Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biolo
Coatings are provided in which surfaces may be activated by covalently bonding a silane derivative to the metal surface, covalently bonding a lactone polymer to the silane derivative by in situ ring opening polymerization, and depositing at least one layer of a polyester on the bonded lactone. Biologically active agents may be deposited with the polyester layers. Such coated surfaces may be useful in medical devices, in particular stents.
대표청구항▼
We claim: 1. A method for coating a medical device comprising: (a) reacting the surface of a medical device with a silane-based activating reagent to form a polymerized silane derivative covalently bonded to the surface of the medical device, said polymerized silane derivative containing hydroxyl o
We claim: 1. A method for coating a medical device comprising: (a) reacting the surface of a medical device with a silane-based activating reagent to form a polymerized silane derivative covalently bonded to the surface of the medical device, said polymerized silane derivative containing hydroxyl or other functional groups that can be transformed into hydroxyl groups; (b) reacting the device of step (a) with at least one lactone monomer in the presence of a metal catalyst to form a lactone polymer chain covalently bonded to the polymerized silane derivative, said chains grown on the hydroxyl or amino functional groups of the silane derivative through in-situ ringopening graft polymerization of lactone monomers, said polymerization initiated by said hydroxyl or amino functional groups of the silane derivative covalently bonded to the surface of the medical device, said lactone polymer chains and said silane derivative together forming a grafted lactone polymer layer; and (c) treating the device of step (b) with at least one polyester polymer layer deposited on the grafted lactone polymer layer, wherein at least the first of the deposited polyester polymer layers is chemically compatible with the grafted lactone polymer layer to allow for entanglement of said deposited polyester polymer chains with the chains of said grafted lactone polymer chains for strong adhesion. 2. The method of claim 1 wherein the silane-based activating reagent comprises a compound of the formula R1--Si(R2)3, wherein R1 is independently selected from substituted alkyl, substituted alkenyl, substituted alkynyl, substituted araalkyl, substituted heteroaryl, and substituted alkoxy, with the proviso that R1 contains a hydroxy or amino group, or a functional group that can be transformed to a radical that contains a hydroxy or amino group, wherein R2 is independently selected from halo, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted silyloxy, or optionally substituted alkyl, with the proviso that all three R2 substituents are not simultaneously substituted alkyl. 3. The method of claim 1 wherein step (c) is repeated two or more times to provide multiple layers of polyester polymer deposited on the covalently grafted lactone polymer layer. 4. The method of claim 3 that further comprises depositing a barrier or skin layer on top of the deposited polyester polymer layers. 5. The method of claim 4 wherein the barrier or skin layer comprises a lactone polymer. 6. The method of claim 5 wherein the lactone polymer comprises polyglycolide, poly(L-lactide), poly(D-lactide), poly(ε-caprolactone), poly(p-dioxanone), poly(dioxepanone), poly(D,L-lactide), poly(L-lactide-co-D-lactide), poly(L-lactide-co-glycolide), poly(D-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(lactide-co-caprolactone), poly(lactide-co-dioxanone), or poly(lactide-co-dioxepanone). 7. The method of claim 1 that further comprises depositing a barrier or skin layer on top of the deposited polyester polymer layer. 8. The method of claim 7 wherein the barrier or skin layer comprises a lactone polymer. 9. The method of claim 8 wherein the lactone polymer comprises polyglycolide, poly(L-lactide), poly(D-lactide), poly(ε-caprolactone), poly(p-dioxanone), poly(dioxepanone), poly(D,L-lactide), poly(L-lactide-co-D-lactide), poly(L-lactide-co-glycolide), poly(D-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(lactide-co-caprolactone), poly(lactide-co-dioxanone), or poly(lactide-co-dioxepanone). 10. The method of claim 1 wherein the polyester polymer layer deposited on the grafted lactone polymer layer comprises two or more polyester polymer sublayers. 11. The method of claim 10 wherein the deposited polyester polymer sublayers each independently comprise a lactone polymer, wherein the lactone polymer comprises polyglycolide, poly(L-lactide), poly(D-lactide), poly(ε-caprolactone), poly(p-dioxanone), poly(dioxepanone), poly(D,L-lactide), poly(L-lactide-co-D-lactide), poly(L-lactide-co-glycolide), poly(D-lactide-co-glycolide), poly(D,L-lactide-co-glycolide), poly(lactide-co-caprolactone), poly(lactide-co-dioxanone), or poly(lactide-co-dioxepanone). 12. The method of claim 11 wherein the deposited polyester polymer layer comprises poly(L-lactide) or poly(D,L-lactide). 13. The method of claim 1 wherein the polyester polymer layer of step (c) is deposited by spray coating. 14. The method of claim 1 wherein the polyester polymer layer deposited includes a biologically active agent. 15. The method of claim 1 wherein the coated device is sterilized prior to use.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (44)
Paul O. Zamora ; Shigemasa Osaki ; Ray Tsang, Amphipathic coating for modulating cellular adhesion composition and methods.
Stack Richard S. (Chapel Hill NC) Clark Howard G. (Durham NC) Walker William F. (Holcomb NY) McElhaney James H. (Durham NC), Bioabsorbable stent and method of making the same.
Fox ; Jr. Charles L. (New York NY) Modak Shanta M. (River Edge NJ) Sampath Lester A. (Nyack NY), Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same.
Tang Reginald T. (Warren NJ) Mares Frank (Whippany NJ) Boyle ; Jr. William J. (Parsippany NJ) Chiu Tin-Ho (Millburn NJ) Patel Kundanbhai M. (Landing NJ), Medical devices fabricated totally or in part from copolymers of recurring units derived from cyclic carbonates and lact.
Decker Gary Thomas ; Graiver Daniel ; Tselepis Arthur James ; Williams Dwight Edward, Method of rendering substrates water repellent using hyperbranched polymers containing silicon atoms.
Decker Gary Thomas ; Graiver Daniel ; Tselepis Arthur James ; Williams Dwight Edward, Method of rendering substrates water repellent using hyperbranched polymers containing silicon atoms.
Hostettler Fritz ; Rhum David ; Forman Michael R. ; Helmus Michael N. ; Ding Ni, Process for the preparation of slippery, tenaciously adhering, hydrophilic polyurethane hydrogel coatings, coated polymer and metal substrate materials, and coated medical devices.
Timothy Francis Gallagher ; Jeffrey Charles Boehm ; Jerry Leroy Adams, compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses.
Ehrenreich, Kevin J.; Newhauser, Richard R.; von Oepen, Randolf; Stankus, John, Expandable member formed of a fibrous matrix for intraluminal drug delivery.
Ehrenreich, Kevin J.; Newhauser, Richard R.; von Oepen, Randolf; Stankus, John, Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery.
Von Oepen, Randolf; Stankus, John; Stamberg, Barbara; Yribarren, Travis R.; Newhauser, Richard R., Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery.
Coulembier, Olivier; Hedrick, James L.; Nelson, Alshakim; Rice, Julia E.; Sanders, Daniel P., Method of ring-opening polymerization, and related compositions and articles.
Ehrenreich, Kevin J.; Newhauser, Richard; von Oepen, Randolf; Stankus, John, Stent delivery system having a fibrous matrix covering with improved stent retention.
Ehrenreich, Kevin J.; Newhauser, Richard; von Oepen, Randolf; Stankus, John J., Stent delivery system having a fibrous matrix covering with improved stent retention.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.