An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device.
An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.
대표청구항▼
What is claimed is: 1. A method for making an implantable medical device comprising: forming a patterned mask on a designated region of a surface of the implantable medical device, the patterned mask including openings to expose the surface of the implantable medical device; etching through the ope
What is claimed is: 1. A method for making an implantable medical device comprising: forming a patterned mask on a designated region of a surface of the implantable medical device, the patterned mask including openings to expose the surface of the implantable medical device; etching through the openings with an etchant to form asperities on the surface on the implantable medical device; and applying a layer of a coating material over the asperities, wherein at least some of the asperities extend out from the layer of the coating material, wherein the implantable medical device comprises a generally tubular structure having an inner surface and an outer surface. 2. The method of claim 1, wherein the outer surface is the surface on which the asperities are formed. 3. The method of claim 2, further comprising masking the inner surface while forming the asperities. 4. The method of claim 1, wherein the designated region comprises the entire outer surface of the implantable medical device. 5. The method of claim 1, wherein the coating material comprises a therapeutic substance. 6. A method for making an implantable medical device comprising: forming a patterned mask on a designated region of a surface of the implantable medical device, the patterned mask including openings to expose the surface of the implantable medical device; etching through the openings with an etchant to form asperities on the surface on the implantable medical device; applying a layer of a coating material over the asperities, wherein at least some of the asperities extend out from the layer of the coating material; and applying a second layer of a coating material to the implantable medical device or a portion thereof so as to cover at least a part of the layer of coating material. 7. The method of claim 6, wherein at least one of the layers comprises a therapeutic substance. 8. The method of claim 1, wherein the implantable medical device includes a plurality of depots in the surface. 9. The method of claim 8, further comprising depositing a material comprising a therapeutic substance into the depots and over the asperities. 10. A method for making an implantable medical device comprising: forming a patterned mask on a designated region of a surface of the implantable medical device, the patterned mask including openings to expose the surface of the implantable medical device; etching through the openings with an etchant to form asperities on the surface on the implantable medical device; and applying a layer of a coating material over the asperities, wherein at least some of the asperities extend out from the layer of the coating material, wherein the implantable medical device is a stent or a graft. 11. The method of claim 1, wherein the implantable medical device is made of a composite material including more than one component, and wherein at least one of the components can be dissolved by the etchant. 12. A method for making an implantable medical device comprising: forming a patterned mask on a designated region of a surface of the implantable medical device, the patterned mask including openings to expose the surface of the implantable medical device; etching through the openings with an etchant to form asperities on the surface on the implantable medical device, wherein the asperities include cavities, and wherein at least some of the cavities have a depth between 0.1 μm and 10 μm; and applying a layer of a coating material over the asperities, wherein at least some of the asperities extend out from the layer of the coating material. 13. A method for making an implantable medical device comprising: forming a patterned mask on a designated region of a surface of the implantable medical device, the patterned mask including openings to expose the surface of the implantable medical device; etching through the openings with an etchant to form asperities on the surface on the implantable medical device, wherein the surface including the asperities has a roughness factor between 50 nm and 5 μm; and applying a layer of a coating material over the asperities, wherein at least some of the asperities extend out from the layer of the coating material. 14. A method of manufacturing an implantable medical device, comprising: depositing a protective coating on a portion of an implantable medical device; exposing the device to an etchant to form asperities on a second portion of the implantable medical device not protected by the protective coating; and applying a layer of a coating material over the asperities, wherein at least some of the asperities extend out from the layer of the coating material, wherein the implantable medical device comprises a generally tubular structure having an inner surface and an outer surface. 15. The method of claim 14, wherein the protective coating includes a polymer. 16. The method of claim 14, wherein the protective coating is deposited on the inner surface. 17. The method of claim 14, wherein the implantable medical device is a stent or a graft.
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