초록

Provided are a novel class of fumaric-and itaconic-containing prepolymers and compositions comprising the prepolymers used in the manufacture of medical devices.

대표청구항 ▼

What is claimed is: 1. A prepolymer selected from the group consisting of compounds having the following formula: description="In-line Formulae" end="lead"YCO--CH═CHCOW(R1)(SiR2R3O) m(SiR2R3)(R1)WOCCH═CH--COY description="In-line Formulae" end="tail" description="In-line Formulae"

What is claimed is: 1. A prepolymer selected from the group consisting of compounds having the following formula: description="In-line Formulae" end="lead"YCO--CH═CHCOW(R1)(SiR2R3O) m(SiR2R3)(R1)WOCCH═CH--COY description="In-line Formulae" end="tail" description="In-line Formulae" end="lead"CH2═C(CH2COY)COW(R1)(SiR2 R3O)m(SiR2R3)(R1)WOC(CH 2COY)C═CH2 description="In-line Formulae" end="tail" description="In-line Formulae" end="lead"anddescription="In-line Formulae" end="tail" description="In-line Formulae" end="lead"CH2═C(CH2COY)COW(R1)(SiR2 R3O)m(SiR2R3)(R1)WOCCH 2(COY)C═CH2 description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are independently alkyl or phenyl groups, unsubstituted or substituted with halogen and ether linkages, W is O or NH, m is an integer between 2 and 200, and Y is a residue derived from a reactive oligomer of hydrophilic monomers. 2. The prepolymer of claim 1 wherein R1 contains 1-10 carbon atoms. 3. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"YCO--CH═CHCOW(R1)(SiR2R3O) m(SiR2R3)(R1)WOCCH═CH--COY description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 200, W is O and Y is a residue derived from a reactive oligomer derived from hydrophilic monomers selected from the group consisting of amide, hydroxyl and zwitterionic containing hydrophilic monomers and is in a trans configuration. 4. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"YCO--CH═CHCOW(R1)(SiR2R3O) m(SiR2R3)(R1)WOCCH═CH--COY description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 200, W is O and Y is a residue derived from a reactive oligomer derived from hydrophilic monomers selected from the group consisting of amide, hydroxyl and zwitterionic containing hydrophilic monomers and is in a cis configuration. 5. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"CH2═C(CH2COY)COW(R1)(SiR2 R3O)m(SiR2R3)(R1)WOC(CH 2COY)C═CH2 description="In-line Formulae" end="tail" description="In-line Formulae" end="lead"ordescription="In-line Formulae" end="tail" description="In-line Formulae" end="lead"CH2═C(CH2COY)COW(R1)(SiR2 R3O)m(SiR2R3)(R1)WOCCH 2(COY)C═CH2 description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 100, W is O and Y is a residue derived from a reactive oligomer derived from hydrophilic monomers selected from the group consisting of amide, hydroxyl and zwitterionic containing hydrophilic monomers. 6. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"YCO--CH═CHCOW(R1)(SiR2R3O) m(SiR2R3)(R1)WOCCH═CH--COY description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 200, W is O and Y is a residue derived from a reactive oligomer derived from an ethylenically unsaturated lactam containing monomer and is in a trans configuration. 7. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"YCO--CH═CHCOW(R1)(SiR2R3O) m(SiR2R3)(R1)WOCCH═CH--COY description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 200, W is O and Y is a residue derived from a reactive oligomer derived from an ethylenically unsaturated lactam containing monomer and is in a cis configuration. 8. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"CH2═C(CH2COY)COW(R1)(SiR2 R3O)m(SiR2R3)(R1)WOC(CH 2COY)C═CH2 description="In-line Formulae" end="tail" description="In-line Formulae" end="lead"ordescription="In-line Formulae" end="tail" description="In-line Formulae" end="lead"CH2═C(CH2COY)COW(R1)(SiR2 R3O)m(SiR2R3)(R1)WOCCH 2(COY)C═CH2 description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 100, W is O and Y is a residue derived from a reactive oligomer derived from an ethylenically unsaturated lactam containing monomer. 9. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"YCO--CH═CHCOW(R1)(SiR2R3O) m(SiR2R3)(R1)WOCCH═CH--COY description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 200, W is O and Y is a residue derived from a reactive oligomer derived from N-vinylpyrrolidone and is in a trans configuration. 10. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"YCO--CH═CHCOW(R1)(SiR2R3O) m(SiR2R3)(R1)WOCCH═CH--COY description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 200, W is O and Y is a residue derived from a reactive oligomer derived from N-vinylpyrrolidone and is in a cis configuration. 11. The prepolymer of claim 1 wherein the compound has the following formula: description="In-line Formulae" end="lead"CH2═C(CH2COY)COW(R1)(SiR2 R3O)m(SiR2R3)(R1)WOC(CH 2COY)C═CH2 description="In-line Formulae" end="tail" description="In-line Formulae" end="lead"ordescription="In-line Formulae" end="tail" description="In-line Formulae" end="lead"CH2═C(CH2COY)COW(R1)(SiR2 R3O)m(SiR2R3)(R1)WOCCH 2(COY)C═CH2 description="In-line Formulae" end="tail" wherein R1 is selected from the group consisting of alkylenes and alkylenes containing ether linkages, R2 and R3 are methyl, m is an integer between 5 and 100, W is O and Y is a residue derived from a reactive oligomer derived from N-vinylpyrrolidone.