초록 ▼

A delivery device for patient-controlled infusion of a medicament, the delivery device comprising a reservoir for the medicament and a pump having a predetermined delivery dose which is capable of displacing the medicament from the reservoir and delivering it to a patient, wherein the pump comprises

A delivery device for patient-controlled infusion of a medicament, the delivery device comprising a reservoir for the medicament and a pump having a predetermined delivery dose which is capable of displacing the medicament from the reservoir and delivering it to a patient, wherein the pump comprises a pumping means, a first conduit, capable of restricting flow rate, chosen in conjunction with the delivery dose of the pumping means to define a predetermined maximum dosage rate, said conduit connecting the reservoir to a pumping means, a one-way valve in fluid communication with the first conduit and the pumping means which permits medicament flow into the pumping means but prevents reverse flow, a controlling means, and a second conduit extending from the pumping means and having a distal end through which the medicament may be released, wherein the controlling means: (a) is in fluid communication with the pumping means and the second conduit; (b) opens when pressured within the dose chamber exceeds a predetermined minimum opening pressure for the controlling means; and, (c) is adapted to prevent the reverse flow of medicament and air into the pumping means.

대표청구항 ▼

The invention claimed is: 1. A delivery device for patient-controlled infusion of a medicament, the delivery device comprising: (i) a reservoir for the medicament, which reduces in volume as medicament is withdrawn from the reservoir; and (ii) a pump which has a predetermined delivery dose, wherein

The invention claimed is: 1. A delivery device for patient-controlled infusion of a medicament, the delivery device comprising: (i) a reservoir for the medicament, which reduces in volume as medicament is withdrawn from the reservoir; and (ii) a pump which has a predetermined delivery dose, wherein the pump comprises at least a first conduit which connects the reservoir to a pump chamber, a one-way valve in fluid communication with the first conduit and the pump chamber which permits medicament flow into the chamber but prevents reverse flow there from, a second conduit extending from the pump chamber and having a distal end through which the medicament may be released, and a controlling means in fluid communication with said pump chamber and said second conduit, wherein: (a) the first conduit is a fine calibre tube, which is capable of restricting the filling time of the pump chamber to greater than 1 minute, and is suitably adapted to restrict the flow of medicament into the chamber to a predetermined maximum delivery rate; (b) the controlling means: (i) opens when pressure within the pump chamber exceeds a pre-selected minimum opening pressure, said opening pressure being greater than 760 mmHg; (ii) is adapted to prevent the reverse flow of medicament and air into the pump chamber; and (c) the second conduit is adapted to release the medicament in the form of a spray; wherein after expulsion of medicament from the pump chamber a working interrelationship is formed between the fine calibre tubing and the controlling means to generate a lockout phase during which a patient is unable to effectively access a dose of medicament being drawn into the pump chamber until said chamber contains sufficient medicament to aid in treating said patient. 2. A delivery device according to claim 1, wherein the reservoir is a collapsible bag. 3. A delivery device according to claim 2, wherein the collapsible bag is made from any suitable material that preferably does not absorb significant quantities of lipaphyllic drugs used with the delivery device, such as polyethylene. 4. A delivery device according to claim 1 wherein the reservoir is a syringe with plunger that reduces in volume as the fluid is removed. 5. A delivery device according to claim 1 wherein the controlling means is biased towards the closed position by a resilient biasing means. 6. A delivery device according to claim 5 wherein the controlling means has an opening pressure in the range of from 760 mmHg to about 5000 mmHg. 7. A delivery device according to claim 6 wherein the controlling means has an opening a pressure of from 1000 mmHg to about 3500 mmHg. 8. A delivery device according to claim 5 wherein the controlling means has an opening a pressure of 3000 mmHg. 9. A delivery device according to claim 1 wherein the controlling means has a high opening pressure but a low pressure threshold to remain open. 10. A delivery device according to claim 1 wherein there is at least a means for reducing the medicament to fine particles as it passes through the second conduit. 11. A delivery device according to claim 1 wherein the medicament is pumped under high pressure through and along the side walls of the second conduit, preferably in a rotary action. 12. A delivery device according to claim 11 wherein the second conduit narrows at its distal end so that fluid rotating around the conduit increases its centrifugal rotation as it converges on the distal end of the conduit. 13. A delivery device according to claim 1 wherein the pumping means is releasably engaged to the first conduit and may be separated from the first conduit to allow the first conduit to be filled with priming liquid. 14. A delivery device according to claim 1 wherein the reservoir is collapsible bag or syringe with plunger which is adapted to engaged the pump by means of a dismountable connection and which is capable of holding the first conduit. 15. A delivery device according to claim 1 wherein the reservoir has one or more means for introducing a medicament into the reservoir chamber. 16. A delivery device according to claim 1 wherein the reservoir is provided with at least a means for trapping gases inadvertently introduced into reservoir. 17. A delivery device according to claim 1 wherein the reservoir is separated from the delivery device by a fluid control system, comprising: (i) a second reservoir which holds at least two medicament doses and which is located between the end of the flow control tubing and the delivery device; (ii) a fluid delivery means interposed between the reservoir and the second reservoir; and (iii) a high pressure activated valve with an opening pressure above atmospheric pressure which is interposed between the fluid delivery means and the second reservoir, wherein the fluid delivery means is capable of drawing medicament through the flow control tubing, is capable of holding a volume of medicament equivalent to the volume held by the second reservoir and is capable of delivering that medicament across the a high pressure activated valve to the second reservoir. 18. A delivery device according to claim 17 wherein the opening pressure of the high pressure activated valve is greater than 800 mmHg. 19. A delivery device according to claim 1 wherein there is provided a secondary delivery control assembly which is releasably engaged to the second conduit, and which comprises (i) a second delivery chamber (ii) a return tube to the reservoir which extends from the second delivery chamber to the reservoir and (iii) an intravenous delivery line, wherein the housing of the second delivery chamber contains at least an air filter to remove trapped air and a delivery portal, which is connected to the intravenous delivery line. 20. A delivery device according to claim 1 wherein the reservoir contains more than one medicament. 21. A delivery device according to claim 20 wherein the medicaments are a lipophylic drug and a hydrophilic blocker. 22. A delivery device according to claim 1 having a chain or string may be attached. 23. A delivery device according to claim 1 having a counter to record dosage administration. 24. A delivery device for patient-controlled infusion of a medicament, the delivery device comprising: (i) at least a first and second reservoir for medicament storage; and (ii) a pump which has a predetermined delivery dose, wherein the pump comprises a separate conduit feeding into each reservoir to connect said reservoir to the pump chamber, a one-way valve in fluid communication with each conduit extending from the reservoir and the pump chamber which permits medicament flow into the chamber but prevents reverse flow there from, a second conduit extending from the pump chamber and having a distal end through which the medicament may be released, and a controlling means in fluid communication with said pump chamber and said second conduit, wherein: (a) each conduit connecting the reservoir to the dose chamber is a fine calibre tube, which is capable of restricting the filling time of the pump chamber to greater than 1 minute, and is suitably adapted to restrict the flow of medicament into the chamber to a predetermined maximum delivery rate; (b) the controlling means: (i) opens when pressure within the pump chamber exceeds a pre-selected minimum opening pressure, said opening pressure being greater than 760 mmHg; (ii) is adapted to prevent the reverse flow of medicament and air into the pump chamber; and (c) the second conduit is adapted to release the medicament in the form of a spray; wherein after expulsion of medicament from the pump chamber a working interrelationship is formed between the fine calibre tubing and the controlling means to generate a lockout phase during which a patient is unable to effectively access a dose of medicament being drawn into the pump chamber until said chamber contains sufficient medicament to aid in treating said patient. 25. A delivery device for patient-controlled infusion of a medicament, the delivery device comprising: (i) at least a first reservoir for medicament storage; and (ii) a pump which has a predetermined delivery dose, wherein the pump comprises a conduit feeding from each reservoir to connect said reservoir to the pump chamber, a second conduit extending from the pump chamber and having a distal end through which the medicament may be released, and a controlling means in fluid communication with said pump chamber and said second conduit, wherein: (a) Each conduit connecting the reservoir to the dose chamber is a fine calibre tube, which is capable of restricting the filling time of the pump chamber to greater than 1 minute, and is suitably adapted to restrict the flow of medicament into the chamber to a predetermined maximum delivery rate; (b) the controlling means: (i) opens when pressure within the pump chamber exceeds a pre-selected minimum opening pressure, said opening pressure being greater than 760 mmHg; (i) is adapted to prevent the reverse flow of medicament and air into the pump chamber; and (c) the second conduit is adapted to release the medicament in the form of a spray; wherein after expulsion of medicament from the pump chamber a working interrelationship is formed between the fine calibre tubing and the controlling means to generate a lockout phase during which a patient is unable to effectively access a dose of medicament being drawn into the pump chamber until said chamber contains sufficient medicament to aid in treating said patient.