IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0132109
(2005-05-18)
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등록번호 |
US-7340296
(2008-03-04)
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발명자
/ 주소 |
- Stahmann,Jeffrey E.
- Hatlestad,John
- Hartley,Jesse W.
- Fogoros,Richard
|
출원인 / 주소 |
|
대리인 / 주소 |
Schwegman, Lundberg & Woessner, P.A.
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인용정보 |
피인용 횟수 :
90 인용 특허 :
142 |
초록
▼
This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance sig
This patent document discusses systems, devices, and methods for increasing a sensitivity or specificity of thoracic fluid detection in a subject and differentiating between pleural effusion and pulmonary edema. In one example, a thoracic impedance measurement circuit senses a thoracic impedance signal. In another example, a processor receives the thoracic impedance signal and determines whether such thoracic impedance signal is "significant." A significant thoracic impedance signal indicates the presence of thoracic fluid and may be recognized by comparing the thoracic impedance signal (or variation thereof) to a thoracic impedance threshold. When a significant thoracic impedance signal is recognized, the processor is adapted to detect one or both of: a pleural effusion indication and a pulmonary edema indication using one or a combination of: physiologic information, patient symptom information, and posture information. In another example, the thoracic impedance threshold is adjusted using such physiologic, patient symptom, or posture information.
대표청구항
▼
What is claimed is: 1. A system for the detection of thoracic fluid in a subject, the system comprising: an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; and a processor, coupled with the thoracic impedance measurement circuit to
What is claimed is: 1. A system for the detection of thoracic fluid in a subject, the system comprising: an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; and a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal, and adapted to recognize a significant thoracic impedance signal, wherein the processor is adapted to detect one or both of a pleural effusion indication or a pulmonary edema indication upon recognition of the significant thoracic impedance signal and differentiate the pleural effusion indication from the pulmonary edema indication. 2. The system as recited in claim 1, further comprising at least one physiologic information device coupled to the processor, the at least one physiologic information device is adapted to sense or collect physiologic information about the subject, wherein the processor is adapted to differentiate the pleural effusion indication from the pulmonary edema indication using, at least in part, the physiologic information. 3. The system as recited in claim 2, wherein the at least one physiologic information device includes an implantable sensor. 4. The system as recited in claim 2, wherein the physiologic information about the subject includes at least one respiratory sound. 5. The system as recited in claim 2, further comprising a memory storage device adapted to store a history of the thoracic impedance signal and a history of the physiologic information. 6. The system as recited in claim 1, further comprising at least one patient symptom device coupled to the processor, the at least one patient symptom device is adapted to sense or collect patient symptom information about the subject, wherein the processor is adapted to differentiate the pleural effusion indication from the pulmonary edema indication using, at least in part, the patient symptom information. 7. The system as recited in claim 6, wherein the at least one patient symptom device includes an implantable sensor. 8. The system as recited in claim 6, wherein the patient symptom information includes one or both of: a pleuritic chest pain and at least one hiccup. 9. The system as recited in claim 6, further comprising a memory storage device adapted to store a history of the thoracic impedance signal and a history of the patient symptom information. 10. The system as recited in claim 1, further comprising a posture sensor coupled to the processor, the posture sensor adapted to sense a posture signal; and a memory storage device adapted to store a history of the thoracic impedance signal and a history of the posture signal, wherein the processor is adapted to differentiate the pleural effusion indication from the pulmonary edema indication using a rate of change in the thoracic impedance signal associated with a change in the posture signal. 11. The system as recited in claim 10, further comprising a posture compensation module adapted to determine a posture-compensated thoracic impedance signal using the posture signal and the thoracic impedance signal, wherein the processor is adapted to recognize the significant thoracic impedance signal using the posture-compensated thoracic impedance signal. 12. The system as recited in claim 1, further comprising a blood impedance measurement circuit adapted to extract from the thoracic impedance signal a blood resistivity-influenced component, wherein the processor is adapted to recognize the significant thoracic impedance signal using a blood resistivity-compensated thoracic impedance signal. 13. The system as recited in claim 1, further comprising a frequency selective filter circuit adapted to extract from the thoracic impedance signal a near-DC thoracic impedance signal, wherein the processor is adapted to recognize the significant thoracic impedance signal using the new-DC thoracic impedance signal. 14. The system as recited in claim 1, further comprising an external user interface coupled to the processor, wherein the external user interface is adapted to receive from the processor the pleural effusion indication, and provide a user-detectable indication of the pleural effusion indication. 15. The system as recited in claim 1, further comprising an external user interface coupled to the processor, wherein the external user interface includes a user input device, adapted to collect from a user one or a combination of: physiologic information, patient symptom information, and posture information, and transmit the physiologic information, the patient symptom information, or the posture information to the processor. 16. The system as recited in claim 1, further comprising a therapy control module adapted to adjust or initiate a therapy using the pleural effusion indication. 17. A system for the detection of thoracic fluid in a subject, the system comprising: a thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal; and a differentiation module, adapted to differentiate a pleural effusion indication and a pulmonary edema indication using, at least in part, one or a combination of: the thoracic impedance signal, physiologic information, patient symptom information, and posture information. 18. The system as recited in claim 17, wherein the processor detects one or both of: the pleural effusion indication and the pulmonary edema indication when the thoracic impedance signal is less than, or substantially equal to, a thoracic impedance threshold, and wherein the processor includes a threshold adjustment module adapted to adjust the thoracic impedance threshold using, at least in part, one or a combination of: the physiologic information, the patient symptom information, and the posture information. 19. The system as recited in claim 17, further comprising a memory storage device, adapted to store a history of one or a combination of: the thoracic impedance signal, the physiologic information, the patient symptom information, and the posture information. 20. A method for the detection of thoracic fluid in a subject, the method comprising: sensing a thoracic impedance signal using an implantable device from a thorax of the subject; recognizing a significant thoracic impedance signal in the subject, including comparing the thoracic impedance signal to a thoracic impedance threshold; detecting one or both of a pleural effusion indication upon recognizing the significant thoracic impedance signal; and differentiating the pleural effusion indication from the pulmonary edema indication. 21. The method as recited in claim 20, further comprising sensing or receiving physiologic information about the subject, wherein differentiating the pleural effusion indication from the pulmonary edema indication includes using the physiologic information. 22. The method as recited in claim 21, wherein sensing or receiving the physiologic information includes sensing or receiving at least one respiratory sound. 23. The method as recited in claim 20, further comprising sensing or receiving patient symptom information about the subject, wherein differentiating the pleural effusion indication from the pulmonary edema indication includes using the patient symptom information. 24. The method as recited in claim 20, further comprising sensing or receiving a posture orientation of the subject, wherein differentiating the pleural effusion indication from the pulmonary edema indication includes using a change in the thoracic impedance signal with a change in the posture orientation. 25. The method as recited in claim 20, further comprising alerting a user in response to the pleural effusion indication. 26. The method as recited in claim 20, further comprising providing a therapy to the subject in response to the pleural effusion indication. 27. The method as recited in claim 20, further comprising filtering the thoracic impedance signal to obtain a near-DC thoracic impedance signal, wherein recognizing the significant thoracic impedance signal includes comparing the near-DC thoracic impedance signal to the thoracic impedance threshold. 28. The method as recited in claim 20, further comprising compensating the thoracic impedance signal to extract a blood resistivity-influenced component of the thoracic impedance signal, wherein recognizing the significant thoracic impedance signal includes comparing a blood resistivity-compensated thoracic impedance signal to the thoracic impedance threshold. 29. The method as recited in claim 20, further comprising compensating the thoracic impedance signal to attenuate or remove a posture-influenced component of the thoracic impedance signal, wherein recognizing the significant thoracic impedance signal includes comparing a posture-compensated thoracic impedance signal to the thoracic impedance threshold. 30. The method as recited in claim 20, further comprising: computing a change in the thoracic impedance threshold using, at least in part, one or a combination of: physiologic information, patient symptom information, and posture information; adjusting the thoracic impedance threshold using the computed change in the thoracic impedance threshold; and recognizing the significant thoracic impedance signal using an adjusted thoracic impedance threshold. 31. A system for the detection of thoracic fluid in a subject, the system comprising: an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal and adapted to recognize a significant thoracic impedance signal, the processor further adapted to detect a pleural effusion indication upon recognition of the significant thoracic impedance signal; and an external user interface coupled to the processor and adapted to receive from the processor the pleural effusion indication, the external user interface further adapted to provide a user-detectable indication of the pleural effusion indication. 32. A system for the detection of thoracic fluid in a subject, the system comprising: an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from the subject; and a processor, coupled with the thoracic impedance measurement circuit to receive the thoracic impedance signal and adapted to recognize a significant thoracic impedance signal, the processor further adapted to detect a pleural effusion indication upon recognition of the significant thoracic impedance signal; and an external user interface, coupled to the processor and including a user input device, the user input device adapted to collect from a user one or a combination of physiologic information, patient symptom information, and posture information, wherein the external user interface is further adapted to transmit the physiologic information, the patient symptom information, or the posture information to the processor.
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