Compositions containing prodrugs of florfenicol and methods of use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/205
A61K-031/185
A61K-031/53
A61K-031/50
A61K-031/505
A61K-031/44
출원번호
US-0623114
(2003-07-18)
등록번호
US-7439268
(2008-10-21)
발명자
/ 주소
Murthy,Yerramilli V. S. N.
Suva,Robert H.
출원인 / 주소
Idexx Laboratories
대리인 / 주소
Townsend & Townsend & Crew
인용정보
피인용 횟수 :
1인용 특허 :
20
초록▼
The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one o
The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
대표청구항▼
The invention claimed is: 1. A composition comprising florfenicol butyrate and a pharmaceutically acceptable solvent selected from N-methyl pyrrolidone, pyrrolidone, polyethylene glycol, propylene glycol, glycerol formal, isosorbid dimethyl ether, ethanol, dimethyl sulfoxide, tetrahydrofurfuryl alc
The invention claimed is: 1. A composition comprising florfenicol butyrate and a pharmaceutically acceptable solvent selected from N-methyl pyrrolidone, pyrrolidone, polyethylene glycol, propylene glycol, glycerol formal, isosorbid dimethyl ether, ethanol, dimethyl sulfoxide, tetrahydrofurfuryl alcohol, triacetin, and combinations thereof, wherein the composition is formulated as a composition for administration to a mammal by injection. 2. The composition of claim 1, wherein the solvent is selected from propylene glycol, glycerol formal, and combinations thereof. 3. The composition of claim 2, wherein the pharmaceutically acceptable solvent is a combination of propylene glycol and glycerol formal. 4. The composition of claim 1, wherein the concentration of florfenicol butyrate in the composition is at least about 200 mg/mL. 5. A method of treating a bacterial infection in a feline comprising injecting the feline with the pharmaceutical composition of claim 1. 6. A method of treating a bacterial infection in a feline comprising injecting the feline with the pharmaceutical composition of claim 2. 7. A method of treating a bacterial infection in a feline comprising injecting the feline with the pharmaceutical composition of claim 3. 8. A method of treating a bacterial infection in a feline comprising injecting the feline with the pharmaceutical composition of claim 4. 9. The pharmaceutical composition of claim 1, wherein the solvent is selected from the group consisting of propylene glycol, glycerol formal, N-methyl pyrrolidone, and combinations thereof. 10. The pharmaceutical composition of claim 9, wherein the solvent is a combination of propylene glycol, glycerol formal, and N-methyl pyrrolidone. 11. The pharmaceutical composition of claim 9, wherein the solvent is a combination of propylene glycol and N-methyl pyrrolidone. 12. The pharmaceutical composition of claim 9, wherein the solvent is a combination of glycerol formal and N-methyl pyrrolidone. 13. The pharmaceutical composition of claim 1, wherein the solvent is selected from the group consisting of tetrahydrofurfuryl alcohol, N-methyl pyrrolidone, and combinations thereof. 14. The pharmaceutical composition of claim 13, wherein the solvent is a combination of tetrahydrofurfuryl alcohol and N-methyl pyrrolidone. 15. The pharmaceutical composition of claim 1, wherein the solvent is selected from the group consisting of propylene glycol, glycerol formal, N-methyl pyrrolidone, polyethylene glycol, and combinations thereof. 16. The pharmaceutical composition of claim 15, wherein the solvent is a combination of polyethylene glycol and N-methyl pyrrolidone. 17. The pharmaceutical composition of claim 15, wherein the solvent is a combination of polyethylene glycol and glycerol formal. 18. The pharmaceutical composition of claim 15, wherein the solvent is a combination of polyethylene glycol and propylene glycol. 19. The pharmaceutical composition of claim 15, wherein the solvent is a combination of polyethylene glycol, propylene glycol, and N-methyl pyrrolidone.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (20)
Nagabhushan Tattanahalli L. (Parsippany NJ), 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their manufacture and intermediates useful therein, methods.
Nagabhushan Tattanhalli L. (Parsippany NJ), 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful.
Nagabhushan Tattanahalli L. (Parsippany NJ), 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor.
Or Yat Sun ; Ma Zhenkun ; Clark Richard F. ; Chu Daniel T. ; Plattner Jacob J. ; Griesgraber George, 6-O-substituted ketolides having antibacterial activity.
Wu Guang-Zhong (Somerville NJ) Tormos Wanda I. (Elizabeth NJ), Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates.
Camaggi Giovanni (Novara ITX) Chiarino Dario (Monza ITX) Fantucci Mario (Milan ITX) Meazza Giovanni (Saronno ITX), Compositions having herbicidal activity containing N-alkyl-amides as active ingredient.
Schumacher Doris P. (Floraham Park NJ) Clark Jon E. (Highland Park NJ) Murphy Bruce L. (Glen Ridge NJ), Pressurized fluorination of hydroxy alkyl groups.
Clark Jon E. (Highland Park NJ) Schumacher Doris P. (Florham Park NJ) Wu Guang-Zhong (Somerville NJ), Process for preparing florfenicol, its analogs and oxazoline intermediates thereto.
Schoenleber Robert W. (Deerfield IL) Ehrlich Paul P. (Evanston IL) Kebabian John W. (Lake Bluff IL) Campbell James R. (Ft. Sheridan IL), Tetracyclic spirobenzazepine dopamine antagonists.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.