Medical devices for delivering a therapeutic agent and method of preparation
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-033/00
B05D-001/02
B05D-001/18
B05D-001/36
출원번호
US-0292171
(2005-11-30)
등록번호
US-7419696
(2008-09-02)
발명자
/ 주소
Berg,Eric P.
Tuch,Ronald J.
Dror,Michael
Wolff,Rodney G.
출원인 / 주소
Medtronic, Inc.
인용정보
피인용 횟수 :
28인용 특허 :
115
초록▼
A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on t
A method for making an intravascular stent by applying to the body of a stent a solution which includes a solvent, a polymer dissolved in the solvent and a therapeutic substance dispersed in the solvent and then evaporating the solvent. The inclusion of a polymer in intimate contact with a drug on the stent allows the drug to be retained on the stent during expansion of the stent and also controls the administration of drug following implantation. The adhesion of the coating and the rate at which the drug is delivered can be controlled by the selection of an appropriate bioabsorbable or biostable polymer and the ratio of drug to polymer in the solution. By this method, drugs such as dexamethasone can be applied to a stent, retained on a stent during expansion of the stent and elute at a controlled rate.
대표청구항▼
We claim: 1. A method for making an intravascular stent comprising the steps of: (a) providing a radially expandable stent body; (b) applying to the stent body a mixture of a solvent, a polymer, and a therapeutic substance; (c) evaporating the solvent; and (d) repeating application and evaporating
We claim: 1. A method for making an intravascular stent comprising the steps of: (a) providing a radially expandable stent body; (b) applying to the stent body a mixture of a solvent, a polymer, and a therapeutic substance; (c) evaporating the solvent; and (d) repeating application and evaporating steps (b) and (c) to provide an amount of polymer and therapeutic substance on the stent body, wherein the stent body retains the polymer and therapeutic substance when the stent body is radially expanded. 2. The method according to claim 1, wherein the stent body has a metal surface. 3. The method according to claim 1, wherein the mixture is applied to the stent body by spraying. 4. The method according to claim 1, wherein the mixture is applied to the stent body by dipping. 5. The method according to claim 1, wherein the polymer is selected from the group consisting of silicones, polyurethanes, polyesters, vinyl homopolymers and copolymers, acrylate homopolymers and copolymers, polyethers and cellulosics. 6. The method according to claim 1, wherein the ratio of therapeutic substance to polymer in the mixture is in the range of about 10:1 to 1:100. 7. The method according to claim 1, wherein the therapeutic substance is selected from the group consisting of glucocorticoids, dexamethasone, dexamethasone sodium phosphate, anticoagulants, heparin, hirudin, tick anticoagulant peptide, angiopeptin, antimitotic agents, and oligonucleotides. 8. A method for making an intravascular stent having a radially expandable stent body with a mixture of a solvent, a polymer, and a therapeutic substance applied thereto, and the stent body retains the polymer and therapeutic substance when the stent body is radially expanded, said method of making comprising the steps of: (a) providing the radially expandable stent body; (b) applying to the stent body the mixture of the solvent, the polymer, and the therapeutic substance; (c) evaporating the solvent; and (d) repeating application and evaporating steps (b) and (c) to provide an amount of polymer and therapeutic substance on the stent body. 9. The method according to claim 8, wherein the stent body has a metal surface. 10. The method according to claim 8, wherein the stent body is balloon expandable. 11. The method according to claim 8, wherein the mixture is applied to the stent body by spraying. 12. The method according to claim 8, wherein the mixture is applied to the stent body by dipping. 13. The method according to claim 8, wherein the polymer is selected from the group consisting of silicones, polyurethanes, polyesters, vinyl homopolymers and copolymers, acrylate homopolymers and copolymers, polyethers and cellulosics. 14. The method according to claim 8, wherein the ratio of therapeutic substance to polymer in the mixture is in the range of about 10:1 to 1:100. 15. The method according to claim 8, wherein the therapeutic substance is selected from the group consisting of glucocorticoids, dexamethasone, dexamethasone sodium phosphate, anticoagulants, heparin, hirudin, tick anticoagulant peptide, angiopeptin, antimitotic agents, and oligonucleotides. 16. A method for making an intravascular stent having a cylindrical, balloon expandable metal stent body with a mixture of a solvent, a polymer, and a therapeutic substance applied thereto, and the stent body retains the polymer and therapeutic substance when the stent body is radially expanded, said method comprising the steps of: (a) providing the cylindrical, balloon expandable metal stent body; (b) spraying onto the stent body the mixture of the solvent, the polymer, and therapeutic substance; (c) evaporating the solvent; and (d) repeating application and evaporating steps (b) and (c) to provide an amount of polymer and therapeutic substance on the stent body. 17. The method according to claim 16, wherein the polymer is selected from the group consisting of silicones, polyurethanes, polyesters, vinyl homopolymers and copolymers, acrylate homopolymers and copolymers, polyethers and cellulosics. 18. The method according to claim 16, wherein the ratio of therapeutic substance to polymer in the mixture is in the range of about 10:1 to 1:100. 19. The method according to claim 16, wherein the therapeutic substance is selected from the group consisting of glucocorticoids, dexamethasone, dexamethasone sodium phosphate, anticoagulants, heparin, hirudin, tick anticoagulant peptide, angiopeptin, antimitotic agents, and oligonucleotides.
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