Two-stage mixing system, apparatus, and method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B01F-003/08
C12N-007/06
C12N-007/04
출원번호
US-0696818
(2003-10-30)
등록번호
US-7354190
(2008-04-08)
발명자
/ 주소
Demers,Jason A.
Harris,Matthew C.
McGill,David W.
Gray,Larry B.
Staub,Edward J.
출원인 / 주소
DEKA Products Limited Partnership
인용정보
피인용 횟수 :
4인용 특허 :
144
초록▼
A two-stage mixing system, apparatus, and method produces a solution including a first substance and a second substance in a predetermined ratio by first mixing the first substance with a first liquid to produce a first solution and then mixing the first solution with the second substance to produce
A two-stage mixing system, apparatus, and method produces a solution including a first substance and a second substance in a predetermined ratio by first mixing the first substance with a first liquid to produce a first solution and then mixing the first solution with the second substance to produce a second solution. Multiple batches of second solution may be produced from a single batch of first solution. Multiple batches of second solution may be produced in parallel.
대표청구항▼
What is claimed is: 1. In a system for combining a first substance with a second substance that cannot be mixed directly with the first substance without damaging at least one of the first substance and the second substance, a method comprising: mixing the first substance with a first liquid to pro
What is claimed is: 1. In a system for combining a first substance with a second substance that cannot be mixed directly with the first substance without damaging at least one of the first substance and the second substance, a method comprising: mixing the first substance with a first liquid to produce a first solution, the first solution having a first predetermined concentration of first substance capable of being mixed directly with the second substance without damaging one of the first substance and the second substance; maintaining a timer to monitor the age of the first solution; determining whether mixing of the first solution with the second substance to produce a second solution having a second predetermined concentration of first substance relative to the second substance can be completed prior to an expiration time for the first solution based on the timer; and mixing the first solution with the second substance to produce the second solution only if it is determined that mixing of the first solution with the second substance to produce the second solution can be completed prior to the expiration time for the first solution. 2. A method according to claim 1, wherein the first substance comprises an anti-pathogen compound and the second substance comprises red blood cell concentrate. 3. A method according to claim 2, wherein the first liquid comprises a buffer solution. 4. A method according to claim 1, wherein the first liquid comprises a diluting solution. 5. A method according to claim 1, wherein determining whether the first solution can be mixed with the second substance to produce the second solution prior to the expiration time for the first solution comprises: determining an elapsed time since production of the first solution. 6. A method according to claim 5, wherein determining whether the first solution can be mixed with the second substance to produce the second solution prior to the expiration time for the first solution further comprises: comparing the elapsed time with a predetermined time limit. 7. A method according to claim 1, wherein the first substance is mixed with the first liquid in a first process and the first solution is mixed with the second substance in a second process, and wherein the second process is permitted to commence only if it is determined that mixing of the first solution with the second substance to produce the second solution can be completed prior to the expiration time for the first solution. 8. A method according to claim 1, wherein the first substance is mixed with the first liquid in a first process and the first solution is mixed with the second substance in a second process, and wherein the second process is prevented from commencing if it is determined that mixing of the first solution with the second substance to produce the second solution cannot be completed prior to the expiration time for the first solution. 9. A method according to claim 1, further comprising: determining whether there is a sufficient quantity of first solution to mix with the second substance to produce the second solution; and mixing the first solution with the second substance to produce the second solution only if it is determined that there is a sufficient quantity of first solution to mix with the second substance. 10. A method according to claim 9, wherein determining whether there is a sufficient quantity of first solution comprises: monitoring the quantity of first solution produced. 11. A method according to claim 9, wherein determining whether there is a sufficient quantity of first solution comprises: monitoring the quantity of first solution remaining after an earlier production of second solution. 12. A method according to claim 11, wherein monitoring the quantity of first solution remaining after an earlier production of second solution comprises: determining the quantity of first solution initially produced; determining the quantity of first solution used in the earlier production of second solution; and determining the quantity of first solution remaining based on the quantity of first solution initially produced and the quantity of first solution used in the earlier production. 13. A method according to claim 9, wherein the first substance is mixed with the first liquid in a first process and the first solution is mixed with the second substance in a second process, and wherein the second process is permitted to commence only if it is determined that there is a sufficient quantity of first solution to mix with the second substance and mixing of the first solution with the second substance to produce the second solution can be completed prior to the expiration time for the first solution. 14. A method according to claim 9, wherein the first substance is mixed with the first liquid in a first process and the first solution is mixed with the second substance in a second process, and wherein the second process is prevented from commencing if it is determined that there is an insufficient quantity of first solution to mix with the second substance or mixing of the first solution with the second substance to produce the second solution cannot be completed prior to the expiration time for the first solution. 15. In a system for combining a first substance with a second substance that cannot be mixed directly with the first substance without damaging at least one of the first substance and the second substance, a computer controlled method comprising: preparing a first solution having a first predetermined concentration of first substance capable of being mixed directly with the second substance without damaging one of the first substance and the second substance; maintaining a timer to monitor the age of the first solution; determining whether mixing of the first solution with the second substance to produce a second solution having a second predetermined concentration of first substance relative to the second substance can be completed prior to an expiration time for the first solution based on the timer; and permitting mixing of the first solution with the second substance to produce the second solution only if it is determined that mixing of the first solution with the second substance to produce the second solution can be completed prior to the expiration time for the first solution. 16. A method according to claim 15, wherein the first substance comprises an anti-pathogen compound and the second substance comprises red blood cell concentrate. 17. A method according to claim 16, wherein the first liquid comprises a buffer solution. 18. A method according to claim 15, wherein the first liquid comprises a diluting solution. 19. A method according to claim 15, wherein determining whether the first solution can be mixed with the second substance to produce the second solution prior to the expiration time for the first solution comprises: determining an elapsed time since production of the first solution. 20. A method according to claim 19, wherein determining whether the first solution can be mixed with the second substance to produce the second solution prior to the expiration time for the first solution further comprises: comparing the elapsed time with a predetermined time limit. 21. A method according to claim 15, wherein the first substance is mixed with the first liquid in a first process and the first solution is mixed with the second substance in a second process, and wherein the second process is permitted to commence only if it is determined that mixing of the first solution with the second substance to produce the second solution can be completed prior to the expiration time for the first solution. 22. A method according to claim 15, wherein the first substance is mixed with the first liquid in a first process and the first solution is mixed with the second substance in a second process, and wherein the second process is prevented from commencing if it is determined that mixing of the first solution with the second substance to produce the second solution cannot be completed prior to the expiration time for the first solution. 23. A method according to claim 15, further comprising: determining whether there is a sufficient quantity of first solution to mix with the second substance to produce the second solution; and permitting mixing of the first solution with the second substance to produce the second solution only if it is determined that there is a sufficient quantity of first solution to mix with the second substance. 24. A method according to claim 23, wherein determining whether there is a sufficient quantity of first solution comprises: monitoring the quantity of first solution produced. 25. A method according to claim 23, wherein determining whether there is a sufficient quantity of first solution comprises: monitoring the quantity of first solution remaining after an earlier production of second solution. 26. A method according to claim 25, wherein monitoring the quantity of first solution remaining after an earlier production of second solution comprises: determining the quantity of first solution initially produced; determining the quantity of first solution used in the earlier production of second solution; and determining the quantity of first solution remaining based on the quantity of first solution initially produced and the quantity of first solution used in the earlier production. 27. A method according to claim 15, wherein the first substance is mixed with the first liquid in a first process and the first solution is mixed with the second substance in a second process, and wherein the second process is permitted to commence only if it is determined that there is a sufficient quantity of first solution to mix with the second substance and mixing of the first solution with the second substance to produce the second solution can be completed prior to the expiration time for the first solution. 28. A method according to claim 15, wherein the first substance is mixed with the first liquid in a first process and the first solution is mixed with the second substance in a second process, and wherein the second process is prevented from commencing if it determined that there is an insufficient quantity of first solution to mix with the second substance or mixing of the first solution with the second substance to produce the second solution cannot be completed prior to the expiration time for the first solution.
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Bilstad Arnold C. (Deerfield IL) Brown Richard I. (Northbrook IL) Kruger Robert J. (Arlington Heights IL), Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to appl.
Bilstad Arnold C. (Deerfield IL) Brown Richard I. (Northbrook IL) Kruger Robert J. (Arlington Heights IL), Actuator apparatus for a prepackaged fluid processing module having pump and valve elements operable in response to exte.
Hardwick Martha K. (Tustin CA) Pike Kelly A. (Laguna Hills CA) Evans ; II George D. (Arlington CA) Edwards Ronald (San Clemente CA) Norman Jacob J. (Westminster CA), Apparatus for controlling flow and pressure measurement.
Schweitzer ; Jr. Frederick F. (Glencoe MO) Walker Clarence L. (Webster Groves MO) Krohn Randall J. (Ballwin MO), Apparatus for delivering fluid to a patient.
Schweitzer ; Jr. Frederick F. (Glencoe MO) Walker Clarence L. (Webster Groves MO) Krohn Randall J. (Ballwin MO), Apparatus for delivering fluid to a patient.
Krause Friedemann (Feldafing DEX), Apparatus for the detection of a fluid phase boundary in a transparent measuring tube and for the automatic exact meteri.
Sertic James L. (Portage MI) Bancsi Joseph A. (Vernon Hills IL) Sertic Lisa D. (Portage MI) Esche Grace M. (Algonquin IL) Lawson John (McHenry IL), Automatic in-line reconstitution system.
Dennehey T. Michael (1411 N. Hickory Arlington Heights IL 60004) Brown Richard I. (2335 Peach Tree La. Northbrook IL 60062) Williamson Warren P. (101 Southbend Ct. Loveland OH 45140), Blood processing systems using a peristaltic pump module with valve and sensing station for operating a peristaltic pump.
Robinson Thomas C. (1040 Mariposa Ave. Berkeley CA 94707) Kitrilakis Sotiris (1520 Grand Ave. Piedmont CA 94611) Appleby Timothy (105 Willesden Dr. Cary NC 27513) Sahines Thomas P. (2023 Wellington D, Blood pumping and processing system.
Abbott Martyn S. (Richardson TX) Thompson Thomas C. (McKinney TX) Jones Kenneth A. (McKinney TX) Davis Albert M. (Richardson TX) Mattson Andrew P. (Richardson TX), Cardioplegia delivery system.
Zdeb Brian D. (Round Lake Park IL) Jepson Steven C. (Palatine IL), Cartridge and adapter for introducing a beneficial agent into an intravenous delivery system.
Orkin Fredric I. (Deerfield IL) Liber Theodore (Highland Park IL) Smith Charles R. (Libertyville IL) Knowlton Kimball J. (Lindenhurst IL) Huntley Albin (Concord CA), Closed multi-fluid delivery system and method.
Owens Dana J. (Irving TX) Raines Aaron (Dallas TX) Rasmussen Ed G. (Carrollton TX) Harrison David J. (Carrollton TX) Anderson Carl R. (Dallas TX), Disposable cassette with negative head height fluid supply and method.
Lawless Michael W. ; Soberon Peter A. ; Kaul Ashok ; Minick Steven E. ; Hoerner Gregory G. ; Hermann Robert A. ; Kreinick Stephen J., Disposable fluid infusion pumping cassette having an interrelated flow control and pressure monitoring arrangement.
Pastrone John (Los Gatos CA) Chamness Leland D. (Mountain View CA) Fellingham George H. (San Jose CA) Jimison Walter L. (Palo Alto CA), Drive mechanism for disposable fluid infusion pumping cassette.
Snodgrass Ocie T. (Garland TX) Farney Michael K. (Perryton TX) Gibson Gregory M. (Dallas TX), Filtering and dispensing system with independently activated pumps in series.
Kamen Dean L. (Bedford NH) Seale Joseph B. (Gorham ME) Briggs Joseph (Manchester NH) Arnold Finn (Sutton MA), Flow control system with volume-measuring system using a resonatable mass.
Kriesel Marshall S. ; Kazemzadeh Farhad ; Kriesel Matthew B. ; Feng William W. ; Barber Steve C. ; Kluck William J., Fluid delivery device with bolus injection site.
Malmgren Arthur L. (386 NW. 112th. St. Seattle WA 98177) Johnson Bryan E. (21708 80th W. Edmonds WA 98020), Fluid metering and mixing device having inlet and outlet valves.
Cooke James E. (1506 Madrono Ave. Palo Alto CA 94306) Barkan Philip (Stanford CA) Kovacs Gregory (Palo Alto CA), High accuracy disposable cassette infusion pump.
Ford Alan D. (Concord NH) Sims Nathaniel M. (Wellesley Hills MA) Mandro Marc A. (Bow NH), Infusion pump with an electronically loadable drug library and a user interface for loading the library.
Epstein Paul (Brookline MA) Petschek Harry (Lexington MA) LaWhite Eric (South Royalton VT) Strohl Clair (Norfolk MA) Coyne Henry (Framingham MA) Kaleskas Edward (Jefferson MA) Adaniya George (Swampsc, Infusion system having plural fluid input ports and at least one patient output port.
Slocum Laurence S. (Indianapolis IN) Clouser Michael T. (Indianapolis IN) Nelson David J. (Indianapolis IN), Line leak test apparatus measuring rate of pressure change in a liquid storage and dispensing system.
Bryant Robert J. (Manchester NH) Bouchard Clement D. (Pembroke NH) Kamen Dean (Bedford NH) Lanigan Richard (Concord NH) Miller Bradley D. (Londonderry NH) Spencer Geoffrey P. (Manchester NH) Vincent , Liquid pumping mechanisms for peritoneal dialysis systems employing fluid pressure.
Bryant Robert J. (Manchester NH) Bouchard Clement D. (Pembroke NH) Kamen Dean (Bedford NH) Lanigan Richard (Concord NH) Miller Bradley D. (Londonderry NH) Spencer Geoffrey P. (Manchester NH) Vincent , Liquid pumping mechanisms for peritoneal dialysis systems employing fluid pressure.
Walker Richard Bradley (1960 Spectrum Cir. ; Ste. 235 Marietta GA 30067) Evans Robert F. (4909 Audobon Dr. Mobile AL 36619) Hanson Robert (5713 Regency Ct. North Mobile AL 36609) Burrow Michael F. (9, Medication delivery and monitoring system and methods.
Jimison Walter L. (Palo Alto CA) Barker Craig S. (San Carlos CA) Bunyard Marc R. (Milipitas CA), Method and apparatus to test for valve leakage in a pump assembly.
Dean L. Kamen ; Charles M. Grinnell ; Marc A. Mandro ; Dennis Gilbreath ; Kevin Grant ; Jason A. Demers ; William T. Larkins ; Robert Manning ; Richard Lanigan, Method and cassette for delivering intravenous drugs.
Niemi Antti J. (Yrjo Liipolantie 5 SF-02700 Kauniainenn FIX), Method and device for the consideration of varying volume and flow in the control of a continuous flow process.
Wynkoop Richard D. (Des Plaines IL) Ogden John E. (Libertyville IL) Wecker Sheldon M. (Libertyville IL), Method of detecting occlusions in a solution pumping system.
Bryant Robert J. ; Gray Lawrence B. ; Spencer Geoff P., Methods and systems for detecting the presence of a gas in a pump and preventing a gas from being pumped from a pump.
Kamen Dean (Bedford NH) Lanigan Richard (Concord NH) Vincent Douglas E. (Manchester NH), Peritoneal dialysis systems and methods employing a liquid distribution and pump cassette with self-contained air isolat.
Bryant Robert J. (Manchester NH) Kamen Dean (Bedford NH) Vincent Douglas E. (Manchester NH), Peritoneal dialysis systems and methods employing pneumatic pressure and temperature-corrected liquid volume measurement.
Kamen Dean (Bedford NH) Spencer Geoffrey P. (Manchester NH) Vincent Douglas E. (Manchester NH), Peritoneal dialysis systems employing a liquid distribution and pumping cassette that emulates gravity flow.
Horowitz Bernard (New Rochelle NY) Valinsky Jay E. (New York NY) Geacintov Nicholas E. (New York NY) Williams Bolanle (Forest Hills NY) Rywkin Shanti B. (Brooklyn NY), Photodynamic inactivation of viruses in blood cell-containing compositions.
Bilstad Arnold C. (Deerfield IL) Brown Richard I. (Northbrook IL) Kruger Robert J. (Arlington Heights IL), Prepackaged fluid processing module having pump and valve elements operable in response to applied pressures.
Matsuda Shohei (Saitama) Tashima Kazutoshi (Saitama) Furuya Kohichi (Saitama) Myoi Masaaki (Saitama JPX), Pressure supply system having means for controlling an output pressure thereof.
Clement D. Bouchard ; Robert J. Bryant ; Lawrence B. Gray ; Geoff P. Spencer, Pumping cartridge including a bypass valve and method for directing flow in a pumping cartridge.
Valentini Luigi (Milan ITX) Coccia Mario (Cesano Boscone ITX), Safety device for connection of a syringe with the mouth or opening of a bottle containing a drug or a small tube for dr.
Kramer David E. (Northbrook IL) Muetterties Andrew J. (Mundelein IL) Szempruch Walter T. (Gurnee IL), Solution pumping system including disposable pump cassette.
Wecker Sheldon M. (Libertyville IL) Abrahamson Kent D. (Libertyville IL) Joyce Thomas P. (Libertyville IL), Solution pumping system with compressible pump cassette.
Kamen Dean L. ; Grinnell Charles M. ; Mandro Marc A. ; Gilbreath Dennis ; Grant Kevin ; Demers Jason A. ; Larkins William T. ; Manning Robert ; Lanigan Richard, System and method for mixing and delivering intravenous drugs.
Kamen Dean L. ; Grinnell Charles M. ; Mandro Marc A. ; Gilbreath Dennis ; Grant Kevin ; Demers Jason A. ; Larkins William T. ; Manning Robert ; Lanigan Richard, System for delivering intravenous drugs.
Robert J. Bryant ; Larry B. Gray ; Geoff P. Spencer, Systems for determining the volume of a volumetric chamber and pumping a fluid with a pump chamber.
Bryant Robert J. (Manchester NH) Finkelstein Jeffrey (Shelburne VT) Kamen Dean (Bedford NH) Lanigan Richard (Concord NH) Miller Bradley D. (Londonderry NH) Spencer Geoffrey P. (Manchester NH), User interface and monitoring functions for automated peritoneal dialysis systems.
Bloom Nicole D. ; Kamen Dean L. ; Lanigan Richard ; Grinnell Charles M. ; Grant Kevin, Vial loading method and apparatus for intelligent admixture and delivery of intravenous drugs.
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