$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Nucleic acids encoding mutant forms of Fas ligand

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/04
  • C07H-021/00
  • C07K-001/00
  • A61K-039/00
  • A61K-039/12
  • C12P-021/04
출원번호 US-0404466 (2003-04-01)
등록번호 US-7393942 (2008-07-01)
발명자 / 주소
  • Chu,Keting
출원인 / 주소
  • Novartis Vaccines and Diagnostics, Inc.
대리인 / 주소
    Attwell,Gwilym
인용정보 피인용 횟수 : 0  인용 특허 : 44

초록

The invention provides for DNA encoding Fas ligand muteins and chimeras and the proteins encoded thereby. The invention further includes the use of DNA and vectors to produce transformed cells expressing the mutant or chimeric Fas ligand. When the Fas ligand of the invention is a non cleavable form,

대표청구항

What is claimed: 1. A recombinant nucleic acid encoding a polypeptide comprising: a transmembrane domain of a cell surface protein; and a Fas ligand portion, wherein said Fas ligand portion comprises a sequence at least 90% homologous to SEQ ID NO: 8, and wherein the Fas ligand portion binds Fas an

이 특허에 인용된 특허 (44)

  1. Muzyczka Nicholas (Stony Brook NY) Hermonat Paul L. (Bethesda MD) Berns Kenneth I. (Mamaroneck NY) Samulski Richard J. (Princeton NJ), AAV transduction vectors.
  2. Chatterjee Saswati (Sierra Madre CA) Wong ; Jr. K. K. (Sierra Madre CA), Adeno-associated virus (AAV)-based eucaryotic vectors.
  3. Carter Barrie J. (Kensington MD) Tratschin Jon D. (Berne CHX), Adeno-associated virus as eukaryotic expression vector.
  4. McCabe Dennis E. (Middleton WI) Martinell Brian J. (Madison WI), Apparatus for genetic transformation.
  5. Nuti Marco (Pisa ITX), Automatic transmission for vehicles in general.
  6. Cregg James M. (San Diego CA), Autonomous replication sequences for yeast strains of the genus pichia.
  7. Wu George Y. (Bloomfield CT) Wu Catherine H. (Bloomfield CT), Carrier system and method for the introduction of genes into mammalian cells.
  8. Darfler Frederick J. (Derwood MD), Cell culture medium with antioxidant.
  9. Sukhatme Vikas P. (Chicago IL), Cloning and expression of early growth regulatory protein genes.
  10. Miller A. Dusty (Seattle WA), DNA constructs for retrovirus packaging cell lines.
  11. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
  12. Shapland James E. (Shoreview MN) Knudson Mark B. (Shoreview MN) Shimada Jin (Falcon Heights MN), Drug delivery apparatus and method.
  13. Anderson W. French (Bethesda MD) Blaese R. Michael (Rockville MD) Rosenberg Steven A. (Bethesda MD), Gene therapy.
  14. Rutter William J. (San Francisco CA) Santi Daniel V. (San Francisco CA), General method for producing and selecting peptides with specific properties.
  15. Roizman Bernard (Chicago IL), Herpes Simplex virus as a vector.
  16. Kim Sinil (Solana Beach CA), Heterovesicular liposomes.
  17. Kriegler Michael (San Francisco CA) Perez Carl (Berkeley CA), Human Y-interferon signal peptide-tumor necrosis factor(TNF) gene fusions.
  18. Suni Jukka (Helsinki FIX) Vaheri Antti (Helsinki FIX), Human retrovirus-related products and methods of diagnosing and treating conditions associated with said retrovirus.
  19. Huang Henry V. (University City MO) Levis Robin (Takoma Park MD) Rice Charles M. (University City MO) Schlesinger Sondra (University City MO) Shen Ping (University City MO) Xiong Cheng (St. Louis MO), Infectious Sindbis virus vectors.
  20. Stephen Robert L. (2501 Kensington Ave. Salt Lake City UT 84108) Lugnani Franco (Viale Miramare 23 34135 Trieste ITX) Rossi Cino (Via Settala 32 00123 Roma ITX) Eruzzi Silvio (Via A. Mori ; 23 46100 , Intracorporeal iontophoretic method.
  21. Davis Charles P. (Galveston TX) Warren Michael M. (Galveston TX) Arnett David W. (Monrovia CA), Iontophoretic catheter device.
  22. Vande Woude George F. (Berryville VA) McClements William L. (Silver Spring MD) Oskarsson Marianne K. (Bethesda MD) Blair Donald G. (Kensington MD), LTR-Vectors.
  23. Goeddel David V. (Hillsborough CA) Rice Glenn C. (Palo Alto CA) Leung David W. H. (Foster City CA), Method for making variant secreted proteins with altered properties.
  24. Smith Gale E. (Bryan TX) Summers Max D. (Bryan TX), Method for producing a recombinant baculovirus expression vector.
  25. Geysen Hendrik M. (Knoxfield AUX), Method of determining mimotopes.
  26. DeBoer, Herman A., Microbial hybrid promoters.
  27. Paoletti Enzo (Delmar NY) Panicali Dennis (Averill Park NY), Modified vaccinia virus.
  28. Paoletti Enzo (Delmar NY) Panicali Dennis (Averill Park NY), Modified vaccinia virus and methods for making and using the same.
  29. Chu, Keting, Mutant forms of Fas ligand and uses thereof.
  30. Dull Thomas J. (San Francisco CA) Riedel Heimo (San Francisco CA) Ullrich Axel (San Francisco CA), Novel receptors for efficient determination of ligands and their antagonists or agonists.
  31. Lovgren Kurt I. (Mlnlycke SEX) Pilbrant Ake G. (Kungsbacka SEX) Yasumura Mitsuru (Hyogo JPX) Morigaki Satoshi (Hyogo JPX) Oda Minoru (Ohita JPX) Ohishi Naohiro (Fukuoka JPX), Pharmaceutical formulations of acid labile substances for oral use.
  32. Axel Richard (New York NY) Wigler Michael H. (Cold Spring Harbor NY) Silverstein Saul J. (Irvington NY), Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials.
  33. Lebkowski Jane S. (Portola Valley CA) McNally Maureen A. (Palo Alto CA) Okarma Thomas B. (Palo Alto CA), Production of recombinant adeno-associated virus vectors.
  34. Lebkowski Jane S. (Portola Valley CA) McNally Maureen A. (Palo Alto CA) Okarma Thomas B. (Palo Alto CA), Production of recombinant adeno-associated virus vectors.
  35. Temin Howard M. (Madison WI) Dougherty Joseph P. (Madison WI), Promoter deficient retroviral vector.
  36. Cleveland William L. (New York NY) Erlanger Bernard F. (Whitestone NY), Protein-free culture medium.
  37. Kung Viola T. (Menlo Park CA) Redemann Carl T. (Walnut Creek CA), Protein-liposome conjugates.
  38. Palese Peter (Leonia NJ) Parvin Jeffrey D. (Belmont MA) Krystal Mark (Leonia NJ), Recombinant negative strand RNA virus expression-systems.
  39. Samulski Richard J. (Pittsburgh PA) Xiao Xiao (Pittsburgh PA), Recombinant viral vector system.
  40. Miller A. Dusty (Seattle WA) Palmer Theo D. (Bellevue WA), Retroviral gene transfer into diploid fibroblasts for gene therapy.
  41. Srivastava Arun (Indianapolis IN), Safe vector for gene therapy.
  42. Baker, Paul E., Serum-free cell culture medium and process for making same.
  43. Kumar Sudhir (18901 Springfield Flossmoor IL 60422), Serum-free, synthetic, completely chemically defined tissue culture media.
  44. Schlesinger Sondra (St. Louis MO) Huang Henry V. (St. Louis MO) Levis Robin (Takoma Park MD) Weiss Barbara (Clayton MO) Tsiang Manuel (St. Louis MO), Sindbis virus vectors.
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트