Microfluidic test systems with gas bubble reduction
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-035/00
G01N-021/00
출원번호
US-0168775
(2005-06-28)
등록번호
US-7437914
(2008-10-21)
발명자
/ 주소
Harding,Philip
Beatty,Christopher C
출원인 / 주소
Hewlett Packard Development Company, L.P.
인용정보
피인용 횟수 :
2인용 특허 :
13
초록▼
A reservoir for use in testing a liquid as part of a microfluidic testing system, includes a testing chamber configured to receive the liquid to be tested. A liquid inlet is fluidly coupled to the testing chamber to allow ingress of the liquid into the testing chamber. A gas outlet is fluidly couple
A reservoir for use in testing a liquid as part of a microfluidic testing system, includes a testing chamber configured to receive the liquid to be tested. A liquid inlet is fluidly coupled to the testing chamber to allow ingress of the liquid into the testing chamber. A gas outlet is fluidly coupled to the testing chamber to allow egress of gas out of the testing chamber. The gas outlet has an elevation that is higher than an elevation of the liquid inlet such that, as the testing chamber is rotated, the gas is expelled out of the testing chamber through the gas outlet, thereby reducing or preventing a presence of gas bubbles in the liquid.
대표청구항▼
What is claimed is: 1. A device for use in testing a liquid in a microfluidic testing system, comprising: a disk defining an axis of rotation and configured to centripetally manipulate the liquid as the disk is rotated about the axis of rotation, the disk including: a testing chamber configured to
What is claimed is: 1. A device for use in testing a liquid in a microfluidic testing system, comprising: a disk defining an axis of rotation and configured to centripetally manipulate the liquid as the disk is rotated about the axis of rotation, the disk including: a testing chamber configured to receive the liquid to be tested, a liquid inlet fluidly coupled to the testing chamber to allow ingress of the liquid into the testing chamber, and a gas outlet fluidly coupled to the testing chamber to allow egress of gas out of the testing chamber, wherein the gas outlet has an elevation that is higher than an elevation of the liquid inlet such that, as the disk is rotated about the axis of rotation, gas is expelled out of the testing chamber through the gas outlet, thereby reducing a presence of gas bubbles in the test chamber, wherein the gas outlet is formed in an uppermost section of the testing chamber, and wherein the liquid inlet is formed in a lowermost section of the testing chamber. 2. The device of claim 1, wherein the disk has a thickness less than about 2 mm. 3. The device of claim 1, further comprising an outlet microchannel fluidly coupled to the gas outlet of the testing chamber, and an inlet microchannel fluidly coupled to the liquid inlet of the testing chamber, the outlet microchannel and inlet microchannel each being at least partially aligned with a radial axis of the disk. 4. The device of claim 1, wherein the testing chamber is at least partially transparent, to facilitate performance of an optical test on the liquid. 5. The device of claim 1, wherein at least a portion of an inside surface of the testing chamber is treated with a reactant configured to chemically react with the liquid upon entry of the liquid into the testing chamber. 6. The device of claim 1, wherein the testing chamber is substantially cylindrical in shape. 7. A method for forming a device for use in testing a liquid in a microfluidic testing system, the device including a disk defining an axis of rotation and configured to centripetally manipulate the liquid as the disk is rotated about the axis of rotation, the disk including a microfluidic testing chamber that reduces or eliminates the formation or presence of gas bubbles in a liquid entering thereinto, the method comprising the steps of: coupling a liquid inlet fluidly to the testing chamber, such that, as the disk is rotated about the axis of rotation, the liquid is driven centripetally into the testing chamber; and coupling a gas outlet to the testing chamber on a radially inward side of the testing chamber such that, as the disk is rotated about the axis of rotation, gas is expelled out of the testing chamber through the gas outlet on the radially inward side of the testing chamber, wherein the gas outlet is formed in an uppermost section of the testing chamber and wherein the liquid inlet is formed in a lowermost section of the testing chamber. 8. The method of claim 7, wherein the disk has a thickness of less than about 2 mm. 9. The method of claim 7, comprising the further step of fluidly coupling an inlet microchannel to the liquid inlet and an outlet microchannel to the gas outlet of the testing chamber such that the outlet microchannel and the inlet microchannel are each at least partially aligned with a radial axis of the disk. 10. The method of claim 7, wherein the testing chamber is at least partially transparent, to facilitate performance of an optical test on the liquid. 11. The method of claim 7, wherein at least a portion of an inside surface of the testing chamber is treated with a reactant configured to mix with the liquid upon entry of the liquid in the testing chamber. 12. The method of claim 7, wherein the testing chamber is substantially cylindrical in shape. 13. A device for use in testing a liquid in a microfluidic system, comprising: a disk defining an axis of rotation and configured to centripetally manipulate the liquid as the disk is rotated about the axis of rotation, the disk including: a testing chamber configured to receive the liquid to be tested, a liquid inlet fluidly coupled to the testing chamber to allow ingress of the liquid into the testing chamber when the disk is rotated, and a gas outlet fluidly coupled to the testing chamber to allow egress of gas out of the chamber, wherein the gas outlet couples to the testing chamber on a radially inward side of the testing chamber such that, as the disk is rotated, gas is expelled out of the testing chamber through the gas outlet, thereby reducing a presence of gas bubbles in the testing chamber, wherein the gas outlet is formed in an uppermost section of the testing chamber, and wherein the liquid inlet is formed in a lowermost section of the testing chamber. 14. A method for reducing or preventing presence of gas bubbles in a liquid to be tested using the device of claim 13, comprising the steps of: rotating the disk about the axis of rotation such that the liquid is centripetally driven through the liquid inlet into the testing chamber; and venting gas through the gas outlet as the liquid enters the testing chamber. 15. The method of claim 14, wherein the step of rotating the disk and the step of venting gas are performed substantially simultaneously. 16. The method of claim 14, wherein the disk has a thickness less than about 2 mm. 17. The method of claim 14, further comprising an outlet microchannel fluidly coupled to the gas outlet of the testing chamber, and an inlet microchannel fluidly coupled to the liquid inlet of the testing chamber, the outlet microchannel and the inlet microchannel each being at least partially aligned with a radial axis of the disk. 18. The method of claim 14, further comprising a step of performing an optical test on the liquid. 19. The method of claim 14, wherein at least a portion of an inside surface of the testing chamber is treated with a reactant, and wherein the method further comprises a step of chemically reacting the reactant with the liquid in the testing chamber. 20. The device of claim 13, wherein the disk includes a fluid receptacle fluidly coupled to the testing chamber and disposed radially inward from the testing chamber such that liquid in the fluid receptacle is urged to the testing chamber when the disk is rotated about the axis of rotation. 21. The device of claim 13, wherein both the liquid inlet and the gas outlet are disposed on a radially inward side of the testing chamber. 22. The device of claim 13, wherein the gas outlet and the liquid inlet each couples to the testing chamber at a respective elevation, and wherein the elevation of the gas outlet is higher than the elevation of the liquid inlet. 23. The device of claim 13, further comprising an outlet microchannel fluidly coupled to the gas outlet of the testing chamber and an inlet microchannel fluidly coupled to the liquid inlet of the testing chamber, the outlet microchannel and the inlet microchannel each being at least partially aligned with a radial axis of the disk. 24. The device of claim 23, wherein the outlet microchannel is disposed above the inlet microchannel. 25. The device of claim 13, wherein at least a portion of an inside surface of the testing chamber is treated with a reactant configured to chemically react with the liquid upon entry of the liquid into the testing chamber. 26. The device of claim 13, where the testing chamber is substantially cylindrical in shape. 27. A device for use in testing a liquid in a microfluidic system, comprising: a disk defining an axis of rotation and configured to centripetally manipulate the liquid as the disk is rotated about the axis of rotation, the disk including: a testing chamber configured to receive the liquid to be tested, a liquid inlet fluidly coupled to the testing chamber to allow ingress of the liquid into the testing chamber when the disk is rotated, a gas outlet fluidly coupled to the testing chamber to allow egress of gas out of the chamber, an inlet microchannel fluidly coupled to the liquid inlet of the testing chamber, and an outlet microchannel fluidly coupled to the gas outlet of the testing chamber, wherein the gas outlet couples to the testing chamber on a radially inward side of the testing chamber such that, as the disk is rotated, gas is expelled out of the testing chamber through the gas outlet, thereby reducing a presence of gas bubbles in the testing chamber, wherein the outlet microchannel and the inlet microchannel are each at least partially aligned with a radial axis of the disk, and wherein the outlet microchannel is disposed above the inlet microchannel.
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