Latex polymer particles containing fluorescent substance or contrast medium and process for producing the same
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C08F-012/04
C08F-012/00
출원번호
US-0539746
(2003-12-19)
등록번호
US-7470763
(2008-12-30)
우선권정보
JP-2002-368080(2002-12-19)
국제출원번호
PCT/JP03/016325
(2003-12-19)
§371/§102 date
20050620
(20050620)
국제공개번호
WO04/056894
(2004-07-08)
발명자
/ 주소
Shibata,Naoya
Nagasaki,Yukio
Kataoka,Kazunori
출원인 / 주소
Nanocarrier Co., Ltd.
대리인 / 주소
Wenderoth, Lind & Ponack, L.L.P.
인용정보
피인용 횟수 :
2인용 특허 :
3
초록▼
This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show de
This invention provides a method to effectively incorporate inorganic fluorescent substance or inorganic contrast medium into latex polymer particles which are used for diagnostic test or the like, and also provides thus produced fluorescent substance-containing latex polymer particles which show decreased non-specific adsorption of protein or the like. Said latex polymer particles are produced by making latex-forming monomer, macromer which has at least a hydrophilic polymer segment and an inorganic fluorescent substance or an inorganic contrast medium co-existent simultaneously in an aqueous medium, and subjecting them to a polymerization reaction.
대표청구항▼
The invention claimed is: 1. A process for producing fluorescent substance--or inorganic contrast medium--containing latex polymer particles, which comprises conducting a polymerization reaction in an aqueous medium while the aqueous medium is stirred, said aqueous medium comprising: (i) one or mor
The invention claimed is: 1. A process for producing fluorescent substance--or inorganic contrast medium--containing latex polymer particles, which comprises conducting a polymerization reaction in an aqueous medium while the aqueous medium is stirred, said aqueous medium comprising: (i) one or more latex-forming monomers, (ii) a macromer which has, on one terminal, a polymerizable ethylenic group and has, on the other terminal, a hydrophilic polymer segment which is linked or not linked by a hydrophobic polymer segment, (iii) a radical polymerization initiator, and (iv) an inorganic fluorescent substance or an inorganic contrast medium. 2. A process of claim 1 wherein hydrophilic polymer segment is originated from water-soluble polymer which is selected from the group consisting of poly(ethyleneglycol), poly(vinylalcohol), poly(vinylpyrrolidone), poly(dextran), poly(dextrin) and gelatin, and wherein hydrophobic polymer segment is originated from scarcely water-soluble polymer selected from the group consisting of poly(lactide), poly(ε-caprolactone), poly(α-and/or β-benzyl aspartic acid) and poly(γ-benzyl glutamic acid). 3. A process of claim 1 wherein macromer has no hydrophobic polymer segment, and wherein hydrophilic polymer segment is originated from poly(ethyleneglycol). 4. A process of claim 1 wherein macromer is of two or more kinds each of which has no hydrophobic polymer segment, and each of which has, at the other terminal, a poly(ethyleneglycol) segment which carries a group selected from the group consisting of hydroxyl group, carboxyl group, aldehyde group, amino group, imino group, mercapto group, active ester-type protected hydroxyl group, active ester-type protected carboxyl group, acetal-type protected aldehyde group, organic sulfonyl-protected hydroxyl group, reactivity-protected amino group and C1-C4 alkoxyl group. 5. A process of claim 1 wherein there are two macromers, the first macromer having no hydrophobic polymer segment, and having, at the other terminal, a poly(ethyleneglycol) segment which carries a group selected from the group consisting of hydroxyl group and C1-C4 alkoxyl group, the second macromer having no hydrophobic polymer segment, and having, at the other terminal, a poly(ethyleneglycol) segment which carries a group selected from the group consisting of carboxyl group, aldehyde group, amino group, imino group, mercapto group, active ester-type protected hydroxyl group, active ester-type protected carboxyl group, acetal-type protected aldehyde group, reactivity-protected amino group and organic sulfonyl-protected hydroxyl group, said segment of the first macromer having a chain length which is the same as, or shorter than, the chain length of said segment of the second macromer, and the molar proportion of the first macromer to the second macromer ranging from 1:5000 to 5000:1. 6. A process of claim 5 wherein the number of recurring unit of ethyleneglycol in the first macromer is an integer of 5 to 1200, the number of recurring unit of ethyleneglycol in the second macromer is an integer of 5 to 1200, and wherein the number of the first macromer recurring unit is the same as, or smaller than, the number of the second macromer recurring unit. 7. A process of any one of claims 1 to 5 wherein one or more kinds of latex-forming monomers are selected from the group consisting of styrene, α-methylstyrene, p-bromostyrene, vinyltoluene, 1-vinylnaphthalene, C1-C4 alkyl (meth)acrylate and divinyl benzene. 8. A process of claim 1 wherein inorganic fluorescent substance and inorganic contrast medium are in the form of chelate compound. 9. A process of claim 1 wherein macromer has general formula (I) as follows: wherein R denotes hydrogen atom or C1-C4 alkyl group; L1 denotes a linking group comprising a portion other than vinyl group of radically polymerizable monomer; B denotes a moiety of a structure selected from the following: L2 denotes a linking group comprising oxygen atom, C1-C4 alkylene, carbonyl, imino, or a combination of at least two thereof; X denotes hydrogen atom, C1-C4 alkyl, C1-C4 alkylenecarboxyl, C1-C4 alkylenecarboxyl ester, C1-C4 alkylenecarboxylic acid halide, C1-C4 alkyleneamino, C1-C4 alkylenemercapto, C1-C4 alkyleneacetal, C1-C4 alkyleneoxycarbonylimidazol; m denotes an integer of 0 to 500, and n denotes an integer of 5 to 1200.
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이 특허에 인용된 특허 (3)
Kataoka, Kazunori; Nagasaki, Yukio; Shibata, Naoya; Hoshino, Nobuhiro, Core-shell particle including signal-generating substance enclosed therein and process for producing the same.
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Schaeffer James R. (Penfield NY) Chen Tsang J. (Rochester NY) Schen Michael A. (Wellsville NY), Stabilized fluorescent rare earth labels and labeled physiologically reactive species.
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