IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0681899
(2003-10-10)
|
등록번호 |
US-7448389
(2008-11-11)
|
발명자
/ 주소 |
- Kotha,Sanjay
- Sudarshan,Tirumalai S.
|
출원인 / 주소 |
- Materials Modification, Inc.
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
137 |
초록
A method and kit for inducing hypoxia in tumors includes impeding oxygen supply to non-hypoxic cells in a subject in need thereof by using a magnetic fluid.
대표청구항
▼
What is claimed is: 1. A method of inducing hypoxia in a non-hypoxic region of a tumor, comprising the steps of: a) administering a magnetic fluid in a subject in need thereof through a blood vessel feeding a tumor; and b) applying a magnetic field adjacent the tumor to join a plurality of particle
What is claimed is: 1. A method of inducing hypoxia in a non-hypoxic region of a tumor, comprising the steps of: a) administering a magnetic fluid in a subject in need thereof through a blood vessel feeding a tumor; and b) applying a magnetic field adjacent the tumor to join a plurality of particles in the magnetic fluid to form a blockage in the blood vessel thereby impeding the flow of blood to the tumor. 2. The method of claim 1, wherein: the magnetic fluid in step a) is delivered through a catheter or by injection. 3. The method of claim 1, wherein: the magnetic field in step b) is applied by an internal micromagnet, an external rare earth magnet, or an external electromagnet. 4. The method of claim 1, wherein: the magnetic fluid comprises core particles of a magnetic material. 5. The method of claim 4, wherein: the core particles comprise coated particles. 6. The method of claim 4, wherein: the core particles have an average diameter of about 1 nm to 20 μm. 7. The method of claim 6, wherein: the core particles have an average diameter of about 10 nm to 5 μm. 8. The method of claim 7, wherein: the core particles have an average diameter of about 10 nm to 1,000 nm. 9. The method of claim 6, wherein: the core particles are dispersed in a carrier fluid. 10. The method of claim 9, wherein: the carrier fluid comprises a water-based carrier fluid. 11. The method of claim 9, wherein: the carrier fluid is selected from the group consisting of water, Ringer's solution, normal saline, sugar solution, blood plasma, and a combination thereof. 12. The method of claim 9, wherein: the fraction of the core particles is about 1-90%. 13. The method of claim 6, wherein: the core particles comprise a general shape selected from the group consisting of spherical, needle-like, cubic, irregular, cylindrical, diamond, oval, and a combination thereof. 14. The method of claim 4, wherein: the magnetic material is selected from the group consisting of iron, iron oxide, cobalt, cobalt oxide, nickel, nickel oxide, an alloy, and a combination thereof. 15. The method of claim 4, wherein: the core particles comprise a coating of a surfactant. 16. The method of claim 15, wherein: the surfactant is selected from the group consisting of polyethylene oxide, dextran, polyoxypropylene-polyoxyethylene block copolymer, and a combination thereof. 17. The method of claim 4, wherein: the core particles comprise a coating selected from the group consisting of a ceramic material, a metallic material, a polymer material, and a combination thereof. 18. The method of claim 17, wherein: the coating is selected from the group consisting of silica, gold, silver, platinum, steel, cobalt, carbon, polyethylene glycol, dextran, polyoxyethylene sorbitol ester, sorbitol, mannitol, and a combination thereof. 19. The method of claim 4, wherein: the core particles comprise first and second successive coatings. 20. The method of claim 19, wherein: the first coating comprises a coating of a surfactant; and the second coating comprises a coating of a material selected from the group consisting of a ceramic material, a metallic material, a polymer material, and a combination thereof. 21. The method of claim 20, wherein: the surfactant is selected from the group consisting of polyethylene oxide, dextran, polyoxypropylene-polyoxyethylene block copolymer, and a combination thereof. 22. The method of claim 21, wherein: the second coating is selected from the group consisting of silica, gold, silver, platinum, steel, cobalt, carbon, polyethylene glycol, dextran, polyoxyethylene sorbitol ester, sorbitol, mannitol, and a combination thereof. 23. A method of treating a tumor, comprising the steps of: a) administering a magnetic fluid in a subject in need thereof through a blood vessel feeding a tumor; b) applying a magnetic field adjacent the tumor to join a plurality of particles in the magnetic fluid to form a blockage in the blood vessel thereby impeding the flow of blood to the tumor; and c) continuing with step b) for a sufficient time to induce hypoxia in a non-hypoxic region of the tumor. 24. The method of claim 23, further comprising the step of: d) administering a hypoxic drug prior to or after step a), or substantially simultaneously therewith. 25. The method of claim 24, wherein: the hypoxic drug is selected from the group consisting of AQ4N, mitomycin C, porfiromycin, and tirapazamine. 26. The method of claim 24, wherein: the hypoxic drug is administered through a catheter, by injection, or intravenously. 27. The method of claim 23, wherein: the magnetic fluid is delivered through a catheter or by injection. 28. The method of claim 23, wherein: the magnetic field is applied by an internal micromagnet, an external rare earth magnet, or an external electromagnet. 29. The method of claim 23, wherein: the magnetic fluid comprises core particles of a magnetic material. 30. The method of claim 29, wherein: the core particles comprise coated particles. 31. The method of claim 29, wherein: the core particles have an average diameter of about 1 nm to 20 μm. 32. The method of claim 31, wherein: the core particles have an average diameter of about 10 nm to 5 μm. 33. The method of claim 32, wherein: the core particles have an average diameter of about 10 nm to 1,000 nm. 34. The method of claim 31, wherein: the core particles are dispersed in a carrier fluid. 35. The method of claim 34, wherein: the carrier fluid comprises a water-based carrier fluid. 36. The method of claim 34, wherein: the carrier fluid is selected from the group consisting of water, Ringer's solution, normal saline, sugar solution, blood plasma, and a combination thereof. 37. The method of claim 34, wherein: the fraction of the core particles is about 1-90%. 38. The method of claim 31, wherein: the core particles comprise a general shape selected from the group consisting of spherical, needle-like, cubic, irregular, cylindrical, diamond, oval, and a combination thereof. 39. The method of claim 29, wherein: the magnetic material is selected from the group consisting of iron, iron oxide, cobalt, cobalt oxide, nickel, nickel oxide, an alloy, and a combination thereof. 40. The method of claim 29, wherein: the core particles comprise a coating of a surfactant. 41. The method of claim 40, wherein: the surfactant is selected from the group consisting of polyethylene oxide, dextran, polyoxyethylene sorbitol ester, and a combination thereof. 42. The method of claim 29, wherein: the core particles comprise a coating selected from the group consisting of a ceramic material, a metallic material, a polymer material, and a combination thereof. 43. The method of claim 42, wherein: the coating is selected from the group consisting of silica, gold, silver, platinum, steel, cobalt, carbon, polyethylene glycol, dextran, polyoxyethylene sorbitol ester, sorbitol, mannitol, and a combination thereof. 44. The method of claim 29, wherein: the core particles comprise first and second successive coatings. 45. The method of claim 44, wherein: the first coating comprises a coating of a surfactant; and the second coating comprises a coating of a material selected from the group consisting of a ceramic material, a metallic material, a polymer material, and a combination thereof. 46. The method of claim 45, wherein: the surfactant is selected from the group consisting of polyethylene oxide, dextran, polyoxypropylene-polyoxyethylene block copolymer, and a combination thereof. 47. The method of claim 46, wherein: the second coating is selected from the group consisting of silica, gold, silver, platinum, steel, cobalt, carbon, polyethylene glycol, dextran, polyoxyethylene sorbitol ester, sorbitol, mannitol, and a combination thereof.
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