Electroprocessed material made by simultaneously electroprocessing a natural protein polymer and two synthetic polymers
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/02
A61K-009/70
A61K-038/39
C07K-014/78
C07K-014/435
출원번호
US-0668085
(2003-09-22)
등록번호
US-7374774
(2008-05-20)
발명자
/ 주소
Bowlin,Gary L.
Wnek,Gary E.
Simpson,David G.
출원인 / 주소
Virginia Commonwealth University Intellectual Property Foundation
인용정보
피인용 횟수 :
47인용 특허 :
51
초록▼
The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or m
The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.
대표청구항▼
What is claimed is: 1. A composition comprising: an electroprocessed material and a substance, wherein the electroprocessed material is made by a method comprising the step of simultaneously electroprocessing a natural polymer that is an extracellular matrix protein or polymerized thrombin and two
What is claimed is: 1. A composition comprising: an electroprocessed material and a substance, wherein the electroprocessed material is made by a method comprising the step of simultaneously electroprocessing a natural polymer that is an extracellular matrix protein or polymerized thrombin and two or more synthetic polymers, wherein the synthetic polymers are selected from the group consisting of poly(urethanes), poly(siloxanes), silicones, poly(ethylene), poly(vinyl pyrrolidone), poly(2-hydroxyethyl methacrylate), poly(N-vinyl pyrrolidone), poly(methyl methacrylate), poly(vinyl alcohol), poly(acrylic acid), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polyactides (PLA), polyglycolides (PGA), poly(lactide-co-glycolides) (PLGA), polyanhydrides and polyorthoesters, and, wherein the substance comprises a therapeutic substance, a cosmetic substance or a combination thereof. 2. The composition of claim 1, wherein the therapeutic substance is selected from the group consisting of anesthetics, hypnotics, sedatives, sleep inducers, antipsychotics, antidepressants, antiallergics, antianginals, antiarthritics, antiasthmatics, antidiabetics, antidiarrheal drugs, anticonvulsants, antigout drugs, antihistamines, antipruritics, emetics, antiemetics, antispasmondics, appetite suppressants, neuroactive substances, neurotransmitter agonists, antagonists, receptor blockers, reuptake modulators, beta-adrenergic blockers, calcium channel blockers, disulfarim, muscle relaxants, analgesics, antipyretics, stimulants, anticholinesterase agents, parasympathomimetic agents, hormones, anticoagulants, antithrombotics, thrombolytics, immunoglobulins, immunosuppressants, hormone agonists, hormone antagonists, vitamins, antimicrobial agents, antineoplastics, antacids, digestants, laxatives, cathartics, antiseptics, diuretics, disinfectants, fungicides, ectoparasiticides, antiparasitics, heavy metals, heavy metal antagonists, chelating agents, alkaloids, salts, ions, autacoids, digitalis, cardiac glycosides, antiarrhythmics, antihypertensives, vasodilators, vasoconstrictors, antimuscarinics, ganglionic stimulating agents, ganglionic blocking agents, neuromuscular blocking agents, adrenergic nerve inhibitors, anti-oxidants, anti-inflammatories, wound care products, antithrombogenic agents, antitumoral agents, antithrombogenic agents, antiangiogenic agents, antigenic agents, wound healing agents, plant extracts, growth factors, growth hormones, cytokines, immunoglobulins, osteoblasts, myoblasts, neuroblasts, fibroblasts, glioblasts; germ cells, hepatocytes, chondrocytes, keratinocytes, smooth muscle cells, cardiac muscle cells, connective tissue cells, epithelial cells, endothelial cells, hormone-secreting cells, neurons, emollients, humectants, anti-rejection drugs, spermicides, conditioners, antibacterial agents, antifungal agents, antiviral agents, antibiotics, tranquilizers, cholesterol-reducing drugs, antitussives, histamine-blocking drugs and monoamine oxidase inhibitor. 3. The composition of claim 1, wherein the electroprocessed material is crosslinked. 4. A composition comprising an electroprocessed material, wherein the electroprocessed material is made by a process comprising the step of simultaneously electroprocessing a solution comprising a natural polymer that is an extracellular matrix protein or polymerized thrombin and two or more synthetic polymers, wherein the synthetic polymers are selected from the group consisting of poly(urethanes), poly(siloxanes), silicones, poly(ethylene), poly(vinyl pyrrolidone), poly(2-hydroxy ethyl methacrylate), poly(N-vinyl pyrrolidone), poly(methyl methacrylate), poly(vinyl alcohol), poly(acrylic acid), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactides (PLA), polyplycolides (PGA), poly(lactide-co-glycolides) (PLGA), polyanhydrides and polyorthoesters. 5. The composition of claim 4, wherein the extracellular matrix protein is selected from the group consisting of collagen, fibrin, fibrinogen, elastin, laminin and fibronectin. 6. The composition of claim 5, wherein the electroprocessed material comprises collagen and two or more polymers, and wherein the electroprocessed collagen comprises a repeated longitudinal banding pattern, wherein the repeated longitudinal banding pattern occurs at a spacing of about 65 nm to 67 nm. 7. The composition of claim 5, wherein the electroprocessed material comprises one or more collagen types and two or more polymers. 8. The composition of claim 4, further comprising one or more molecules, cells, objects or combinations thereof. 9. The composition of claim 4, further comprising a therapeutic substance, a cosmetic substance or a combination thereof. 10. The composition of claim 9, wherein the therapeutic substance is selected from the group consisting of anesthetics, hypnotics, sedatives, sleep inducers, antipsychotics, antidepressants, antiallergics, antianginals, antiarthritics, antiasthmatics, antidiabetics, antidiarrheal drugs, anticonvulsants, antigout drugs, antihistamines, antipruritics, emetics, antiemetics, antispasmondics, appetite suppressants, neuroactive substances, neurotransmitter agonists, antagonists, receptor blockers, reuptake modulators, beta-adrenergic blockers, calcium channel blockers, disulfarim, muscle relaxants, analgesics, antipyretics, stimulants, anticholinesterase agents, parasympathomimetic agents, hormones, anticoagulants, antithrombotics, thrombolytics, immunoglobulins, immunosuppressants, hormone agonists, hormone antagonists, vitamins, antimicrobial agents, antineoplastics, antacids, digestants, laxatives, cathartics, antiseptics, diuretics, disinfectants, fungicides, ectoparasiticides, antiparasitics, heavy metals, heavy metal antagonists, chelating agents, alkaloids, salts, ions, autacoids, digitalis, cardiac glycosides, antiarrhythmics, antihypertensives, vasodilators, vasoconstrictors, antimuscarinics, ganglionic stimulating agents, ganglionic blocking agents, neuromuscular blocking agents, adrenergic nerve inhibitors, anti-oxidants, anti-inflammatories, wound care products, antithrombogenic agents, antitumoral agents, antithrombogenic agents, antiangiogenic agents, antigenic agents, wound healing agents, plant extracts, growth factors, growth hormones, cytokines, immunoglobulins, osteoblasts, myoblasts, neuroblasts, fibroblasts, glioblasts; germ cells, hepatocytes, chondrocytes, keratinocytes, smooth muscle cells, cardiac muscle cells, connective tissue cells, epithelial cells, endothelial cells, hormone-secreting cells, neurons, emollients, humectants, anti-rejection drugs, spermicides, conditioners, antibacterial agents, antifungal agents, antiviral agents, antibiotics, tranquilizers, cholesterol-reducing drugs, antitussives, histamine-blocking drugs and monoamine oxidase inhibitor. 11. A composition comprising: an electroprocessed material, wherein the electroprocessed material is made by a process comprising the step of simultaneously electroprocessing from a solution a natural polymer that is an extracellular matrix protein or polymerized thrombin and two or more synthetic polymers, wherein the synthetic polymers are selected from the group consisting of poly(urethanes), poly(siloxanes), silicones, poly(ethylene), poly(vinyl pyrrolidone), poly(2-hydroxy ethyl methacrylate), poly(N-vinyl pyrrolidone), poly(methyl methacrylate), poly(vinyl alcohol), poly(acrylic acid), polyacrylamide, poly(ethylene-co-vinyl acetate), poly(ethylene glycol), poly(methacrylic acid), polylactides (PLA), polyglycolides (PGA), poly(lactide-co-glycolides) (PLGA), polyanhydrides and polyorthoesters, and wherein the electroprocessing is selected from the group consisting of electrospraying, electrosputtering, electrospinning or electroaerosol treatment of the solution. 12. The composition of claim 11, further comprising a substance, wherein the substance comprises a therapeutic substance, a cosmetic substance or a combination thereof. 13. The composition of claim 12, wherein the substance is selected from the group consisting of hormones, growth factors, growth hormones, cytokines, immunoglobulins, osteoblasts, keratinocytes, cardiac muscle cells, hormone-secreting cells, antibacterial agents and antibiotics. 14. The composition of claim 1, wherein the substance is selected from the group consisting of hormones, growth factors, growth hormones, cytokines, immunoglobulins, osteoblasts, keratinocytes, cardiac muscle cells, hormone-secreting cells, antibacterial agents and antibiotics. 15. The composition of claim 1, wherein the extracellular matrix protein comprises collagen. 16. The composition of claim 4, wherein the extracellular matrix protein comprises collagen. 17. The composition of claim 11, wherein the extracellular matrix protein comprises collagen. 18. The composition of claim 1, wherein the extracellular matrix protein is selected from the group consisting of collagen, fibrin, fibrinogen, elastin, laminin and fibronectin. 19. The composition of claim 1, further comprising one or more molecules, cells, objects or combinations thereof.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (51)
Bowlin Gary L. ; Rittgers Stanley E., Apparatus and method for electrostatic endothelial cell seeding and DNA transfection in a vascular prosthesis.
Peterson Alvin ; Landeen Lee K. ; Bennett John ; Gee Jason ; Chesla Scott ; Zeltinger Joan ; Flatt James H. ; Applegate Mark A. ; Dunkelman Noushin ; Kemmerrer Stephen V., Apparatus and method for simulating in vivo conditions while seeding and culturing three-dimensional tissue constructs.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof.
Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
Shastri Venkatram R. ; Rahman Nahid ; Martin Ivan ; Langer ; Jr. Robert S., Electroactive materials for stimulation of biological activity of bone marrow stromal cells.
Martin Graham Ernest (Runcorn EN) Cockshott Ian Derek (Runcorn EN) Fildes Francis James Thomas (Macclesfield EN), Fibrillar lining for prosthetic device.
Stein Karl H. (Hemsbach DEX) Krull Manfred (Heiligkreuzsteinach DEX), Fibrous surgical compress with cover layer autogenously bonded to absorption layer.
Vyakarnam Murty N. ; Zimmerman Mark C. ; Scopelianos Angelo George ; Chun Iksoo ; Melican Mora C. ; Bazilio Clairene A. ; Roller Mark B. ; Gorky David V., Foam composite for the repair or regeneration of tissue.
Zarkoob Shahrzad ; Reneker Darrell H. ; Ertley Dale ; Eby R. K. ; Hudson Steven D., Synthetically spun silk nanofibers and a process for making the same.
Setterstrom Jean A. ; Van Hamont John E. ; Reid Robert H. ; Jacob Elliot ; Jeyanthi Ramasubbu ; Boedeker Edgar C. ; McQueen Charles E. ; Jarboe Daniel L. ; Cassels Frederick ; Brown William ; Thies C, Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix.
Bass Lawrence S. (Little Neck NY) Libutti Steven K. (Fort Lee NJ) Eaton Alexander M. (Durham NC), Tissue bonding and sealing composition and method of using the same.
Tranquillo Robert T. ; Mooradian Daniel L. ; Girton Timothy Sanuel ; Guido Stefano,ITX, Tissue-equivalent rods containing aligned collagen fibrils and schwann cells.
Badylak, Stephen F.; Freytes, Donald O.; Gilbert, Thomas W.; Guan, Jianjun; Stankus, John; Wagner, William R., Biohybrid elastomeric scaffolds and methods of use thereof.
Wagner, David; Soletti, Lorenzo; El-Kurdi, Mohammed S.; McGrath, Jon; Garibotto, John T.; Flaherty, J. Christopher, Graft devices and methods of fabrication.
Wagner, David; Soletti, Lorenzo; El-Kurdi, Mohammed S.; McGrath, Jon; Garibotto, John T.; Flaherty, J. Christopher, Graft devices and methods of fabrication.
Soletti, Lorenzo; El-Kurdi, Mohammed S.; McGrath, Jon; Ziegler, Andrew; Flaherty, J. Christopher; Wagner, William R.; Vorp, David, Graft devices and methods of use.
Soletti, Lorenzo; El-Kurdi, Mohammed S.; McGrath, Jon; Ziegler, Andrew; Flaherty, J. Christopher; Wagner, William R.; Vorp, David, Graft devices and methods of use.
Stark, Norman; Streckenbach, Maria S.; Gilchrist, Seth; Schwenke, Thorsten; Thomas, Brian, Synthetic synovial fluid compositions and methods for making the same.
Hong, Yi; Amoroso, Nicholas J.; Fujimoto, Kazuro Lee; Hashizume, Ryotaro; Wagner, William R., Wet-electrospun biodegradable scaffold and uses therefor.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.