The present invention provides a receptacle (30) for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle (30) has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a
The present invention provides a receptacle (30) for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle (30) has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube (40) is sealed in the seal having a proximal end in the receptacle (30), a distal end accessible from outside the receptacle (30), a flow passage (56) extending between said proximal and distal ends, and a closure (54) blocking flow through the flow passage (56) adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube (40) and closure (54) are essentially impermeable to said gas.
대표청구항▼
What is claimed is: 1. A multiple layer polymeric structure consisting of: a first layer of an ethylene vinyl alcohol copolymer having first and second sides; and a second solution contact layer of a modified ethylene vinyl acetate copolymer attached to the first side of the first layer, the second
What is claimed is: 1. A multiple layer polymeric structure consisting of: a first layer of an ethylene vinyl alcohol copolymer having first and second sides; and a second solution contact layer of a modified ethylene vinyl acetate copolymer attached to the first side of the first layer, the second layer having a thickness of greater than 1.6 mils. 2. The structure of claim 1 further comprising a third layer attached to the second side of the first layer. 3. The structure of claim 2 wherein the third layer is selected from the group consisting of polyamides and polyesters. 4. The structure of claim 1 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 25% to about 45% by mole percent. 5. The structure of claim 1 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 28% to about 36% by mole percent. 6. The structure of claim 1 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 30% to about 34% by mole percent. 7. The structure of claim 1 wherein the modified ethylene vinyl acetate copolymer has a modifying group selected from the group consisting of carboxylic acid and carboxylic acid anhydrides. 8. The structure of claim 7 wherein the modifying group is maleic acid, fumaric acid, itaconic acid, citraconic acid, allylsuccinic acid, cyclohex-4-ene-1,2-dicarboxylic acid, 4-methylcyclohex-4-ene-1,2-dicarboxylic acid, bicyclo[2.2.1]hept-5-ene-2, 3-dicarboxylic acid, x-methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, maleic anhydride, itaconic anhydride, citraconic anhydride, allylsuccinic anhydride, cyclohex-4-ene-1,2-dicarboxylic anhydride, 4-methylcyclohex-4-ene-1,2-dicarboxylic anhydride, bicyclo{2.2.1}hept-5-ene2,3-dicarboxylic anhydride, x-methylbicyclo[2.2.1]hept-5-ene-2,2-dicarboxylic anhydride, methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, glycidyl acrylate, glycidal methacrylate, monoethyl maleate, diethyl maleate, monomethyl maleate, diethyl maleate, monomethyl fumarate, dimethyl fumarate, monomethyl itaconate, diethylitaconate, amide derivatives of unsaturated carboxylic acids including acrylamide, methacrylamide, maleicmonoamide, maleic diamide, maleic N-monoethylamide, maleic N,N-diethylamide, maleic N-monobutylamide, maleic N,N dibutylamide, fumaric monoamide, fumaric diamide, fumaric N-monoethylamide, fumaric N,N-diethylamide, fumaric N-monobutylamide and fumaric N,N-dibutylamide, imide derivatives of unsaturated carboxylic acids including maleimide, N-butylmaleimide and N-phenylmaleimide; and metal salts of unsaturated carboxylic acids including sodium acrylate, sodium methacrylate, potassium acrylate or potassium methacrylate. 9. The structure of claim 8 wherein the modifying group is a fused ring carboxylic acid anhydride. 10. The structure of claim 3 wherein the polyamides are aliphatic polyamides obtained from the condensation reaction of di-amines having a carbon number within a range of 2-13, aliphatic polyamides resulting from a condensation reaction of di-acids having a carbon number within a range of 2-13, polyamides resulting from the condensation reaction of dimmer fatty acids, and amide containing copolymers. 11. The structure of claim 3 wherein the polyamide is obtained from a ring-opening reaction of a lactam having from 4-12 carbons. 12. The structure of claim 3 wherein the modified ethylene vinyl acetate copolymer has a modifying group selected from the group consisting of carboxylic acid and carboxylic acid anhydrides. 13. The structure of claim 12 wherein the modifying group is maleic acid, fumaric acid, itaconic acid, citraconic acid, allylsuccinic acid, cyclohex-4-ene-1,2-dicarboxylic acid, 4-methylcyclohex-4-ene-1,2-dicarboxylic acid, bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, x-methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, maleic anhydride, itaconic anhydride, citraconic anhydride, allylsuccinic anhydride, cyclohex-4-ene-1,2-dicarboxylic anhydride, 4-methylcyclohex-4-ene-1,2-dicarboxylic anhydride, bicyclo{2.2.1}hept-5-ene2,3-dicarboxylic anhydride, x-methylbicyclo[2.2.1]hept-5-ene-2,2-dicarboxylic anhydride, methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, glycidyl acrylate, glycidal methacrylate, monoethyl maleate, diethyl maleate, monomethyl maleate, diethyl maleate, monomethyl fumarate, dimethyl fumarate, monomethyl itaconate, diethylitaconate, amide derivatives of unsaturated carboxylic acids including acrylamide, methacrylamide, maleicmonoamide, maleic diamide, maleic N-monoethylamide, maleic N,N-diethylamide, maleic N-monobutylamide, maleic N,N dibutylamide, fumaric monoamide, fumaric diamide, fumaric N-monoethylamide, fumaric N,N-diethylamide, fumaric N-monobutylamide and fumaric N,N-dibutylamide, imide derivatives of unsaturated carboxylic acids including maleimide, N-butylmaleimide and N-phenylmaleimide; and metal salts of unsaturated carboxylic acids including sodium acrylate, sodium methacrylate, potassium acrylate or potassium methacrylate. 14. The structure of claim 13 wherein the modifying group is a fused ring carboxylic acid anhydride. 15. The structure of claim 3 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 25% to about 45% by mole percent. 16. The structure of claim 3 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 28% to about 36% by mole percent. 17. The structure of claim 3 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 30% to about 34% by mole percent. 18. A multiple layer polymeric structure consisting of: an outside layer selected from the group consisting of polyamides, polyesters and combinations thereof; a core layer having a first side and a second side of an ethylene vinyl alcohol copolymer; and a sealing solution contact layer of a modified ethylene vinyl acetate copolymer wherein the outside layer is attached to the first side of the core layer and the sealing layer is attached to the second side of the core layer. 19. The structure of claim 18 further comprising a tie layer interposed between the core layer and the outside layer. 20. The structure of claim 19 wherein the tie layer is a modified ethylene vinyl acetate copolymer. 21. The structure of claim 18 wherein the polyamides are aliphatic polyamides obtained from the condensation reaction of di-amines having a carbon number within a range of 2-13, aliphatic polyamides resulting from a condensation reaction of di-acids having a carbon number within a range of 2-13, polyamides resulting from the condensation reaction of dimer fatty acids, and amide containing copolymers. 22. The structure of claim 18 wherein the polyamide is obtained from a ring-opening reaction of a lactam having from 4-12 carbons. 23. The structure of claim 18 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 25% to about 45% by mole percent. 24. The structure of claim 18 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 28% to about 36% by mole percent. 25. The structure of claim 18 wherein the ethylene vinyl alcohol copolymer has an ethylene content of from about 30% to about 34% by mole percent. 26. The structure of claim 18 wherein the modified ethylene vinyl acetate copolymer has a modifying group selected from carboxylic acid and carboxylic acid anhydrides. 27. The structure of claim 26 wherein the modifying group is maleic acid, fumaric acid, itaconic acid, citraconic acid, allylsuccinic acid, cyclohex-4-ene-1,2-dicarboxylic acid, 4-methylcyclohex-4-ene-1,2-dicarboxylic acid, bicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, x-methylbicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid, maleic anhydride, itaconic anhydride, citraconic anhydride, allylsuccinic anhydride, cyclohex-4-ene-1,2-dicarboxylic anhydride, 4-methylcyclohex-4-ene-1,2-dicarboxylic anhydride, bicyclo{2.2.1}hept-5-ene2,3-dicarboxylic anhydride, x-methylbicyclo[2.2.1]hept-5-ene-2,2-dicarboxylic anhydride, methyl acrylate, methyl methacrylate, ethyl acrylate, ethyl methacrylate, butyl acrylate, butyl methacrylate, glycidyl acrylate, glycidal methacrylate, monoethyl maleate, diethyl maleate, monomethyl maleate, diethyl maleate, monomethyl fumarate, dimethyl fumarate, monomethyl itaconate, diethylitaconate, amide derivatives of unsaturated carboxylic acids including acrylamide, methacrylamide, maleicmonoamide, maleic diamide, maleic N-monoethylamide, maleic N,N-diethylamide, maleic N-monobutylamide, maleic N,N dibutylamide, fumaric monoamide, fumaric diamide, fumaric N-monoethylamide, fumaric N,N-diethylamide, fumaric N-monobutylamide and fumaric N,N-dibutylamide, imide derivatives of unsaturated carboxylic acids including maleimide, N-butylmaleimide and N-phenylmaleimide; and metal salts of unsaturated carboxylic acids including sodium acrylate, sodium methacrylate, potassium acrylate or potassium methacrylate. 28. The structure of claim 27 wherein the modifying group is a fused ring carboxylic acid anhydride. 29. The structure of claim 28 wherein the sealing layer has a thickness of greater than 1.2 mils. 30. The structure of claim 28 wherein the sealing layer has a thickness of greater than 1.6 mils. 31. The structure of claim 28 wherein the sealing layer has a thickness of greater than 1.8 mils. 32. The structure of claim 28 wherein the sealing layer has a thickness of greater than 2.0 mils. 33. The structure of claim 1 wherein the second layer has a thickness of greater than 1.8 mils. 34. The structure of claim 1 wherein the second layer has a thickness of greater than 2.0 mils.
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