Stable bicarbonate-based solution in a single container
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-033/00
A61K-031/047
A61K-031/045
A61K-031/195
A61K-031/185
A61K-031/7004
A61P-007/08
A61P-007/00
B01D-061/24
출원번호
US-0165482
(2002-06-07)
등록번호
US-7445801
(2008-11-04)
발명자
/ 주소
Faict,Dirk
Duponchelle,Annick
Taminne,Michel
Balteau,Patrick
Peluso,Francesco
출원인 / 주소
Baxter International Inc.
Baxter Healthcare S.A
대리인 / 주소
Kelly,Paula J.
인용정보
피인용 횟수 :
6인용 특허 :
40
초록▼
Stable single bicarbonate-based solutions are provided. The bicarbonate-based single solution of the present invention includes at least calcium and bicarbonate and is stored or packaged in a sterile manner within a container with a gas barrier. The single solutions of the present invention can rema
Stable single bicarbonate-based solutions are provided. The bicarbonate-based single solution of the present invention includes at least calcium and bicarbonate and is stored or packaged in a sterile manner within a container with a gas barrier. The single solutions of the present invention can remain stable for three months or more. In this regard, the stable and single bicarbonate-based solutions of the present invention can be readily and effectively used during medical therapy, such as dialysis therapy.
대표청구항▼
The invention is claimed as follows: 1. A container including a bicarbonate-based solution comprising: a single solution comprising about 0 g/L to about 100 g/L of an osmotic agent, about 1 mmol/L to about 45 mmol/L of bicarbonate, about 0.1 mmol/L to about 2.5 mmol/L of calcium, 100 mmol/L to abou
The invention is claimed as follows: 1. A container including a bicarbonate-based solution comprising: a single solution comprising about 0 g/L to about 100 g/L of an osmotic agent, about 1 mmol/L to about 45 mmol/L of bicarbonate, about 0.1 mmol/L to about 2.5 mmol/L of calcium, 100 mmol/L to about 150 mmol/L of sodium, about 0.2 mmol/L to about 1.0 mmol/L of magnesium, about 70 mmol/L to about 120 mmol/L of chloride, about 0 mmol/L to about 5 mmol/L of potassium, and stored in a single chamber of the container having a gas barrier that is not in a form of an over pouch, wherein the single solution is heat sterilized in the single chamber and remains stable at a pH ranging from about 6.9 to about 7.9 for at least three months after heat sterilization, wherein the pH is adjusted prior to heat sterilization, and wherein the single solution excludes organic acids except for amino acids. 2. The container of claim 1 wherein the amount of calcium is about 0.2 mmol/L to about 2 mmol/L. 3. The container of claim 1 wherein the bicarbonate-based solution comprises a dialysis solution. 4. The container of claim 1 wherein the bicarbonate-based solution comprises an infusion solution. 5. The container of claim 1 wherein the osmotic agent is selected from the group consisting of glycerol, an amino acid, glucose, and combinations thereof. 6. A method of providing a bicarbonate-based solution, the method comprising: forming a single solution comprising about 0 g/L to about 100 g/L of an osmotic agent, about 1 mmol/L to about 45 mmol/L of bicarbonate, about 0.1 mmol/L to about 2.5 mmol/L of calcium, about 100 mmol/L to about 150 mmol/L of sodium, about 0.2 mmol/L to about 1.0 mmol/L of magnesium, about 70 mmol/L to about 120 mmol/L of chloride, about 0 mmol/L to about 5 mmol/L of potassium, wherein the single solution excludes organic acids except for amino acids; and storing the single solution in a container having a gas barrier that is not in a form of an over pouch wherein the single solution is heat sterilized in a single chamber of the container, wherein the single solution remains stable for at least three months after heat sterilization at a pH ranging from about 6.9 to about 7.9, and wherein the pH is adjusted prior to heat sterilization. 7. The method of claim 6 wherein the single solution can be used during dialysis therapy. 8. The method of claim 6 wherein the single solution can be used during infusion therapy. 9. The method of claim 6 wherein the osmotic agent is selected from the group consisting of glycerol, an amino acid, glucose, and combinations thereof. 10. A method of storing a dialysis solution, the method comprising: preparing a single solution comprising about 0 g/L to about 100 g/L of an osmotic agent, about 1 mmol/L to about 45 mmol/L of bicarbonate, about 0.1 mmol/L to about 2.5 mmol/L of calcium, about 100 mmol/L to about 150 mmol/L of sodium, about 0.2 mmol/L to about 1.0 mmol/L of magnesium, about 70 mmol/L to about 120 mmol/L of chloride, and about 0 mmol/L to about 5 mmol/L of potassium, wherein the single solution excludes organic acids except for amino acids; packaging the single solution in a container having a gas barrier that is not in a form of an over pouch, wherein the single solution is heat sterilized in a single chamber of the container; and storing the single solution in the container wherein the single solution remains stable at a pH that ranges from about 6.9 to about 7.9 in the container for at least 3 months prior to use, and wherein the pH is adjusted prior to heat sterilization. 11. The method of claim 10 wherein the single solution includes a dialysis solution. 12. The method of claim 10 wherein the single solution includes an infusion solution. 13. The method of claim 10 wherein the osmotic agent is selected from the group consisting of glycerol, an amino acid, glucose, and combinations thereof. 14. A method of providing dialysis therapy to a patient, the method comprising: providing a dialysis solution that does not require admixing, the dialysis solution comprising about 0 g/L to about 100 g/L of an osmotic agent, about 1 mmol/L to about 45 mmol/L of bicarbonate, about 0.1 mmol/L to about 2.5 mmol/L of calcium, about 0 mmol/L to about 5 mmol/L of potassium, about 100 mmol/L to about 150 mmol/L of sodium, about 0.2 mmol/L to about 1.0 mmol/L of magnesium, and about 70 mmol/L to about 120 mmol/L of chloride, wherein the dialysis solution is stored in a container having a gas barrier that is not in a form of an over pouch, wherein the dialysis solution is heat sterilized in a single chamber of the container and remains stable for at least three months at a pH ranging from about 6.9 to about 7.9, wherein the pH is adjusted prior to heat sterilization, and wherein the dialysis solution excludes organic acids except for amino acids; and providing a therapeutically effective amount of the dialysis solution to a patient in need of same. 15. The method of claim 14 wherein the dialysis solution is used during dialysis therapy selected from the group consisting of hemodialysis, hemofiltration, hemodiafiltration, peritoneal dialysis and continuous renal replacement therapy. 16. The method of claim 14 wherein the dialysis solution is used as a dialysate. 17. The method of claim 14 wherein the dialysis solution is infused into the patient as an infusion solution. 18. The method of claim 14 wherein the osmotic agent is selected from the group consisting of glycerol, an amino acid, glucose, and combinations thereof.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (40)
Steudle Volker (Giessen DEX) Bartz Volker (Giessen DEX), Aqueous dialysis and rinsing solution for intraperitoneal administration.
Richmond Frank M. (Harvard IL) Larson Kenneth W. (Libertyville IL) Miller Robert A. (Schaumburg IL), Collapsible multi-chamber medical fluid container.
Gilchrist Thomas,GB6 ; Manson William,GB6, Dialysis fluid containing peptides obtained from casein as osmotic agents and bicarbonate ions as buffering agents and.
Faict Dirk (Assenede B BEX) Peluso Francesco (Heverlee BEX) Balteau Patrick (Saint Georges Sur Meuse BEX), Histidine buffered peritoneal dialysis solution.
Dadson Joseph E. (7 Harrow Smith Place Richmond Hill ; Ontario CAX L4E 2E1) Agarwal Mahesh (7 Grant\s Place Markham ; Ontario CAX L3S 2W2), Method and apparatus for performing peritoneal dialysis.
Oliver James C. (3989 Garfield Rd. Stone Mountain GA 30083) Oettinger Carl W. (747 Houston Mill Rd. NE. Atlanta GA 30329), Method and apparatus for storing bicarbonate dialysate.
Inoue Fujio (Naruto JPX) Izumi Masamitsu (Naruto JPX) Hayashi Satoru (Tokushima-ken JPX), Package form for bicarbonate-containing powdery pharmaceutical compositions and a method of stabilizing the compositions.
Miller Robert A. (Crystal Lake IL) Larson Kenneth W. (Keene NH) Schopen Joseph L. (Crystal Lake IL), Process and apparatus for compounding hyperalimentation solutions.
Page Roger E. (Hayling Island GBX) Morris Keith S. (Emsworth GBX) Lowe Graham D. (Hayling Island GBX) Matkovich Vlado I. (Glen Cove NY), Process and apparatus for removal of unwanted fluids from processed blood products.
Bunke Paul Ralph ; Ekanayake Athula ; Smith Kenneth Thomas, Shelf-stable complete pre-mixes that are combinable to form ready-to-cook mixes or food beverage products.
Jonsson Sven (Staffanstorp SEX) Kjellstrand Per (Sodra Sandby SEX) Martinson Evi (Sodra Sandby SEX) Wieslander Anders (Lund SEX) Svensson Eva (Malmo SEX) Andren Anders (Malmo SEX), System employing a sterile medical solution containing glucose or glucose-like compounds and a solution intended for sai.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.