IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0028518
(2001-12-21)
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등록번호 |
US-7348055
(2008-03-25)
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발명자
/ 주소 |
- Chappa,Ralph A.
- Stucke,Sean M.
- Amos,Richard A.
- Everson,Terrence P.
- Chudzik,Stephen J.
- Swan,Dale G.
- Duquette,Peter H.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
47 인용 특허 :
34 |
초록
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A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin,
A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.
대표청구항
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What is claimed is: 1. A porous support surface bearing a polymeric coating prepared according to a method comprising the steps of: a) providing a porous support surface; b) providing a nonpolymeric grafting reagent comprising at least two photoinitiator groups, the grafting reagent having one or m
What is claimed is: 1. A porous support surface bearing a polymeric coating prepared according to a method comprising the steps of: a) providing a porous support surface; b) providing a nonpolymeric grafting reagent comprising at least two photoinitiator groups, the grafting reagent having one or more substituents comprising positively charged groups; c) providing at least one polymerizable monomer solution to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer solution to the surface to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent, wherein the polymeric coating is covalently attached to the surface by the residues of one or more photoinitiator groups provided by the grafting reagent and the polymeric coating is less than about 100 nanometers in thickness. 2. A porous support surface bearing a polymeric coating prepared according to a method of forming a polymeric coating on a support surface, the method comprising: a) providing a porous support surface; b) providing a nonpolymeric grafting reagent comprising at least two photoinitiator groups, at least one of which to be activated in order to covalently attach the grafting reagent to the surface itself, and further comprising one or more substituents comprising positively charged groups; c) providing at least one polymerizable monomer solution to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the grafting reagent; and d) applying the grafting reagent and monomer solution to the surface to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent and the covalent attachment of the reagent to the surface, wherein the polymeric coating is less than about 100 nanometers in thickness. 3. A porous surface according to claim 2 wherein the support surface comprises a material selected from the group consisting of polyolefins, polystyrenes, poly(alkyl)methacrylates and poly(alkyl) acrylates, polyacrylonitriles, poly(vinylacetates), poly(vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, polyvinylidene difluoride (PVDF), phenolics, amino-epoxy resins, polyesters, silicones, polyethylene terephthalates (PET), polyglycolic acids (PGA), poly-(p-phenyleneterephthalamides), polyphosphazenes, polypropylenes, parylenes, silanes, and silicone elastomers, as well as copolymers and combinations thereof, and the grafting reagent is selected from: ethylenebis(4-benzoylbenzyldimethylammonium) dibromide (Diphoto-Diquat); hexamethylenebis(4-benzoylbenzyldimethylammonium) dibromide (Diphoto-Diquat); 1,4-bis(4-benzoylbenzyl)-1,4-dimethylpiperazinediium dibromide (Diphoto-Diquat); bis(4-benzoylbenzyl)hexamethylenetetraminediium dibromide (Diphoto-Diquat): bis[2-(4-benzoylbenzyldimethylammonio)ethyl]-4-benzoylbenzylmethylammonium tribromide (Triphoto-Triquat): 4,4-bis(4-benzoylbenzyl)morpholinium bromide (Diphoto-Monoquat); ethylenebis[(2-(4-benzoylbenzyldimethylammonio)ethyl)-4-benzoylbenzylmethylammonium]tetrabromide (Tetraphoto-Tetraquat); and 1,1,4,4-tetrakis(4-benzoylbenzyl)piperazinediium Dibromide (Tetraphoto-Diquat) and analogues thereof, and wherein the polymer is formed by the polymerization of polymerizable monomers selected from: a) neutral hydrophilic structural monomers selected from acrylamide, methacrylamide, N-alkylacrylamides, N-vinylpyrrolidinone, N-vinylacetamide, N-vinyl formamide, hydroxyethylacrylate, hydroxyethylmethacrylate, hydroxypropyl acrylate or methacrylate, glycerolmonomethacrylate, and glycerolmonoacrylate; b) negatively charged hydrophilic functional monomers selected from acrylic acid, methacrylic acid, maleic acid, fumaric acid, itaconic acid, AMPS (acrylamidomethylpropane sulfonic acid), vinyl phosphoric acid, vinylbenzoic acid; and c) positively charged monomers selected from 3-aminopropylmethacrylamide (APMA), methacrylamidopropyltrimethylammonium chloride (MAPTAC), N,N-dimethylaminoethylmethacrylate, N,N-diethylaminoethylacrylate. 4. A device comprising a surface bearing a polymer coating formed according a method comprising the steps of: a) providing a support surface; b) providing a nonpolymeric grafting reagent comprising at least two photoinitiator groups, the grafting reagent having one or more substituents comprising positively charged groups; c) providing at least one polymerizable monomer solution to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer solution to the surface to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent, wherein the support surface comprises a porous support surface and the polymer coating is covalently attached to the surface by the residues of one or more latent reactive groups provided by the grafting reagent and the polymer coating is less than about 100 nanometers in thickness. 5. A device comprising a surface bearing a polymer coating, the polymer coating being formed by a method comprising the steps of: a) providing a porous support surface; b) providing a nonpolymeric grafting reagent comprising at least two photoinitiator groups, at least one of which is to be activated in order to covalently attach the grafting reagent to the surface itself, and further comprising one or more substituents comprising positively charged groups; c) providing at least one polymerizable monomer solution to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the grafting reagent; and d) applying the grafting reagent and monomer solution to the surface to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent and the covalent attachment of the reagent to the surface, wherein the polymer coating is less than about 100 nanometers in thickness, and further wherein the support surface comprises a material selected from the group consisting of polyolefins, polystyrenes, poly(alkyl)methacrylates and poly(alkyl) acrylates, polyacrylonitriles, poly(vinylacetates), poly(vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, polyvinylidene difluoride (PVDF), phenolics, amino-epoxy resins, polyesters, silicones, polyethylene terephthalates (PET), polyglycolic acids (PGA), poly-(p-phenyleneterephthalamides), polyphosphazenes, polypropylenes, parylenes, silanes, and silicone elastomers, as well as copolymers and combinations thereof, and the grafting reagent is selected from: ethylenebis(4-benzoylbenzyldimethylammonium) dibromide (Diphoto-Diquat); hexamethylenebis(4-benzoylbenzyldimethylammonium) dibromide (Diphoto-Diquat); 1,4-bis(4-benzoylbenzyl)-1,4-dimethylpiperazinediium dibromide (Diphoto-Diquat); bis(4-benzoylbenzyl)hexamethylenetetraminediium dibromide (Diphoto-Diquat): bis[2-(4-benzoylbenzyldimethylammonio)ethyl]-4-benzoylbenzylmethylammonium tribromide (Triphoto-Triquat): 4,4-bis(4-benzoylbenzyl)morpholinium bromide (Diphoto-Monoquat); ethylenebis[(2-(4-benzoylbenzyldimethylammonio)ethyl)-4-benzoylbenzylmethylammonium]tetrabromide (Tetraphoto-Tetraquat); and 1,1,4,4-tetrakis(4-benzoylbenzyl)piperazinediium Dibromide (Tetraphoto-Diquat), and analogues thereof, and wherein the polymer is formed by the polymerization of polymerizable monomers selected from: a) neutral hydrophilic structural monomers selected from acrylamide, methacrylamide, N-alkylacrylamides, N-vinylpyrrolidinone, N-vinylacetamide, N-vinyl formamide, hydroxyethylacrylate, hydroxyethylmethacrylate, hydroxypropyl acrylate or methacrylate, glycerolmonomethacrylate, and glycerolmonoacrylate; b) negatively charged hydrophilic functional monomers selected from acrylic acid, methacrylic acid, maleic acid, fumaric acid, itaconic acid, AMPS (acrylamidomethylpropane sulfonic acid), vinyl phosphoric acid, vinylbenzoic acid; and c) positively charged monomers selected from 3-aminopropylmethacrylamide (APMA), methacrylamidopropyltrimethylammonium chloride (MAPTAC), N,N-dimethylaminoethylmethacrylate, N,N-diethylaminoethylacrylate, and combinations thereof. 6. A device comprising a surface bearing a polymer coating formed according a method comprising the steps of: a) providing a support surface; b) providing a nonpolymeric grafting reagent comprising at least two photoinitiator groups, the grafting reagent having one or more substituents comprising positively charged groups; c) providing at least one polymerizable monomer solution to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer solution to the surface to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent, wherein the support surface comprises a porous support surface and the polymer coating is covalently attached to the surface and the polymer coating is less than about 100 nanometers in thickness. 7. A support surface bearing a polymeric coating prepared according to a method comprising the steps of: a) providing a support surface; b) providing a nonpolymeric grafting reagent comprising four photoinitiator groups, the grafting reagent having a nonpolymeric core molecule with the four photoinitiator groups attached to the core molecule; c) providing at least one polymerizable monomer to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of at least one of the photoinitiator groups; and d) applying the grafting reagent and monomer solution to the surface to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent, wherein the support surface comprises a porous support surface and the polymeric coating is less than about 100 nanometers in thickness, and the polymeric coating is covalently attached to the surface. 8. A porous surface according to claim 7 wherein the support surface comprises a material selected from the group consisting of polyolefins, polystyrenes, poly(alkyl)methacrylates and poly(alkyl) acrylates, polyacrylonitriles, poly(vinylacetates), poly(vinyl alcohols), chlorine-containing polymers such as poly(vinyl) chloride, polyoxymethylenes, polycarbonates, polyamides, polyimides, polyurethanes, polyvinylidene difluoride (PVDF), phenolics, amino-epoxy resins, polyesters, silicones, polyethylene terephthalates (PET), polyglycolic acids (PGA), poly-(p-phenyleneterephthalamides), polyphosphazenes, polypropylenes, parylenes, silanes, and silicone elastomers, as well as copolymers and combinations thereof, and the grafting reagent is selected from: tetrakis (4-benzoylbenzyl ether), the tetrakis (4-benzoylbenzoate ester) of pentaerythritol, and an acylated derivative of tetraphenylmethane, and wherein the polymer is formed by the polymerization of polymerizable monomers selected from: a) neutral hydrophilic structural monomers selected from acrylamide, methacrylamide, N-alkylacrylamides, N-vinylpyrrolidinone, N-vinylacetamide, N-vinyl formamide, hydroxyethylacrylate, hydroxyethylmethacrylate, hydroxypropyl acrylate or methacrylate, glycerolmonomethacrylate, and glycerolmonoacrylate; b) negatively charged hydrophilic functional monomers selected from acrylic acid, methacrylic acid, maleic acid, fumaric acid, itaconic acid, AMPS (acrylamidomethyipropane sulfonic acid), vinyl phosphoric acid, vinylbenzoic acid; c) positively charged monomers selected from 3-aminopropylmethacrylamide (APMA), methacrylamidopropyltrimethylammonium chloride (MAPTAC), N,N-dimethylaminoethylmethacrylate, N,N-diethylaminoethylacrylate; and d) macromeric polymerizable molecule selected from poly(ethylene glycol)monomethyacrylate, methoxypoly(ethylene glycol)monomethacrylate, poly(ethylene glycol)monoacrylate, methyacrylamidopoly(acrylamide), poly(acrylamide-co-3-methacrylamidopropylacrylamide), poly(vinylalcohol)methacrylate, poly(vinylalcohol)acrylate, poly(vinylalcohol)dimethacrylate, and combinations thereof.
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