An elongated hollow microporous fiber comprises an inner wall surface defining an interior fiber lumen, an outer wall surface, and a microporous fiber wall therebetween, the fiber wall having one or more continuous, cohesive, elongated filaments embedded in the fiber and extending lengthwise of the
An elongated hollow microporous fiber comprises an inner wall surface defining an interior fiber lumen, an outer wall surface, and a microporous fiber wall therebetween, the fiber wall having one or more continuous, cohesive, elongated filaments embedded in the fiber and extending lengthwise of the elongated fiber along substantially the full length of the fiber.
대표청구항▼
What is claimed is: 1. A filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation comprising: a plurality of elongated hollow tubes comprising one or more first and one or more second elongated hollow tubes, and a plurality of elongated fibers each fiber having
What is claimed is: 1. A filter device for being implanted in a blood vessel for carrying out in-vivo plasma separation comprising: a plurality of elongated hollow tubes comprising one or more first and one or more second elongated hollow tubes, and a plurality of elongated fibers each fiber having a microporous membrane fiber wall with an outer wall surface and an inner wall surface defining an interior lumen extending along the length thereof wherein the fiber wall morphology of each of the elongated fibers is asymmetrical between the inner wall surface and the outer wall surface, said fiber wall having a higher mass density zone adjacent to the outer wall surface and a lower mass density zone adjacent to the inner wall surface, said higher mass density zone having a smaller average nominal pore size than the average nominal pore size in the lower mass density zone, each fiber having a first end secured to a first said elongated hollow tube and a second end secured to a second said elongated hollow tube, wherein the interior of the said plurality of elongated hollow tubes communicates with the interior lumen of each of the fibers, said fibers including one or more continuous filaments embedded in the microporous fiber wall between the first and second ends of the fiber. 2. A filter device of claim 1 comprising two of said elongated hollow tubes, each of said tubes having a plurality of holes spaced apart along a substantial portion of the length thereof, each hole receiving a first or a second end of an elongated microporous fiber. 3. A filter device of claim 1 wherein said one or more filaments extend along said fiber wall substantially uniformly between said inner wall surface and said outer wall surface. 4. A filter device of claim 1 wherein said one or more filaments extend along said fiber wall substantially equidistant between said inner wall surface and said outer wall surface. 5. A filter device of claim 1 wherein the one or more filaments have a substantially uniform tensile strength along the length thereof. 6. A filter device of claim 1 wherein said one or more filaments occupy less than about 15% of the fiber wall cross-sectional area of said fiber. 7. A filter device of claim 1 wherein said one or more filaments occupy less than about 10% of the fiber wall cross-sectional area of said fiber. 8. A filter device of claim 1 wherein each of said one or more filaments has a cross-sectional area occupying between about 0.1% and about 2% of the cross-sectional area of said fiber. 9. A filter device of claim 1 wherein each of said one or more filaments has a cross-sectional area occupying between about 0.2 and about 2% of the cross-sectional area of said fiber. 10. A filter device of claim 1 comprising a plurality of said filaments and wherein each filament has a cross-sectional area occupying between about 0.2% and about 2% of the cross-sectional area of said fiber. 11. A filter device of claim 1 wherein said one or more filaments have a tensile strength of at least about 5,000 psi. 12. A filter device of claim 1 wherein said one or more filaments comprise fiberglass, polypropylene, silk, polysulfone, polyethersulfone, polyimide, polyamide or aramid. 13. A filter device of claim 1 comprising two of said filaments. 14. A filter device of claim 13 wherein said one or more filaments comprise fiberglass, polypropylene, silk, polysulfone, polyethersulfone, polyimide, polyamide or aramid. 15. A filter device of claim 14 wherein each of said one or more filaments has a cross-sectional area occupying between about 0.2% and about 2% of the cross-sectional area of said fiber. 16. A filter device of claim 14 comprising a plurality of said filaments occupying between about 0.5% and about 5% of the cross-sectional area of said fiber. 17. A filter device of claim 16 wherein said higher mass density zone is characterized by a nominal average pore diameter of between about 0.005 μm and about 0.05 μm. 18. A filter device of claim 1 wherein the fiber wall structure comprises a continuous change in mass density from the outer wall surface to the inner wall surface. 19. A filter device of claim 18 wherein the fiber wall structure comprises a continuum of voids bounded by solid frames. 20. A filter device of claim 1 wherein said membrane fiber wall has three mass density zones and wherein each of said zones is characterized by a different average nominal pore size. 21. A filter device of claim 1 wherein said membrane fiber wall has four or more mass density zones and wherein each of said zones is characterized by a different average nominal pore size. 22. A filter device of claim 1, 20, or 21 wherein said lower mass density zone is characterized by a nominal average pore diameter of between about 1 μm and about 60 μm. 23. A filter device of claim 22 wherein said higher mass density zone is characterized by a nominal average pore diameter of between about 0.3 μm and about 1 μm. 24. A filter device of claim 1, 20, or 21 wherein said higher mass density zone is characterized by a nominal average pore diameter of between about 0.3 μm and about 1 μm. 25. A filter device of claim 1 wherein said lower mass density zone is characterized by a nominal average pore diameter of between about 2 μm and about 6 μm. 26. A filter device of claim 25 wherein said higher mass density zone is characterized by a nominal average pore diameter of between about 0.4 μm and about 0.8 μm. 27. A filter device of claim 26 having one or more intermediate mass density zones having a nominal average pore diameter of between about 0.8 μm and about 2 μm. 28. A filter device of claim 27 having two intermediate mass density zones, a first intermediate zone having a nominal average pore diameter of between about 0.8 μm and about 1.2 μm and a second intermediate zone having a nominal average pore diameter of between about 1.2 μm and about 2 μm. 29. A filter device of claim 1 wherein said higher mass density zone is characterized by a nominal average pore diameter of between about 0.4 μm and about 0.8 μm.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (35)
Gorsuch, Reynolds G., Apparatus and method for in vivo hemodialysis.
Gorsuch Reynolds G. ; Venkat Kris, Apparatus and method for the treatment of acute and chronic renal disease by continuous passive plasma ultrafiltration.
Carlsen Daniel B. (Minneapolis MN) Andrus Robert G. (Minneapolis MN) Hall ; II Robert T. (Welch MN), Dialysate filter including an asymmetric microporous, hollow fiber membrane incorporating a polyimide.
Wenthold Randal M. ; Hall ; II Robert T. ; Andrus Robert G. ; Brinda Paul D. ; Cosentino Louis C. ; Reggin Robert F. ; Pigott Daniel T., Hollow fiber membranes and method of manufacture.
Aptel Philippe (Toulouse FRX) Espenan Jean-Michel (Toulouse FRX), Hollow fibers production method thereof and their applications particularly in the field of membrane-type separations.
Pizziconi Vincent B. (3535 E. Highline Canal Rd. Phoenix AZ 85040) Towe Bruce C. (2331 S. Paseo Loma Cir. Mesa AZ 85202), Method and apparatus for withdrawing, collecting and biosensing chemical constituents from complex fluids.
Gorsuch, Reynolds G., Process and apparatus for utilization of in vivo extracted plasma with tissue engineering devices, bioreactors, artificial organs, and cell therapy applications.
Buck Reinhold J. (Alleshausen DEX) Goehl Hermann J. (Bisingen-Zimmern DEX), Selectively permeable asymmetric membranes suitable for use in hemodialysis and processes for manufacturing such membran.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.