The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and pharmaceutical compositions (e.g., vaccines) comprising the HER-2/neu fusion proteins and/or nucleic acid molec
The present invention is generally directed to HER-2/neu fusion proteins, nucleic acid molecules encoding HER-2/neu fusion proteins, viral vectors expressing HER-2/neu fusion proteins, and pharmaceutical compositions (e.g., vaccines) comprising the HER-2/neu fusion proteins and/or nucleic acid molecules encoding the HER-2/neu fusion proteins. The present invention is also directed to methods of treating or preventing cancer by eliciting or enhancing an immune response to the HER-2/neu protein, including for uses in the treatment of malignancies associated with the HER-2/neu oncogene.
대표청구항▼
What is claimed is: 1. A method for eliciting or enhancing an immune response to HER-2/neu protein in a warm-blooded animal, the method comprising administering to said warm-blooded animal a composition comprising a polypeptide, where said polypeptide comprises SEQ ID NO:6, and where said polypepti
What is claimed is: 1. A method for eliciting or enhancing an immune response to HER-2/neu protein in a warm-blooded animal, the method comprising administering to said warm-blooded animal a composition comprising a polypeptide, where said polypeptide comprises SEQ ID NO:6, and where said polypeptide is administered in an amount effective to elicit or enhance the immune response to HER-2/neu, and wherein the response to HER-2/neu is elicited or enhanced in said animal. 2. A method for eliciting or enhancing an immune response to HER-2/neu protein in a warm-blooded animal, the method comprising administering to said warm-blooded animal a composition comprising a polypeptide, where said polypeptide comprises SEQ ID NO:7, and where said polypeptide is administered in an amount effective to elicit or enhance the immune response to HER-2/neu, and wherein the response to HER-2/neu is elicited or enhanced in said animal. 3. The method of claim 1, wherein said polypeptide is lipidated. 4. The method of claim 1, wherein the composition comprises a physiologically acceptable carrier or diluent. 5. The method of claim 4, wherein the composition comprises an oil-in-water emulsion. 6. The method of claim 5, wherein the composition comprises tocopherol. 7. The method of claim 1, wherein the composition comprises an immunostimulatory substance. 8. The method of claim 7, wherein the composition comprises an immunostimulatory substance comprising 3D-MPL, QS21, or a combination of 3D-MPL and QS21. 9. The method of claim 7, wherein the composition comprises an immunostimulatory substance comprising 3D-MPL and QS21 in an oil-in-water emulsion. 10. The method of claim 9, wherein the composition comprises tocopherol. 11. The method of claim 1, wherein the composition comprises a CpG-containing oligonucleotide. 12. The method of claim 2, wherein said polypeptide is lipidated. 13. The method of claim 2, wherein the composition comprises a physiologically acceptable carrier or diluent. 14. The method of claim 13, wherein the composition comprises an oil-in-water emulsion. 15. The method of claim 14, wherein the composition comprises tocopherol. 16. The method of claim 2, wherein the composition comprises an immunostimulatory substance. 17. The method of claim 16, wherein the composition comprises an immunostimulatory substance comprising 3D-MPL, QS21, or a combination of 3D-MPL and QS21. 18. The method of claim 16, wherein the composition comprises an immunostimulatory substance comprising 3D-MPL and QS21 in an oil-in-water emulsion. 19. The method of claim 18, wherein the composition comprises tocopherol. 20. The method of claim 2, wherein the composition comprises a CpG-containing oligonucleotide. 21. The method of claim 1 where said warm-blooded animal is a human. 22. The method of claim 2, where said warm-blooded animal is a human.
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이 특허에 인용된 특허 (21)
Hancock Gerald E. ; Speelman Dan J. ; Frenchick Patrick J., Adjuvants for vaccines against respiratory syncytial virus.
Plowman Gregory D. ; Culouscou Jean-Michel ; Shoyab Mohammed ; Siegall Clay B. ; Hellstrom Ingegerd ; Hellstrom Karl E., Antibodies to HER4, human receptor tyrosine kinase.
Cheever, Martin A.; Disis, Mary L., Compounds for eliciting or enhancing immune reactivity to HER-2/neu protein for prevention or treatment of malignancies in which the HER-2/neu oncogene is associated.
Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is a.
Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is a.
Cheever, Martin A.; Disis, Mary L., Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the HER-2/neu oncogene is associated.
Cheever Martin A. ; Disis Mary L., Immune reactivity to HER-2/neu protein for diagnosis and treatment of malignancies in which the her-2/neu oncogene is a.
Cheever, Martin A.; Disis, Mary L., Methods and compositions to generate immunity in humans against self tumor antigens by immunization with homologous foreign proteins.
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