured to inhibit dislodgment of the particle during use, the cover layer comprising a substantially transparent cover plate positioned such that a first channel is formed between an upper surface of the supporting member and the cover layer, and wherein the fluid passes through the first channel during use; and wherein the spacer layer provides for a second channel under the sensor layer and above the support layer, and wherein the fluid passes through the second channel during use; and a detector disposed within the body, wherein the detector is configured to detect the signal produced by the interaction of the analyte with the particle during use; wherein the light source and the detector are positioned such that light passes from the light source, to the particle, and onto the detector during use. 2. The system of claim 1, further comprising a sample input port, wherein the sample input is positioned on the body, and wherein the sample input port is coupled to the sensor array such that samples introduced into the input port are transferred to the sensor array. 3. The system of claim 1, further comprising a sample input port, wherein the sample input is positioned on the body, and wherein the sample input port is coupled to the sensor array such that samples introduced into the input port are transferred to the sensor array, and wherein the sample input port is configured to receive a syringe. 4. The system of claim 1, further comprising a sample input port and a filter, wherein the sample input is positioned on the body, and wherein the sample input port is coupled to the sensor array such that samples introduced into the input port are transferred to the sensor array, and wherein the filter is coupled to the sample input port. 5. The system of claim 1, further comprising a fluid cartridge coupled to the body and the sensor array. 6. The system of claim 1, further comprising: an electronic controller disposed in the body and coupled to the sensor array, the light source, and the detector; wherein the electronic controller is configured to control the operation of the sensor array system. 7. The system of claim 1, further comprising a global positioning system coupled to the body. 8. The system of claim 1, further comprising a data transfer system. 9. The system of claim 1, wherein the detector comprises a monochrome detector. 10. The system of claim 1, wherein the detector comprises a color detector. 11. The system of claim 1, wherein the light source comprises at least one light-emitting diode. 12. The system of claim 1, further comprising a fluid delivery system coupled to the sensor layer. 13. The system of claim 1, wherein the detector comprises a charge-coupled device. 14. The system of claim 1, wherein the system comprises a plurality of particles positioned within the plurality of cavities, and wherein the system is configured to substantially simultaneously detect a plurality of analytes in the fluid. 15. The system of claim 1, wherein the particle ranges from about 0.05 micron to about 500 microns. 16. The system of claim 1, wherein a volume of the particle changes when contacted with the fluid. 17. The system of claim 1, wherein the particle further comprises a first indicator and a second indicator, wherein the first and second indicators are configured to be coupled to the receptor, wherein the interaction of the receptor with the analyte causes the first and second indicators to interact such that the signal is produced. 18. The system of claim 1, wherein the particle further comprises an indicator, wherein the indicator is associated with the receptor such that in the presence of the analyte the indicator is displaced from the receptor to produce the signal. 19. The system of claim 1, wherein the sensor layer comprises silicon. 20. The system of claim 1, wherein the sensor layer comprises a plastic material. 21. The system of claim 1, wherein the sensor layer comprises a dry film photoresist material. 22. The system of claim 1, wherein the cavity is configured such that the fluid entering the cavity passes through the cavity during use. 23. The system of claim 1, further comprising a pump coupled to the sensor layer, wherein the pump is configured to direct the fluid towards the cavity. 24. The system of claim 1, further comprising a vacuum apparatus coupled to the sensor array, wherein the vacuum apparatus is configured to pull the fluid through the cavity during use. 25. The system of claim 1, wherein the sensor array is positioned within a cartridge, and wherein the cartridge is removable from the body.