$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Oligoribonucleotides and ribonucleases for cleaving RNA

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/70
  • C07H-021/02
  • C07H-021/00
  • C07H-021/04
  • C12N-005/00
출원번호 US-0281297 (2002-10-25)
등록번호 US-7432249 (2008-10-07)
발명자 / 주소
  • Crooke,Stanley T.
출원인 / 주소
  • Isis Pharmaceuticals, Inc.
대리인 / 주소
    Woodcock Washburn LLP
인용정보 피인용 횟수 : 40  인용 특허 : 68

초록

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementa

대표청구항

What is claimed is: 1. A composition comprising a pharmaceutically acceptable diluent or carrier and a single-stranded oligomeric compound, wherein said compound: is 15 to 25 nucleoside subunits in length; specifically hybridizes with a preselected target RNA; comprises at least four consecutive nu

이 특허에 인용된 특허 (68)

  1. Beigelman, Leonid; Karpeisky, Alex, 2′-O-alkylthioalkyl and 2′-C-alkylthioalkyl-containing nucleic acids.
  2. Buhr Chris A. (Daly City CA) Matteucci Mark (Burlingame CA), 2\modified nucleoside and nucleotide compounds.
  3. Cook P. Dan (Carlsbad CA) Acevedo Oscar L. (San Diego CA) Andrews Robert S. (San Juan Capistrano CA), 3-deazapurines.
  4. Cook Philip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA), 4′-desmethyl nucleoside analog compounds.
  5. Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR) Stirchak Eugene P. (Corvallis OR), Alpha-morpholino ribonucleoside derivatives and polymers thereof.
  6. Bennett C. Frank ; Cooke Stanley T. ; Manoharan Muthiah ; Wyatt Jacqueline R. ; Baker Brenda F. ; Monia Brett P. ; Freier Susan M. ; McKay Robert ; Karras James G., Alteration of cellular behavior by antisense modulation of mRNA processing.
  7. Fung Steven (Palo Alto CA) Woo Sam L. (Redwood City CA) Smith Lloyd M. (South Pasadena CA), Amino-derivatized phosphite and phosphate linking agents, phosphoramidite precursors, and useful conjugates thereof.
  8. Bennett C. Frank ; Condon Thomas P. ; Flournoy Shin Cheng ; Zhang Hong, Antisense modulation of PECAM-1.
  9. McKay Robert ; Dean Nicholas ; Monia Brett P. ; Nero Pamela S. ; Gaarde William A., Antisense oligonucleotide compositions and methods for the modulation of JNK proteins.
  10. Cook Philip D. (Carlsbad CA) Sanghvi Yogesh S. (Carlsbad CA), Backbone modified oligonucleotide analogs.
  11. Sanghvi Yogesh S. (Carlsbad CA) Cook Phillip D. (Carlsbad CA), Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling.
  12. Usman Nassim ; Beigelman Leonid ; McSwiggen James ; Karpeisky Alex, Base-modified enzymatic nucleic acid.
  13. Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Ramsay Shaw Barbara (Durham NC), Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same.
  14. Hogan James J. (Coronado CA) Arnold ; Jr. Lyle J. (San Diego CA) Nelson Norman C. (San Diego CA) Bezverkov Robert (Cardiff by the Sea CA), Branched nucleic acid probes.
  15. Cook Phillip D. (Carlsbad CA) Bruice Thomas (Carlsbad CA) Guinosso Charles J. (Carlsbad CA) Kawasaki Andrew M. (Oceanside CA), Compositions for inhibiting RNA activity.
  16. Ohtsuka Eiko (Sappro JPX) Inoue Hideo (Sappro JPX) Morisawa Hirokazu (Kawasaki JPX) Shibahara Susumu (Kawasaki JPX) Mukai Sachiko (Kawasaki JPX) Nishihara Tohru (Kurashiki JPX), Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and st.
  17. Dellinger Douglas J. (Cardiff by the Sea CA), Copolymers of N-vinyl-lactams suitable for oligomer solid phase synthesis.
  18. Saba Don (Tucson AZ) Glass Richard S. (Tucson AZ) Yabusaki Kenichi K. (Albany CA), Coumarin derivatives for use as nucleotide crosslinking reagents.
  19. Cook Phillip Dan ; Manoharan Muthiah ; Bruice Thomas, Covalently cross-linked oligonucleotides.
  20. Cook Phillip D. (Carlsbad CA) Baschang Gerhard (Bettingen CHX), Cyclobutyl oligonucleotide surrogates.
  21. Nilsen Thor W., Dendritic nucleic acids exhibiting maximal self-assembly.
  22. Usman Nassim ; Wincott Francine E. ; Tracz Danuta, Deprotection of RNA with alkylamine.
  23. Goodchild John, Enhancement of ribozyme catalytic activity by A 2'-O-substituted facilitator oligonucleotide.
  24. Goodchild John (Worcester MA), Enhancement of ribozyme catalytic activity by a neighboring facilitator oligonucleotide.
  25. Matulic-Adamic Jasenka ; Beigelman Leonid ; Karpeisky Alexander ; Jarvis Thale ; Usman Nassim ; DiRenzo Anthony ; Wincott Francine, Enzymatic nucleic acids containing 5'-and/or 3'-cap structures.
  26. Froehler Brian C. (Belmont CA), Exonuclease-resistant oligonucleotides.
  27. Fire, Andrew; Kostas, Stephen; Montgomery, Mary; Timmons, Lisa; Xu, SiQun; Tabara, Hiroaki; Driver, Samuel E.; Mello, Craig C., Genetic inhibition by double-stranded RNA.
  28. Bayer Ernst (Bei der Ochsenweide D-7400 Tubingen DEX) Rapp Wolfgang (Stuttgart DEX), Graft copolymers of crosslinked polymers and polyoxyethylene, processes for their production, and their usage.
  29. Arnold ; Jr. Lyle J. ; Reynolds Mark A. ; Giachetti Cristina, Method for inhibiting RNA translation using chimeric oligonucleoside compounds.
  30. Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
  31. Pederson Thoru (Worcester MA) Agrawal Sudhir (Shrewsbury MA) Mayrand Sandra (Shrewsbury MA) Zamecnik Paul C. (Shrewsbury MA), Method of site-specific alteration of RNA and production of encoded polypeptides.
  32. Stec Wojciech J. (Lodz PLX) Uznanski Bogdan (Lodz CA PLX) Bergot B. John (Redwood City CA) Hirschbein Bernard L. (San Francisco CA) Fearon Karen L. (Union City CA), Method of synethesizing sulfurized oligonucleotide analogs.
  33. Walder Joseph A. ; Walder Roxanne Y. ; Eder Paul S. ; Dagle John M., Methods for decreasing the expression of specifically targeted genes.
  34. Summerton James E. (Corvallis OR) Weller Dwight D. (Corvallis OR), Morpholino-subunit combinatorial library and method.
  35. Cook P. Dan (Carlsbad CA) Ramasamy Kanda S. (Laguna Hills CA) Manoharan Muthiah (Carlsbad CA), N-2 substituted purines.
  36. Usman, Nassim; Wincott, Francine; Matulic-Adamic, Jasenka; Beigelman, Leonid; Karpeisky, Alex, Non-nucleotide containing RNA.
  37. Usman Nassim ; Wincott Francine ; Matulic-Adamic Jasenka ; Beigelman Leonid ; Karpeisky Alex, Non-nucleotide containing enzymatic nucleic acid.
  38. Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.
  39. Cook Philip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA), Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression.
  40. Walder Joseph A. (Iowa City IA) Walder Roxanne Y. (Iowa City IA), Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled.
  41. Baxter Anthony D. (Northwich GB2) Baylis Eric K. (Stockport GB2) Collingwood Stephen P. (Westhoughton GB2) Taylor Roger J. (Stretford GB2) Mesmaeker Alain (Kanerkinden CHX) Schmit Chantal (Basel CHX), Nucleoside phosphinate compounds and compositions.
  42. Letsinger Robert L. (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Oligodeoxyribonucleotides including 3′-aminonucleoside-phosphoramidate linkages and terminal 3′-amino groups.
  43. Sanghvi Yogesh S. (Carlsbad CA) Cook Phillip D. (Carlsbad CA), Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms.
  44. Matteucci Mark (Burlingame CA), Oligonucleotide analogs with novel linkages.
  45. Matteucci Mark (Burlingame CA), Oligonucleotide analogs with novel linkages.
  46. Tullis Richard H. (La Jolla CA), Oligonucleotide therapeutic agent and method of making same.
  47. Froehler Brian (Belmont CA) Jones Robert J. (Daly City CA), Oligonucleotides containing 5-propynyl pyrimidines.
  48. Hoke Glenn (Mt. Airy MD) Cook Phillip D. (San Marcos CA), Oligonucleotides with substantially chirally pure phosphorothioate linkages.
  49. Jansz Hendrik S. (Zeist NLX) Lips Cornelis J. M. (The Hague NLX) Steenbergh Paul H. (Bunnik NLX) Rink Hans (Riehen CHX) Sieber Peter (Reinach CHX), Oligopeptides and intermediates and processes for their manufacture.
  50. Crooke Stanley T., Oligoribonucleotides and ribonucleases for cleaving RNA.
  51. Crooke Stanley T., Oligoribonucleotides for cleaving RNA.
  52. Barascut Jean-Louis (Combaillaux FRX) Imbach Jean-Louis (Montpellier FRX), Oligothionucleotides.
  53. Cook Phillip D. (Carlsbad CA) Kiely John (San Diego CA) Sprankle Kelly (Vista CA), Peptide nucleic acid combinatorial libraries and improved methods of synthesis.
  54. Miller Paul S. (Baltimore MD) Ts\O Paul O. P. (Lutherville MD), Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates.
  55. Spielvogel Bernard F. (Raleigh NC) Sood Anup (Durham NC) Hall Iris H. (Chapel Hill NC) Ramsay Shaw Barbara (Durham NC), Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates.
  56. McGee Daniel P. C. (Carlsbad CA), Process for the preparation of 2′-O-alkyl guanosine and related compounds.
  57. Cook Phillip Dan ; Springer Robert H. ; Sprankle Kelly G. ; Ross Bruce S., Process for the synthesis of 2'-O-substituted pyrimidines.
  58. Cook Phillip Dan ; Springer Robert H. ; Sprankle Kelly G. ; Ross Bruce S., Process for the synthesis of 2'-O-substituted pyrimidines.
  59. Cook Phillip Dan ; Sanghvi Yogesh S. ; Sprankle Kelly G. ; Ross Bruce S. ; Griffey Rich H. ; Springer Robert H., Process for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom.
  60. Acevedo Oscar L. (San Diego CA) Hebert Normand (San Marcos CA), Pyrrolidine-containing monomers and oligomers.
  61. Goodchild, John, Ribozymes having 2'-O substituted nucleotides in the flanking sequences.
  62. Urdea Michael S. (Alamo CA), Ribozymes with product ejection by strand displacement.
  63. Cantor Charles R. (Boston MA) Niemeyer Christof M. (Bremen DEX) Smith Cassandra L. (Boston MA) Sano Takeshi (Boston MA) Hnatowich Donald J. (Brookline MA) Rusckowski Mary (Southborough MA), Self-assembling multimeric nucleic acid constructs.
  64. Itakura Keiichi (Arcadia CA), Solid-phase synthesis of polynucleotides.
  65. Itakura Keiichi (Arcadia CA), Solid-phase synthesis of polynucleotides.
  66. Buendia Jean (Le Perreux Sur Marne FRX) Nierat Jeanine (Suresnes FRX), Supports and their use.
  67. Summerton James (Corvallis OR) Weller Dwight (Corvallis OR) Stirchak Eugene (Corvallis OR), Uncharged polynucleotide-binding polymers.
  68. McSwiggen,James A., siRNA treatment of diseases or conditions related to levels of IKK-gamma.

이 특허를 인용한 특허 (40)

  1. Shimizu, Mamoru; Wada, Takeshi, Asymmetric auxiliary group.
  2. Shimizu, Mamoru; Wada, Takeshi, Asymmetric auxiliary group.
  3. Butler, David; Iwamoto, Naoki; Meena; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral control.
  4. Butler, David; Iwamoto, Naoki; Meena; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral control.
  5. Meena; Butler, David; Iwamoto, Naoki; Svrzikapa, Nenad; Verdine, Gregory L.; Zlatev, Ivan, Chiral design.
  6. Gemba, Takefumi, Chiral nucleic acid adjuvant.
  7. Gemba, Takefumi; Nagata, Ryoichi; Torikai, Yusuke, Chiral nucleic acid adjuvant having antitumor effect and antitumor agent.
  8. Gemba, Takefumi; Nagata, Ryoichi; Shiga, Ikumi, Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator.
  9. Feinstein, Elena; Erlich, Shai, Compositions and methods for reducing or protecting against delayed graft function (DGF).
  10. Weiler, Jan; Hall, Jonathan; Bologna, Jean-Charles; Natt, Francois Jean-Charles; Haner, Robert, Interfering RNA duplex having blunt-ends and 3′-modifications.
  11. Wada, Takeshi; Shimizu, Mamoru, Method for the synthesis of phosphorus atom modified nucleic acids.
  12. Wada, Takeshi; Shimizu, Mamoru, Method for the synthesis of phosphorus atom modified nucleic acids.
  13. Gilman, Vladimir Leo, Methods for identifying nucleic acid ligands.
  14. Gilman, Vladimir Leo, Methods for identifying nucleic acid ligands.
  15. Verdine, Gregory L.; Meena; Iwamoto, Naoki; Butler, David Charles Donnell, Methods for the synthesis of functionalized nucleic acids.
  16. Vorechovsky, Igor; Kralovicova, Jana, Modulation of gene expression and screening for deregulated protein expression.
  17. Gilman, Vladimir Leo, Nucleic acid ligands against infectious prions.
  18. Verdine, Gregory L.; ., Meena; Iwamoto, Naoki, Nucleic acid prodrugs and methods of use thereof.
  19. Feinstein, Elena; Ehrlich, Shai, Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases.
  20. Feinstein, Elena; Zurr, Daniel; Ehrlich, Shai, Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases.
  21. Puri, Nitin; Charles, Irudaya; Magdaleno, Susan; Vlassov, Alexander; Burnett, Chris, RNAi sequence-independent modification formats, and stabilized forms thereof.
  22. Vorechovsky, Igor; Kralovicova, Jana, Reducing intron retention.
  23. Vorechovsky, Igor; Kralovicova, Jana, Reducing intron retention.
  24. Hutvagner, Gyorgy; Zamore, Phillip D., Sequence-specific inhibition of small RNA function.
  25. Hutvagner, Gyorgy; Zamore, Phillip D., Sequence-specific inhibition of small RNA function.
  26. Hutvágner, György; Zamore, Phillip D., Sequence-specific inhibition of small RNA function.
  27. Natt, Francois Jean-Charles; Billy, Eric; Hunziker, Juerg; Schnell, Christian Rene, Short interfering ribonucleic acid (siRNA) for oral administration.
  28. Natt, Francois Jean-Charles; Billy, Eric; Hunziker, Juerg; Schnell, Christian Rene, Short interfering ribonucleic acid (siRNA) for oral administration.
  29. Natt, Francois Jean-Charles; Billy, Eric; Hunziker, Juerg; Schnell, Christian Rene, Short interfering ribonucleic acid (siRNA) for oral administration.
  30. Natt, Francois Jean-Charles; Billy, Eric; Hunziker, Juerg; Schnell, Christian Rene, Short interfering ribonucleic acid (siRNA) for oral administration.
  31. Natt, Francois Jean-Charles; Billy, Eric; Hunziker, Juerg; Schnell, Christian Rene, Short interfering ribonucleic acid (siRNA) for oral administration.
  32. Puri, Nitin; Charles, Irudaya; Magdaleno, Susan; Vlassov, Alexander; Burnett, Christopher, SiRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAi, and stabilized forms thereof.
  33. Lim, Lee; Chorn, Guillaume; Willingham, Aarron T.; Zhao, Lihong, Single-stranded RNAi agents containing an internal, non-nucleic acid spacer.
  34. Lim, Lee; Chorn, Guillaume; Willingham, Aarron; Zhao, Lihong, Single-stranded RNAi agents containing an internal, non-nucleic acid spacer.
  35. Krainer, Adrian; Aznarez, Isabel, Targeted augmentation of nuclear gene output.
  36. Feinstein, Elena; Skaliter, Rami, Therapeutic uses of inhibitors of RTP801.
  37. Feinstein, Elena; Skaliter, Rami, Therapeutic uses of inhibitors of RTP801.
  38. Feinstein, Elena, Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes.
  39. Puri, Nitin; Charles, Irudaya; Magdaleno, Susan; Vlassov, Alexander; Burnett, Christopher, siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAI, and stabilized forms thereof.
  40. Puri, Nitin; Charles, Irudaya; Magdaleno, Susan; Vlassov, Alexander; Burnett, Chris, siRNA sequence-independent modification formats for reducing off-target phenotypic effects in RNAi, and stabilized forms thereof.
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트