초록 ▼

Blister packages are provided which are formed from multilayered films having a lid-stock film which is heat sealed directly to a fluoropolymer film. A polymeric base layer is adhered to a fluoropolymer layer via a first intermediate adhesive tie layer; a support layer is adhered to the fluoropolyme

Blister packages are provided which are formed from multilayered films having a lid-stock film which is heat sealed directly to a fluoropolymer film. A polymeric base layer is adhered to a fluoropolymer layer via a first intermediate adhesive tie layer; a support layer is adhered to the fluoropolymer layer via a second intermediate adhesive tie layer; and a metallic foil layer is adhered to the support layer via a third intermediate adhesive tie layer. The blister has a greatly improved moisture barrier over blister packages of the prior art.

대표청구항 ▼

What is claimed is: 1. A process for forming a pharmaceutical package comprising: a) forming a multilayered film for holding a pharmaceutical product by: i) forming a polymeric base layer; ii) applying a fluoropolymer layer onto said polymeric base layer, which layers are attached via a first inter

What is claimed is: 1. A process for forming a pharmaceutical package comprising: a) forming a multilayered film for holding a pharmaceutical product by: i) forming a polymeric base layer; ii) applying a fluoropolymer layer onto said polymeric base layer, which layers are attached via a first intermediate adhesive tie layer; and iii) molding said film into a shaped blister container, which container has an outer surface, an inner surface, and a cavity; b) placing a pharmaceutical product into said cavity; and c) heat sealing a lid onto the outer surface of said container to close said product filled cavity, which lid comprises: i) a support layer adhered to said fluoropolymer layer via a second intermediate adhesive tie layer; and ii) a metallic foil layer adhered to said support layer. 2. The process of claim 1 wherein said pharmaceutical product comprises a tablet or a capsule. 3. The process of claim 1 wherein said base layer and said fluoropolymer layer are coextruded. 4. The process of claim 1 wherein said base layer and said fluoropolymer layer are laminated together. 5. The process of claim 1 wherein said molding comprises thermoforming. 6. The process of claim 1 further comprising adhering a paper to said foil layer via an intermediate adhesive layer. 7. The process of claim 1 wherein said fluoropolymer layer comprises a polychlorotrifluoroethylene homopolymer or copolymer. 8. The process of claim 1 wherein said the polymeric base layer comprises a material selected from the group consisting of polyamides, polyolefins, cyclic olefin copolymers, polyesters, poly(vinyl chloride), polyvinylidene chloride, polystyrene, acrylics and combinations thereof. 9. The process of claim 1 wherein said support layer comprises a material selected from the group consisting of polyolefins, polyamides, polyesters, polystyrene, poly(vinyl chloride), polyvinylidene chloride, polyurethanes and combinations thereof. 10. The process of claim 1 wherein said support layer comprises polyethylene terephthalate. 11. The process of claim 1 wherein said metaflic foil comprises an aluminum foil. 12. The process of claim 1 wherein said first intermediate adhesive tie layer comprises a material selected from the group consisting of a polyurethane, an epoxy, a polyester, an acrylic, an anhydride modified polyolefin and blends thereof. 13. The process of claim 1 wherein said second intermediate adhesive tie layer comprises a blend of (1) an olefin-containing polymer selected from the group consisting of at least one functionalized polyolefin; at least one copolymer of ethylene and at least one comonomer selected from the group consisting of acrylic acid, alkyl acrylic acid, acrylates, and alkyl acrylates; and blends thereof and (2) a styrene-ethylene-butylene-s-tyrene block copolymer. 14. A process for forming a package comprising: a) forming a multilayered film for holding a product by: i) forming a polymeric base layer; ii) applying a fluoropolymer layer onto said polymeric base layer, which layers are attached via a first intermediate adhesive tie layer; and iii) molding said film into a shaped container, which container has an outer surface, an inner surface, and a cavity; b) placing a product into the cavity; and c) heat sealing a lid onto the outer surface of the container to close the product filled cavity, which lid comprises: i) a support layer adhered to said fluoropolymer layer via a second intermediate adhesive tie layer; and ii) a metallic foil layer adhered to said support layer.