Methods of treating conditions with a metal-containing material
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/14
A61K-031/28
A61K-033/24
A61K-033/38
A61P-001/00
출원번호
US-0985204
(2004-11-10)
등록번호
US-7470437
(2008-12-30)
발명자
/ 주소
Burrell,Robert E.
Wright,John B.
Lam,Kan
Naylor,Antony G.
Moxham,Peter H.
Gillis,Scott H.
Schechter,Paul
출원인 / 주소
Nucryst Pharmaceuticals Corp.
대리인 / 주소
Fish & Richardson P.C.
인용정보
피인용 횟수 :
3인용 특허 :
77
초록▼
Methods of treating conditions with a metal-containing material are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apopt
Methods of treating conditions with a metal-containing material are disclosed. The metal-containing material can be, for example, an antimicrobial material, an antibacterial material, an anti-inflammatory material, an anti-fungal material, an anti-viral material, an anti-cancer material, a pro-apoptosis material, and/or an MMP modulating material. In certain embodiments, the metal-containing material is an atomically disordered, silver-containing material.
대표청구항▼
What is claimed is: 1. A method of treating a subject having a condition, comprising: contacting an inflamed or infected problem area of a mucosal membrane of the subject having the condition with a nanocrystalline silver-containing compound to provide a localized anti-inflammatory effect, the silv
What is claimed is: 1. A method of treating a subject having a condition, comprising: contacting an inflamed or infected problem area of a mucosal membrane of the subject having the condition with a nanocrystalline silver-containing compound to provide a localized anti-inflammatory effect, the silver-containing compound is characterized by sufficient atomic disorder so that the silver-containing compound, in contact with an alcohol or water-based electrolyte, releases atoms, ions, molecules, or clusters of the silver-containing compound on a sustainable basis and at a concentration sufficient to provide a localized anti-inflammatory effect or antimicrobial effect, wherein the condition is mucositis or stomatitis. 2. The method of claim 1, wherein the nanocrystalline silver-containing compound is further selected from the group consisting of silver oxides, silver nitrides, silver borides, silver halides, silver hydrides. 3. The method of claim 1, wherein the nanocrystalline silver-containing compound comprises an antimicrobial compound. 4. The method of claim 1, wherein, when contacted with the area of the subject having the condition, the nanocrystalline silver-containing compound is in a solution. 5. The method of claim 4, wherein the solution is injected. 6. The method of claim 5, wherein the solution is injected via a needleless injector. 7. The method of claim 5, wherein the solution is injected via a needle. 8. The method of claim 4, wherein the solution contains at least about 0.001 weight percent of the nanocrystalline silver-containing compound. 9. The method of claim 8, wherein the solution contains about 10 weight percent or less of the nanocrystalline silver-containing compound. 10. The method of claim 4, wherein the solution further comprises a solvent. 11. The method of claim 1, wherein, when contacted with the area of the subject having the condition, the nanocrystalline silver-containing compound is disposed in a pharmaceutically acceptable carrier. 12. The method of claim 11, wherein the composition contains at least about 0.01 weight percent of the nanocrystalline silver-containing compound. 13. The method of claim 12, wherein the composition contains about 50 weight percent or less of the nanocrystalline silver-containing compound. 14. The method of claim 11, wherein the pharmaceutically acceptable carrier is selected from the group consisting of creams, ointments, gels, lotions, pastes and foams. 15. The method of claim 1, wherein, when contacted with the area of the subject having the condition, the nanocrystalline silver-containing compound is in the form of a free-standing powder. 16. The method of claim 15, wherein the free-standing powder is injected. 17. The method of claim 1, wherein the condition is mucositis. 18. The method of claim 1, wherein the condition is stomatitis. 19. The method of claim 4, wherein the solution is contacted with the problem area as a rinse, wash, gargle, or drop. 20. The method of claim 1, wherein, when contacted with the subject having the condition, the nanocrystalline silver-containing compound is in a tape, pill, capsule, tablet, or lozenge.
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