IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
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출원번호 |
US-0140265
(2005-05-27)
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등록번호 |
US-7463761
(2008-12-09)
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발명자
/ 주소 |
- Eichhorn,Ole
- Crandall,Greg
- Hashagen,Steven
- Soenksen,Dirk
- Wrenn,Mark
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출원인 / 주소 |
- Aperio Technologies, Inc.
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
18 인용 특허 :
47 |
초록
▼
Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images
Systems and methods for creating and viewing three dimensional virtual slides are provided. One or more microscope slides are positioned in an image acquisition device that scans the specimens on the slides and makes two dimensional images at a medium or high resolution. This two dimensional images are provided to an image viewing workstation where they are viewed by an operator who pans and zooms the two dimensional image and selects an area of interest for scanning at multiple depth levels (Z-planes). The image acquisition device receives a set of parameters for the multiple depth level scan, including a location and a depth. The image acquisition device then scans the specimen at the location in a series of Z-plane images, where each Z-plane image corresponds to a depth level portion of the specimen within the depth parameter.
대표청구항
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The invention claimed is: 1. A system for creating and viewing three dimensional virtual microscope slides, comprising: an image acquisition device configured to scan a microscope slide and create a digital image of a specimen on the microscope slide; an image data server communicatively coupled wi
The invention claimed is: 1. A system for creating and viewing three dimensional virtual microscope slides, comprising: an image acquisition device configured to scan a microscope slide and create a digital image of a specimen on the microscope slide; an image data server communicatively coupled with the image acquisition device, the image data server configured to receive virtual microscope slide images from the image acquisition device, store the virtual microscope slide images, and provide the virtual microscope slide images upon request; an image viewing workstation communicatively coupled with the image acquisition device and the image data server, the image viewing workstation configured to display a two dimensional image of a specimen on a microscope slide in the image acquisition device, receive commands from an operator, and in cooperation with the image data server, allow the operator to pan said two dimensional image; the image viewing workstation further configured to receive a set of three dimensional scan parameters from the operator, said set including location, length, width, depth, number of Z-planes, and spacing between Z-planes and in response to receiving said parameters, instruct the image acquisition device to capture a Z-stack of images corresponding to said parameters from the specimen on the microscope slide; wherein the image data server is further configured to store said Z-stack of images with said two dimensional image to create a three dimensional virtual microscope slide. 2. The system of claim 1, wherein the image viewing workstation further comprises a Z-plane access module configured to present to a user one or more Z-plane images of a Z-stack in response to a request from the user for said one or more Z-plane images. 3. The system of claim 2, wherein the image viewing workstation integrates the display of one or more Z-plane images of a Z-stack into the display of a two dimensional view of the entire slide. 4. The system of claim 1, wherein the instruction from the image viewing workstation to the image acquisition device includes a set of three dimensional scan parameters comprising length, width and depth. 5. The system of claim 4, wherein the set of three dimensional scan parameters further comprises a number of Z-planes and a spacing between Z-planes. 6. A computer implemented method for creating and viewing three dimensional virtual microscope slides, comprising: orienting a microscope slide on a stage of an image acquisition device configured to scan the microscope slide and create a digital image of a specimen on the microscope slide; scanning a first two dimensional image of the specimen at a first resolution; providing the two dimensional image to an image viewing device; receiving a set of revisit parameters from the image viewing device, the set of revisit parameters comprising a first location; scanning a second two dimensional image of the specimen at the first location at a second resolution that is higher than the first resolution; providing the second two dimensional image to the image viewing device; receiving a set of three dimensional scan parameters from the image viewing device, the set of revisit parameters comprising a length, width, and depth; scanning a three dimensional Z-stack in accordance with the length, width, and depth, the Z-stack comprising a plurality of Z-plane images, each Z-plane image corresponding to a portion of the specimen in said depth; and storing the two dimensional image and the three dimensional Z-stack together as a three dimensional virtual microscope slide. 7. The method of claim 6, further comprising presenting the three dimensional virtual microscope slide on the display of an image viewing workstation. 8. The method of claim 7, further comprising presenting one or more Z-plane images of a Z-stack on the display of the image viewing workstation in response to a request for said one or more Z-plane images. 9. The method of claim 8, further comprising integrating the presentation of one or more Z-plane images of a Z-stack into the presentation of a two dimensional view of the entire slide. 10. A system for creating and viewing three dimensional virtual microscope slides, comprising: an image acquisition device configured to scan a microscope slide and create a digital image of a specimen on the microscope slide, wherein portions of said digital image comprise a Z-stack including a plurality of images from the specimen that create a three dimensional virtual microscope slide; an image data server communicatively coupled with the image acquisition device, the image data server configured to receive a three dimensional virtual microscope slide from the image acquisition device, store the three dimensional virtual microscope slide, and provide image data from the three dimensional virtual microscope slide upon request; an image viewing workstation communicatively coupled with the image acquisition device and the image data server, the image viewing workstation configured to interpolate and display an image at a first focus depth level in a Z-stack, wherein said first focus depth level does not correspond to the focus depth level of any of the plurality of images in the Z-stack. 11. A computer implemented method for creating and viewing three dimensional virtual microscope slides, comprising: scanning a two dimensional image of a specimen at a high resolution; receiving a set of three dimensional scan parameters comprising length, width, and depth; scanning a three dimensional Z-stack in accordance with the length, width, and depth, the Z-stack comprising a plurality of Z-plane images wherein each Z-plane image corresponds to a portion of the specimen in said depth; combining the two dimensional image and the Z-stack to form a three dimensional virtual microscope slide image; storing the three dimensional virtual microscope slide; interpolating a first Z-plane image that does not correspond to any Z-plane image in the Z-stack; and providing the first Z-plane image to an image viewing device.
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