Thermal regulation of fluidic samples within a diagnostic cartridge
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-033/543
출원번호
US-0981440
(2001-10-16)
등록번호
US-7344894
(2008-03-18)
발명자
/ 주소
Greenstein,Michael
Stawitcke,Frederick
Drbal,Vladimir
Mauze,Ganapati R.
Pittaro,Rick
Pering,Richard
Verdonk,Ed
Alden,Don
Ingle,Frank
Drese,Klaus Stefan
Hartmann,Hans Joachim
Soerensen,Olaf
출원인 / 주소
Agilent Technologies, Inc.
인용정보
피인용 횟수 :
28인용 특허 :
924
초록▼
A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes ("LED"s) and vertical cavity surface emitting lasers ("VCSEL"s), generating internal heat, such as resistive, induct
A method and miniature analytical device with thermal regulation of reactant using a localized heat source capable of emitting electromagnetic radiation, such as light emitting diodes ("LED"s) and vertical cavity surface emitting lasers ("VCSEL"s), generating internal heat, such as resistive, inductive and Peltier heaters, or external heating. The miniature analytical device comprises of array of temperature-controlled zones to restrict the volume heated and localize the heating by having the localized heat source comprise an array of emitters or heaters.
대표청구항▼
What is claimed is: 1. A point of care miniature analytical device with thermal regulation comprising: a cartridge comprising one or more portions constructed of a material, wherein the one or more portions define an array of temperature-controlled zones including reactants, wherein each said tempe
What is claimed is: 1. A point of care miniature analytical device with thermal regulation comprising: a cartridge comprising one or more portions constructed of a material, wherein the one or more portions define an array of temperature-controlled zones including reactants, wherein each said temperature-controlled zones is constrained by cartridge portions that surround an area of space in which a reactant is contained and confine the reactant from flowing into other of said temperature-controlled zones, and wherein the cartridge portions include clear or translucent portions that allow direct irradiation of reactant molecules to facilitate thermal regulation of the reactants and to transmit light through the reactants; an array of infrared radiation emitting heat sources, wherein the array of heat sources is positioned to correspond to the array of temperature-controlled zones so that each heat source is arranged to provide temperature regulation to a corresponding temperature-controlled zone, and wherein one or more of the heat sources emit localized radiation to provide heating in the corresponding temperature-controlled zone; an optical temperature monitor, not in contact with the cartridge and disposed adjacent to a portion of the cartridge surrounding the temperature controlled zones, that monitors reactant temperature by measuring electromagnetic radiation; a controller comprising a modulator; a power supply configured to supply drive current to the array of heat sources and coupled to the controller to provide that current from the power supply achieves the desired thermal regulation in the temperature-controlled zones; a feedback loop configured to provide measured temperatures to the controller, and to modulate the power supply to drive the infrared light heat sources to achieve a desired temperature with a smooth control curve at the desired temperature, and an instrument for measurement of electromagnetic emission obtained from irradiation of the reactants with the infrared radiation emitting heat sources, wherein the transmission of infrared radiation through the reactants allows a determination of a concentration of a material within the reactants. 2. A point of care miniature analytical device with thermal regulation according to claim 1, wherein: the array of infrared radiation emitting heat sources comprise vertical cavity surface emitting laser light sources. 3. A point of care miniature analytical device with thermal regulation according to claim 1, wherein: the array of infrared radiation emitting heat sources comprise at least one light source chosen from a vertical cavity surface emitting laser light source, a light emitting diode, an infrared lamp, an infrared laser, and infrared diode laser. 4. A point of care miniature analytical device with thermal regulation according to claim 3, wherein: at least one of the infrared radiation emitting heat sources in the array of heat sources generates infrared light of a different wavelength from the remainder of the infrared radiation emitting heat sources. 5. A point of care miniature analytical device with thermal regulation according to claim 3, wherein: the at least one light source generates infrared light with a wavelength of at least 0.775 micrometers. 6. A point of care miniature analytical device with thermal regulation according to claim 3, wherein: the at least one light source generates infrared light with a wavelength of at most 7000 micrometers. 7. A point of care miniature analytical device with thermal regulation according to claim 1, wherein: the controller modulates the power supply based on a temperature measured from the zones. 8. A point of care miniature analytical device with thermal regulation according to claim 1, further comprising: an array of temperature monitors, wherein the array of temperature monitors is positioned to correspond to the array of temperature-controlled zones. 9. A point of care miniature analytical device with thermal regulation according to claim 1, wherein: the reactants comprise assay elements for body fluid analysis. 10. A point of care miniature analytical device with thermal regulation according to claim 1, wherein: the array of heat sources provides a reactant temperature that is one or both of achieved with a smooth control curve or maintained at a desired temperature.
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이 특허에 인용된 특허 (924)
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Desai,Shashi P.; Dunn,Timothy C.; Lesho,Matthew J.; Potts,Russell O.; Tamada,Janet A.; Wei,Charles W., Methods for computing rolling analyte measurement values, microprocessors comprising programming to control performance of the methods, and analyte monitoring devices employing the methods.
Uhland, Scott A.; Polito, Benjamin F.; Herman, Stephen J.; Santini, Jr., John T.; Maloney, John M., Methods for hermetically sealing microchip reservoir devices.
Miekka, Shirley I.; Burgess, Wilson; Drohan, William N.; Griko, Yuri; MacPhee, Martin J.; Mann, David M., Methods for sterilizing biological materials.
MacPhee, Martin; Calvert, Glenn; Lynch, Tom; Kent, Randall S.; Mann, David; Burgess, Wilson; Miekka, Shirley; Drohan, William N., Methods for sterilizing biological materials by irradiation over a temperature gradient.
Santini, Jr., John T.; Cima, Michael J.; Sheppard, Jr., Norman F.; Flynn, Nolan T.; Uhland, Scott A.; Sbiaa, Zouhair; Maloney, John M., Microchip devices with improved reservoir opening.
Bohm,Sebastian; Rodgers,James Iain; McNeilage,Alan; Moffat,James; Stiene,Matthias; Richter,Tanja, Microfluidic analytical system with position electrodes.
Delmore, Michael D.; Fleming, Patrick R.; Huntley, Douglas A.; Keister, Jamieson C.; Thomas, Cristina U.; Ferber, Richard H., Microneedle arrays and methods of manufacturing the same.
Grtzel Michael (St-Sulpice CHX) Fraser David (Vevey CHX) Zakeeruddin Shaik M. (Renens CHX) Nazeeruddin Mohammed K. (Chavannes CHX), Mono, bis or tris(substituted 2,2′-bipyridine) iron, ruthenium, osmium or vanadium complexes and their methods of prepa.
Rice Mark J. ; Sweat ; Jr. Robert H. ; Rioux James M. ; Williams William T. ; Routt Wilson, Non-invasive measurement of blood component using retinal imaging.
Mark J. Rice ; Robert H. Sweat, Jr. ; James M. Rioux ; William T. Williams ; Wilson Routt, Non-invasive measurement of blood components using retinal imaging.
Mendelson Yitzhak (Worcester MA) Wang Yi (Worcester MA) Gross Brian D. (Worcester MA), Noninvasive measurement of hematocrit and hemoglobin content by differential optical analysis.
Brown Stephen J. ; Jensen Erik K., On-line health education and feedback system using motivational driver profile coding and automated content fulfillment.
Barnard Steven M. ; Collins Thomas C. ; Cudmore Susan L. ; Mason Richard W. ; Munkholm Christiane ; Slovacek Rudolf E. ; Sullivan Kevin J., Optical sensors with reflective materials.
Gardner,Craig; Haass,Michael J.; Rowe,Robert K.; Jones,Howland; Strohl,Steven T.; Novak,Matthew J.; Abbink,Russell E.; Nu챰ez,David; Gruner,William; Johnson,Robert D., Optically similar reference samples and related methods for multivariate calibration models used in optical spectroscopy.
Schaffar Bernhard (Graz ATX) Kontschieder Heinz (Graz ATX) Dolezal Andreas (Graz ATX) Ritter Christoph (Graz ATX), Planar sensor for determining a chemical parameter of a sample.
Anderson Carter R. ; Giddings David T. ; Kurkowski James D. ; Thompson Robbi T. ; Sin Kee Van, Portable immediate response medical analyzer having multiple testing modules.
Yoshioka Toshihiko (Osaka JPX) Kawaguri Mariko (Moriguchi JPX) Nankai Shiro (Hirataka JPX), Preparation of biosensor having a layer containing an enzyme, electron acceptor and hydrophilic polymer on an electrode.
Bourland Joe D. (W. Lafayette IN) Babbs Charles F. (W. Lafayette IN) Geddes Leslie A. (W. Lafayette IN) Tacker ; Jr. Willis A. (W. Lafayette IN) Graber George P. (W. Lafayette IN), Pressure mapping system with capacitive measuring pad.
Bourland Joe D. (W. Lafayette IN) Barbs Charles F. (W. Lafayette IN) Geddes Leslie A. (W. Lafayette IN) Tacker ; Jr. Willis A. (W. Lafayette IN) Graber George P. (W. Lafayette IN), Pressure mapping system with capacitive measuring pad.
Say James ; Tomasco Michael F. ; Heller Adam ; Gal Yoram,ILX ; Aria Behrad ; Heller Ephraim ; Plante Phillip John ; Vreeke Mark S., Process for producing an electrochemical biosensor.
Steinberger, Michael; Miklautsch, Josef, Process for the continuous production of mixtures of substances and reaction mixtures and device for its implementation.
Sterling, Bernhard B.; Hartstein, Philip C.; Li, Ken I.; Agostino, Mark D.; Klonoff, David C.; Gaffney, Robert D.; Gable, Jennifer H.; Witte, Ken G.; Munrow, Mike A.; Goldberger, Daniel S.; Cortella,, Reagent-less whole-blood glucose meter.
Vreeke,Mark S.; Warchal Windham,Mary Ellen; Blaschke,Christina; Mikel,Barbara J.; Cooper,Howard A., Reagents and methods for detecting analytes, and devices comprising reagents for detecting analytes.
Phillips, Roger; McGarraugh, Geoffery; Jurik, Franklin A.; Underwood, Raymond D., Reagents test strip adapted for receiving an unmeasured sample while in use in an apparatus.
Shin, John J.; Holtzclaw, Kris R.; Dangui, Nandita D.; Kanderian, Jr., Sami; Mastrototaro, John J.; Hong, Peter I., Real time self-adjusting calibration algorithm.
Reghabi,Bahar; Shah,Rajiv; Jin,Eunjoo; Gottlieb,Rebecca; Miller,Michael E.; Van Antwerp,Nannette M.; Enegren,Bradley J.; Van Antwerp,William P.; Mastrototaro,John J., Reusable analyte sensor site and method of using the same.
Cronenberg Richard A. (Mahwah NJ) Shapiro Stephen I. (Scarsdale NY), Sensor assembly suitable for blood gas analysis and the like and the method of use.
Grtzel Michael (St-Sulpice CHX) Fraser David (Vevey CHX) Zakeeruddin Shaik M. (Renens CHX) Randin Jean-Paul (Cortaillod CHX) Frenkel Erik J. (Neuchtel CHX), Sensor for measuring the amount of a component in solution.
Karinka, Shridhara Alva; Moser, Isabella; Jobst, Gerhard; Tietjen, Uwe; Petrou, Panagiota S.; Herberth, Uwe; Urban, Gerald, Sensor having electrode for determining the rate of flow of a fluid.
Berner Bret ; Dunn Timothy C. ; Farinas Kathleen C. ; Garrison Michael D. ; Kurnik Ronald T. ; Lesho Matthew J. ; Potts Russell O. ; Tamada Janet A. ; Tierney Michael J., Signal processing for measurement of physiological analysis.
Nikkels Ben H. (Pitman NJ) Hegarty John M. (Reading MA) Field Gregory T. (Winthrop MA) Rosone Steven (Burlington MA), Slicing disposable blood sampling device.
Liamos, Charles T.; Feldman, Benjamin J.; Funderburk, Jeffery V.; Krishnan, Rajesh; Plante, Phillip John; Vivolo, Joseph A.; Jin, Robert Y.; Cloud, Michael S., Small volume in vitro analyte sensor and methods.
Benjamin J. Feldman ; Adam Heller ; Ephraim Heller ; Fei Mao ; Joseph A. Vivolo ; Jeffrey V. Funderburk ; Fredric C. Colman ; Rajesh Krishnan, Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator.
Feldman Benjamin J. ; Heller Adam ; Heller Ephraim ; Mao Fei ; Vivolo Joseph A. ; Funderburk Jeffery V. ; Colman Fredric C. ; Krishnan Rajesh, Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator.
Hill Hugh A. O. (Oxford GB3) Higgins Irving J. (Bedford GB3) McCann James M. (Oxford NJ GB3) Davis Graham (Plainsborough NJ), Strip electrode including screen printing of a single layer.
Hill Hugh Allen Oliver (Oxford GB3) Higgins Irving John (Bedford GB3) McCann James Michael (Oxford GB3) Davis Graham (Plainsborough NJ), Strip electrode with screen printing.
Yacynych Alexander M. (East Brunswick NJ) Piznik Sylvia S. (Jackson NJ) Reynolds Eugene R. (Highland Park NJ) Geise Robert J. (Piscataway NJ), Surface-modified electochemical biosensor.
Keith,Steven; Parker,Robert S.; Harvey,Noel G.; Pettis,Ronald J.; DeNuzzio,John D.; Vonk,Glenn, System and method for initiating and maintaining continuous, long-term control of a concentration of a substance in a patient using a feedback or model-based controller coupled to a single-needle or .
Trippel, Christine G.; Schell, Robert D.; Miller, Randall W.; Perry, Joseph E.; Moore, Starke S., System, method and biosensor apparatus for data communications with a personal data assistant.
Custer,Linda; Elstrom,Tuan A.; Kellogg,Scott C.; Kost,Joseph; Warner,Nicholas F., System, method, and device for non-invasive body fluid sampling and analysis.
Neel, Gary T.; Bell, Douglas E.; Wong, T. Philip; Voss, Houston F.; Caban, Allan Javier; Boehm, David K., Systems and methods for blood glucose sensing.
Ratzlaff Marc H. (Moscow ID) Grant Barrie D. (Pullman WA) Frame John M. (Pullman WA), Systems for measurement and analysis of forces exerted during human locomotion.
Hieb Martin G. (Roseville MN) Blomberg Scott E. (St. Anthony Village MN), Temperature control for portable diagnostic system using a non-contact temperature probe.
Hildenbrand Karlheinz (Krefeld DEX) von Dhren Hans-Hagen (Bochum-Langendreer DEX) Perrey Hermann (Krefeld IN DEX) Frank Georg (Elkhart IN) Dhein Rolf (Krefeld DEX), Test device and a method for the detection of a component of a liquid sample.
Fraser David (Nyon CHX) Zakeeruddin Shaik M. (Renens CHX) Graetzel Michael (Renens CHX), Transition metal complexes having 2,2′-bipyridine ligands substituted by at least one ammonium alkyl radical.
Bird, Dylan Hilmer; Ching, Jesus; Johnson, Bruce A.; Moravick, Keith E.; Richardson, Bruce, Apparatus and methods for integrated sample preparation, reaction and detection.
Bird, Dylan Hilmer; Ching, Jesus; Johnson, Bruce A.; Moravick, Keith E.; Richardson, Bruce, Apparatus and methods for integrated sample preparation, reaction and detection.
Bird, Dylan Hilmer; Ching, Jesus; Johnson, Bruce A.; Moravick, Keith E.; Richardson, Bruce, Apparatus and methods for integrated sample preparation, reaction and detection.
Bird, Dylan Hilmer; Ching, Jesus; Johnson, Bruce A.; Moravick, Keith E.; Richardson, Bruce, Apparatus and methods for integrated sample preparation, reaction and detection.
DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
Verhoef, Erik T.; DiPerna, Paul M.; Rosinko, Mike; Williamson, Mark; Kruse, Geoffrey A.; Ulrich, Thomas R.; Lamb, Phil; Saint, Sean; Michaud, Michael; Trevaskis, William, Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
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